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Conserved domains on  [gi|2740924189|ref|WP_349070722|]
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methyltransferase [Bacteroides salyersiae]

Protein Classification

tRNA1(Val) (adenine(37)-N6)-methyltransferase( domain architecture ID 11467886)

tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase is a class I SAM-dependent methyltransferase that specifically methylates the adenine in position 37 of tRNA(1)(Val)

CATH:  2.20.25.110
EC:  2.1.1.223
Gene Ontology:  GO:0016430|GO:1904047|GO:0008170|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 5-230 5.99e-92

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 270.09  E-value: 5.99e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189   5 YFQFKQFTVWHDKCAMKVGTDGVLLGAWPHVDGAQRILDIGTGTGLVALMLAQRS-KAFIVALEIDCSAVRQAIENVSHS 83
Cdd:COG4123     5 GFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEAAELARRNVALN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  84 PWQDRIEVVEADFKHYTSTAQ---FDVIVSNPPYFTD--SLKCPNQQRNTARHDNELTYKELLEGVSQLLSADGAFTVIV 158
Cdd:COG4123    85 GLEDRITVIHGDLKEFAAELPpgsFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFALIH 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2740924189 159 PADVSDRVKEIALNYSLYPYKQLNIITKPGLSPKRSLITFNFQDQK-CQIEN-MIIELARHEYSREYIDLTKEY 230
Cdd:COG4123   165 PAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAgLRILPpLVIHDEDGEYTPEVKALLRDF 238
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 5-230 5.99e-92

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 270.09  E-value: 5.99e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189   5 YFQFKQFTVWHDKCAMKVGTDGVLLGAWPHVDGAQRILDIGTGTGLVALMLAQRS-KAFIVALEIDCSAVRQAIENVSHS 83
Cdd:COG4123     5 GFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEAAELARRNVALN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  84 PWQDRIEVVEADFKHYTSTAQ---FDVIVSNPPYFTD--SLKCPNQQRNTARHDNELTYKELLEGVSQLLSADGAFTVIV 158
Cdd:COG4123    85 GLEDRITVIHGDLKEFAAELPpgsFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFALIH 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2740924189 159 PADVSDRVKEIALNYSLYPYKQLNIITKPGLSPKRSLITFNFQDQK-CQIEN-MIIELARHEYSREYIDLTKEY 230
Cdd:COG4123   165 PAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAgLRILPpLVIHDEDGEYTPEVKALLRDF 238
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 37-114 6.82e-18

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 80.21  E-value: 6.82e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2740924189  37 GAQRILDIGTGTGLVALMLAQ-RSKAFIVALEIDCSAVRQAIENVSHSpWQDRIEVVEADFKHYTSTAQFDVIVSNPPY 114
Cdd:PRK09328  108 EPLRVLDLGTGSGAIALALAKeRPDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDWFEPLPGGRFDLIVSNPPY 185
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 40-184 6.08e-15

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 71.73  E-value: 6.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILDIGTGTGLVALMLA-QRSKAFIVALEIDCSAVRQAIENV-SHSPwqDRIEVVEAD-FKHYTSTaQFDVIVSNPPYFT 116
Cdd:TIGR03534  89 RVLDLGTGSGAIALALAkERPDARVTAVDISPEALAVARKNArRLGL--ENVEFLQGDwFEPLPSG-KFDLIVSNPPYIP 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2740924189 117 DSLKCpNQQRNTARHD--NELT--------YKELLEGVSQLLSADGAFTVIVPADVSDRVKEIALNyslYPYKQLNII 184
Cdd:TIGR03534 166 EADIH-LLDPEVRDFEprLALFggedgldfYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEA---AGFADVETR 239
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 40-158 1.22e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHsPWQDRIEVVEADFKHYTSTA--QFDVIVSNPPYftd 117
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEAdeSFDVIISDPPL--- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2740924189 118 slkcpnqqrntarHDNELTYKELLEGVSQLLSADGAFTVIV 158
Cdd:cd02440    77 -------------HHLVEDLARFLEEARRLLKPGGVLVLTL 104
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 41-111 6.17e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.88  E-value: 6.17e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740924189  41 ILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPWqdRIEVVEADFKHYT-STAQFDVIVSN 111
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPfPDGSFDLVVSS 70
rADc smart00650
Ribosomal RNA adenine dimethylases;
34-114 1.08e-07

