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Conserved domains on  [gi|2739770159|ref|WP_348656170|]
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GAF domain-containing protein, partial [uncultured Sulfitobacter sp.]

Protein Classification

GAF domain-containing protein( domain architecture ID 10005003)

GAF (cyclic GMP, adenylyl cyclase, FhlA) domain-containing protein similar to Saccharomyces cerevisiae free methionine-R-sulfoxide reductase (fRMsr), which catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine, protecting the cell from oxidative stress

CATH:  3.30.450.40
Gene Ontology:  GO:0005515
PubMed:  12518043|11032796
SCOP:  4001852

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MsrC COG1956
GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, ...
 1-121 2.55e-59

GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms];


:

Pssm-ID: 441559 [Multi-domain]  Cd Length: 156  Bit Score: 179.64  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159   1 CEVHHADDRFDWTGFYRVTAPELLKIGPYQGGHGCLVIPFARGVCGAAARTGETQLVADVDAFPGHIACASSTRSELVLP 80
Cdd:COG1956    35 ALLFEALPDYNWVGFYLVDGGGELVLGPFQGPPACTRIPFGKGVCGTAAAEGETQLVPDVHAFPGHIACDSASRSEIVVP 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2739770159  81 VWKGaGELLGVFDIDSNQPAAFDQTDADELAAILKSVFANV 121
Cdd:COG1956   115 IFKD-GEVIGVLDIDSPTPGRFDEEDQAGLEALAALLAEAL 154
 
Name Accession Description Interval E-value
MsrC COG1956
GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, ...
 1-121 2.55e-59

GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms];


Pssm-ID: 441559 [Multi-domain]  Cd Length: 156  Bit Score: 179.64  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159   1 CEVHHADDRFDWTGFYRVTAPELLKIGPYQGGHGCLVIPFARGVCGAAARTGETQLVADVDAFPGHIACASSTRSELVLP 80
Cdd:COG1956    35 ALLFEALPDYNWVGFYLVDGGGELVLGPFQGPPACTRIPFGKGVCGTAAAEGETQLVPDVHAFPGHIACDSASRSEIVVP 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2739770159  81 VWKGaGELLGVFDIDSNQPAAFDQTDADELAAILKSVFANV 121
Cdd:COG1956   115 IFKD-GEVIGVLDIDSPTPGRFDEEDQAGLEALAALLAEAL 154
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 27-113 2.60e-07

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 45.92  E-value: 2.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159  27 GPYQGGHGCLVIPFARGVCGAAARTGETQLVADVDAFPGHI---ACASSTRSELVLPVWKGaGELLGVFDIDSNQPAAFD 103
Cdd:pfam13185  40 GAADELSAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKglpAGHAGLRSFLSVPLVSG-GRVVGVLALGSNRPGAFD 118

                          90
                  ....*....|
gi 2739770159 104 QTDADELAAI 113
Cdd:pfam13185 119 EEDLELLELL 128
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 38-113 8.19e-03

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 33.89  E-value: 8.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159   38 IPFARGVCGAAARTGETQLVADVDA---FPGHIAC-ASSTRSELVLPVWKGaGELLGVFDIDS-NQPAAFDQTDADELAA 112
Cdd:smart00065  52 FPLDEGLAGRVAETGRPLNIPDVEAdplFAEDLLGrYQGVRSFLAVPLVAD-GELVGVLALHNkKSPRPFTEEDEELLQA 130


                   .
gi 2739770159  113 I 113
Cdd:smart00065 131 L 131
 
Name Accession Description Interval E-value
MsrC COG1956
GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, ...
 1-121 2.55e-59

GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms];


Pssm-ID: 441559 [Multi-domain]  Cd Length: 156  Bit Score: 179.64  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159   1 CEVHHADDRFDWTGFYRVTAPELLKIGPYQGGHGCLVIPFARGVCGAAARTGETQLVADVDAFPGHIACASSTRSELVLP 80
Cdd:COG1956    35 ALLFEALPDYNWVGFYLVDGGGELVLGPFQGPPACTRIPFGKGVCGTAAAEGETQLVPDVHAFPGHIACDSASRSEIVVP 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2739770159  81 VWKGaGELLGVFDIDSNQPAAFDQTDADELAAILKSVFANV 121
Cdd:COG1956   115 IFKD-GEVIGVLDIDSPTPGRFDEEDQAGLEALAALLAEAL 154
GAF COG2203
GAF domain [Signal transduction mechanisms];
38-113 3.39e-08

GAF domain [Signal transduction mechanisms];


Pssm-ID: 441805 [Multi-domain]  Cd Length: 712  Bit Score: 50.19  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159  38 IPFARGVCGAAARTGETQLVADVDAFPGHIACASS------TRSELVLPVWKGaGELLGVFDIDSNQPAAFDQTDADELA 111
Cdd:COG2203   256 LPLGEGLAGRALRTGEPVVVNDASTDPRFAPSLRElllalgIRSLLCVPLLVD-GRLIGVLALYSKEPRAFTEEDLELLE 334


                  ..
gi 2739770159 112 AI 113
Cdd:COG2203   335 AL 336
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 27-113 2.60e-07

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 45.92  E-value: 2.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159  27 GPYQGGHGCLVIPFARGVCGAAARTGETQLVADVDAFPGHI---ACASSTRSELVLPVWKGaGELLGVFDIDSNQPAAFD 103
Cdd:pfam13185  40 GAADELSAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKglpAGHAGLRSFLSVPLVSG-GRVVGVLALGSNRPGAFD 118

                          90
                  ....*....|
gi 2739770159 104 QTDADELAAI 113
Cdd:pfam13185 119 EEDLELLELL 128
PtsP COG3605
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
38-114 1.04e-03

Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];


Pssm-ID: 442824 [Multi-domain]  Cd Length: 188  Bit Score: 36.80  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159  38 IPFARGVCGAAARTGETQLVADVDAFPGhIACASSTRSE-----LVLPVwKGAGELLGVFDIDSNQPAAFDQTD------ 106
Cdd:COG3605    69 LPLGEGLVGLVAERGEPLNLADAASHPR-FKYFPETGEEgfrsfLGVPI-IRRGRVLGVLVVQSREPREFTEEEveflvt 146


                  ....*....
gi 2739770159 107 -ADELAAIL 114
Cdd:COG3605   147 lAAQLAEAI 155
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 38-113 8.19e-03

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 33.89  E-value: 8.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2739770159   38 IPFARGVCGAAARTGETQLVADVDA---FPGHIAC-ASSTRSELVLPVWKGaGELLGVFDIDS-NQPAAFDQTDADELAA 112
Cdd:smart00065  52 FPLDEGLAGRVAETGRPLNIPDVEAdplFAEDLLGrYQGVRSFLAVPLVAD-GELVGVLALHNkKSPRPFTEEDEELLQA 130


                   .
gi 2739770159  113 I 113
Cdd:smart00065 131 L 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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