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Conserved domains on  [gi|2678286443|ref|WP_333486298|]
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PfkB family carbohydrate kinase [Megamonas funiformis]

Protein Classification

bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase( domain architecture ID 11458310)

bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase is involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RfaE COG2870
ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell wall/membrane ...
 1-131 1.92e-51

ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442117 [Multi-domain]  Cd Length: 321  Bit Score: 166.14  E-value: 1.92e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443   1 MKPELIDFVEKFKGKRILIIGDMIADIYLKGDISRISREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGED 80
Cdd:COG2870     2 SRERLKELLPRFSRARVLVVGDVMLDRYWYGDVERISPEAPVPVVRVEREEERPGGAANVAANLAALGAQVTLVGVVGDD 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2678286443  81 KGALNLKQILEENNVNTEGMFCDQNRKTITKTRVIAGGratvsQQVVRIDY 131
Cdd:COG2870    82 EAGRELRRLLEEAGIDTDGLVVDPRRPTTTKTRVIAGG-----QQLLRLDF 127
 
Name Accession Description Interval E-value
RfaE COG2870
ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell wall/membrane ...
 1-131 1.92e-51

ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442117 [Multi-domain]  Cd Length: 321  Bit Score: 166.14  E-value: 1.92e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443   1 MKPELIDFVEKFKGKRILIIGDMIADIYLKGDISRISREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGED 80
Cdd:COG2870     2 SRERLKELLPRFSRARVLVVGDVMLDRYWYGDVERISPEAPVPVVRVEREEERPGGAANVAANLAALGAQVTLVGVVGDD 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2678286443  81 KGALNLKQILEENNVNTEGMFCDQNRKTITKTRVIAGGratvsQQVVRIDY 131
Cdd:COG2870    82 EAGRELRRLLEEAGIDTDGLVVDPRRPTTTKTRVIAGG-----QQLLRLDF 127
rfaE_dom_I TIGR02198
rfaE bifunctional protein, domain I; RfaE is a protein involved in the biosynthesis of ...
 10-131 7.52e-43

rfaE bifunctional protein, domain I; RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in E. coli, and separate proteins in some other genome. The longer, N-terminal domain I (this family) is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (TIGR02199) adds ADP to yield ADP-D-glycero-D-manno-heptose. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274029 [Multi-domain]  Cd Length: 315  Bit Score: 143.91  E-value: 7.52e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  10 EKFKGKRILIIGDMIADIYLKGDISRISREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDKGALNLKQI 89
Cdd:TIGR02198   3 ASFKGAKVLVVGDVMLDRYWYGKVSRISPEAPVPVVKVEREEDRLGGAANVARNIASLGARVFLVGVVGDDEAGKRLEAL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2678286443  90 LEENNVNTEGMFCDQNRKTITKTRVIAGgratvSQQVVRIDY 131
Cdd:TIGR02198  83 LAEEGIDTSGLIRDKDRPTTTKTRVLAR-----NQQLLRVDF 119
RfaE_like cd01172
RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the ...
 16-142 5.70e-40

RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer membrane of gram-negative bacteria. RfaE consists of two domains, a sugar kinase domain, represented here, and a domain belonging to the cytidylyltransferase superfamily.


Pssm-ID: 238577 [Multi-domain]  Cd Length: 304  Bit Score: 136.15  E-value: 5.70e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  16 RILIIGDMIADIYLKGDISRISREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDKGALNLKQILEENNV 95
Cdd:cd01172     1 KVLVVGDVILDEYLYGDVERISPEAPVPVVKVEREEIRLGGAANVANNLASLGAKVTLLGVVGDDEAGDLLRKLLEKEGI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2678286443  96 NTEGmFCDQNRKTITKTRVIAGGratvsQQVVRIDYCEPHTCDLNHE 142
Cdd:cd01172    81 DTDG-IVDEGRPTTTKTRVIARN-----QQLLRVDREDDSPLSAEEE 121
PRK11316 PRK11316
bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose ...
 1-134 5.72e-24

bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE;