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 50.20  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189   34 HVDGAQRILDIGTGTGLVALMLAQRSKaFIVALEID---CSAVRQaienvsHSPWQDRIEVVEADF-KHYTSTAQFDVIV 109
Cdd:smart00650  10 NLRPGDTVLEIGPGKGALTEELLERAK-RVTAIEIDprlAPRLRE------KFAAADNLTVIHGDAlKFDLPKLQPYKVV 82


                   ....*
gi 2740924189  110 SNPPY 114
Cdd:smart00650  83 GNLPY 87
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 5-230 5.99e-92

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 270.09  E-value: 5.99e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189   5 YFQFKQFTVWHDKCAMKVGTDGVLLGAWPHVDGAQRILDIGTGTGLVALMLAQRS-KAFIVALEIDCSAVRQAIENVSHS 83
Cdd:COG4123     5 GFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEAAELARRNVALN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  84 PWQDRIEVVEADFKHYTSTAQ---FDVIVSNPPYFTD--SLKCPNQQRNTARHDNELTYKELLEGVSQLLSADGAFTVIV 158
Cdd:COG4123    85 GLEDRITVIHGDLKEFAAELPpgsFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFALIH 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2740924189 159 PADVSDRVKEIALNYSLYPYKQLNIITKPGLSPKRSLITFNFQDQK-CQIEN-MIIELARHEYSREYIDLTKEY 230
Cdd:COG4123   165 PAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAgLRILPpLVIHDEDGEYTPEVKALLRDF 238
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 37-114 6.82e-18

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 80.21  E-value: 6.82e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2740924189  37 GAQRILDIGTGTGLVALMLAQ-RSKAFIVALEIDCSAVRQAIENVSHSpWQDRIEVVEADFKHYTSTAQFDVIVSNPPY 114
Cdd:PRK09328  108 EPLRVLDLGTGSGAIALALAKeRPDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDWFEPLPGGRFDLIVSNPPY 185
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 31-114 1.85e-17

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 79.04  E-value: 1.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  31 AWPHVDGAQRILDIGTGTGLVALMLAQ-RSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEAD-FKHYTSTAQFDVI 108
Cdd:COG2890   106 ALLPAGAPPRVLDLGTGSGAIALALAKeRPDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDlFEPLPGDGRFDLI 185


                  ....*.
gi 2740924189 109 VSNPPY 114
Cdd:COG2890   186 VSNPPY 191
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 40-184 6.08e-15

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 71.73  E-value: 6.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILDIGTGTGLVALMLA-QRSKAFIVALEIDCSAVRQAIENV-SHSPwqDRIEVVEAD-FKHYTSTaQFDVIVSNPPYFT 116
Cdd:TIGR03534  89 RVLDLGTGSGAIALALAkERPDARVTAVDISPEALAVARKNArRLGL--ENVEFLQGDwFEPLPSG-KFDLIVSNPPYIP 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2740924189 117 DSLKCpNQQRNTARHD--NELT--------YKELLEGVSQLLSADGAFTVIVPADVSDRVKEIALNyslYPYKQLNII 184
Cdd:TIGR03534 166 EADIH-LLDPEVRDFEprLALFggedgldfYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEA---AGFADVETR 239
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 39-159 4.59e-14

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 67.26  E-value: 4.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  39 QRILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHYTSTAQFDVIVSNppyftds 118
Cdd:COG2230    53 MRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQFDAIVSI------- 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2740924189 119 lkcpnqqrNTARHDNELTYKELLEGVSQLLSADGAFTVIVP 159
Cdd:COG2230   126 --------GMFEHVGPENYPAYFAKVARLLKPGGRLLLHTP 158
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
34-110 4.82e-14

