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Conserved domains on  [gi|2672003220|ref|WP_331223824.1|]
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phosphopyruvate hydratase

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
1-414 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 701.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   1 MTlVIENVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVAL 79
Cdd:COG0148     1 MS-RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKsRYLGKGVLKAVENVNEEIAPAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  80 KGGDPFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGGTDL-ELPQTFHNVINGGEHANNQ 158
Cdd:COG0148    80 IGMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAkTLPVPMMNIINGGAHADNN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 159 IDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAI 238
Cdd:COG0148   160 VDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIAL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 239 AFDAAASYFYNRETKNYDFEGRTYTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTN 318
Cdd:COG0148   240 ALDVAASEFYKDGKYHLKGEGKELTSEEMIDYYADLVDKYP-IVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 319 PRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERV 398
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398
                         410
                  ....*....|....*.
gi 2672003220 399 EKYNQLLRIEEELGKA 414
Cdd:COG0148   399 AKYNQLLRIEEELGDA 414
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
1-414 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 701.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   1 MTlVIENVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVAL 79
Cdd:COG0148     1 MS-RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKsRYLGKGVLKAVENVNEEIAPAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  80 KGGDPFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGGTDL-ELPQTFHNVINGGEHANNQ 158
Cdd:COG0148    80 IGMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAkTLPVPMMNIINGGAHADNN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 159 IDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAI 238
Cdd:COG0148   160 VDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIAL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 239 AFDAAASYFYNRETKNYDFEGRTYTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTN 318
Cdd:COG0148   240 ALDVAASEFYKDGKYHLKGEGKELTSEEMIDYYADLVDKYP-IVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 319 PRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERV 398
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398
                         410
                  ....*....|....*.
gi 2672003220 399 EKYNQLLRIEEELGKA 414
Cdd:COG0148   399 AKYNQLLRIEEELGDA 414
eno PRK00077
enolase; Provisional
1-422 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 699.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   1 MTlVIENVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVAL 79
Cdd:PRK00077    1 MS-KIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKsRYLGKGVLKAVENVNEEIAPAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  80 KGGDPFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGGTDL-ELPQTFHNVINGGEHANNQ 158
Cdd:PRK00077   80 IGLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAkVLPVPMMNIINGGAHADNN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 159 IDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAI 238
Cdd:PRK00077  160 VDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIAL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 239 AFDAAASYFYnrETKNYDFEGRTYTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTN 318
Cdd:PRK00077  240 ALDCAASEFY--KDGKYVLEGEGLTSEEMIDYLAELVDKYP-IVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTN 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 319 PRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERV 398
Cdd:PRK00077  317 TKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERI 396
                         410       420
                  ....*....|....*....|....
gi 2672003220 399 EKYNQLLRIEEELGKAgtrlAHFP 422
Cdd:PRK00077  397 AKYNQLLRIEEELGDA----ARYA 416
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
7-410 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 650.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   7 NVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVALKGGDPF 85
Cdd:cd03313     1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKsRYLGKGVLKAVKNVNEIIAPALIGMDVT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  86 NQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGG-TDLELPQTFHNVINGGEHANNQIDIQEF 164
Cdd:cd03313    81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGlAAYVLPVPMFNVINGGAHAGNKLDFQEF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 165 MITPVERTSFREGFEKIVNTYHVLKKIIADAG--YSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAIAFDA 242
Cdd:cd03313   161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 243 AASYFYNRETKNYD-FEGRTYTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTNPRL 321
Cdd:cd03313   241 AASEFYDEGKYVYDsDEGKKLTSEELIDYYKELVKKYP-IVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPER 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 322 IREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERVEKY 401
Cdd:cd03313   320 LKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAKY 399

                  ....*....
gi 2672003220 402 NQLLRIEEE 410
Cdd:cd03313   400 NQLLRIEEE 408
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
5-415 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 600.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   5 IENVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVALKGGD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKkRYLGKGVLKAVENVNEIIAPELIGMD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  84 PFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGGTD-LELPQTFHNVINGGEHANNQIDIQ 162
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNaYVLPVPMMNIINGGAHADNNLDFQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 163 EFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAIAFDA 242
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 243 AASYFYNRETKNYDFEGRT--YTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTNPR 320
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGENkqLTSEEMIEYYEELVEKYP-IISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 321 LIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERVEK 400
Cdd:TIGR01060 320 ILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAK 399
                         410
                  ....*....|....*
gi 2672003220 401 YNQLLRIEEELGKAG 415
Cdd:TIGR01060 400 YNQLLRIEEELGDSA 414
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
141-415 4.53e-117