Pssm-ID: 183085 [Multi-domain]  Cd Length: 473  Bit Score: 96.05  E-value: 5.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443   1 MKPELIDFvEKfkgKRILIIGDMIADIYLKGDISRISREAPVLV--LIESEEKtvAGGAANVVNNVATLGGKAFAVGILG 78
Cdd:PRK11316    1 MKVTLPDF-ER---AGVLVVGDVMLDRYWYGPTSRISPEAPVPVvkVNQIEER--PGGAANVAMNIASLGAQARLVGLTG 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  79 EDKGALNLKQILEENNVNtegmfCD----QNRKTITKTRVIagGRatvSQQVVRIDYCEP 134
Cdd:PRK11316   75 IDEAARALSKLLAAVGVK-----CDfvsvPTHPTITKLRVL--SR---NQQLIRLDFEEG 124
PfkB pfam00294
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ...
 16-121 2.46e-10

pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.


Pssm-ID: 425587 [Multi-domain]  Cd Length: 294  Bit Score: 56.97  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  16 RILIIGDMIADIYLKGDisrisREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDKGALNLKQILEENNV 95
Cdd:pfam00294   1 KVVVIGEANIDLIGNVE-----GLPGELVRVSTVEKGPGGKGANVAVALARLGGDVAFIGAVGDDNFGEFLLQELKKEGV 75

                          90       100
                  ....*....|....*....|....*.
gi 2678286443  96 NTEGMFCDQNRKTITKTRVIAGGRAT 121
Cdd:pfam00294  76 DTDYVVIDEDTRTGTALIEVDGDGER 101
 
Name Accession Description Interval E-value
RfaE COG2870
ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell wall/membrane ...
 1-131 1.92e-51

ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442117 [Multi-domain]  Cd Length: 321  Bit Score: 166.14  E-value: 1.92e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443   1 MKPELIDFVEKFKGKRILIIGDMIADIYLKGDISRISREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGED 80
Cdd:COG2870     2 SRERLKELLPRFSRARVLVVGDVMLDRYWYGDVERISPEAPVPVVRVEREEERPGGAANVAANLAALGAQVTLVGVVGDD 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2678286443  81 KGALNLKQILEENNVNTEGMFCDQNRKTITKTRVIAGGratvsQQVVRIDY 131
Cdd:COG2870    82 EAGRELRRLLEEAGIDTDGLVVDPRRPTTTKTRVIAGG-----QQLLRLDF 127
rfaE_dom_I TIGR02198
rfaE bifunctional protein, domain I; RfaE is a protein involved in the biosynthesis of ...
 10-131 7.52e-43

rfaE bifunctional protein, domain I; RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in E. coli, and separate proteins in some other genome. The longer, N-terminal domain I (this family) is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (TIGR02199) adds ADP to yield ADP-D-glycero-D-manno-heptose. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274029 [Multi-domain]  Cd Length: 315  Bit Score: 143.91  E-value: 7.52e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  10 EKFKGKRILIIGDMIADIYLKGDISRISREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDKGALNLKQI 89
Cdd:TIGR02198   3 ASFKGAKVLVVGDVMLDRYWYGKVSRISPEAPVPVVKVEREEDRLGGAANVARNIASLGARVFLVGVVGDDEAGKRLEAL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2678286443  90 LEENNVNTEGMFCDQNRKTITKTRVIAGgratvSQQVVRIDY 131
Cdd:TIGR02198  83 LAEEGIDTSGLIRDKDRPTTTKTRVLAR-----NQQLLRVDF 119
RfaE_like cd01172
RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the ...
 16-142 5.70e-40

RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer membrane of gram-negative bacteria. RfaE consists of two domains, a sugar kinase domain, represented here, and a domain belonging to the cytidylyltransferase superfamily.


Pssm-ID: 238577 [Multi-domain]  Cd Length: 304  Bit Score: 136.15  E-value: 5.70e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  16 RILIIGDMIADIYLKGDISRISREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDKGALNLKQILEENNV 95
Cdd:cd01172     1 KVLVVGDVILDEYLYGDVERISPEAPVPVVKVEREEIRLGGAANVANNLASLGAKVTLLGVVGDDEAGDLLRKLLEKEGI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2678286443  96 NTEGmFCDQNRKTITKTRVIAGGratvsQQVVRIDYCEPHTCDLNHE 142
Cdd:cd01172    81 DTDG-IVDEGRPTTTKTRVIARN-----QQLLRVDREDDSPLSAEEE 121
PRK11316 PRK11316
bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose ...
 1-134 5.72e-24

bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE;


Pssm-ID: 183085 [Multi-domain]  Cd Length: 473  Bit Score: 96.05  E-value: 5.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443   1 MKPELIDFvEKfkgKRILIIGDMIADIYLKGDISRISREAPVLV--LIESEEKtvAGGAANVVNNVATLGGKAFAVGILG 78
Cdd:PRK11316    1 MKVTLPDF-ER---AGVLVVGDVMLDRYWYGPTSRISPEAPVPVvkVNQIEER--PGGAANVAMNIASLGAQARLVGLTG 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  79 EDKGALNLKQILEENNVNtegmfCD----QNRKTITKTRVIagGRatvSQQVVRIDYCEP 134
Cdd:PRK11316   75 IDEAARALSKLLAAVGVK-----CDfvsvPTHPTITKLRVL--SR---NQQLIRLDFEEG 124
PfkB pfam00294
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ...
 16-121 2.46e-10

pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.


Pssm-ID: 425587 [Multi-domain]  Cd Length: 294  Bit Score: 56.97  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  16 RILIIGDMIADIYLKGDisrisREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDKGALNLKQILEENNV 95
Cdd:pfam00294   1 KVVVIGEANIDLIGNVE-----GLPGELVRVSTVEKGPGGKGANVAVALARLGGDVAFIGAVGDDNFGEFLLQELKKEGV 75

                          90       100
                  ....*....|....*....|....*.
gi 2678286443  96 NTEGMFCDQNRKTITKTRVIAGGRAT 121
Cdd:pfam00294  76 DTDYVVIDEDTRTGTALIEVDGDGER 101
RbsK COG0524
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ...
 16-108 1.28e-09

Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440290 [Multi-domain]  Cd Length: 301  Bit Score: 54.89  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  16 RILIIGDMIADIYLKGDISRISREapvLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDKGALNLKQILEENNV 95
Cdd:COG0524     1 DVLVIGEALVDLVARVDRLPKGGE---TVLAGSFRRSPGGAAANVAVALARLGARVALVGAVGDDPFGDFLLAELRAEGV 77

                          90
                  ....*....|...
gi 2678286443  96 NTEGMFCDQNRKT 108
Cdd:COG0524    78 DTSGVRRDPGAPT 90
PLN02323 PLN02323
probable fructokinase
 51-108 5.45e-09

probable fructokinase


Pssm-ID: 215183 [Multi-domain]  Cd Length: 330  Bit Score: 53.47  E-value: 5.45e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2678286443  51 KTVAGGA-ANVVNNVATLGGKAFAVGILGEDKGALNLKQILEENNVNTEGMFCDQNRKT 108
Cdd:PLN02323   39 KKAPGGApANVAVGISRLGGSSAFIGKVGDDEFGHMLADILKKNGVNNEGVRFDPGART 97
bac_FRK cd01167
Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for ...
 16-121 5.68e-08

Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.


Pssm-ID: 238572 [Multi-domain]  Cd Length: 295  Bit Score: 50.33  E-value: 5.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  16 RILIIGDMIADIylkgdisrISREAPVLVLIESeektVAGGA-ANVVNNVATLGGKAFAVGILGEDK-GALnLKQILEEN 93
Cdd:cd01167     1 KVVCFGEALIDF--------IPEGSGAPETFTK----APGGApANVAVALARLGGKAAFIGKVGDDEfGDF-LLETLKEA 67

                          90       100
                  ....*....|....*....|....*....
gi 2678286443  94 NVNTEGMFCDQNRKT-ITKTRVIAGGRAT 121
Cdd:cd01167    68 GVDTRGIQFDPAAPTtLAFVTLDADGERS 96
PRK09434 PRK09434
aminoimidazole riboside kinase; Provisional
 23-110 1.73e-05

aminoimidazole riboside kinase; Provisional


Pssm-ID: 236514 [Multi-domain]  Cd Length: 304  Bit Score: 43.39  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  23 MIADIYLKGDisrisreAPVLVLIESEEK--TVAGGA-ANVVNNVATLGGKAFAVGILGEDK-GALnLKQILEENNVNTE 98
Cdd:PRK09434    1 MMNKVWVLGD-------AVVDLIPEGENRylKCPGGApANVAVGIARLGGESGFIGRVGDDPfGRF-MQQTLQDEGVDTT 72

                          90
                  ....*....|..
gi 2678286443  99 GMFCDQNRKTIT 110
Cdd:PRK09434   73 YLRLDPAHRTST 84
KdgK cd01166
2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form ...
 16-108 2.42e-05

2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.


Pssm-ID: 238571 [Multi-domain]  Cd Length: 294  Bit Score: 42.56  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  16 RILIIGDMIADIYlkgdisriSREAPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDK-GALNLKQILEEnN 94
Cdd:cd01166     1 DVVTIGEVMVDLS--------PPGGGRLEQADSFRKFFGGAEANVAVGLARLGHRVALVTAVGDDPfGRFILAELRRE-G 71

                          90
                  ....*....|....
gi 2678286443  95 VNTEGMFCDQNRKT 108
Cdd:cd01166    72 VDTSHVRVDPGRPT 85
ribokinase_pfkB_like cd00287
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including ...
 16-76 8.94e-04

ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-dehydro-3-deoxygluconokinase, 1-phosphofructokinase, the minor 6-phosphofructokinase (PfkB), inosine-guanosine kinase, and adenosine kinase. Even though there is a high degree of structural conservation within this superfamily, their multimerization level varies widely, monomeric (e.g. adenosine kinase), dimeric (e.g. ribokinase), and trimeric (e.g THZ kinase).


Pssm-ID: 238177 [Multi-domain]  Cd Length: 196  Bit Score: 37.84  E-value: 8.94e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2678286443  16 RILIIGDMIADIYLKGDISRISreaPVLVLIESEEKTVAGGAANVVNNVATLGGKAFAVGI 76
Cdd:cd00287     1 RVLVVGSLLVDVILRVDALPLP---GGLVRPGDTEERAGGGAANVAVALARLGVSVTLVGA 58
ribokinase_group_A cd01942
Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ...
 16-100 3.45e-03

Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.


Pssm-ID: 238917 [Multi-domain]  Cd Length: 279  Bit Score: 36.52  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  16 RILIIGDMIADIYLKGD-ISRISREapvlVLIESEEKTVAGGAANVVNNVATLGGKAFAVGILGEDKGALNLKQILEENN 94
Cdd:cd01942     1 DVAVVGHLNYDIILKVEsFPGPFES----VLVKDLRREFGGSAGNTAVALAKLGLSPGLVAAVGEDFHGRLYLEELREEG 76


                  ....*.
gi 2678286443  95 VNTEGM 100
Cdd:cd01942    77 VDTSHV 82
adenosine_kinase cd01168
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside ...
 15-98 4.22e-03

Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway.


Pssm-ID: 238573 [Multi-domain]  Cd Length: 312  Bit Score: 36.05  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2678286443  15 KRILIIGDMIADIYLKGD---ISRISREAPVLVLIESEE----------KTVAGG-AANVVNNVATLGGKAFAVGILGED 80
Cdd:cd01168     2 YDVLGLGNALVDILAQVDdafLEKLGLKKGDMILADMEEqeellaklpvKYIAGGsAANTIRGAAALGGSAAFIGRVGDD 81

                          90
                  ....*....|....*...
gi 2678286443  81 KGALNLKQILEENNVNTE 98
Cdd:cd01168    82 KLGDFLLKDLRAAGVDTR 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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