|
Name |
Accession |
Description |
Interval |
E-value |
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
110-776 |
1.60e-68 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 242.95 E-value: 1.60e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 110 RGHYIVKAGAGTGKTTTMINRImfLKHM-QGDLDLRSVVMITFTNEAAANMRSKLLEKLKN--------YYDLTKDKKYL 180
Cdd:COG1074 18 GGSVLVEASAGSGKTYTLVARY--LRLLlERGLDPEEILVVTFTRAAAAEMRERIRERLAEaadledpdLEELARARRRL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 181 EW-MEEAGRMFIGTIHSFA----REF-----------LVTEGQTLGFSRSME---VRSYKHERRRLIEKYIDQFSVEcPG 241
Cdd:COG1074 96 ARaLENLDRAAISTIHSFCqrllREFafeagldpnfeLLDDAEALLLEEAVDdllREAYAPLDALALARLLDAFGRD-DD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 242 --------IYERFRHIPHYQIIRSLIAMIEQLHNKSLS----VEAIGQLNFGTDSHGFHEFADyVIKHVIRELDEQKKTE 309
Cdd:COG1074 175 sleelllaLYKLRSRPDWLEELAELDEALEALREALLKakeaLAALREALAAAAAPLLAALLR-LLAAVLARYERRKRER 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 310 ETLEISDLISHLAS-LKNLPSDQLELSIR----YLFVDEFQDTDESQTAFISWLVEKY---GCQLFAVGDVKQSIYRFRG 381
Cdd:COG1074 254 GLLDFDDLLHRALRlLRDEDAPWVAERLReryrHILVDEFQDTSPLQWEILRRLAGEAladGRTLFLVGDPKQSIYRFRG 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 382 ADYTAFLQLQQQLETADQVyKEYSLQKNYRSSPTLLTQLNALFQK-WTKVVEKFPFDDTDKLIPAQEESCE------EGL 454
Cdd:COG1074 334 ADPELFLEARRALEGRVDG-ERLTLTTNFRSTPEVVDAVNALFAQlMGAGFGEIPYEPVEALRPGAYPAVElwplepDDV 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 455 VALDIDDVTLKYL---LRRLYREG--------------VVVLVRSNREVLEMVNRIENMGFFCEAAVSGTFYRSLPVREF 517
Cdd:COG1074 413 SEEDAREREARAVaarIRRLLAEGttvegggrpvrpgdIAVLVRTRSEAAAIARALKAAGIPVAASDRLSLFESPEVRDL 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 518 YLLIRRFTHPyvpkdrylfhqssygENELTIAKVLsaYTPEMPF----ILDLLQT------FDNMKRWECQWNTSSALAV 587
Cdd:COG1074 493 LALLRALLNP---------------EDDLALAAVL--RSPLFGLsdedLAALAADrkgeslWEALRAYERLARALERLRA 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 588 LQNIIDEVRPHEVFR-----LRYYNQLRSRfPDGDVEMHRkeaiakmkeyKMNLDRLIFFIKKEFGDFRASFYDLEKFLA 662
Cdd:COG1074 556 LRELARRLGLAELLErlleeTGLLERLLAL-PGGERRLAN----------LLHLDELLQLALEYEQTGGPGLAGFLRWLE 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 663 IKMATDTLENELKITSGVNhRIKVMTVHKAKGLEFDYVLMPltrhpfmkqgktdvmlisdraqwklgysihwddmefenn 742
Cdd:COG1074 625 RLIEDGGDEEKRRLESDAD-AVRIMTIHKSKGLEFPVVFLP--------------------------------------- 664
|
730 740 750
....*....|....*....|....*....|....
gi 2750086525 743 yynEYARSEKKELIGEEARLLYVALTRARKAVYV 776
Cdd:COG1074 665 ---ALRERARAEELAEELRLLYVALTRARDRLVL 695
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
107-392 |
6.05e-41 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 151.24 E-value: 6.05e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 107 AYDRGHYIVKAGAGTGKTTTMINRIMFLKHmQGDLDLRSVVMITFTNEAAANMRSKLLEKLKNYydltkdkkylewmeEA 186
Cdd:pfam00580 10 THLGGPLLVLAGAGSGKTRVLTERIAYLIL-EGGIDPEEILAVTFTNKAAREMKERILKLLGKA--------------EL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 187 GRMFIGTIHSFAREFLVTEGQTLGFSRSMEVRSYkHERRRLIEKYIDQFSVECPgiyerfrhiPHYQIIRSLIAMIEQLH 266
Cdd:pfam00580 75 SELNISTFHSFCLRILRKYANRIGLLPNFSILDE-LDQLALLKELLEKDRLNLD---------PKLLRKLELKELISKAK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 267 NKSLSVEAIGQlnfgtdshGFHEFADYVIKHVIRELDEQKKTEETLEISDLISHLASLKNLPSDQLEL---SIRYLFVDE 343
Cdd:pfam00580 145 NRLLSPEELQQ--------GAADPRDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAyreRFKYILVDE 216
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2750086525 344 FQDTDESQTAFISWLVEKyGCQLFAVGDVKQSIYRFRGADYTAFLQLQQ 392
Cdd:pfam00580 217 FQDTNPIQYRLLKLLAGG-HENLFLVGDPDQSIYGFRGADIENILKFEK 264
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
111-410 |
2.66e-32 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 123.78 E-value: 2.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 111 GHYIVKAGAGTGKTTTMINRIMFLKHmQGDLDLRSVVMITFTNEAAANMRSKLLEKLKNyydltkdkkylewmEEAGRMF 190
Cdd:cd17932 13 GPLLVLAGAGSGKTRVLTHRIAYLIL-EGGVPPERILAVTFTNKAAKEMRERLRKLLGE--------------QLASGVW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 191 IGTIHSFAreflvtegqtlgfsrsmevrsykherrrliekyidqfsvecpgiyerfrhiphYQIIRsliamieqlhnksl 270
Cdd:cd17932 78 IGTFHSFA-----------------------------------------------------LRILR-------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 271 sveaigqlnfgtdshgfhEFADYvikhvireldeqkkteetleiSDLISHLASLKNLPSDQLEL---SIRYLFVDEFQDT 347
