NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2668073198|ref|WP_330221726|]
View 

MULTISPECIES: AAA domain-containing protein [Bacteroides]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 11437895)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DNA2 COG1112
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
41-346 3.19e-63

Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];


:

Pssm-ID: 440729 [Multi-domain]  Cd Length: 819  Bit Score: 214.99  E-value: 3.19e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198  41 RRIIPIVSSTFASIQRMFsRIRPGTIPWLFVDEAGQAVPQAAAGAIWCSKRAVIVGDPFQIEPVITIPEQVVnniSRYFG 120
Cdd:COG1112   532 LELAPVVGMTPASVARLL-PLGEGSFDLVIIDEASQATLAEALGALARAKRVVLVGDPKQLPPVVFGEEAEE---VAEEG 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 121 LDktqiqtslsvQSMADRAnpygwITNDTWTGSPLRVHRRCVDPMFSIANEIAYNGMMYNSTLADNPHLFIQNG---FVQ 197
Cdd:COG1112   608 LD----------ESLLDRL-----LARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARRLADPDSplvFID 672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 198 VEG---KVSGRHYVPEQGALIRQMIIDEIRQLQDLSDLFVISPFSeipsilkkelrqpiKQALMVYKQIENNELQKWLDA 274
Cdd:COG1112   673 VDGvyeRRGGSRTNPEEAEAVVELVRELLEDGPDGESIGVITPYR--------------AQVALIRELLREALGDGLEPV 738

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2668073198 275 HIGTVHTFQGKQAAGVILCLGL--DQKSKGAASWASSKPNLLNVALTRAKQRFVAVGDGTIWLRQPYFSKLKAL 346
Cdd:COG1112   739 FVGTVDRFQGDERDVIIFSLVYsnDEDVPRNFGFLNGGPRRLNVAVSRARRKLIVVGSRELLDSDPSTPALKRL 812
 
Name Accession Description Interval E-value
DNA2 COG1112
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
41-346 3.19e-63

Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];


Pssm-ID: 440729 [Multi-domain]  Cd Length: 819  Bit Score: 214.99  E-value: 3.19e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198  41 RRIIPIVSSTFASIQRMFsRIRPGTIPWLFVDEAGQAVPQAAAGAIWCSKRAVIVGDPFQIEPVITIPEQVVnniSRYFG 120
Cdd:COG1112   532 LELAPVVGMTPASVARLL-PLGEGSFDLVIIDEASQATLAEALGALARAKRVVLVGDPKQLPPVVFGEEAEE---VAEEG 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 121 LDktqiqtslsvQSMADRAnpygwITNDTWTGSPLRVHRRCVDPMFSIANEIAYNGMMYNSTLADNPHLFIQNG---FVQ 197
Cdd:COG1112   608 LD----------ESLLDRL-----LARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARRLADPDSplvFID 672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 198 VEG---KVSGRHYVPEQGALIRQMIIDEIRQLQDLSDLFVISPFSeipsilkkelrqpiKQALMVYKQIENNELQKWLDA 274
Cdd:COG1112   673 VDGvyeRRGGSRTNPEEAEAVVELVRELLEDGPDGESIGVITPYR--------------AQVALIRELLREALGDGLEPV 738

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2668073198 275 HIGTVHTFQGKQAAGVILCLGL--DQKSKGAASWASSKPNLLNVALTRAKQRFVAVGDGTIWLRQPYFSKLKAL 346
Cdd:COG1112   739 FVGTVDRFQGDERDVIIFSLVYsnDEDVPRNFGFLNGGPRRLNVAVSRARRKLIVVGSRELLDSDPSTPALKRL 812
SF1_C_Upf1 cd18808
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ...
 185-343 1.45e-12

C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350195 [Multi-domain]  Cd Length: 184  Bit Score: 65.33  E-value: 1.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 185 DNPHLFIQNGFVQVEGKVSGRHYVPEQGALIRQMIIDEIRQLQDLSDLFVISPFSEipsiLKKELRQPIKQALMVYKQIE 264
Cdd:cd18808    37 SKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLLKSGVKPSSIGVITPYRA----QVALIRELLRKRGGLLEDVE 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2668073198 265 nnelqkwldahIGTVHTFQGKQAAGVILCLGLDQKSKGAASWASSkPNLLNVALTRAKQRFVAVGDGTIWLRQPYFSKL 343
Cdd:cd18808   113 -----------VGTVDNFQGREKDVIILSLVRSNESGGSIGFLSD-PRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKL 179
AAA_11 pfam13086
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 46-105 2.09e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.


Pssm-ID: 404072 [Multi-domain]  Cd Length: 248  Bit Score: 42.33  E-value: 2.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2668073198  46 IVSSTFASI--QRMFSRIRpgtIPWLFVDEAGQAV-PQAAAGAIWCSKRAVIVGDPFQIEPVI 105
Cdd:pfam13086 186 IVCSTLSGAgsRLLSSLAN---FDVVIIDEAAQALePSTLIPLLRGPKKVVLVGDPKQLPPTV 245
 
Name Accession Description Interval E-value
DNA2 COG1112
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
41-346 3.19e-63

Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];


Pssm-ID: 440729 [Multi-domain]  Cd Length: 819  Bit Score: 214.99  E-value: 3.19e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198  41 RRIIPIVSSTFASIQRMFsRIRPGTIPWLFVDEAGQAVPQAAAGAIWCSKRAVIVGDPFQIEPVITIPEQVVnniSRYFG 120
Cdd:COG1112   532 LELAPVVGMTPASVARLL-PLGEGSFDLVIIDEASQATLAEALGALARAKRVVLVGDPKQLPPVVFGEEAEE---VAEEG 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 121 LDktqiqtslsvQSMADRAnpygwITNDTWTGSPLRVHRRCVDPMFSIANEIAYNGMMYNSTLADNPHLFIQNG---FVQ 197
Cdd:COG1112   608 LD----------ESLLDRL-----LARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARRLADPDSplvFID 672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 198 VEG---KVSGRHYVPEQGALIRQMIIDEIRQLQDLSDLFVISPFSeipsilkkelrqpiKQALMVYKQIENNELQKWLDA 274
Cdd:COG1112   673 VDGvyeRRGGSRTNPEEAEAVVELVRELLEDGPDGESIGVITPYR--------------AQVALIRELLREALGDGLEPV 738

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2668073198 275 HIGTVHTFQGKQAAGVILCLGL--DQKSKGAASWASSKPNLLNVALTRAKQRFVAVGDGTIWLRQPYFSKLKAL 346
Cdd:COG1112   739 FVGTVDRFQGDERDVIIFSLVYsnDEDVPRNFGFLNGGPRRLNVAVSRARRKLIVVGSRELLDSDPSTPALKRL 812
SF1_C_Upf1 cd18808
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ...
 185-343 1.45e-12

C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350195 [Multi-domain]  Cd Length: 184  Bit Score: 65.33  E-value: 1.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 185 DNPHLFIQNGFVQVEGKVSGRHYVPEQGALIRQMIIDEIRQLQDLSDLFVISPFSEipsiLKKELRQPIKQALMVYKQIE 264
Cdd:cd18808    37 SKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLLKSGVKPSSIGVITPYRA----QVALIRELLRKRGGLLEDVE 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2668073198 265 nnelqkwldahIGTVHTFQGKQAAGVILCLGLDQKSKGAASWASSkPNLLNVALTRAKQRFVAVGDGTIWLRQPYFSKL 343
Cdd:cd18808   113 -----------VGTVDNFQGREKDVIILSLVRSNESGGSIGFLSD-PRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKL 179
DEXXQc_Upf1-like cd17934
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ...
 48-106 7.93e-11

DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438708 [Multi-domain]  Cd Length: 121  Bit Score: 58.79  E-value: 7.93e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2668073198  48 SSTFASIQRMFSRIRPG--------------TIPWLFVDEAGQAVPQAAAGAIWCSKRAVIVGDPFQIEPVIT 106
Cdd:cd17934    13 TTTIAAIVLQLLKGLRGkrvlvtaqsnvavdNVDVVIIDEASQITEPELLIALIRAKKVVLVGDPKQLPPVVQ 85
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
 45-124 1.15e-05

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 46.07  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198  45 PIVSSTFASIQRMFS-RIRPGTIPWLFVDEAGQAV-PQAAAGAIW-CSKRAVIV--GDPFQIEPVItipeqvVNNISRYF 119
Cdd:cd18038   121 RIVVCTLMTAGRLVQaGVPNGHFTHIFIDEAGQATePEALIPLSElASKNTQIVlaGDPKQLGPVV------RSPLARKY 194


