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Conserved domains on  [gi|2561014549|ref|WP_305359508|]
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endonuclease III [Hydrogenophaga sp.]

Protein Classification

endonuclease III domain-containing protein( domain architecture ID 11415064)

endonuclease III domain-containing protein such as endonuclease III, a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

CATH:  1.10.1670.10
Gene Ontology:  GO:0016798|GO:0006284|GO:0051539
PubMed:  10908318|1411536
SCOP:  4001141

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
10-206 2.84e-120

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 338.99  E-value: 2.84e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  10 FATLQAANPHPVTELEYTSVFELLTAVLLSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSKAKHL 89
Cdd:COG0177     1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  90 MATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGTTPLAVEQQLMKRVPP 169
Cdd:COG0177    81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2561014549 170 AYAVDSHHWLILLGRYVCQARKPLCHTCAVSAYCDFK 206
Cdd:COG0177   161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLCPYY 197
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
10-206 2.84e-120

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 338.99  E-value: 2.84e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  10 FATLQAANPHPVTELEYTSVFELLTAVLLSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSKAKHL 89
Cdd:COG0177     1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  90 MATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGTTPLAVEQQLMKRVPP 169
Cdd:COG0177    81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2561014549 170 AYAVDSHHWLILLGRYVCQARKPLCHTCAVSAYCDFK 206
Cdd:COG0177   161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLCPYY 197
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 6-194 4.81e-106

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 303.15  E-value: 4.81e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549   6 IEAFFATLQAANPHPVTELEYTSVFELLTAVLLSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSK 85
Cdd:TIGR01083   4 AQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  86 AKHLMATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGTTPLAVEQQLMK 165
Cdd:TIGR01083  84 AKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEEDLMK 163

                         170       180
                  ....*....|....*....|....*....
gi 2561014549 166 RVPPAYAVDSHHWLILLGRYVCQARKPLC 194
Cdd:TIGR01083 164 LVPREFWVKLHHWLILHGRYTCKARKPLC 192
PRK10702 PRK10702
endonuclease III; Provisional
 8-208 9.61e-106

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 303.09  E-value: 9.61e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549   8 AFFATLQAANPHPVTELEYTSVFELLTAVLLSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSKAK 87
Cdd:PRK10702    8 EILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  88 HLMATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGTTPLAVEQQLMKRV 167
Cdd:PRK10702   88 NVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEEKLLKVV 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2561014549 168 PPAYAVDSHHWLILLGRYVCQARKPLCHTCAVSAYCDFKPK 208
Cdd:PRK10702  168 PAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 38-185 1.51e-55

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 173.60  E-value: 1.51e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549   38 LSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSKAKHLMATCRILVERHGGEVPRTREALEALPGV 117
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2561014549  118 GRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGT-TPLAVEQQLMKRVPPAYAVDSHHWLILLGRY 185
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKsTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 30-183 3.06e-52

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 165.49  E-value: 3.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  30 FELLTAVLLSAQATDVGVNKATRKLFP-VANTPQKILDLGQEGLEGYIKTIGlYRSKAKHLMATCRILVERHGGEV---P 105
Cdd:cd00056     1 FEVLVSEILSQQTTDKAVNKAYERLFErYGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2561014549 106 RTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGT-TPLAVEQQLMKRVPPAYAVDSHHWLILLG 183
Cdd:cd00056    80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPKKkTPEELEELLEELLPKPYWGEANQALMDLG 158
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-169 4.65e-44

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 143.96  E-value: 4.65e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  35 AVLLSAQATDVGVNKATRKLF-PVANTPQKILDLGQEGLEGYIKTIGLYRSKAKHLMATCRILVERHGGEVPRTREALEA 113
Cdd:pfam00730   2 SAILSQQTSDKAVNKITERLFeKFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELEA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549 114 -LPGVGRKTANVVLNVAFG--QPTMAVDTHIFRVSNRTGLAPGT-TPLAVEQQLMKRVPP 169
Cdd:pfam00730  82 lLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEKpTPKEVERELEELWPP 141
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
10-206 2.84e-120