Cdd:cd17932 91 ------------------RYGDF---------------------DDLLLYALELLEENPDVREKlqsRFRYILVDEYQDT 131
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2750086525 348 DESQTAFISWLVEKyGCQLFAVGDVKQSIYRFRGADYTAFLQLQQQLETAdqvyKEYSLQKNY 410
Cdd:cd17932 132 NPLQYELLKLLAGD-GKNLFVVGDDDQSIYGFRGADPENILDFEKDFPDA----KVIKLEENY 189
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
111-776 |
1.18e-30 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 129.86 E-value: 1.18e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 111 GHYIVKAGAGTGKTTTMINRIMFLKHMQGDLDLRSVVMITFTNEAAANMRSKLLEKLKNYYDL----------------- 173
Cdd:TIGR00609 10 GTFLIEASAGTGKTFTIAQLYLRLLLEGGPLTVEEILVVTFTNAATEELKTRIRGRIHQALRAlkaaltsqelpeplkea 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 174 ----------TKDKKYLEWMEEAGrmfIGTIHSFAR---------------EFLVTEGQTLgfsRSMEVRSYKHER---- 224
Cdd:TIGR00609 90 iqdekvkqaiTRLRNALATMDEAA---IYTIHGFCQrmleqhafesdeifdVELIEDESLL---LAEITKDFWRRNfynl 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 225 RRLIEKYIDQ--------FSVECPGI----YERFRHIP---------HYQIIRSLIAMIEQLHNKSLSVEAIGQLNFGTD 283
Cdd:TIGR00609 164 PFDIAQIVLKtkkspqavLTQILADLllqsYLAFPSPPldleqlikwHEQIYKDLDKLDHAVFEEIDKLNAERNNLFCLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 284 SHGFHEFADYVIKHVIREldeqKKTEETLEISDLISHLAS-LKNLPSDQLELSIR----YLFVDEFQDTDESQTAFIS-- 356
Cdd:TIGR00609 244 DRVFLTLLKEVQEELKKE----KKRRREIGFDDLLSRLETaLKSAEGEKLAQAIReqypIALIDEFQDTDPQQYRIFSkl 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 357 WLVEKYGcQLFAVGDVKQSIYRFRGADYTAFLQlqqqleTADQVYKEYSLQKNYRSSPTLLTQLNALFQK---------- 426
Cdd:TIGR00609 320 FIAQKET-SLFLIGDPKQAIYSFRGADIFTYLQ------AKSKADARYTLGTNWRSTPALVGSLNKLFSLisnpflekpi 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 427 ---------------WTKVVEKFPFddtdKLIPAQEESCEEGLVALDIDDVT---LKYLL----------------RRLY 472
Cdd:TIGR00609 393 fipvlahqknskgsfVINGQEQPPI----HFFTTEVESEGVDDYRQTIAQKCareIALWLasaalglanfiatfggRPLR 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 473 REGVVVLVRSNREVLEMVNRIENMGFfceAAV----SGTFYRSLPVREFYLLIRRFTHPYVPKD-RYLFHQSSYGENelt 547
Cdd:TIGR00609 469 AGDIAVLVRGRKEANQIRKALKKAQI---PSVylsdKSSVFATEEAQELLALLEALLEPENEGTlRAALASSIFGLS--- 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 548 iAKVLSAYTPEMPFILDLLQTFDNMKRWecqWNTSSALAVLQNIIDEvrpHEVfrlryYNQLRSRfPDGDVEMhrkeaia 627
Cdd:TIGR00609 543 -ALELETLNQDEITWERVVEKFREYHDI---WRKIGVLAMFQRLMLE---KGI-----GERLLSQ-PGGERIL------- 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 628 kmkeykMNLDRLIFFIKKEFGDFRASFYDLEKFLAIKMATDTLENELKITSGVNHRIKVMTVHKAKGLEFDYVLMPLTrH 707
Cdd:TIGR00609 603 ------TNLLHLAELLQEAAHQERNKLSLLRWLEDQISNEEEEEEEIIRLESDAELVKIVTIHKSKGLEYPIVFLPFI-T 675
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 708 PFMKqgktdvmliSDRAQWK-LGYSIHWDDMEFENNYYNEYARSEKkelIGEEARLLYVALTRARKAVYV 776
Cdd:TIGR00609 676 DAKK---------SNFASLHdQHSHEYQLYDFNQSEENQKLARVER---LAEDLRLLYVALTRAKKQLFI 733
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
111-493 |
1.59e-20 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 96.83 E-value: 1.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 111 GHYIVKAGAGTGKTTTMINRIMFLKHMQGdLDLRSVVMITFTNEAAANMRSKLLEKLKNyydltkdkkylewmEEAGRMF 190
Cdd:PRK10919 16 GPCLVLAGAGSGKTRVITNKIAHLIRGCG-YQARHIAAVTFTNKAAREMKERVAQTLGR--------------KEARGLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 191 IGTIHSFAREFLVTEGQTLGFSRSMEVRSYKHER---RRLIEKYIDQFSVecpgiyerfrhiphyqIIRSLIAMIEQLHN 267
Cdd:PRK10919 81 ISTFHTLGLDIIKREYAALGMKSNFSLFDDTDQLallKELTEGLIEDDKV----------------LLQQLISTISNWKN 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 268 KSLSVEAIGQLNFGTDSHGFhefadyviKHVIRELDEQKKTEETLEISDLIS--HLASLKNLP-SDQLELSIRYLFVDEF 344
Cdd:PRK10919 145 DLKTPAQAAAGAKGERDRIF--------AHCYGLYDAHLKACNVLDFDDLILlpTLLLQRNEEvRERWQNKIRYLLVDEY 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 345 QDTDESQTAFISWLVEKYGcQLFAVGDVKQSIYRFRGADYTAFLQLQQQLeTADQVYKeysLQKNYRSSPTLLTQLNALF 424
Cdd:PRK10919 217 QDTNTSQYELVKLLVGSRA-RFTVVGDDDQSIYSWRGARPQNLVLLSQDF-PALQVIK---LEQNYRSSGRILKAANILI 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2750086525 425 QKWTKVVEKFPFD-----DTDKLIPAQEESCEEGLValdIDDVTLKYLLRRLYREGVVVLVRSNR-----EVLEMVNRI 493
Cdd:PRK10919 292 ANNPHVFEKRLFSelgygDELKVLSANNEEHEAERV---TGELIAHHFVNKTQYKDYAILYRGNHqsrvfEKFLMQNRI 367
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
110-776 |
1.60e-68 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 242.95 E-value: 1.60e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 110 RGHYIVKAGAGTGKTTTMINRImfLKHM-QGDLDLRSVVMITFTNEAAANMRSKLLEKLKN--------YYDLTKDKKYL 180
Cdd:COG1074 18 GGSVLVEASAGSGKTYTLVARY--LRLLlERGLDPEEILVVTFTRAAAAEMRERIRERLAEaadledpdLEELARARRRL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 181 EW-MEEAGRMFIGTIHSFA----REF-----------LVTEGQTLGFSRSME---VRSYKHERRRLIEKYIDQFSVEcPG 241
Cdd:COG1074 96 ARaLENLDRAAISTIHSFCqrllREFafeagldpnfeLLDDAEALLLEEAVDdllREAYAPLDALALARLLDAFGRD-DD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 242 --------IYERFRHIPHYQIIRSLIAMIEQLHNKSLS----VEAIGQLNFGTDSHGFHEFADyVIKHVIRELDEQKKTE 309
Cdd:COG1074 175 sleelllaLYKLRSRPDWLEELAELDEALEALREALLKakeaLAALREALAAAAAPLLAALLR-LLAAVLARYERRKRER 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 310 ETLEISDLISHLAS-LKNLPSDQLELSIR----YLFVDEFQDTDESQTAFISWLVEKY---GCQLFAVGDVKQSIYRFRG 381
Cdd:COG1074 254 GLLDFDDLLHRALRlLRDEDAPWVAERLReryrHILVDEFQDTSPLQWEILRRLAGEAladGRTLFLVGDPKQSIYRFRG 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 382 ADYTAFLQLQQQLETADQVyKEYSLQKNYRSSPTLLTQLNALFQK-WTKVVEKFPFDDTDKLIPAQEESCE------EGL 454
Cdd:COG1074 334 ADPELFLEARRALEGRVDG-ERLTLTTNFRSTPEVVDAVNALFAQlMGAGFGEIPYEPVEALRPGAYPAVElwplepDDV 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 455 VALDIDDVTLKYL---LRRLYREG--------------VVVLVRSNREVLEMVNRIENMGFFCEAAVSGTFYRSLPVREF 517
Cdd:COG1074 413 SEEDAREREARAVaarIRRLLAEGttvegggrpvrpgdIAVLVRTRSEAAAIARALKAAGIPVAASDRLSLFESPEVRDL 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 518 YLLIRRFTHPyvpkdrylfhqssygENELTIAKVLsaYTPEMPF----ILDLLQT------FDNMKRWECQWNTSSALAV 587
Cdd:COG1074 493 LALLRALLNP---------------EDDLALAAVL--RSPLFGLsdedLAALAADrkgeslWEALRAYERLARALERLRA 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 588 LQNIIDEVRPHEVFR-----LRYYNQLRSRfPDGDVEMHRkeaiakmkeyKMNLDRLIFFIKKEFGDFRASFYDLEKFLA 662
Cdd:COG1074 556 LRELARRLGLAELLErlleeTGLLERLLAL-PGGERRLAN----------LLHLDELLQLALEYEQTGGPGLAGFLRWLE 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 663 IKMATDTLENELKITSGVNhRIKVMTVHKAKGLEFDYVLMPltrhpfmkqgktdvmlisdraqwklgysihwddmefenn 742
Cdd:COG1074 625 RLIEDGGDEEKRRLESDAD-AVRIMTIHKSKGLEFPVVFLP--------------------------------------- 664
|
730 740 750
....*....|....*....|....*....|....
gi 2750086525 743 yynEYARSEKKELIGEEARLLYVALTRARKAVYV 776
Cdd:COG1074 665 ---ALRERARAEELAEELRLLYVALTRARDRLVL 695
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
98-776 |
1.07e-51 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 192.84 E-value: 1.07e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 98 NKGQYELEHAYDrGHYIVKAGAGTGKTTTMINRIMFLKHMQGdLDLRSVVMITFTNEAAANMRSKLLEKLKnyydltkdk 177
Cdd:COG0210 8 NPEQRAAVEHPE-GPLLVLAGAGSGKTRVLTHRIAYLIAEGG-VDPEQILAVTFTNKAAREMRERIEALLG--------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 178 kylewmEEAGRMFIGTIHSFAREFLVTEGQTLGFSRSMEVRSyKHERRRLIEKYIDQFSVEcpgiYERFRhiphyqiIRS 257
Cdd:COG0210 77 ------RLARGLWVGTFHSLALRILRRHAELLGLPPNFTILD-GDDQLRLIKELLKELGLD----EKRFP-------PRE 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 258 LIAMIEQLHNKSLSVEAIgqlnfgtDSHGFHEFADYVIKHVIRELDEQKKTEETLEISDLISHLASL-KNLPS--DQLEL 334
Cdd:COG0210 139 LLSLISRAKNEGLTPEEL-------AELLAADPEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLlEENPEvlEKYQN 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 335 SIRYLFVDEFQDTDESQTAFISWLVEKYGcQLFAVGDVKQSIYRFRGADYTAFLQLQQQLETAdqvyKEYSLQKNYRSSP 414
Cdd:COG0210 212 RFRYILVDEYQDTNPAQYELLRLLAGDGR-NLCVVGDDDQSIYGFRGADPENILRFEKDFPDA----KVIKLEQNYRSTQ 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 415 TLLTQLNALFQKWTKVVEKfpfddtdKLIPAQEESCE-EGLVALDIDDvTLKYL---LRRLYREGV-----VVLVRSNR- 484
Cdd:COG0210 287 NILDAANAVIANNPGRLGK-------NLWTDNGEGEKvRLYVAPDEEE-EARFVadeIRELHEEGVplsdiAVLYRTNAq 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 485 -EVLEMVNRIENMGFFceaAVSGT-FYRSLPVREFYLLIRRFTHPY----------VPKdRYL-------------FHQS 539
Cdd:COG0210 359 sRALEEALRRAGIPYR---VVGGLrFYERAEIKDLLAYLRLLANPDddvallrilnVPR-RGIgaatlerlreaarEEGI 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 540 SYGE--NELTIAKVLSAYTPEMpfILDLLQTFDNMKRwecQWNTSSALAVLQNIIDEvrphevfrLRYYNQLRSRFPDgd 617
Cdd:COG0210 435 SLLEalRDLGELAGLSGRAAKA--LRRFAELLEALRA---AAERLPLEELLEALLDE--------SGYEEELREEAGE-- 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 618 vemhrkEAIAKMKeykmNLDRLIFFIkKEFGDfRASFYDLEKFLA-IKMATDTLENELKitsgvNHRIKVMTVHKAKGLE 696
Cdd:COG0210 500 ------EAERRLE----NLEELVDAA-ARFEE-RNPGASLEAFLEeLALLSDLDAADED-----EDAVTLMTLHAAKGLE 562
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 697 FDYVLMPltrhpfmkqgktdvmlisdraqwklgysihwdDMEfENNYYNEYARSEKKELIgEEARLLYVALTRARKAVYV 776
Cdd:COG0210 563 FPVVFLV--------------------------------GLE-EGLFPHQRSLDDEEELE-EERRLFYVAITRARERLYL 608
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
107-392 |
6.05e-41 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 151.24 E-value: 6.05e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 107 AYDRGHYIVKAGAGTGKTTTMINRIMFLKHmQGDLDLRSVVMITFTNEAAANMRSKLLEKLKNYydltkdkkylewmeEA 186
Cdd:pfam00580 10 THLGGPLLVLAGAGSGKTRVLTERIAYLIL-EGGIDPEEILAVTFTNKAAREMKERILKLLGKA--------------EL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 187 GRMFIGTIHSFAREFLVTEGQTLGFSRSMEVRSYkHERRRLIEKYIDQFSVECPgiyerfrhiPHYQIIRSLIAMIEQLH 266
Cdd:pfam00580 75 SELNISTFHSFCLRILRKYANRIGLLPNFSILDE-LDQLALLKELLEKDRLNLD---------PKLLRKLELKELISKAK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 267 NKSLSVEAIGQlnfgtdshGFHEFADYVIKHVIRELDEQKKTEETLEISDLISHLASLKNLPSDQLEL---SIRYLFVDE 343
Cdd:pfam00580 145 NRLLSPEELQQ--------GAADPRDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAyreRFKYILVDE 216
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2750086525 344 FQDTDESQTAFISWLVEKyGCQLFAVGDVKQSIYRFRGADYTAFLQLQQ 392
Cdd:pfam00580 217 FQDTNPIQYRLLKLLAGG-HENLFLVGDPDQSIYGFRGADIENILKFEK 264
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
111-410 |
2.66e-32 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 123.78 E-value: 2.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 111 GHYIVKAGAGTGKTTTMINRIMFLKHmQGDLDLRSVVMITFTNEAAANMRSKLLEKLKNyydltkdkkylewmEEAGRMF 190
Cdd:cd17932 13 GPLLVLAGAGSGKTRVLTHRIAYLIL-EGGVPPERILAVTFTNKAAKEMRERLRKLLGE--------------QLASGVW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 191 IGTIHSFAreflvtegqtlgfsrsmevrsykherrrliekyidqfsvecpgiyerfrhiphYQIIRsliamieqlhnksl 270
Cdd:cd17932 78 IGTFHSFA-----------------------------------------------------LRILR-------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 271 sveaigqlnfgtdshgfhEFADYvikhvireldeqkkteetleiSDLISHLASLKNLPSDQLEL---SIRYLFVDEFQDT 347
Cdd:cd17932 91 ------------------RYGDF---------------------DDLLLYALELLEENPDVREKlqsRFRYILVDEYQDT 131
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2750086525 348 DESQTAFISWLVEKyGCQLFAVGDVKQSIYRFRGADYTAFLQLQQQLETAdqvyKEYSLQKNY 410
Cdd:cd17932 132 NPLQYELLKLLAGD-GKNLFVVGDDDQSIYGFRGADPENILDFEKDFPDA----KVIKLEENY 189
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
111-776 |
1.18e-30 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 129.86 E-value: 1.18e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 111 GHYIVKAGAGTGKTTTMINRIMFLKHMQGDLDLRSVVMITFTNEAAANMRSKLLEKLKNYYDL----------------- 173
Cdd:TIGR00609 10 GTFLIEASAGTGKTFTIAQLYLRLLLEGGPLTVEEILVVTFTNAATEELKTRIRGRIHQALRAlkaaltsqelpeplkea 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 174 ----------TKDKKYLEWMEEAGrmfIGTIHSFAR---------------EFLVTEGQTLgfsRSMEVRSYKHER---- 224
Cdd:TIGR00609 90 iqdekvkqaiTRLRNALATMDEAA---IYTIHGFCQrmleqhafesdeifdVELIEDESLL---LAEITKDFWRRNfynl 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 225 RRLIEKYIDQ--------FSVECPGI----YERFRHIP---------HYQIIRSLIAMIEQLHNKSLSVEAIGQLNFGTD 283
Cdd:TIGR00609 164 PFDIAQIVLKtkkspqavLTQILADLllqsYLAFPSPPldleqlikwHEQIYKDLDKLDHAVFEEIDKLNAERNNLFCLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 284 SHGFHEFADYVIKHVIREldeqKKTEETLEISDLISHLAS-LKNLPSDQLELSIR----YLFVDEFQDTDESQTAFIS-- 356
Cdd:TIGR00609 244 DRVFLTLLKEVQEELKKE----KKRRREIGFDDLLSRLETaLKSAEGEKLAQAIReqypIALIDEFQDTDPQQYRIFSkl 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 357 WLVEKYGcQLFAVGDVKQSIYRFRGADYTAFLQlqqqleTADQVYKEYSLQKNYRSSPTLLTQLNALFQK---------- 426
Cdd:TIGR00609 320 FIAQKET-SLFLIGDPKQAIYSFRGADIFTYLQ------AKSKADARYTLGTNWRSTPALVGSLNKLFSLisnpflekpi 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 427 ---------------WTKVVEKFPFddtdKLIPAQEESCEEGLVALDIDDVT---LKYLL----------------RRLY 472
Cdd:TIGR00609 393 fipvlahqknskgsfVINGQEQPPI----HFFTTEVESEGVDDYRQTIAQKCareIALWLasaalglanfiatfggRPLR 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 473 REGVVVLVRSNREVLEMVNRIENMGFfceAAV----SGTFYRSLPVREFYLLIRRFTHPYVPKD-RYLFHQSSYGENelt 547
Cdd:TIGR00609 469 AGDIAVLVRGRKEANQIRKALKKAQI---PSVylsdKSSVFATEEAQELLALLEALLEPENEGTlRAALASSIFGLS--- 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 548 iAKVLSAYTPEMPFILDLLQTFDNMKRWecqWNTSSALAVLQNIIDEvrpHEVfrlryYNQLRSRfPDGDVEMhrkeaia 627
