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Conserved domains on  [gi|2730304920|ref|WP_344496744|]
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ABC transporter permease subunit, partial [Nonomuraea monospora]

Protein Classification

ABC transporter permease( domain architecture ID 10003065)

ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of substrates including gylcine betaine, choline, and carnitine

Gene Ontology:  GO:0140359|GO:0042626|GO:0055085|GO:0016020
PubMed:  25750732|24638992|31571164|27273632|26517919|18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 1-112 1.50e-39

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 130.94  E-value: 1.50e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920   1 LPLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGLL 80
Cdd:COG1174    95 LPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAGGLGDLIFDGLQ 174

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2730304920  81 SSALDLVLLGVVPTIALAVVVDALFALWGAWL 112
Cdd:COG1174   175 LNNTALILAGAILVALLALLVDLLLALLERLL 206
 
Name Accession Description Interval E-value
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 1-112 1.50e-39

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 130.94  E-value: 1.50e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920   1 LPLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGLL 80
Cdd:COG1174    95 LPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAGGLGDLIFDGLQ 174

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2730304920  81 SSALDLVLLGVVPTIALAVVVDALFALWGAWL 112
Cdd:COG1174   175 LNNTALILAGAILVALLALLVDLLLALLERLL 206
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
2-104 5.78e-12

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 60.49  E-value: 5.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920   2 PLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGLLS 81
Cdd:PRK10952  222 PIVRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGR 301

                          90       100
                  ....*....|....*....|...
gi 2730304920  82 SALDLVLLGVVPTIALAVVVDAL 104
Cdd:PRK10952  302 LDMGLATVGGVGIVILAIILDRL 324
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 2-112 1.27e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 50.38  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920   2 PLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAG-GFGALVFQGLL 80
Cdd:pfam00528  66 YARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWpGLGLLLIEAIL 145

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2730304920  81 SSALDLVLLGVVPTIALAVVVDALFALWGAWL 112
Cdd:pfam00528 146 GYDYPEIQGPVLAAALILLLLNLLVDILQRLL 177
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 10-101 8.30e-04

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 36.87  E-value: 8.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920  10 GLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGLLSSALDLVLL 89
Cdd:cd06261    95 ALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGD 174

                          90
                  ....*....|..
gi 2730304920  90 GVVPTIALAVVV 101
Cdd:cd06261   175 LGVAAAVALILL 186
 
Name Accession Description Interval E-value
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 1-112 1.50e-39

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 130.94  E-value: 1.50e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920   1 LPLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGLL 80
Cdd:COG1174    95 LPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAGGLGDLIFDGLQ 174

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2730304920  81 SSALDLVLLGVVPTIALAVVVDALFALWGAWL 112
Cdd:COG1174   175 LNNTALILAGAILVALLALLVDLLLALLERLL 206
ProW COG4176
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 2-79 4.84e-13

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443335  Cd Length: 275  Bit Score: 63.19  E-value: 4.84e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2730304920   2 PLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGL 79
Cdd:COG4176   168 PAIRLTNLGIRQVPKELVEAADAFGATPWQLLFKVQLPLALPTIMAGVNQTIMLALSMVVIASMIGAGGLGQEVLRAL 245
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
2-104 5.78e-12

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 60.49  E-value: 5.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920   2 PLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGLLS 81
Cdd:PRK10952  222 PIVRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGR 301

                          90       100
                  ....*....|....*....|...
gi 2730304920  82 SALDLVLLGVVPTIALAVVVDAL 104
Cdd:PRK10952  302 LDMGLATVGGVGIVILAIILDRL 324
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 2-112 8.92e-12

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 59.39  E-value: 8.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920   2 PLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAG-GFGALVFQGLL 80
Cdd:COG0600   139 PILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALGLAWIGLVVAELLGASsGLGYLILDARQ 218

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2730304920  81 SSALDLVLLGVVPTIALAVVVDALFALWGAWL 112
Cdd:COG0600   219 LLDTDLVFAAILVIGLLGLLLDLLLRLLERRL 250
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 2-112 1.27e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 50.38  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920   2 PLVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAG-GFGALVFQGLL 80
Cdd:pfam00528  66 YARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWpGLGLLLIEAIL 145

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2730304920  81 SSALDLVLLGVVPTIALAVVVDALFALWGAWL 112
Cdd:pfam00528 146 GYDYPEIQGPVLAAALILLLLNLLVDILQRLL 177
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
3-77 2.36e-04

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 38.56  E-value: 2.36e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2730304920   3 LVRGVVTGLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQ 77
Cdd:PRK10782  104 IARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQ 178
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 10-101 8.30e-04

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 36.87  E-value: 8.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2730304920  10 GLQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLLRSLRVVSVQTVGMAVVAALIGAGGFGALVFQGLLSSALDLVLL 89
Cdd:cd06261    95 ALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGD 174

                          90
                  ....*....|..
gi 2730304920  90 GVVPTIALAVVV 101
Cdd:cd06261   175 LGVAAAVALILL 186
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 11-46 7.89e-03

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 34.43  E-value: 7.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2730304920  11 LQQVPQDALESATAMGMSAGQRFRQVQLPLAMPVLL 46
Cdd:COG4986   156 LRTVPRDLDEAARIFRLSGWQRFWRLELPFAMPGLV 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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