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 343.69  E-value: 4.53e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 141 LPQTFHNVINGGEHANNQIDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYS--TGLGDEGGFAPDLPSSEDAL 218
Cdd:pfam00113   4 LPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQsaTNVGDEGGFAPNLQSNKEAL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 219 KMLHEAIVKAGYVPgkEVAIAFDAAASYFYNRETKNYDFEG--------RTYTPQELGEYYGKLLNEFPeIISIEDPYGE 290
Cdd:pfam00113  84 DLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFkgeksdksKKLTSAQLADLYEELVKKYP-IVSIEDPFDE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 291 EDWDNFSKFTSEYGQRVQIVADDPVCTNPRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGET 370
Cdd:pfam00113 161 DDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGET 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2672003220 371 ADTFVADFTVATNAAQLKAGAPARSERVEKYNQLLRIEEELGKAG 415
Cdd:pfam00113 241 EDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEA 285
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
1-414 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 701.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   1 MTlVIENVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVAL 79
Cdd:COG0148     1 MS-RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKsRYLGKGVLKAVENVNEEIAPAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  80 KGGDPFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGGTDL-ELPQTFHNVINGGEHANNQ 158
Cdd:COG0148    80 IGMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAkTLPVPMMNIINGGAHADNN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 159 IDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAI 238
Cdd:COG0148   160 VDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIAL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 239 AFDAAASYFYNRETKNYDFEGRTYTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTN 318
Cdd:COG0148   240 ALDVAASEFYKDGKYHLKGEGKELTSEEMIDYYADLVDKYP-IVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 319 PRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERV 398
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398
                         410
                  ....*....|....*.
gi 2672003220 399 EKYNQLLRIEEELGKA 414
Cdd:COG0148   399 AKYNQLLRIEEELGDA 414
eno PRK00077
enolase; Provisional
1-422 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 699.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   1 MTlVIENVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVAL 79
Cdd:PRK00077    1 MS-KIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKsRYLGKGVLKAVENVNEEIAPAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  80 KGGDPFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGGTDL-ELPQTFHNVINGGEHANNQ 158
Cdd:PRK00077   80 IGLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAkVLPVPMMNIINGGAHADNN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 159 IDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAI 238
Cdd:PRK00077  160 VDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIAL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 239 AFDAAASYFYnrETKNYDFEGRTYTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTN 318
Cdd:PRK00077  240 ALDCAASEFY--KDGKYVLEGEGLTSEEMIDYLAELVDKYP-IVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTN 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 319 PRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERV 398
Cdd:PRK00077  317 TKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERI 396
                         410       420
                  ....*....|....*....|....
gi 2672003220 399 EKYNQLLRIEEELGKAgtrlAHFP 422
Cdd:PRK00077  397 AKYNQLLRIEEELGDA----ARYA 416
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
7-410 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 650.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   7 NVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVALKGGDPF 85
Cdd:cd03313     1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKsRYLGKGVLKAVKNVNEIIAPALIGMDVT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  86 NQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGG-TDLELPQTFHNVINGGEHANNQIDIQEF 164
Cdd:cd03313    81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGlAAYVLPVPMFNVINGGAHAGNKLDFQEF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 165 MITPVERTSFREGFEKIVNTYHVLKKIIADAG--YSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAIAFDA 242
Cdd:cd03313   161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 243 AASYFYNRETKNYD-FEGRTYTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTNPRL 321
Cdd:cd03313   241 AASEFYDEGKYVYDsDEGKKLTSEELIDYYKELVKKYP-IVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPER 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 322 IREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERVEKY 401
Cdd:cd03313   320 LKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAKY 399