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 68.91  E-value: 4.82e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2740924189  34 HVDGAQRILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHYTSTAQFDVIVS 110
Cdd:COG4076    32 VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEKADVIIS 108
PRK14968 PRK14968
putative methyltransferase; Provisional
 39-114 2.76e-13

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 66.08  E-value: 2.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  39 QRILDIGTGTGLVALMLAQRSKaFIVALEIDCSAVRQAIENVSHSPWQDR-IEVVEAD----FKHYTstaqFDVIVSNPP 113
Cdd:PRK14968   25 DRVLEVGTGSGIVAIVAAKNGK-KVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDlfepFRGDK----FDVILFNPP 99


                  .
gi 2740924189 114 Y 114
Cdd:PRK14968  100 Y 100
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 40-158 1.22e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHsPWQDRIEVVEADFKHYTSTA--QFDVIVSNPPYftd 117
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEAdeSFDVIISDPPL--- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2740924189 118 slkcpnqqrntarHDNELTYKELLEGVSQLLSADGAFTVIV 158
Cdd:cd02440    77 -------------HHLVEDLARFLEEARRLLKPGGVLVLTL 104
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 36-154 2.64e-12

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 64.68  E-value: 2.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  36 DGAQRILDIGTGTGLVALMLA-QRSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEAD-FKHYTStAQFDVIVSNPP 113
Cdd:TIGR00536 113 PPILHILDLGTGSGCIALALAyEFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNlFEPLAG-QKIDIIVSNPP 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2740924189 114 YFtdSLKCPNQQRNTARHDNELT----------YKELLEGVSQLLSADGAF 154
Cdd:TIGR00536 192 YI--DEEDLADLPNVVRFEPLLAlvggddglniLRQIIELAPDYLKPNGFL 240
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 41-111 6.17e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.88  E-value: 6.17e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2740924189  41 ILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPWqdRIEVVEADFKHYT-STAQFDVIVSN 111
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPfPDGSFDLVVSS 70
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
37-111 2.03e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 58.68  E-value: 2.03e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2740924189  37 GAQRILDIGTGTGLVALMLAQRSKAF-IVALEIDCSAVRQAIENVShspwqdRIEVVEADFKHYTSTAQFDVIVSN 111
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGArVTGVDLSPEMLARARARLP------NVRFVVADLRDLDPPEPFDLVVSN 70
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 23-114 2.40e-11

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 60.59  E-value: 2.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  23 GTDgVLLGAWPhVDGAQRILDIGTGTGLVALMLAQRS-KAFIVALEIDCSAVRQAIENVSHSPWQDrIEVVEAD-FKHYt 100
Cdd:COG2813    37 GTR-LLLEHLP-EPLGGRVLDLGCGYGVIGLALAKRNpEARVTLVDVNARAVELARANAAANGLEN-VEVLWSDgLSGV- 112

                          90
                  ....*....|....
gi 2740924189 101 STAQFDVIVSNPPY 114
Cdd:COG2813   113 PDGSFDLILSNPPF 126
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 41-173 3.51e-11

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 62.19  E-value: 3.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  41 ILDIGTGTGLVAL-MLAQRSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHYTSTAQFDVIVSNPPYFTDSL 119
Cdd:PRK01544  142 ILELGTGSGCIAIsLLCELPNANVIATDISLDAIEVAKSNAIKYEVTDRIQIIHSNWFENIEKQKFDFIVSNPPYISHSE 221

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2740924189 120 KcPNQQRNT----------ARHDNELTYKELLEGVSQLLSADGAFTVIVPADVSDRVKEIALNY 173
Cdd:PRK01544  222 K-SEMAIETinyepsialfAEEDGLQAYFIIAENAKQFLKPNGKIILEIGFKQEEAVTQIFLDH 284
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
40-113 2.09e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 57.99  E-value: 2.09e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2740924189  40 RILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVshSPWQDRIEVVEADFKHYTSTAQFDVIVSNPP 113
Cdd:COG2263    48 TVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENA--ERLGVRVDFIRADVTRIPLGGSVDTVVMNPP 119
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
34-111 7.63e-10

