NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2623843906|ref|WP_319789021|]
View 

SpaA isopeptide-forming pilin-related protein, partial [Bacillus cereus group sp. BfR-BA-01363]

Protein Classification

prealbumin-like fold domain-containing protein( domain architecture ID 16050634)

prealbumin-like fold domain-containing protein similar to Pseudomonas aeruginosa protein PA1324 that may be be involved in the binding and transport of sugars or polysaccharides associated with the peptidoglycan matrix during biofilm formation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SpaA pfam17802
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
 1-47 8.41e-13

Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.


:

Pssm-ID: 465513 [Multi-domain]  Cd Length: 72  Bit Score: 57.60  E-value: 8.41e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 2623843906  1 ADLTTDKDGKISVSDLRPGDYQFIETKAPTHYDLNQTPINFTVEKSQ 47
Cdd:pfam17802 26 GTLTTDEDGKATFDGLPPGTYTLKETKAPDGYVLDDTPIEFTVTEDG 72
 
Name Accession Description Interval E-value
SpaA pfam17802
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
 1-47 8.41e-13

Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.


Pssm-ID: 465513 [Multi-domain]  Cd Length: 72  Bit Score: 57.60  E-value: 8.41e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 2623843906  1 ADLTTDKDGKISVSDLRPGDYQFIETKAPTHYDLNQTPINFTVEKSQ 47
Cdd:pfam17802 26 GTLTTDEDGKATFDGLPPGTYTLKETKAPDGYVLDDTPIEFTVTEDG 72
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 4-90 2.19e-11

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 58.06  E-value: 2.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2623843906   4 TTDKDGKISVSDLRPGDYQFIETKAPTHYDLNQTPINFTVEKSQTTTASVT-AKNSLTKGAVELTKVDDIDGST-LEGAI 81
Cdd:COG4932   299 VTDADGSYTFTDLPPGTYTVTETKAPAGYDLDGEAVKVTITAGQTTTVTVTnGNNEVKTGSVTLTKVDADDGEApLAGAE 378


                  ....*....
gi 2623843906  82 FKIVDMNGN 90
Cdd:COG4932   379 FTLTDADGT 387
iso_D2_wall_anc NF033902
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 3-54 4.27e-03

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 34.35  E-value: 4.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2623843906   3 LTTDKDGKISVSDLRPGDYQF--------------IETKAPTHYDLNQTPINFTVEKSQTTTASVT 54
Cdd:NF033902  418 FTTGADGTVSIDGLHVTDLEDgasvkaaagkdyclVETKAPAGYVLPPKPVEVTVVKVTVTAATTA 483
 
Name Accession Description Interval E-value
SpaA pfam17802
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
 1-47 8.41e-13

Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.


Pssm-ID: 465513 [Multi-domain]  Cd Length: 72  Bit Score: 57.60  E-value: 8.41e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 2623843906  1 ADLTTDKDGKISVSDLRPGDYQFIETKAPTHYDLNQTPINFTVEKSQ 47
Cdd:pfam17802 26 GTLTTDEDGKATFDGLPPGTYTLKETKAPDGYVLDDTPIEFTVTEDG 72
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 4-90 2.19e-11

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 58.06  E-value: 2.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2623843906   4 TTDKDGKISVSDLRPGDYQFIETKAPTHYDLNQTPINFTVEKSQTTTASVT-AKNSLTKGAVELTKVDDIDGST-LEGAI 81
Cdd:COG4932   299 VTDADGSYTFTDLPPGTYTVTETKAPAGYDLDGEAVKVTITAGQTTTVTVTnGNNEVKTGSVTLTKVDADDGEApLAGAE 378


                  ....*....
gi 2623843906  82 FKIVDMNGN 90
Cdd:COG4932   379 FTLTDADGT 387
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 1-90 1.36e-10

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 55.75  E-value: 1.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2623843906   1 ADLTTDKDGKISVSDLRPGDYQFIETKAPTHYDLNQTPINFTVEKSQTTTAsVTAKNSLTKGAVELTKVDdidgSTLEGA 80
Cdd:COG4932   390 ATITTDADGTASFKGLAPGTYTLTETKAPEGYTLDSTPITVTVTDGGTGAI-DTITNERKKGSVQVTKVD----APLAGA 464

                          90
                  ....*....|
gi 2623843906  81 IFKIVDMNGN 90
Cdd:COG4932   465 TFTLTDADGT 474
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 3-90 1.93e-08

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 49.59  E-value: 1.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2623843906   3 LTTDKDGKISVSDLRPGDYQFIETKAPTHYDLNQT-----PINFTVEKSQTTTASVTAKNSLTKGAVELTKVDDIDGSTL 77
Cdd:COG4932   198 VTTDADGKYTFTDLPPGTYTLTETKAPEGYVLDTKdptgaTITVTVNAGGTVTVTLKNTPKYTKGSVTVTKTDADTGEPL 277

                          90
                  ....*....|...
gi 2623843906  78 EGAIFKIVDMNGN 90
Cdd:COG4932   278 AGATFTLTDADGN 290
iso_D2_wall_anc NF033902
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 3-54 4.27e-03

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 34.35  E-value: 4.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2623843906   3 LTTDKDGKISVSDLRPGDYQF--------------IETKAPTHYDLNQTPINFTVEKSQTTTASVT 54
Cdd:NF033902  418 FTTGADGTVSIDGLHVTDLEDgasvkaaagkdyclVETKAPAGYVLPPKPVEVTVVKVTVTAATTA 483
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH