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Conserved domains on  [gi|2666835023|ref|WP_330043020|]
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MULTISPECIES: flagellar hook capping FlgD N-terminal domain-containing protein [Anaerovibrio]

Protein Classification

flagellar hook assembly protein FlgD( domain architecture ID 11448786)

flagellar hook assembly protein FlgD may act as a scaffolding protein required for flagellar hook formation

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
5-166 3.66e-29

Flagellar hook-capping protein FlgD [Cell motility];


:

Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 107.01  E-value: 3.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023   5 MNTITVNGVTynyeEYMASQNATKKNVNADYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKME 84
Cdd:COG1843     1 MATSSSSSVL----SSLSTSSTSSSSSSSSSLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  85 NvhtLVENLDTSvLVGQLTSMIGQTVQWattdsEGKTTLHEGTAKSVSISDGAPSLMVETEVKDADGNIskaVTKVDIST 164
Cdd:COG1843    77 S---LASSLTSS-QALQASSLIGKEVLV-----EGNTISLDGGSASGGFELPSAADSVTVTITDANGNV---VRTIDLGA 144


                  ..
gi 2666835023 165 LT 166
Cdd:COG1843   145 QS 146
 
Name Accession Description Interval E-value
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
5-166 3.66e-29

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 107.01  E-value: 3.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023   5 MNTITVNGVTynyeEYMASQNATKKNVNADYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKME 84
Cdd:COG1843     1 MATSSSSSVL----SSLSTSSTSSSSSSSSSLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  85 NvhtLVENLDTSvLVGQLTSMIGQTVQWattdsEGKTTLHEGTAKSVSISDGAPSLMVETEVKDADGNIskaVTKVDIST 164
Cdd:COG1843    77 S---LASSLTSS-QALQASSLIGKEVLV-----EGNTISLDGGSASGGFELPSAADSVTVTITDANGNV---VRTIDLGA 144


                  ..
gi 2666835023 165 LT 166
Cdd:COG1843   145 QS 146
flgD PRK09618
flagellar hook assembly protein FlgD;
20-136 2.84e-25

flagellar hook assembly protein FlgD;


Pssm-ID: 236594 [Multi-domain]  Cd Length: 142  Bit Score: 94.68  E-value: 2.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  20 YMASQNATKKNVNADYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKMEnvhTLVENLDTsvlV 99
Cdd:PRK09618   11 WLANSKKAERRTGNQNLGKDDFLKLLITQLQNQDPTNPMEDKEFIAQMAQFSSLEQMTNMNKSME---KLVSSSDG---L 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2666835023 100 GQLTSMIGQTVQWATTDSEGKTtlheGTAKSVSISDG 136
Cdd:PRK09618   85 TKYSELIGKEVEWEGEDGEIVS----GTVTSVKQKDG 117
FlgD pfam03963
Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required ...
 20-85 2.28e-19

Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum. It appears to act as a hook-capping protein to enable assembly of hook protein subunits. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerization and also plays a role in determination of the correct hook length, with the help of the FliK protein. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallization.


Pssm-ID: 427619 [Multi-domain]  Cd Length: 75  Bit Score: 77.28  E-value: 2.28e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2666835023  20 YMASQNATKKNVNADYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKMEN 85
Cdd:pfam03963  10 TSTSSSSSTSAKSSSTLGKDDFLKLLTTQLQNQDPLNPMDNTQFTSQLAQFSSVEQIEKLNKTLDS 75
 
Name Accession Description Interval E-value
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
5-166 3.66e-29

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 107.01  E-value: 3.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023   5 MNTITVNGVTynyeEYMASQNATKKNVNADYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKME 84
Cdd:COG1843     1 MATSSSSSVL----SSLSTSSTSSSSSSSSSLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  85 NvhtLVENLDTSvLVGQLTSMIGQTVQWattdsEGKTTLHEGTAKSVSISDGAPSLMVETEVKDADGNIskaVTKVDIST 164
Cdd:COG1843    77 S---LASSLTSS-QALQASSLIGKEVLV-----EGNTISLDGGSASGGFELPSAADSVTVTITDANGNV---VRTIDLGA 144


                  ..
gi 2666835023 165 LT 166
Cdd:COG1843   145 QS 146
flgD PRK09618
flagellar hook assembly protein FlgD;
20-136 2.84e-25

flagellar hook assembly protein FlgD;


Pssm-ID: 236594 [Multi-domain]  Cd Length: 142  Bit Score: 94.68  E-value: 2.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  20 YMASQNATKKNVNADYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKMEnvhTLVENLDTsvlV 99
Cdd:PRK09618   11 WLANSKKAERRTGNQNLGKDDFLKLLITQLQNQDPTNPMEDKEFIAQMAQFSSLEQMTNMNKSME---KLVSSSDG---L 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2666835023 100 GQLTSMIGQTVQWATTDSEGKTtlheGTAKSVSISDG 136
Cdd:PRK09618   85 TKYSELIGKEVEWEGEDGEIVS----GTVTSVKQKDG 117
flgD PRK06655
flagellar hook assembly protein FlgD;
5-153 5.33e-20

flagellar hook assembly protein FlgD;


Pssm-ID: 235847 [Multi-domain]  Cd Length: 225  Bit Score: 83.07  E-value: 5.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023   5 MNTITVNGVTYNYEEYMASQNATKKNVNadyISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKME 84
Cdd:PRK06655    2 SIANTVGSSSTSGLSTTSSSSSSKKGAA---DLQDDFLTLLVAQLKNQDPLNPMDNSQMTSQLAQFSTVSGIEKLNTTLG 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2666835023  85 NVHTLVenldTSVLVGQLTSMIGQTVQWATTDSEGKTTlhEGTAKSVSISDGAPSLMVetEVKDADGNI 153
Cdd:PRK06655   79 SLSSQM----TSSQALQASSLVGRGVLVPGDTVLVGTG--GTTPFGVELPSAADNVTV--TITDSAGQV 139
FlgD pfam03963
Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required ...
 20-85 2.28e-19

Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum. It appears to act as a hook-capping protein to enable assembly of hook protein subunits. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerization and also plays a role in determination of the correct hook length, with the help of the FliK protein. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallization.


Pssm-ID: 427619 [Multi-domain]  Cd Length: 75  Bit Score: 77.28  E-value: 2.28e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2666835023  20 YMASQNATKKNVNADYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKMEN 85
Cdd:pfam03963  10 TSTSSSSSTSAKSSSTLGKDDFLKLLTTQLQNQDPLNPMDNTQFTSQLAQFSSVEQIEKLNKTLDS 75
flgD PRK06009
flagellar hook assembly protein FlgD;
1-138 6.92e-17

flagellar hook assembly protein FlgD;


Pssm-ID: 235670 [Multi-domain]  Cd Length: 140  Bit Score: 72.82  E-value: 6.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023   1 MATSMNTITVNGVTYNYEEYMASQNATKKNVNADYiskDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTeva 80
Cdd:PRK06009    1 MAVDATTSATSSSTTSSTSTASNSTSAANKASVNY---DSFLQLLIAQMKNQDPTDPMDATQYVSQLATFSQVEQSI--- 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2666835023  81 dkmeNVHTLVENLDTSVLVGQLTSMIGQTVqwatTDSEGKTTlheGTAKSVSISDGAP 138
Cdd:PRK06009   75 ----QTNSKLDTLLASSSLTQAEGLIGRTV----TSADGSIT---GVVKSVTVYSDGV 121
flgD PRK12813
flagellar basal body rod modification protein; Reviewed
 22-153 2.45e-16

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 237214 [Multi-domain]  Cd Length: 223  Bit Score: 73.22  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  22 ASQNATKKNVNADYiskDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKMENvhtLVENLDTSVLvGQ 101
Cdd:PRK12813   19 RGSASAASALTSDF---ETFLRMLTTQLQNQDPLNPMDSSDYAAQLATFSGVEQQVKTNDLLTG---LGASLGVMGL-SQ 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2666835023 102 LTSMIGQTVQwatTDSEGKTTlheGTAKSVSISDGAPSLMVETEVKDADGNI 153
Cdd:PRK12813   92 LAGWIGREAR---AEAPVWFD---GTPVTISPNPAADADKAELVVRDAAGAE 137
flgD PRK09619
flagellar hook assembly protein FlgD;
20-155 2.00e-13

flagellar hook assembly protein FlgD;


Pssm-ID: 181996 [Multi-domain]  Cd Length: 218  Bit Score: 65.58  E-value: 2.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  20 YMASQNATKKNVNADYIS-KDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKMENVHTLVENLDTSVL 98
Cdd:PRK09619   11 NVGNQSPAPEGGLPGAEQlNNQFMTLLVAQIQNQDPLNPADGTEFVSQLAQLSQVQSTENMAKLMKSNTVLMDNMQTLAT 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2666835023  99 VGqltsMIGQTVQWATTdsegKTTLHEGTAKS-VSISDGAPSLMVetEVKDADGNISK 155
Cdd:PRK09619   91 AN----LVGQQVMVESH----EITLGEDPVAGrLTLKHPAPTLTL--HITDILGQEKK 138
flgD PRK12633
flagellar basal body rod modification protein; Provisional
 38-164 2.04e-11

flagellar basal body rod modification protein; Provisional


Pssm-ID: 183638 [Multi-domain]  Cd Length: 230  Bit Score: 60.37  E-value: 2.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  38 KDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEVADKMENVHTLV---ENLDTSVLVGQLTSMIGQTVQWAT 114
Cdd:PRK12633   28 QDQFLTLLVTQLRNQDPLNPMENAELTSQLAQISTVEGINNLKNTMLAISGQIdvsQSMDAVSMIGKGVLMPGDKVSLGT 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2666835023 115 TDSEGKttlhEGTAKSVSISDGAPSLMVETEVKDADGNISKAVTKVDIST 164
Cdd:PRK12633  108 DPNDPA----QRGATPFGIDLQGDATKVTVKVLDPSGAVVRTMELGDLKT 153
flgD PRK12812
flagellar basal body rod modification protein; Reviewed
 1-155 1.29e-10

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 139245 [Multi-domain]  Cd Length: 259  Bit Score: 58.35  E-value: 1.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023   1 MATSMNTITVNGVTYNYEEYMASQNATKKNVNAD--------YISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSA 72
Cdd:PRK12812    1 MISSSDWNLNTTATTSTTTKSASTSGATRTDSSSstgsnpnsQLDKDAFLKLLLIELQHQDPTDPMDSDKMLTQTSQLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  73 LEQMTEVADKMEN-VHTLVENLDTSVL--VGQLTSMIGQTVQWATTDSEGKTTLH---EGTAKSVSISDGAPSLMVETEV 146
Cdd:PRK12812   81 LEMQENTNTTMQKlVEQMQSSMSTSALsaLGKMATVSDNAVKLTGADELIALKLYfpeDSDEGTLEIYDSNNKLVEKIDF 160


                  ....*....
gi 2666835023 147 KDADGNISK 155
Cdd:PRK12812  161 KEISQGLFT 169
flgD PRK12634
flagellar basal body rod modification protein; Reviewed
 9-158 2.34e-10

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 183639 [Multi-domain]  Cd Length: 221  Bit Score: 57.25  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023   9 TVNGVTYNYEEYMASQNATKKNvnaDYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQMTEvadkmenVHT 88
Cdd:PRK12634    3 TIASDLYKSLGLSTSSKTAKKE---EALGQADFLKLMTEQLQHQDPLKPMENSAFLGQLAQFSTVQGIGD-------LNT 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2666835023  89 LVENLDTSVLVGQL---TSMIGQTVqwaTTDSEGKTTLHEGTAKSVSISDGAPslMVETEVKDADGNISKAVT 158
Cdd:PRK12634   73 KVSNFSDSMSSDQVlkgAALVGHNV---LVPSAQVAIDATGSAKGVVAATSAG--FVNFEITDANGAFVKQIS 140
flgD PRK11911
flagellar basal body rod modification protein; Provisional
 36-118 1.05e-07

flagellar basal body rod modification protein; Provisional


Pssm-ID: 138812 [Multi-domain]  Cd Length: 140  Bit Score: 48.68  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  36 ISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQmteVADKMENVHTLVENLDTSVLVGQLtSMIGQTVQWATT 115
Cdd:PRK11911   26 LGKDDFMKLFLTSLQYQDPSSPLDTNEMMSQMAQLSLMEQ---VANMTTAVDKLSEQAQNSALQSAV-NFIGKDIKGVSL 101


                  ...
gi 2666835023 116 DSE 118
Cdd:PRK11911  102 NGE 104
flgD PRK06792
flagellar basal body rod modification protein; Validated
 36-85 4.82e-07

flagellar basal body rod modification protein; Validated


Pssm-ID: 180695 [Multi-domain]  Cd Length: 190  Bit Score: 47.70  E-value: 4.82e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2666835023  36 ISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQ---MTEVADKMEN 85
Cdd:PRK06792   51 MDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQvqnMTKAVDKLQS 103
flgD PRK05842
flagellar hook assembly protein FlgD;
22-95 6.47e-06

flagellar hook assembly protein FlgD;


Pssm-ID: 235621 [Multi-domain]  Cd Length: 295  Bit Score: 44.99  E-value: 6.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2666835023  22 ASQNATKKNV-NADYISKDTFLKLLVTQMQYQDPLDPMDNGEYLSQLAQFSALEQ-------MTEVADKMENVHTLVENL 93
Cdd:PRK05842   13 AAQERKKEQPtIANGLDKNAFMKLFLEQLKNQDPTAPMETDKIITQTAQLTQVEMqeenkktMQEVASAMKSNKETNESL 92


                  ..
gi 2666835023  94 DT 95
Cdd:PRK05842   93 KD 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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