Cdd:TIGR00609 543 -ALELETLNQDEITWERVVEKFREYHDI---WRKIGVLAMFQRLMLE---KGI-----GERLLSQ-PGGERIL------- 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 628 kmkeykMNLDRLIFFIKKEFGDFRASFYDLEKFLAIKMATDTLENELKITSGVNHRIKVMTVHKAKGLEFDYVLMPLTrH 707
Cdd:TIGR00609 603 ------TNLLHLAELLQEAAHQERNKLSLLRWLEDQISNEEEEEEEIIRLESDAELVKIVTIHKSKGLEYPIVFLPFI-T 675
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 708 PFMKqgktdvmliSDRAQWK-LGYSIHWDDMEFENNYYNEYARSEKkelIGEEARLLYVALTRARKAVYV 776
Cdd:TIGR00609 676 DAKK---------SNFASLHdQHSHEYQLYDFNQSEENQKLARVER---LAEDLRLLYVALTRAKKQLFI 733
|
|
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
108-800 |
1.20e-22 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 104.40 E-value: 1.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 108 YDRGHYI-VKAGAGTGKTTTMINRIMflKHMQGDLDLRSVVMITFTNEAAANMRSKLLEKLKNYYDLTKDKKYL-EWMEE 185
Cdd:TIGR02785 11 YTRGQDIlVSASAGSGKTAVLVERII--RKITRGVDVDRLLVVTFTNAAAREMKERIAEALEKELVQEPNSKHLrRQLAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 186 AGRMFIGTIHSFAREFLV-----------------TEGQTLG---FSRSMEVRSYKHER-------------------RR 226
Cdd:TIGR02785 89 LNTANISTLHSFCLKVIRkhyylldldpsfriltdTEQLLLIkevLDDVFEEEYYKEDKeaffelvdnfsgdrsddglRD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 227 LI-------------EKYIDQFsvecPGIYE-----RFRHIPHYQIIRSLIAMI-------------------------- 262
Cdd:TIGR02785 169 LIlqlydfsrstpnpEKWLNNL----AEAYEvkekfTIESLKLQQQIKELLKNEleglqeklqralelfmaedglaprle 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 263 --------------EQLHNKSLS----------------------------------------VEAIGQLNFGTDSHGF- 287
Cdd:TIGR02785 245 nfqldlqnideliqESLAQADWNelrkavaafkfknlkaakgdeedadlleeadklreeakkqLEKLKTDYFTRSEEDHl 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 288 ----------HEFADyVIKHVIRELDEQKKTEETLEISDLiSH--LASLKNLPSDQLELSIRY------LFVDEFQDTDE 349
Cdd:TIGR02785 325 rimqemkpvvKTLVQ-LVKDFIERFGAEKREKNILDFSDL-EHyaLQILTNENESPSEAAEFYrekfheVLVDEYQDTNL 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 350 SQTAFISWLV--EKYGCQLFAVGDVKQSIYRFRGADYTAFLQLQQQL-ETADQVYKEYSLQKNYRSSPTLLTQLNALFQK 426
Cdd:TIGR02785 403 VQESILQLVKrgPEEEGNLFMVGDVKQSIYRFRQADPLLFLEKYHRFaQEGEEHGKRIDLAENFRSRAEVLDTTNFLFKQ 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 427 W--TKVVE---------KFPFD---------------DTDKLIPAQEESCEEGLVALDIDDVTLKYLLRRlyregVVVLV 480
Cdd:TIGR02785 483 LmdEEVGEidydeeaqlKFGAAkypenpdnkteellyEKLLIEEAEEEEIDEEAEILDKAQQEATMVAER-----IKALI 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 481 RSNREVLEMVNrienmgffceaavsGTfYRSLPVREFYLLIRRFthpyvpkdrylfhqssygENELTIAKVLSAY----- 555
Cdd:TIGR02785 558 KEGFKVYDKKT--------------GT-YRPVTYRDIVILTRSR------------------GWNLQIMEEFKKYgipvf 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 556 ---------TPEMPFILDLLQTFDNmkrwecQWNTSSALAVLQNIIDEVRPHEVFRLR-------YYNQLRSRFPDGDV- 618
Cdd:TIGR02785 605 andaenyfqTTEVRVMLSLLRVIDN------PYQDIPLVAVLRSPIVGFDENELALIRlenkdssYYEAVKDYVKAGLIe 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 619 -EMHRK-----EAIAKMKEY--KMNLDRLIFFIKKEFG--DF-------------------RA------SFYDLEKFL-- 661
Cdd:TIGR02785 679 dELYEKlntflDSLQKWREFarTHSVSELIWKIYNDTGyyDYvgglpggkqrqanlyalyeRArqyestSFKGLFQFIrf 758
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 662 --AIKMATDTLENELKITSGVNhRIKVMTVHKAKGLEFDYVLMPLTRHPFMKQGKTDVMLISDRAQWKLGYSIHWDDMEF 739
Cdd:TIGR02785 759 ieRMQERQKDLASAVAVGEAEN-AVRLMTIHKSKGLEFPVVFVLGMGKQFNKQDLNSSYLLDRQLGLGIKYIDPQERLSY 837
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2750086525 740 ENNYYNEYARSEKKELIGEEARLLYVALTRARKAVYVNSSSQMNPYQAQCWSDLLESGEML 800
Cdd:TIGR02785 838 PSLPKVAIKQKMKRELLSEEMRVLYVALTRAKEKLILVGSVKDEKKELKKWLAALAQSDWL 898
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
299-797 |
1.84e-21 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 100.53 E-value: 1.84e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 299 IRELDEQKKTEETLEISDLISHLASLKNLPSD------QLELSIRYLFVDEFQDTDESQTAFISWLVEKY----GCQ--- 365
Cdd:TIGR02784 348 LQRYARLKKARGLLDFNDLIERTVALLARPGAgawvhyKLDRGIDHILVDEAQDTSPEQWDIIQALAEEFfsgeGARsgv 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 366 ---LFAVGDVKQSIYRFRGADYTAFLQLQQ----QLETADQVYKEYSLQKNYRSSPTLLTQLNALFQK------------ 426
Cdd:TIGR02784 428 ertIFAVGDEKQSIYSFQGADPERFAEERRefsrKVRAVGRKFEDLSLNYSFRSTPDVLAAVDLVFADpenarglsadsd 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 427 -----------------W---TKVVEKFPFDDTDKLIPAQEESCEEGL---VALDIDDV----TLKYLLRRLYREG-VVV 478