                  ....*
gi 2668073198 120 GLDKT 124
Cdd:cd18038   195 GLGKS 199
DEXXQc_Mov10L1 cd18078
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ...
 37-106 8.87e-05

DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350836 [Multi-domain]  Cd Length: 230  Bit Score: 43.13  E-value: 8.87e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2668073198  37 RVIHRRIIPIVSSTFASIQRMfsRIRPGTIPWLFVDEAGQAV-PQAAAGAIWCSKRA---VIVGDPFQIEPVIT 106
Cdd:cd18078   110 KASRHRIVISTCSTAGLLYQM--GLPVGHFTHVFVDEAGQATePESLIPLGLISSRDgqiILAGDPMQLGPVIK 181
DEXXQc_SF1 cd18043
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ...
 71-106 1.70e-04

DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350801 [Multi-domain]  Cd Length: 127  Bit Score: 41.03  E-value: 1.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2668073198  71 VDEAGQAVPQAAAGAIWCSKRAVIVGDPFQIEPVIT 106
Cdd:cd18043    86 FDEASQIPIEEALPALFRGKQVVVVGDDKQLPPSIL 121
AAA_11 pfam13086
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 46-105 2.09e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.


Pssm-ID: 404072 [Multi-domain]  Cd Length: 248  Bit Score: 42.33  E-value: 2.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2668073198  46 IVSSTFASI--QRMFSRIRpgtIPWLFVDEAGQAV-PQAAAGAIWCSKRAVIVGDPFQIEPVI 105
Cdd:pfam13086 186 IVCSTLSGAgsRLLSSLAN---FDVVIIDEAAQALePSTLIPLLRGPKKVVLVGDPKQLPPTV 245
AAA_12 pfam13087
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 217-330 3.06e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.


Pssm-ID: 463780 [Multi-domain]  Cd Length: 196  Bit Score: 41.38  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 217 QMIIDEIRQL-----QDLSDLFVISPFSEipsiLKKELRQPIKQALMVYKQIEnnelqkwldahIGTVHTFQGKQAAGVI 291
Cdd:pfam13087  93 ELVVQLVEKLiksgpEEPSDIGVITPYRA----QVRLIRKLLKRKLGGKLEIE-----------VNTVDGFQGREKDVII 157

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2668073198 292 LCL--GLDQKSKGAASwassKPNLLNVALTRAKQRFVAVGD 330
Cdd:pfam13087 158 FSCvrSNEKGGIGFLS----DPRRLNVALTRAKRGLIIVGN 194
DEXXQc_DNA2 cd18041
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ...
 71-122 6.61e-04

DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350799 [Multi-domain]  Cd Length: 203  Bit Score: 40.30  E-value: 6.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2668073198  71 VDEAGQaVPQAAA-GAIWCSKRAVIVGDPFQIEPVitipeqVVNNISRYFGLD 122
Cdd:cd18041   135 VDEASQ-ITLPIClGPLRLAKKFVLVGDHYQLPPL------VKSREARELGMD 180
SF1_C cd18786
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ...
 260-329 3.65e-03

C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350173 [Multi-domain]  Cd Length: 89  Bit Score: 36.26  E-value: 3.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2668073198 260 YKQIENNELQKWLDAHIGTVHTFQGKQAAGVILCLgldqkskgaASWASSKPNLLNVALTRAKQRFVAVG 329
Cdd:cd18786    29 YLQGLSLDEFDLQLVGAITIDSSQGLTFDVVTLYL---------PTANSLTPRRLYVALTRARKRLVIYD 89
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 278-336 6.46e-03

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 38.42  E-value: 6.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2668073198 278 TVHTFQGKQAAGVILCLGldqkskgAASWASSKPNLLNVALTRAKQRFVAVGDGTIWLR 336
Cdd:COG0507   446 TVHKSQGSTFDRVILVLP-------SEHSPLLSRELLYTALTRARELLTLVGDRDALAR 497
SF1_C_RecD cd18809
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ...
 278-329 8.37e-03

C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350196 [Multi-domain]  Cd Length: 80  Bit Score: 34.84  E-value: 8.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2668073198 278 TVHTFQGKQAAGVILCLGldqKSKGAASWasskpNLLNVALTRAKQRFVAVG 329
Cdd:cd18809    37 TIHKSQGSEFDRVIVVLP---TSHPMLSR-----GLLYTALTRARKLLTLVG 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH