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Conserved domains on  [gi|2646269687|ref|WP_323859312|]
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MULTISPECIES: SymE family type I addiction module toxin [unclassified Xenorhabdus]

Protein Classification

SymE_toxin domain-containing protein( domain architecture ID 10556081)

SymE_toxin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SymE_toxin pfam08845
Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ...
 19-69 1.53e-15

Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin.


:

Pssm-ID: 370150  Cd Length: 54  Bit Score: 65.05  E-value: 1.53e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2646269687  19 ERYQKVVYRPKGPNRT---IPAINLSGNWLSEAGFYVNDPLKIRVMPGCLIITA 69
Cdd:pfam08845   1 PRYYTVGYVPYRGSPNyqrVPALRLKGRWLEQAGFATGQPLTITVMPGRLVITP 54
 
Name Accession Description Interval E-value
SymE_toxin pfam08845
Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ...
 19-69 1.53e-15

Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin.


Pssm-ID: 370150  Cd Length: 54  Bit Score: 65.05  E-value: 1.53e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2646269687  19 ERYQKVVYRPKGPNRT---IPAINLSGNWLSEAGFYVNDPLKIRVMPGCLIITA 69
Cdd:pfam08845   1 PRYYTVGYVPYRGSPNyqrVPALRLKGRWLEQAGFATGQPLTITVMPGRLVITP 54
PRK13605 PRK13605
endoribonuclease SymE; Provisional
 1-70 8.75e-15

endoribonuclease SymE; Provisional


Pssm-ID: 237442  Cd Length: 113  Bit Score: 64.88  E-value: 8.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2646269687   1 MANAHSNAETCIYKISQPE-RYQKVVYRPKGPNRT-IPAINLSGNWLSEAGFYVNDPLKIRVMPGCLIITAQ 70
Cdd:PRK13605    1 MTDTHSIAQPFEAEVSPTNnRQLTVSYASRYPDYSrIPAITLKGQWLEAAGFATGTAVDVRVMEGCIVLTAQ 72
 
Name Accession Description Interval E-value
SymE_toxin pfam08845
Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ...
 19-69 1.53e-15

Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin.


Pssm-ID: 370150  Cd Length: 54  Bit Score: 65.05  E-value: 1.53e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2646269687  19 ERYQKVVYRPKGPNRT---IPAINLSGNWLSEAGFYVNDPLKIRVMPGCLIITA 69
Cdd:pfam08845   1 PRYYTVGYVPYRGSPNyqrVPALRLKGRWLEQAGFATGQPLTITVMPGRLVITP 54
PRK13605 PRK13605
endoribonuclease SymE; Provisional
 1-70 8.75e-15

endoribonuclease SymE; Provisional


Pssm-ID: 237442  Cd Length: 113  Bit Score: 64.88  E-value: 8.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2646269687   1 MANAHSNAETCIYKISQPE-RYQKVVYRPKGPNRT-IPAINLSGNWLSEAGFYVNDPLKIRVMPGCLIITAQ 70
Cdd:PRK13605    1 MTDTHSIAQPFEAEVSPTNnRQLTVSYASRYPDYSrIPAITLKGQWLEAAGFATGTAVDVRVMEGCIVLTAQ 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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