                  ....*....
gi 2672003220 402 NQLLRIEEE 410
Cdd:cd03313   400 NQLLRIEEE 408
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
5-415 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 600.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   5 IENVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVALKGGD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKkRYLGKGVLKAVENVNEIIAPELIGMD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  84 PFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGGTD-LELPQTFHNVINGGEHANNQIDIQ 162
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNaYVLPVPMMNIINGGAHADNNLDFQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 163 EFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVPGKEVAIAFDA 242
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 243 AASYFYNRETKNYDFEGRT--YTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGQRVQIVADDPVCTNPR 320
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGENkqLTSEEMIEYYEELVEKYP-IISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 321 LIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQLKAGAPARSERVEK 400
Cdd:TIGR01060 320 ILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAK 399
                         410
                  ....*....|....*
gi 2672003220 401 YNQLLRIEEELGKAG 415
Cdd:TIGR01060 400 YNQLLRIEEELGDSA 414
PTZ00081 PTZ00081
enolase; Provisional
4-413 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 519.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   4 VIENVKAREIFDSRGNPTVEVDVTLSNGIMgRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVALKGG 82
Cdd:PTZ00081    3 TIKSIKAREILDSRGNPTVEVDLTTEKGVF-RAAVPSGASTGIYEALELRDGDKsRYLGKGVLKAVENVNEIIAPALIGK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  83 DPFNQANVDQIMID-LDGTNN-----KRKLGANAILGVSMATARAAANALHIPLYRYLGG------TDLELPQTFHNVIN 150
Cdd:PTZ00081   82 DVTDQKKLDKLMVEqLDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQlagkptDKFVLPVPCFNVIN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 151 GGEHANNQIDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIA-----DAgysTGLGDEGGFAPDLPSSEDALKMLHEAI 225
Cdd:PTZ00081  162 GGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKkkyglDA---TNVGDEGGFAPNIKDPEEALDLLVEAI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 226 VKAGYvPGKeVAIAFDAAASYFYNRETKNYDF-------EGRTY-TPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFS 297
Cdd:PTZ00081  239 KKAGY-EGK-VKICMDVAASEFYDKEKKVYDLdfknpnnDKSNKlTGEELVELYLDLVKKYP-IVSIEDPFDQDDWEAYA 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 298 KFTSEYGQRVQIVADDPVCTNPRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVAD 377
Cdd:PTZ00081  316 KLTAAIGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIAD 395
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2672003220 378 FTVATNAAQLKAGAPARSERVEKYNQLLRIEEELGK 413
Cdd:PTZ00081  396 LVVGLGTGQIKTGAPCRSERLAKYNQLLRIEEELGS 431
PLN00191 PLN00191
enolase
1-412 6.65e-176

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 499.23  E-value: 6.65e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   1 MTLVIENVKAREIFDSRGNPTVEVDVTLSNGiMGRAAVPSGASTGEKEAVELRDGGKRLSGKGVLKAIGNVNNNIAVALK 80
Cdd:PLN00191   24 VMATITKVKARQIIDSRGNPTVEVDLHTSKG-MFRAAVPSGASTGIYEALELRDGDKDYLGKGVLKAVKNVNEIIAPALI 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  81 GGDPFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYL----GGTDLELPQTFHNVINGGEHAN 156
Cdd:PLN00191  103 GMDPTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIadlaGNKKLVLPVPAFNVINGGSHAG 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 157 NQIDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIAD--AGYSTGLGDEGGFAPDLPSSEDALKMLHEAIVKAGYVpGK 234
Cdd:PLN00191  183 NKLAMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKkyGQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYT-GK 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 235 eVAIAFDAAASYFYNRETKnYDFEGRT--------YTPQELGEYYGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEygQR 306
Cdd:PLN00191  262 -IKIGMDVAASEFYTKDKK-YDLDFKEenndgsnkKSGDELIDLYKEFVSDYP-IVSIEDPFDQDDWEHWAKLTSL--ED 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 307 VQIVADDPVCTNPRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGETADTFVADFTVATNAAQ 386
Cdd:PLN00191  337 VQIVGDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQ 416
                         410       420
                  ....*....|....*....|....*.
gi 2672003220 387 LKAGAPARSERVEKYNQLLRIEEELG 412
Cdd:PLN00191  417 IKTGAPCRSERLAKYNQLLRIEEELG 442
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
141-415 4.53e-117