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 57.49  E-value: 7.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  34 HVDGAQRILDIGTGTG---LVALML-AQRskafIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFkhyTSTAQFDVIV 109
Cdd:COG2264   145 LLKPGKTVLDVGCGSGilaIAAAKLgAKR----VLAVDIDPVAVEAARENAELNGVEDRIEVVLGDL---LEDGPYDLVV 217


                  ..
gi 2740924189 110 SN 111
Cdd:COG2264   218 AN 219
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 37-120 8.78e-10

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 55.96  E-value: 8.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  37 GAQRILDIGTGTGLVALMLAQ--RSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHY---TSTAQFDVIV-- 109
Cdd:COG4122    16 GAKRILEIGTGTGYSTLWLARalPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEVlprLADGPFDLVFid 95

                          90
                  ....*....|....*
gi 2740924189 110 ----SNPPYFTDSLK 120
Cdd:COG4122    96 adksNYPDYLELALP 110
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 38-113 1.12e-09

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 55.67  E-value: 1.12e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2740924189  38 AQRILDIGTGTGLVALMLAQRS-KAFIVALEIDCSAVRQAIENV-SHSPwqDRIEVVEADFKHYTSTAQFDVIVSNPP 113
Cdd:pfam05175  32 SGKVLDLGCGAGVLGAALAKESpDAELTMVDINARALESARENLaANGL--ENGEVVASDVYSGVEDGKFDLIISNPP 107
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 39-111 1.34e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 55.00  E-value: 1.34e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2740924189  39 QRILDIGTGTGLVALMLAQRSkAFIVALEIDCSAVRQAIENVSHSPWqdRIEVVEADFKHYT-STAQFDVIVSN 111
Cdd:COG2226    24 ARVLDLGCGTGRLALALAERG-ARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDLPfPDGSFDLVISS 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 28-161 4.44e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 54.54  E-value: 4.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  28 LLGAWPHVDGAQRILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPwQDRIEVVEADFKHYT--STAQF 105
Cdd:COG0500    17 LLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAG-LGNVEFLVADLAELDplPAESF 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2740924189 106 DVIVSNppyftdslkcpnqqrNTARHDNELTYKELLEGVSQLLSADGAFtVIVPAD 161
Cdd:COG0500    96 DLVVAF---------------GVLHHLPPEEREALLRELARALKPGGVL-LLSASD 135
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 33-111 6.85e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.33  E-value: 6.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  33 PHVDGAQRILDIGTGTGLVALMLAQRSkAFIVALEIDCSAVRQAIENVSHSpwqdRIEVVEADFKHYT-STAQFDVIVSN 111
Cdd:COG2227    20 RLLPAGGRVLDVGCGTGRLALALARRG-ADVTGVDISPEALEIARERAAEL----NVDFVQGDLEDLPlEDGSFDLVICS 94
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 40-168 1.65e-08

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 52.26  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILD--IGTGTGLV-ALMLAQRskafIVALEIDCSAVRQAIENVSHSPWQDrIEVVEADFKH-YTSTAQFDVIVSNPPYf 115
Cdd:COG1041    29 TVLDpfCGTGTILIeAGLLGRR----VIGSDIDPKMVEGARENLEHYGYED-ADVIRGDARDlPLADESVDAIVTDPPY- 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2740924189 116 tdslkcpNQQRNTARHDNELTYKELLEGVSQLLsADGAFTVIV-PADVSDRVKE 168
Cdd:COG1041   103 -------GRSSKISGEELLELYEKALEEAARVL-KPGGRVVIVtPRDIDELLEE 148
PRK14967 PRK14967
putative methyltransferase; Provisional
 40-114 1.91e-08

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 53.13  E-value: 1.91e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2740924189  40 RILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIEN-VSHSPwqdRIEVVEADFKHYTSTAQFDVIVSNPPY 114
Cdd:PRK14967   39 RVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNaLLAGV---DVDVRRGDWARAVEFRPFDVVVSNPPY 111
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 39-114 1.94e-08