Cdd:TIGR02784 508 apvheafrddlpgrvdlWdliSKEEGEEPEDWTDPVDELGERAPEVRLaerIAAEIRAWldrgTPIPGRGRAVRPGdILV 587
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 479 LVRSNREVLEMVNRIenmgffCEAA---VSGTFYRSLP----VREFYLLIRRFTHPyvpkdrylfhqssygENELTIAKV 551
Cdd:TIGR02784 588 LVRKRDAFFSALIRA------LKRRgipVAGADRLKLTshiaVKDLMALGRFVLQP---------------EDDLSLAAL 646
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 552 LSAytpemPFI-------LDLLQT------FDNMKRWECQWntSSALAVLQNIIDEVRPHEVFRLryYNQLRSRfpDGDv 618
Cdd:TIGR02784 647 LKS-----PLFgldeddlFRLAAGrsggslWAALRRREAEF--AATLAVLRDWLSLADFLTPFEF--YARLLGR--DGG- 714
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 619 emhRKEAIAKM-KEYKMNLDrliffikkEFGDF-----RASFYDLEKFLAIKMATDTlenELKITSGVNHR-IKVMTVHK 691
Cdd:TIGR02784 715 ---RRKLLARLgAEAEDILD--------EFLSQalayeRTGLPGLQAFLSWLEADDP---EIKREMDQARDeVRVMTVHG 780
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 692 AKGLEFDYVLMP-LTRHPFMKQGKTDVMlisdrAQWKLGYSIH-WDDMEFENNYYNEYARSEKKELIGEEA-RLLYVALT 768
Cdd:TIGR02784 781 AKGLEAPVVFLVdTGSKPFASQRAPLLL-----ATGGSGGKAPlWRPASAFDPSLSAAARERLKERAEDEYrRLLYVAMT 855
|
570 580
....*....|....*....|....*....
gi 2750086525 769 RARKAVYVNSSSQMNPYQAQCWSDLLESG 797
Cdd:TIGR02784 856 RAEDRLIVCGYRGKRESPKDSWHALVKRA 884
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
111-493 |
1.59e-20 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 96.83 E-value: 1.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 111 GHYIVKAGAGTGKTTTMINRIMFLKHMQGdLDLRSVVMITFTNEAAANMRSKLLEKLKNyydltkdkkylewmEEAGRMF 190
Cdd:PRK10919 16 GPCLVLAGAGSGKTRVITNKIAHLIRGCG-YQARHIAAVTFTNKAAREMKERVAQTLGR--------------KEARGLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 191 IGTIHSFAREFLVTEGQTLGFSRSMEVRSYKHER---RRLIEKYIDQFSVecpgiyerfrhiphyqIIRSLIAMIEQLHN 267
Cdd:PRK10919 81 ISTFHTLGLDIIKREYAALGMKSNFSLFDDTDQLallKELTEGLIEDDKV----------------LLQQLISTISNWKN 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 268 KSLSVEAIGQLNFGTDSHGFhefadyviKHVIRELDEQKKTEETLEISDLIS--HLASLKNLP-SDQLELSIRYLFVDEF 344
Cdd:PRK10919 145 DLKTPAQAAAGAKGERDRIF--------AHCYGLYDAHLKACNVLDFDDLILlpTLLLQRNEEvRERWQNKIRYLLVDEY 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 345 QDTDESQTAFISWLVEKYGcQLFAVGDVKQSIYRFRGADYTAFLQLQQQLeTADQVYKeysLQKNYRSSPTLLTQLNALF 424
Cdd:PRK10919 217 QDTNTSQYELVKLLVGSRA-RFTVVGDDDQSIYSWRGARPQNLVLLSQDF-PALQVIK---LEQNYRSSGRILKAANILI 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2750086525 425 QKWTKVVEKFPFD-----DTDKLIPAQEESCEEGLValdIDDVTLKYLLRRLYREGVVVLVRSNR-----EVLEMVNRI 493
Cdd:PRK10919 292 ANNPHVFEKRLFSelgygDELKVLSANNEEHEAERV---TGELIAHHFVNKTQYKDYAILYRGNHqsrvfEKFLMQNRI 367
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
313-776 |
1.86e-16 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 84.25 E-value: 1.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 313 EISDLISHLASLKNLPSD----QLELSIRYLFVDEFQDTDESQ----TAFISWLVEKYGCQ----LFAVGDVKQSIYRFR 380
Cdd:PRK13909 302 DISKKVYELLGEEEIDKDflyfRLDSKISHILIDEFQDTSVLQykilLPLIDEIKSGEGQKkfrsFFYVGDVKQSIYRFR 381
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 381 GADYTAFlqlqqqletaDQVYKEY-----SLQKNYRSSPTLLTQLNALFQKwtkvveKFPFDDTDKLIPAQEESCEEGLV 455
Cdd:PRK13909 382 GGKKELF----------DKVSKDFkqkvdNLDTNYRSAPLIVDFVNEVFKK------KYKNYKTQYAEQHKSGGYVEVVE 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 456 ALDIDDVTLKYLL---RRLYREGV-----VVLVRSNREVLEMVNRIE---NMGFFCEAAVSGTFYRSLPVREFYLLIRrf 524
Cdd:PRK13909 446 VADESEELLEQLLqeiQFLLEKGIdpddiAILCWTNDDALEIKEFLQeqfGIKAVTESSAKLINQPEVKALIEALKYC-- 523
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 525 thpyvpkdryLFHQSSYGENELTIAKvlsaytpempFILDLLQTFDNMKRwecqwntssalAVLQNiidevrpheVFRLr 604
Cdd:PRK13909 524 ----------LFGEEIYKHNVLKLLG----------KEPDKIPSFLPKEE-----------SVAEF---------VKKL- 562
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 605 yynqlrsrfpdgdvemhrkeaiakMKEYKMNLDRLIFFIkkefgDFRASFYDLEKFLaikmatDTLEN-ELKITSGVNHR 683
Cdd:PRK13909 563 ------------------------IEELKLYDENLLKFL-----ELASGYEDIEEFL------FKLEPcDKEIASEESKG 607
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 684 IKVMTVHKAKGLEFDYVLMpLTRHPFMKQGKTDVMLisdraqwklgysiHWDDMEFENNYYN---------EYAR----- 749
Cdd:PRK13909 608 VQIMTVHKSKGLEFEHVIV-CDRLGKPNSDSSNLLF-------------EYDGIELWQIYYRikgrenfdkDYARaleke 673
|
490 500
....*....|....*....|....*....
gi 2750086525 750 --SEKKELIGEearlLYVALTRARKAVYV 776
Cdd:PRK13909 674 kaLKYEEEINV----LYVAFTRAKNSLIV 698
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
404-781 |
2.48e-16 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 81.68 E-value: 2.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 404 YSLQKNYRSSPTLLTQLNALFQKWTKVVEKFPFD-------DTDK--LIPAQEESCEEGLVALDIddvtlKYLLRRLY-R 473
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNFGRATIYPKKilaetveDGEKikIIEAETEEEEAEWIALEI-----KKLVARDEkY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 474 EGVVVLVRSNRE--VLEMVNRIENMGFFCeaaVSGT-FYRSLPVREF--YL-----------LIRRFTHPYV-------- 529
Cdd:pfam13361 76 NDIAVLTRSNSDadLIEEALKKLGIPYFV---VGQTkFFRREEIKDIlaYLrliankhdsisLKRILNGPKRgignatle 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 530 ----PKDRYLFHQSSYGENELT-IAKVLSAYTPEMPFILDLLQTFDNMKRWECQWNTSSALAVLQNIIDE----VRPHEV 600
Cdd:pfam13361 153 rireYKKRGLRLSDFINPDTLTyGDPFVIALEQDNIVVFDVETTGLDTTEDEIIQIAAIKLNKKGVVIESferfLRLKKP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 601 FRLRYYNQLRSRFPDGDVEMHRKEAIAKMKEYKMNLDRLIFFIKkEFGDFRASFYDLEKFLAIkMATDTLENELKITSGV 680
Cdd:pfam13361 233 VGDSLQVHGFSDEFLQENGETPAEALRDFLEKLENLRELYSILR-EYDDIEETPEPEDALRNF-LEIATLSNSELEGSDI 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 681 NHRIKVMTVHKAKGLEFDYVLMPltrhpfmkqgktdvmlisdraqwklgysihwdDMEfENNYYNEYARSEKKELiGEEA 760
Cdd:pfam13361 311 KERIPIMTIHQAKGLEFDTVFLA--------------------------------GLE-EGIFPSYRSIKDEGNL-EEER 356
|
410 420
....*....|....*....|.
gi 2750086525 761 RLLYVALTRARKAVYVNSSSQ 781
Cdd:pfam13361 357 RLFYVAITRAKKRLYISYSKS 377
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
110-423 |
2.17e-14 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 77.22 E-value: 2.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 110 RGHYIVKAGAGTGKTTTMINRIMFLKHMQGdLDLRSVVMITFTNEAAANMRSKLLEKLKNYydltkdkkylewmeeAGRM 189
Cdd:PRK11773 22 LGNMLVLAGAGSGKTRVLVHRIAWLMQVEN-ASPYSIMAVTFTNKAAAEMRHRIEQLLGTS---------------QGGM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 190 FIGTIHSFAREFLVTEGQTLGFSRSMEV-RSYKHER--RRLI------EK---------YIDQFSVEcpGIyeRFRHI-- 249
Cdd:PRK11773 86 WVGTFHGLAHRLLRAHWQDANLPQDFQIlDSDDQLRllKRLIkalnldEKqwpprqaqwYINGQKDE--GL--RPQHIqs 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 250 PHYQIIRSLIAmIEQLHNKSlsveaigqlnfgTDSHGFHEFADYVIK-HvirELDEQKKTeetleisdLISHLASlknlp 328
Cdd:PRK11773 162 YGDPVEQTWLK-IYQAYQEA------------CDRAGLVDFAELLLRaH---ELWLNKPH--------ILQHYQE----- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 329 sdqlelSIRYLFVDEFQDTDESQTAFISWLVEKyGCQLFAVGDVKQSIYRFRGAdytaflqlqqQLETADQVYKEYS--- 405
Cdd:PRK11773 213 ------RFTHILVDEFQDTNAIQYAWIRLLAGD-TGKVMIVGDDDQSIYGWRGA----------QVENIQRFLNDFPgae 275
|
330 340
....*....|....*....|.
gi 2750086525 406 ---LQKNYRSSPTLLTQLNAL 423
Cdd:PRK11773 276 tirLEQNYRSTANILKAANAL 296
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
299-426 |
5.16e-13 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 73.08 E-value: 5.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 299 IRE-LDEQKKTEETLEISDLISHL-ASLKNLPSDQLELSIRYLF----VDEFQDTDESQ-TAFISWLVEKYGCQLFAVGD 371
Cdd:PRK10876 335 IREtVAQEKRRRGELGFDDLLSRLdSALQSEGGEALAAAIRTRYpvamIDEFQDTDPQQyRIFRRIYRHQPETALLLIGD 414
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2750086525 372 VKQSIYRFRGADYTAFLQLQQqletadQVYKEYSLQKNYRSSPTLLTQLNALFQK 426
Cdd:PRK10876 415 PKQAIYAFRGADIFTYMKARS------EVSAHYTLDTNWRSAPGMVNSVNKLFSQ 463
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
668-775 |
2.32e-10 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 59.55 E-value: 2.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 668 DTLENELKITsgvnhrikVMTVHKAKGLEFDYVLMpltrhPFMKQGktdvMLISDRAQwklgysihwddmefennyyneY 747
Cdd:cd18807 78 RVIEEALRVT--------LMTIHASKGLEFPVVFI-----VGLGEG----FIPSDASY---------------------H 119
|
90 100
....*....|....*....|....*...
gi 2750086525 748 ARSEKKELIGEEARLLYVALTRARKAVY 775
Cdd:cd18807 120 AAKEDEERLEEERRLLYVALTRAKKELY 147
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
317-410 |
9.15e-07 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 48.64 E-value: 9.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 317 LISHLASLKNL---------PSDQLELSIRYLFVDEFQDTDESQTAFISWLVEKYGcQLFAVGDVKQSIYRFRGADYTAF 387
Cdd:cd17914 19 IVAALMQNKNGepgrillvtPTNKAAAQLDNILVDEAAQILEPETSRLIDLALDQG-RVILVGDHDQLGPVWRGAVLAKI 97
|
90 100
....*....|....*....|....
gi 2750086525 388 LQLQQQLETADQVYKEY-SLQKNY 410
Cdd:cd17914 98 CNEQSLFTRLVRLGVSLiRLQVQY 121
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
337-387 |
1.19e-06 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 52.26 E-value: 1.19e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2750086525 337 RYLFVDEFQDTDESQTAFISWLVEK-YGCQLFAVGDVKQSIYRFRGADY---TAF 387
Cdd:PRK11054 432 KHILVDEFQDISPQRAALLAALRKQnSQTTLFAVGDDWQAIYRFSGADLsltTAF 486
|
|
| SF1_C_RecD |
cd18809 |
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
681-776 |
1.46e-06 |
|
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 46.79 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 681 NHRIK--VMTVHKAKGLEFDYVLMPLTRHPFMkqgktdvmlisdraqwklgysihwddmefennyyneyarsekkeligE 758
Cdd:cd18809 28 NERLQayAMTIHKSQGSEFDRVIVVLPTSHPM-----------------------------------------------L 60
|
90
....*....|....*...
gi 2750086525 759 EARLLYVALTRARKAVYV 776
Cdd:cd18809 61 SRGLLYTALTRARKLLTL 78
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
329-380 |
1.01e-05 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 45.67 E-value: 1.01e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2750086525 329 SDQLELSIRYLFVDEFQDTD-ESQTAFISWLVEkyGCQLFAVGDVKQSIYRFR 380
Cdd:pfam13245 86 DEEEPLDGDLLIVDEFSMVDlPLAYRLLKALPD--GAQLLLVGDPDQLPSVGP 136
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
686-776 |
2.11e-05 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 43.58 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 686 VMTVHKAKGLEFDYVLMPLTrHPFMkqgktdvmlisdraqwklgysihwddmefennyyneyarsekkeligEEARLLYV 765
Cdd:cd18786 45 AITIDSSQGLTFDVVTLYLP-TANS-----------------------------------------------LTPRRLYV 76
|
90
....*....|.
gi 2750086525 766 ALTRARKAVYV 776
Cdd:cd18786 77 ALTRARKRLVI 87
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
686-776 |
2.47e-05 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 42.18 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 686 VMTVHKAKGLEFDYVlmpltrhpfmkqgktdVMLISDRAQwklgysiHWDDMEFennyyneyarsekkeligeeARLLYV 765
Cdd:pfam13538 4 ALTVHKAQGSEFPAV----------------FLVDPDLTA-------HYHSMLR--------------------RRLLYT 40
|
90
....*....|.
gi 2750086525 766 ALTRARKAVYV 776
Cdd:pfam13538 41 AVTRARKKLVL 51
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
110-250 |
3.36e-05 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 44.13 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 110 RGHYIVKAGAGTGKTTTMINRIMFLKHMQGdlDLRSVVMITFTNEAAANMRSKLLEKLKnyydltkdkkylewmeeagrm 189
Cdd:pfam13245 11 SKVVLLTGGPGTGKTTTIRHIVALLVALGG--VSFPILLAAPTGRAAKRLSERTGLPAS--------------------- 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2750086525 190 figTIHSFareflvtegqtLGFSRSMEVrSYKHERRRLIEKY---IDQFS-VECPGIYERFRHIP 250
Cdd:pfam13245 68 ---TIHRL-----------LGFDDLEAG-GFLRDEEEPLDGDlliVDEFSmVDLPLAYRLLKALP 117
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
114-165 |
4.34e-05 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 43.63 E-value: 4.34e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 2750086525 114 IVKAGAGTGKTTTMINRIMFLKHMQgDLDLRSVVMITFTNEAAANMRSKLLE 165
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALMQNK-NGEPGRILLVTPTNKAAAQLDNILVD 53
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
687-776 |
9.37e-05 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 45.74 E-value: 9.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750086525 687 MTVHKAKGLEFDYVLMPLTRHPFMkqgktdvMLisDRaqwklgysihwddmefennyyneyarsekkeligeeaRLLYVA 766
Cdd:COG0507 445 ITVHKSQGSTFDRVILVLPSEHSP-------LL--SR-------------------------------------ELLYTA 478
|
90
....*....|
gi 2750086525 767 LTRARKAVYV 776
Cdd:COG0507 479 LTRARELLTL 488
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
758-776 |
9.40e-03 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 39.55 E-value: 9.40e-03
|
| |