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 343.69  E-value: 4.53e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 141 LPQTFHNVINGGEHANNQIDIQEFMITPVERTSFREGFEKIVNTYHVLKKIIADAGYS--TGLGDEGGFAPDLPSSEDAL 218
Cdd:pfam00113   4 LPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQsaTNVGDEGGFAPNLQSNKEAL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 219 KMLHEAIVKAGYVPgkEVAIAFDAAASYFYNRETKNYDFEG--------RTYTPQELGEYYGKLLNEFPeIISIEDPYGE 290
Cdd:pfam00113  84 DLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFkgeksdksKKLTSAQLADLYEELVKKYP-IVSIEDPFDE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 291 EDWDNFSKFTSEYGQRVQIVADDPVCTNPRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMMSHRSGET 370
Cdd:pfam00113 161 DDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGET 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2672003220 371 ADTFVADFTVATNAAQLKAGAPARSERVEKYNQLLRIEEELGKAG 415
Cdd:pfam00113 241 EDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEA 285
Enolase_N pfam03952
Enolase, N-terminal domain;
5-134 2.35e-73

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 225.72  E-value: 2.35e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   5 IENVKAREIFDSRGNPTVEVDVTLSNGIMGRAAVPSGASTGEKEAVELRDGGK-RLSGKGVLKAIGNVNNNIAVALKGGD 83
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGDKsRYGGKGVLKAVENVNEIIAPALIGMD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2672003220  84 PFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYL 134
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
255-387 7.05e-11

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 61.96  E-value: 7.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 255 YDFEGRtYTPQELGEYyGKLLNEFPeIISIEDPYGEEDWDNFSKFTSEYGqrVQIVADDpVCTNPRLIREAIKKGMANSI 334
Cdd:cd00308    99 VDANGA-WTPKEAIRL-IRALEKYG-LAWIEEPCAPDDLEGYAALRRRTG--IPIAADE-SVTTVDDALEALELGAVDIL 172
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2672003220 335 LIKLNQIGTVTETLEAIRVARKNGyATMMSHRSGE--TADTFVADFTVATNAAQL 387
Cdd:cd00308   173 QIKPTRVGGLTESRRAADLAEAFG-IRVMVHGTLEssIGTAAALHLAAALPNDRA 226
PRK08350 PRK08350
hypothetical protein; Provisional
4-142 6.59e-08

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 54.04  E-value: 6.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220   4 VIENVKAREIFDSRGNPTVEVDVTLSNGiMGRAAVPSgastgekeavelrDGGKRLSGKGVLKAIGNVNNNIAVALKGGD 83
Cdd:PRK08350    3 VIENIIGRVAVLRGGKYSVEVDVITDSG-FGRFAAPI-------------DENPSLYIAEAHRAVSEVDEIIGPELIGFD 68
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220  84 PFNQANVDQIMIDLDGTNNKRKLGANAILGVSMATARAAANALHIPLYRYLGGT-DLELP 142
Cdd:PRK08350   69 ASEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTfTTELP 128
RspA COG4948
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ...
206-363 4.20e-04

L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 443975 [Multi-domain]  Cd Length: 359  Bit Score: 42.12  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2672003220 206 GFAPDLPSSEDALKMLHEAIvkagyvpGKEVAIAFDAaasyfynretkNydfeGRtYTPQELGEYyGKLLNEFPeIISIE 285
Cdd:COG4948   160 VGGPDPEEDVERVRAVREAV-------GPDARLRVDA-----------N----GA-WTLEEAIRL-LRALEDLG-LEWIE 214
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2672003220 286 DPYGEEDWDNFSKFTseygQRVQI-VADDPVCTNPRLIREAIKKGMANSILIKLNQIGTVTETLEAIRVARKNGYATMM 363
Cdd:COG4948   215 QPLPAEDLEGLAELR----RATPVpIAADESLTSRADFRRLIEAGAVDIVNIKLSKVGGLTEALRIAALAEAHGVPVMP 289
 
Blast search parameters
Data Source: Live blast search RID = S9NJ5WPH013
User Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01   Maximum number of hits: 500

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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