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 52.36  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  39 QRILD--IGTGTGLV--ALM--------LAQRSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHYT-STAQF 105
Cdd:pfam01170  30 DPLLDpmCGSGTILIeaALMganiapgkFDARVRAPLYGSDIDRRMVQGARLNAENAGVGDLIEFVQADAADLPlLEGSV 109


                  ....*....
gi 2740924189 106 DVIVSNPPY 114
Cdd:pfam01170 110 DVIVTNPPY 118
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 25-114 4.57e-08

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 51.39  E-value: 4.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  25 DGVLLGAWPHVDGAQRILDIGTGTGLVALMLAQRSKAfIVALEIDCSAVRQAIENVSHSpwQDRIEVVEAD-FKHYtsTA 103
Cdd:TIGR00537   7 DSLLLEANLRELKPDDVLEIGAGTGLVAIRLKGKGKC-ILTTDINPFAVKELRENAKLN--NVGLDVVMTDlFKGV--RG 81

                          90
                  ....*....|.
gi 2740924189 104 QFDVIVSNPPY 114
Cdd:TIGR00537  82 KFDVILFNPPY 92
rADc smart00650
Ribosomal RNA adenine dimethylases;
34-114 1.08e-07

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 50.20  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189   34 HVDGAQRILDIGTGTGLVALMLAQRSKaFIVALEID---CSAVRQaienvsHSPWQDRIEVVEADF-KHYTSTAQFDVIV 109
Cdd:smart00650  10 NLRPGDTVLEIGPGKGALTEELLERAK-RVTAIEIDprlAPRLRE------KFAAADNLTVIHGDAlKFDLPKLQPYKVV 82


                   ....*
gi 2740924189  110 SNPPY 114
Cdd:smart00650  83 GNLPY 87
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 37-113 4.57e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 49.79  E-value: 4.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  37 GAQRILDIGTGTGLVALMLAQRSKAfIVALEIDCSAVRQAIENVSHSPWqDRIEVVEAD----FKHYTSTAQFDVIVSNP 112
Cdd:COG2265   233 GGERVLDLYCGVGTFALPLARRAKK-VIGVEIVPEAVEDARENARLNGL-KNVEFVAGDleevLPELLWGGRPDVVVLDP 310


                  .
gi 2740924189 113 P 113
Cdd:COG2265   311 P 311
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
39-111 6.57e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 48.61  E-value: 6.57e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2740924189  39 QRILDIGTGTG---LVALML-AQRskafIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKhytstaqFDVIVSN 111
Cdd:PRK00517  121 KTVLDVGCGSGilaIAAAKLgAKK----VLAVDIDPQAVEAARENAELNGVELNVYLPQGDLK-------ADVIVAN 186
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 7-115 1.35e-06

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 47.49  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189   7 QFKQFTVWHDKCAMKVGTD-GVLLGAWPHVDGAQRILDIGTGTGLVALMLAQR--SKAFIVALEIDCSAVRQAIENVSHS 83
Cdd:pfam01596  12 ELREETAKLPLAPMQVSPDeGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALAlpEDGKITAIDIDPEAYEIAKKFIQKA 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2740924189  84 PWQDRIEVVEAD-------FKHYTSTAQFDVIV-----SNPPYF 115
Cdd:pfam01596  92 GVAHKISFILGPalkvleqLTQDKPLPEFDFIFidadkSNYPNY 135
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 35-120 3.29e-06

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 46.23  E-value: 3.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  35 VDGAQRILDIGTGTGLVALMLAQRSKAfIVALEIDCSAVRQAIENVSHSPWqDRIEVVEADFKH-YTSTAQFDVIVSN-- 111
Cdd:COG2518    64 LKPGDRVLEIGTGSGYQAAVLARLAGR-VYSVERDPELAERARERLAALGY-DNVTVRVGDGALgWPEHAPFDRIIVTaa 141

                          90
                  ....*....|...
gi 2740924189 112 ----PPYFTDSLK 120
Cdd:COG2518   142 apevPEALLEQLA 154
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 34-111 6.18e-06

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 46.10  E-value: 6.18e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2740924189  34 HVDGAQRILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEV-VEADFKHytstAQFDVIVSN 111
Cdd:pfam06325 158 LVKPGESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARLEVyLPGDLPK----EKADVVVAN 232
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 36-111 1.00e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 44.33  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  36 DGAQRILDIGTGTGLVALMLAQR--SKAFIVALEIDCSAVRQAIENVSHSPWqDRIEVVEADFKHYTST---AQFDVIVS 110
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEElgPNAEVVGIDISEEAIEKARENAQKLGF-DNVEFEQGDIEELPELledDKFDVVIS 80


                  .
gi 2740924189 111 N 111
Cdd:pfam13847  81 N 81
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 40-145 1.15e-05

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 45.46  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILDIGTGTGLVALMLA-QRSKAFIVALEIDCSAVRQAIENVS---------HSPWQDrievveadfKHYTSTAQFDVIV 109
Cdd:PRK14966  254 RVWDLGTGSGAVAVTVAlERPDAFVRASDISPPALETARKNAAdlgarvefaHGSWFD---------TDMPSEGKWDIIV 324

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2740924189 110 SNPPYFTDSLKCPNQqrNTARHDNELTYKELLEGVS 145
Cdd:PRK14966  325 SNPPYIENGDKHLLQ--GDLRFEPQIALTDFSDGLS 358
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 63-114 1.37e-05

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 45.09  E-value: 1.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2740924189  63 IVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHYTSTAQFDVIVSNPPY 114
Cdd:COG0116   253 IFGSDIDPRAIEAARENAERAGVADLIEFEQADFRDLEPPAEPGLIITNPPY 304
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
40-156 1.93e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.83  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILDIGTGTGLVALMLAQRSKaFIVALEIDCSAVRQAIENvshspwQDRIEVVEADFKHYTST-AQFDVIVSnppyfTDS 118
Cdd:COG4976    49 RVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKAREK------GVYDRLLVADLADLAEPdGRFDLIVA-----ADV 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2740924189 119 LkcpnqqrnTARHDNEltykELLEGVSQLLSADG--AFTV 156
Cdd:COG4976   117 L--------TYLGDLA----AVFAGVARALKPGGlfIFSV 144
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 34-114 3.12e-05

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 43.96  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  34 HVDGAQRILDIGTGTGlvAL--MLAQRSKAfIVALEIDCSAVRQAIENVSHSPwqdRIEVVEADFKHYT----STAQFDV 107
Cdd:COG0030    34 GITPGDTVLEIGPGLG--ALtrALLERAAR-VTAVEIDRRLAAILRETFAAYP---NLTVIEGDALKVDlpalAAGEPLK 107


                  ....*..
gi 2740924189 108 IVSNPPY 114
Cdd:COG0030   108 VVGNLPY 114
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
33-114 3.73e-05

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 43.00  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  33 PHVDGAqRILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPWQDRiEVVEADFKHYTSTA----QFDVI 108
Cdd:pfam03602  38 PYIEGA-RVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQILKENLQLLGLPGA-VLVMDALLALLRLAgkgpVFDIV 115


                  ....*.
gi 2740924189 109 VSNPPY 114
Cdd:pfam03602 116 FLDPPY 121
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 42-111 4.48e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 41.11  E-value: 4.48e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2740924189  42 LDIGTGTGLVALMLAQRSkAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEA-DFKHytstAQFDVIVSN 111
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG-ARVTGVDISPEMLELAREKAPREGLTFVVGDAEDlPFPD----NSFDLVLSS 66
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 41-114 4.52e-05

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 43.45  E-value: 4.52e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2740924189  41 ILDIGTGTGLVALMLAQRSKAfIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHyTSTAQFDVIVSNPPY 114
Cdd:PTZ00338   40 VLEIGPGTGNLTEKLLQLAKK-VIAIEIDPRMVAELKKRFQNSPLASKLEVIEGDALK-TEFPYFDVCVANVPY 111
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 40-117 5.33e-05

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 43.31  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHYTSTA--QFDVIVSNPPYFTD 117
Cdd:COG2520   183 RVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKENIRLNKVEDRVTPILGDAREVAPELegKADRIIMNLPHSAD 262
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
20-116 8.50e-05

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 42.59  E-value: 8.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  20 MKVGTDGVLLGAwphvdgaqRILDIGTGTGLVALMLAQRSKAFIVALEIDcsavrqaiENV----SHSPW-----QDRIE 90
Cdd:COG2521   123 RKVKLVGVRRGD--------RVLDTCTGLGYTAIEALKRGAREVITVEKD--------PNVlelaELNPWsrelaNERIK 186

                          90       100
                  ....*....|....*....|....*....
gi 2740924189  91 VVEAD---FKHYTSTAQFDVIVSNPPYFT 116
Cdd:COG2521   187 IILGDaseVIKTFPDESFDAIIHDPPRFS 215
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
39-114 1.03e-04

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 42.35  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  39 QRILDIGTGTGLVALMLAQRSKAfIVALEIDCSAVRQAIENVSHSPwqdRIEVVEADF------KHYTSTAQFDVIVSNP 112
Cdd:pfam00398  32 DTVLEIGPGKGALTVILAKRAKQ-VVAIEIDPRLAKLLQKKLSLDE---NLTVIHQDFlkfefpSLVTHIHQEFLVVGNL 107


                  ..
gi 2740924189 113 PY 114
Cdd:pfam00398 108 PY 109
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 35-110 1.68e-04

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 41.96  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  35 VDGAQRILDIGTGTGLVALMLAQR-SKAFIVALEID---CSAVRQAIENVSHSPWqdrieVVEAD-FKHYTSTAQFDVIV 109
Cdd:TIGR04188 105 VEDGHRVLEIGTGTGYSAALLCHRlGDDNVTSVEVDpglAARAASALAAAGYAPT-----VVTGDgLLGHPPRAPYDRII 179


                  .
gi 2740924189 110 S 110
Cdd:TIGR04188 180 A 180
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 29-110 5.24e-04

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 39.75  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  29 LGAWPHVD-GAQRILDIGTGTGL----VALMLAQRSkafIVALEID---CSAVRQAIE-----NVshSPWQDRIEVVEAD 95
Cdd:COG0357    58 LALLPLLPkEGARVLDVGSGAGFpgipLAIARPDLQ---VTLVDSLgkkIAFLREVVRelglkNV--TVVHGRAEELAPR 132

                          90
                  ....*....|....*
gi 2740924189  96 fkhytstAQFDVIVS 110
Cdd:COG0357   133 -------EKFDVVTA 140
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
33-120 6.06e-04

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 40.31  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  33 PHVDGaqRILDIGTGTGLVALMLAQRSKAFIVALEiDCSAVrqAIENVSHSPWQDRIE--VVEAD-FKHYtsTAQFDVIV 109
Cdd:PRK09489  194 PHTKG--KVLDVGCGAGVLSAVLARHSPKIRLTLS-DVSAA--ALESSRATLAANGLEgeVFASNvFSDI--KGRFDMII 266

                          90
                  ....*....|.
gi 2740924189 110 SNPPyFTDSLK 120
Cdd:PRK09489  267 SNPP-FHDGIQ 276
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 33-114 1.28e-03

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 38.52  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  33 PHVDGAqRILDIGTGTGLVALMLAQRSKAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADFKHY---TSTAQFDVIV 109
Cdd:COG0742    38 PDIEGA-RVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVIRKNLEKLGLEDRARVIRGDALRFlkrLAGEPFDLVF 116


                  ....*
gi 2740924189 110 SNPPY 114
Cdd:COG0742   117 LDPPY 121
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 42-111 1.39e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.96  E-value: 1.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2740924189  42 LDIGTGTGLVALMLAQRSK-AFIVALEIDCSAVRQAIENVSHSPWQD--RIEVVEADFkHYTSTAQFDVIVSN 111
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPgLEYTGLDISPAALEAARERLAALGLLNavRVELFQLDL-GELDPGSFDVVVAS 72
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 39-95 3.03e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 37.83  E-value: 3.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2740924189  39 QRILDIGTGTGLVALMLAQRS--KAFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEAD 95
Cdd:PRK00216   53 DKVLDLACGTGDLAIALAKAVgkTGEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGD 111
PHA03411 PHA03411
putative methyltransferase; Provisional
 40-114 3.41e-03

putative methyltransferase; Provisional


Pssm-ID: 177639 [Multi-domain]  Cd Length: 279  Bit Score: 37.77  E-value: 3.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2740924189  40 RILDIGTGTGLVALMLAQRSKA-FIVALEIDCSAVRQAIENVSHSPWqdrievVEADFKHYTSTAQFDVIVSNPPY 114
Cdd:PHA03411   67 KVLDLCAGIGRLSFCMLHRCKPeKIVCVELNPEFARIGKRLLPEAEW------ITSDVFEFESNEKFDVVISNPPF 136
GidB pfam02527
rRNA small subunit methyltransferase G; This is a family of bacterial glucose inhibited ...
 29-110 4.78e-03

rRNA small subunit methyltransferase G; This is a family of bacterial glucose inhibited division proteins these are probably involved in the regulation of cell devision. GidB has been shown to be a methyltransferase G specific to the rRNA small subunit. Previously identified as a glucose-inhibited division protein B that appears to be present and in a single copy in all complete eubacterial genomes so far sequenced. GidB specifically methylates the N7 position of a guanosine in 16S rRNA.


Pssm-ID: 396880  Cd Length: 184  Bit Score: 36.87  E-value: 4.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  29 LGAWPHVDGAQR-ILDIGTGTGL--VALMLAQRSKAFIValeIDCSAVRQA-IENVSHSPWQDRIEVVEADFKHYTSTAQ 104
Cdd:pfam02527  39 LVVLEYLDNDRDhVLDVGSGAGFpgIPLAIARPDKKVTL---LESLLKKINfLEEVKSELGLDNVTIVHARAEEYQPEEQ 115


                  ....*.
gi 2740924189 105 FDVIVS 110
Cdd:pfam02527 116 YDVITS 121
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 40-173 6.64e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 36.25  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  40 RILDIGTGTGLVALMLAQRSKAfIVALEIDCSAVRQAIENVSHSPWQDRIEVVEADfkhytstaQFDVIVSNppYFTDSL 119
Cdd:pfam13489  25 RVLDFGCGTGIFLRLLRAQGFS-VTGVDPSPIAIERALLNVRFDQFDEQEAAVPAG--------KFDVIVAR--EVLEHV 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2740924189 120 KCPnqqrntarhdneltyKELLEGVSQLLSADGAFTVIVPaDVSDRVKEIALNY 173
Cdd:pfam13489  94 PDP---------------PALLRQIAALLKPGGLLLLSTP-LASDEADRLLLEW 131
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 61-152 7.20e-03

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 37.08  E-value: 7.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2740924189  61 AFIVALEIDCSAVRQAIENVSHSPWQDRIEVVEAD-FK----HYTSTAQFDVIVSNPPYFTDSLKcpnqQRNTARHDnel 135
Cdd:COG1092   240 KSVTSVDLSATALEWAKENAALNGLDDRHEFVQADaFDwlreLAREGERFDLIILDPPAFAKSKK----DLFDAQRD--- 312

                          90
                  ....*....|....*..
gi 2740924189 136 tYKELLEGVSQLLSADG 152
Cdd:COG1092   313 -YKDLNRLALKLLAPGG 328
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 39-111 9.24e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 36.50  E-value: 9.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2740924189  39 QRILDIGTGTGLVALMLAQR-SKAFIVALEIDCSAVRQAIENVShspwqDRIEVVEADFKHY-TSTAQFDVIVSN 111
Cdd:TIGR02072  36 ASVLDIGCGTGYLTRALLKRfPQAEFIALDISAGMLAQAKTKLS-----ENVQFICGDAEKLpLEDSSFDLIVSN 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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