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Conserved domains on  [gi|2556262223|ref|WP_304031060|]
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MOSC domain-containing protein [Methyloversatilis discipulorum]

Protein Classification

MOSC domain-containing protein( domain architecture ID 11455027)

MOSC (molybdenum cofactor sulfurase C-terminal) domain-containing protein similar to Haemophilus influenzae protein HI_0278

Gene Ontology:  GO:0003824|GO:0030170|GO:0030151
PubMed:  11886751
SCOP:  4000907

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YiiM COG2258
N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and ...
 14-155 1.99e-46

N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


:

Pssm-ID: 441859  Cd Length: 162  Bit Score: 148.78  E-value: 1.99e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556262223  14 AGQVTWIGVRPARMQPLRVVETVQAIESLGLEGDRYASP----DGKRQVTLIQAEHLQTVADLLGLgEVDPGLVRRNIVV 89
Cdd:COG2258     1 MGKVLAVNIGKESGIPKRPVEGAVLVAGLGLEGDAQADRkhhgGPDRAVTLYAAEHYDAWAAELGR-DLPPGAFGENLTT 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556262223  90 SGLNLLAL-KGKRFRVGDALLEYTGPCDPCSRMETNLG-KGGYNVMR--GHGGITARVLRSGLIRQGDAV 155
Cdd:COG2258    80 EGLDLSDLpIGDRLRIGEALLEVTQPRKPCHKLEARLGgPGLAKAMCqmGRGGIYARVLEGGEVRAGDEV 149
 
Name Accession Description Interval E-value
YiiM COG2258
N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and ...
 14-155 1.99e-46

N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


Pssm-ID: 441859  Cd Length: 162  Bit Score: 148.78  E-value: 1.99e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556262223  14 AGQVTWIGVRPARMQPLRVVETVQAIESLGLEGDRYASP----DGKRQVTLIQAEHLQTVADLLGLgEVDPGLVRRNIVV 89
Cdd:COG2258     1 MGKVLAVNIGKESGIPKRPVEGAVLVAGLGLEGDAQADRkhhgGPDRAVTLYAAEHYDAWAAELGR-DLPPGAFGENLTT 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556262223  90 SGLNLLAL-KGKRFRVGDALLEYTGPCDPCSRMETNLG-KGGYNVMR--GHGGITARVLRSGLIRQGDAV 155
Cdd:COG2258    80 EGLDLSDLpIGDRLRIGEALLEVTQPRKPCHKLEARLGgPGLAKAMCqmGRGGIYARVLEGGEVRAGDEV 149
MOSC pfam03473
MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich ...
 56-155 2.67e-16

MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.


Pssm-ID: 460936  Cd Length: 116  Bit Score: 70.30  E-value: 2.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556262223  56 RQVTLIQAEHLQTVADLLGLGEVDPGLVRRNIVVSGLNLLALK-GKRFRVGDALLEYTG--PCDPCSRMETNLG-KGGYN 131
Cdd:pfam03473  10 KAVLLYSRESYDAWNAELGRGPLDPGRFRENLVVSGGTWKEVCiGDRFRIGGACLRLEVtqPREPCKTLAKRFGeRRVDK 89

                          90       100
                  ....*....|....*....|....*.
gi 2556262223 132 VMRGHG--GITARVLRSGLIRQGDAV 155
Cdd:pfam03473  90 RFKGSGrfGWYLRVLEEGTVRVGDEV 115
 
Name Accession Description Interval E-value
YiiM COG2258
N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and ...
 14-155 1.99e-46

N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


Pssm-ID: 441859  Cd Length: 162  Bit Score: 148.78  E-value: 1.99e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556262223  14 AGQVTWIGVRPARMQPLRVVETVQAIESLGLEGDRYASP----DGKRQVTLIQAEHLQTVADLLGLgEVDPGLVRRNIVV 89
Cdd:COG2258     1 MGKVLAVNIGKESGIPKRPVEGAVLVAGLGLEGDAQADRkhhgGPDRAVTLYAAEHYDAWAAELGR-DLPPGAFGENLTT 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556262223  90 SGLNLLAL-KGKRFRVGDALLEYTGPCDPCSRMETNLG-KGGYNVMR--GHGGITARVLRSGLIRQGDAV 155
Cdd:COG2258    80 EGLDLSDLpIGDRLRIGEALLEVTQPRKPCHKLEARLGgPGLAKAMCqmGRGGIYARVLEGGEVRAGDEV 149
MOSC pfam03473
MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich ...
 56-155 2.67e-16

MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.


Pssm-ID: 460936  Cd Length: 116  Bit Score: 70.30  E-value: 2.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556262223  56 RQVTLIQAEHLQTVADLLGLGEVDPGLVRRNIVVSGLNLLALK-GKRFRVGDALLEYTG--PCDPCSRMETNLG-KGGYN 131
Cdd:pfam03473  10 KAVLLYSRESYDAWNAELGRGPLDPGRFRENLVVSGGTWKEVCiGDRFRIGGACLRLEVtqPREPCKTLAKRFGeRRVDK 89

                          90       100
                  ....*....|....*....|....*.
gi 2556262223 132 VMRGHG--GITARVLRSGLIRQGDAV 155
Cdd:pfam03473  90 RFKGSGrfGWYLRVLEEGTVRVGDEV 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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