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Conserved domains on  [gi|2562027160|ref|WP_305562394|]
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methyltransferase domain-containing protein [Limnobacter sp.]

Protein Classification

methyltransferase domain-containing protein( domain architecture ID 1002315)

methyltransferase domain-containing protein similar to vertebrate mitochondrial arginine-hydroxylase NDUFAF5 and bacterial malonyl-[acyl-carrier protein] O-methyltransferase

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BioC super family cl37044
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 123-280 9.67e-17

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


The actual alignment was detected with superfamily member TIGR02072:

Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 77.71  E-value: 9.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2562027160 123 LPLVDASQAMVWSPLWLHCVEDPGQQLAEWLRVLKPEGGVFFSCFGPDTAKELQGvalSLGEDFPDFADMHDIGDLMgKQ 202
Cdd:TIGR02072  92 LPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQ---SFGQHGLRYLSLDELKALL-KN 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2562027160 203 GFSDPVMEMEKLTLTYTTPEKLLADWRAL-VGNPLQQRQ-----KGLCApvRYsealiylEGLRNPDTgrIPLTLELVYG 276
Cdd:TIGR02072 168 SFELLTLEEELITLSFDDPLDVLRHLKKTgANGLSSGRTsrkqlKAFLE--RY-------EQEFQPDG--LPLTYHVVYG 236


                  ....
gi 2562027160 277 HAWK 280
Cdd:TIGR02072 237 IAKK 240
 
Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 123-280 9.67e-17

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 77.71  E-value: 9.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2562027160 123 LPLVDASQAMVWSPLWLHCVEDPGQQLAEWLRVLKPEGGVFFSCFGPDTAKELQGvalSLGEDFPDFADMHDIGDLMgKQ 202
Cdd:TIGR02072  92 LPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQ---SFGQHGLRYLSLDELKALL-KN 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2562027160 203 GFSDPVMEMEKLTLTYTTPEKLLADWRAL-VGNPLQQRQ-----KGLCApvRYsealiylEGLRNPDTgrIPLTLELVYG 276
Cdd:TIGR02072 168 SFELLTLEEELITLSFDDPLDVLRHLKKTgANGLSSGRTsrkqlKAFLE--RY-------EQEFQPDG--LPLTYHVVYG 236


                  ....
gi 2562027160 277 HAWK 280
Cdd:TIGR02072 237 IAKK 240
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 123-176 9.20e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 9.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2562027160 123 LPLVDASQAMVWSPLWLHCVEDPGQQLAEWLRVLKPEGGVFFSCFGPDTAKELQ 176
Cdd:COG2226    81 LPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELE 134
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 123-164 4.07e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.80  E-value: 4.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2562027160 123 LPLVDASQAMVWSPLWLHCVEDPGQQLAEWLRVLKPeGGVFF 164
Cdd:pfam08241  53 LPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKP-GGILI 93
 
Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 123-280 9.67e-17

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 77.71  E-value: 9.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2562027160 123 LPLVDASQAMVWSPLWLHCVEDPGQQLAEWLRVLKPEGGVFFSCFGPDTAKELQGvalSLGEDFPDFADMHDIGDLMgKQ 202
Cdd:TIGR02072  92 LPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQ---SFGQHGLRYLSLDELKALL-KN 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2562027160 203 GFSDPVMEMEKLTLTYTTPEKLLADWRAL-VGNPLQQRQ-----KGLCApvRYsealiylEGLRNPDTgrIPLTLELVYG 276
Cdd:TIGR02072 168 SFELLTLEEELITLSFDDPLDVLRHLKKTgANGLSSGRTsrkqlKAFLE--RY-------EQEFQPDG--LPLTYHVVYG 236


                  ....
gi 2562027160 277 HAWK 280
Cdd:TIGR02072 237 IAKK 240
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 123-176 9.20e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 9.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2562027160 123 LPLVDASQAMVWSPLWLHCVEDPGQQLAEWLRVLKPEGGVFFSCFGPDTAKELQ 176
Cdd:COG2226    81 LPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELE 134
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 123-164 4.07e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.80  E-value: 4.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2562027160 123 LPLVDASQAMVWSPLWLHCVEDPGQQLAEWLRVLKPeGGVFF 164
Cdd:pfam08241  53 LPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKP-GGILI 93
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 123-160 7.94e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 35.23  E-value: 7.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2562027160 123 LPLVDASQAMVWSPLWLHCVEDPGQQ--LAEWLRVLKPEG 160
Cdd:pfam13649  57 LPFPDGSFDLVVSSGVLHHLPDPDLEaaLREIARVLKPGG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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