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 338.99  E-value: 2.84e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  10 FATLQAANPHPVTELEYTSVFELLTAVLLSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSKAKHL 89
Cdd:COG0177     1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  90 MATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGTTPLAVEQQLMKRVPP 169
Cdd:COG0177    81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2561014549 170 AYAVDSHHWLILLGRYVCQARKPLCHTCAVSAYCDFK 206
Cdd:COG0177   161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLCPYY 197
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 6-194 4.81e-106

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 303.15  E-value: 4.81e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549   6 IEAFFATLQAANPHPVTELEYTSVFELLTAVLLSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSK 85
Cdd:TIGR01083   4 AQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  86 AKHLMATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGTTPLAVEQQLMK 165
Cdd:TIGR01083  84 AKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEEDLMK 163

                         170       180
                  ....*....|....*....|....*....
gi 2561014549 166 RVPPAYAVDSHHWLILLGRYVCQARKPLC 194
Cdd:TIGR01083 164 LVPREFWVKLHHWLILHGRYTCKARKPLC 192
PRK10702 PRK10702
endonuclease III; Provisional
 8-208 9.61e-106

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 303.09  E-value: 9.61e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549   8 AFFATLQAANPHPVTELEYTSVFELLTAVLLSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSKAK 87
Cdd:PRK10702    8 EILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  88 HLMATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGTTPLAVEQQLMKRV 167
Cdd:PRK10702   88 NVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEEKLLKVV 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2561014549 168 PPAYAVDSHHWLILLGRYVCQARKPLCHTCAVSAYCDFKPK 208
Cdd:PRK10702  168 PAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 38-185 1.51e-55

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 173.60  E-value: 1.51e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549   38 LSAQATDVGVNKATRKLFPVANTPQKILDLGQEGLEGYIKTIGLYRSKAKHLMATCRILVERHGGEVPRTREALEALPGV 117
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2561014549  118 GRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGT-TPLAVEQQLMKRVPPAYAVDSHHWLILLGRY 185
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKsTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 30-183 3.06e-52

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 165.49  E-value: 3.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  30 FELLTAVLLSAQATDVGVNKATRKLFP-VANTPQKILDLGQEGLEGYIKTIGlYRSKAKHLMATCRILVERHGGEV---P 105
Cdd:cd00056     1 FEVLVSEILSQQTTDKAVNKAYERLFErYGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2561014549 106 RTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTGLAPGT-TPLAVEQQLMKRVPPAYAVDSHHWLILLG 183
Cdd:cd00056    80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPKKkTPEELEELLEELLPKPYWGEANQALMDLG 158
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-169 4.65e-44

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 143.96  E-value: 4.65e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  35 AVLLSAQATDVGVNKATRKLF-PVANTPQKILDLGQEGLEGYIKTIGLYRSKAKHLMATCRILVERHGGEVPRTREALEA 113
Cdd:pfam00730   2 SAILSQQTSDKAVNKITERLFeKFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELEA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549 114 -LPGVGRKTANVVLNVAFG--QPTMAVDTHIFRVSNRTGLAPGT-TPLAVEQQLMKRVPP 169
Cdd:pfam00730  82 lLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEKpTPKEVERELEELWPP 141
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 70-203 1.37e-18

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 82.49  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  70 EGLeGYiktiglYrSKAKHLMATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVsnrtg 149
Cdd:COG1194    77 EGL-GY------Y-SRARNLHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVDGNVKRV----- 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2561014549 150 LA--------PGTTplAVEQQLMKRV--------PPAY--AV-DshhwlilLGRYVCQARKPLCHTCAVSAYC 203
Cdd:COG1194   144 LSrlfaiegpIGSP--AAKKELWALAeellpperPGDFnqALmD-------LGATVCTPKKPKCLLCPLQDDC 207
PRK10880 PRK10880
adenine DNA glycosylase;
80-203 2.35e-14

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 70.51  E-value: 2.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  80 GL-YRSKAKHLMATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNR----TGLaPGT 154
Cdd:PRK10880   79 GLgYYARARNLHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARcyavSGW-PGK 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2561014549 155 TplAVEQQLMK---RVPPAYAVDSHHWLIL-LGRYVCQARKPLCHTCAVSAYC 203
Cdd:PRK10880  158 K--EVENRLWQlseQVTPAVGVERFNQAMMdLGAMVCTRSKPKCELCPLQNGC 208
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 52-203 6.24e-12

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 6.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  52 RKLFPVANTPQKILDLGQEGLEGYI---KTIGLYrSKAKHLMATCRILVERHGGEVPRTREALEALPGVGRKTANVVLNV 128
Cdd:PRK13910   13 RFYSPFLEAFPTLKDLANAPLEEVLllwRGLGYY-SRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGIGAYTANAILCF 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2561014549 129 AFGQPTMAVDTHIFRVSNRT-GLAPGTTPLAVEQQLMKRVPPAYAVDSHHWLILLGRYVCQArKPLCHTCAVSAYC 203
Cdd:PRK13910   92 GFREKSACVDANIKRVLLRLfGLDPNIHAKDLQIKANDFLNLNESFNHNQALIDLGALICSP-KPKCAICPLNPYC 166
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 99-128 1.12e-07

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 46.26  E-value: 1.12e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 2561014549  99 RHGGEVPRTREALEALPGVGRKTANVVLNV 128
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAILSY 30
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 43-141 2.11e-07

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 49.88  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  43 TDVGVNKATRKLFPvanTPQKILDLGQEGLegyiKTIGLYRSKAKHLMATCRILVER-------HGGEVPRTREALEALP 115
Cdd:COG0122   115 EPIEGPGGGLYAFP---TPEALAAASEEEL----RACGLSRRKARYLRALARAVADGeldlealAGLDDEEAIARLTALP 187

                          90       100
                  ....*....|....*....|....*...
gi 2561014549 116 GVGRKTANVVLNVAFGQPT--MAVDTHI 141
Cdd:COG0122   188 GIGPWTAEMVLLFALGRPDafPAGDLGL 215
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 68-147 1.37e-06

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 47.60  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  68 GQEGlEGYIKTIGL-YRskAKHLMATCRILVERHGG----------EVPRTREALEALPGVGRKTANVVLNVAFGQP-TM 135
Cdd:TIGR00588 171 GPEA-EAHLRKLGLgYR--ARYIRETARALLEEQGGrawlqqirgaSYEDAREALCELPGVGPKVADCICLMGLDKPqAV 247

                          90
                  ....*....|..
gi 2561014549 136 AVDTHIFRVSNR 147
Cdd:TIGR00588 248 PVDVHVWRIANR 259
PRK13913 PRK13913
3-methyladenine DNA glycosylase; Provisional
 30-149 3.22e-05

3-methyladenine DNA glycosylase; Provisional


Pssm-ID: 184390  Cd Length: 218  Bit Score: 43.30  E-value: 3.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2561014549  30 FELLTAVLLSAQATDVGVNKAT---RKLFPVANTPQ----KILDLGQEGLEGYIKTIGLYRSKAKHLMATCRILVERHGG 102
Cdd:PRK13913   31 FEALLGAVLTQNTKFEAVEKSLenlKNAFILENDDEinlkKIAYIEFSKLAECVRPSGFYNQKAKRLIDLSENILKDFGS 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2561014549 103 ------EVprTREALEALPGVGRKTANVVLNVAFGQPTMAVDTHIFRVSNRTG 149
Cdd:PRK13913  111 fenfkqEV--TREWLLDQKGIGKESADAILCYVCAKEVMVVDKYSYLFLKKLG 161
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 186-206 2.55e-03

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 34.06  E-value: 2.55e-03
                           10        20
                   ....*....|....*....|.
gi 2561014549  186 VCQARKPLCHTCAVSAYCDFK 206
Cdd:smart00525   1 ICTARKPRCDECPLKDLCPAY 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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