NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2590208331|ref|WP_315323475|]
View 

type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein [Stomatobaculum longum]

Protein Classification

type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein( domain architecture ID 11475017)

type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein is part of the innate immunity bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection;

PubMed:  24465005|29518409

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 8-197 4.70e-45

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


:

Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 147.84  E-value: 4.70e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2590208331   8 MFEAHGGVMRTAELQR----EGLYYRKVQSLLEEGRLEQLRRGYYQYVD---ENSFSDLPILKALFPDAVICMESALDYY 80
Cdd:COG5340     1 MRTQGRGVFTTADARAaglsAGISRRLLSRLVKKGELERVRRGLYVLPPaeaDKEHDELLIAARLVPPGYISLLSALALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2590208331  81 GYTDRTPAYWHLAVSNRtaRKRFQIEYPLVKPHFIQEERYSAGIEEAEIDGCTVKIYDKERTICDLLLHRNKVDA-EVFA 159
Cdd:COG5340    81 GLTDQIPFTVYVAVPRR--SRPIKIGGPPIRFVRFSKELFFEGVEEVKIDGGKVRVTSPERTIVDCLRYRNKIGGiDEVL 158

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2590208331 160 TAIQRYLRDPEKFTARLFQYAKLLRVeRKVREILGPWL 197
Cdd:COG5340   159 EALREYLRRKKLDLDKLLEYAERLRN-SAVEKRLGYLL 195
 
Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 8-197 4.70e-45

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 147.84  E-value: 4.70e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2590208331   8 MFEAHGGVMRTAELQR----EGLYYRKVQSLLEEGRLEQLRRGYYQYVD---ENSFSDLPILKALFPDAVICMESALDYY 80
Cdd:COG5340     1 MRTQGRGVFTTADARAaglsAGISRRLLSRLVKKGELERVRRGLYVLPPaeaDKEHDELLIAARLVPPGYISLLSALALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2590208331  81 GYTDRTPAYWHLAVSNRtaRKRFQIEYPLVKPHFIQEERYSAGIEEAEIDGCTVKIYDKERTICDLLLHRNKVDA-EVFA 159
Cdd:COG5340    81 GLTDQIPFTVYVAVPRR--SRPIKIGGPPIRFVRFSKELFFEGVEEVKIDGGKVRVTSPERTIVDCLRYRNKIGGiDEVL 158

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2590208331 160 TAIQRYLRDPEKFTARLFQYAKLLRVeRKVREILGPWL 197
Cdd:COG5340   159 EALREYLRRKKLDLDKLLEYAERLRN-SAVEKRLGYLL 195
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 3-51 1.16e-07

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 463849  Cd Length: 49  Bit Score: 46.38  E-value: 1.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2590208331   3 EALKQMFEAHGGVMRTAELQREGLYYRKVQSLLEEGRLEQLRRGYYQYV 51
Cdd:pfam13338   1 ERLLELAARQKGIFTTADLAAAGISRRALRRLVRKGLLERLRRGVYALP 49
 
Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 8-197 4.70e-45

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 147.84  E-value: 4.70e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2590208331   8 MFEAHGGVMRTAELQR----EGLYYRKVQSLLEEGRLEQLRRGYYQYVD---ENSFSDLPILKALFPDAVICMESALDYY 80
Cdd:COG5340     1 MRTQGRGVFTTADARAaglsAGISRRLLSRLVKKGELERVRRGLYVLPPaeaDKEHDELLIAARLVPPGYISLLSALALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2590208331  81 GYTDRTPAYWHLAVSNRtaRKRFQIEYPLVKPHFIQEERYSAGIEEAEIDGCTVKIYDKERTICDLLLHRNKVDA-EVFA 159
Cdd:COG5340    81 GLTDQIPFTVYVAVPRR--SRPIKIGGPPIRFVRFSKELFFEGVEEVKIDGGKVRVTSPERTIVDCLRYRNKIGGiDEVL 158

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2590208331 160 TAIQRYLRDPEKFTARLFQYAKLLRVeRKVREILGPWL 197
Cdd:COG5340   159 EALREYLRRKKLDLDKLLEYAERLRN-SAVEKRLGYLL 195
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 3-51 1.16e-07

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 463849  Cd Length: 49  Bit Score: 46.38  E-value: 1.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2590208331   3 EALKQMFEAHGGVMRTAELQREGLYYRKVQSLLEEGRLEQLRRGYYQYV 51
Cdd:pfam13338   1 ERLLELAARQKGIFTTADLAAAGISRRALRRLVRKGLLERLRRGVYALP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH