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Conserved domains on  [gi|2555830609|ref|WP_303662835|]
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VWA-like domain-containing protein [Sulfuricurvum kujiense]

Protein Classification

VWA domain-containing protein( domain architecture ID 11467510)

VWA (von Willebrand factor type A) domain-containing protein similar to mammalian von Willebrand factor that plays an essential role in the formation of a platelet plug, to stop bleeding, by anchoring blood platelets to the damaged vessel wall under conditions of high shear stress

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG3864 COG3864
Predicted metal-dependent peptidase [General function prediction only];
5-385 4.99e-86

Predicted metal-dependent peptidase [General function prediction only];


:

Pssm-ID: 443073 [Multi-domain]  Cd Length: 384  Bit Score: 266.07  E-value: 4.99e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609   5 PKDTPIKNRLEKIRVQFLFDHPFLSVLALSIPHKYQNNPHMlFETDGV-SIRVDESKMLGYDDARLKYLYAHVLLHILLK 83
Cdd:COG3864     2 SGPADAETKLEAARLRLLLEDPFLGALLLALRHVEDDAVPT-AAVDGRwTLYYNPAFFARLSLEELAFVLAHEVLHLALR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  84 HPFRMKDRDKPTWNRSCDIVIGLLLRDfQRVGQAdEEAMVIESF---RDKSVEEVYHALYRESDE-------GEGQQSEE 153
Cdd:COG3864    81 HLARRKGRDPLLWNLACDYAINDYLDE-AGLGLP-PGAVTLERLgleEGLSAEEIYRELREDLRPepkdqlcGSPADGHD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 154 NPTEqKMDIIEHEGDTqvAEEELDALIIQAMGAARKQGNIPASLLEMFDEITKPSIDLHTLLHTYMSESFFDkESDFSH- 232
Cdd:COG3864   159 RQWE-LPDLSPEEREE--LREEWARAIAQALEAARGRGKLPGGLRRLLAALLQPPLPWRRLLRRFLARALRD-EPDYSYa 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 233 -PNRRFIHQgLYLPGYRYDRnRLSFFIFLDRSMSITGDVFSRFLGIIDSIVRLSHDFEVSVIPFDERVYSEEKksYDAQG 311
Cdd:COG3864   235 rPSRRQGAR-LILPGLRRRR-RPRVVVAIDTSGSISDEELGRFLGEVAAILRALGAVRITVLQCDAAVQRVGK--FEPEG 310
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2555830609 312 ILPQIEFaKGNGGTQFSPVLEFLNSHAGEKNLAVILSDGYFTV-DKAPAMQTLFLLSEKQnLKRFERYGDVVYFD 385
Cdd:COG3864   311 LLREIRL-KGGGGTDFRPVFEYAERAGPRPDLLVYFTDGEGPFpERPPPYPVLWLLPGEG-LSAPPPWGRVVRLG 383
 
Name Accession Description Interval E-value
COG3864 COG3864
Predicted metal-dependent peptidase [General function prediction only];
5-385 4.99e-86

Predicted metal-dependent peptidase [General function prediction only];


Pssm-ID: 443073 [Multi-domain]  Cd Length: 384  Bit Score: 266.07  E-value: 4.99e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609   5 PKDTPIKNRLEKIRVQFLFDHPFLSVLALSIPHKYQNNPHMlFETDGV-SIRVDESKMLGYDDARLKYLYAHVLLHILLK 83
Cdd:COG3864     2 SGPADAETKLEAARLRLLLEDPFLGALLLALRHVEDDAVPT-AAVDGRwTLYYNPAFFARLSLEELAFVLAHEVLHLALR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  84 HPFRMKDRDKPTWNRSCDIVIGLLLRDfQRVGQAdEEAMVIESF---RDKSVEEVYHALYRESDE-------GEGQQSEE 153
Cdd:COG3864    81 HLARRKGRDPLLWNLACDYAINDYLDE-AGLGLP-PGAVTLERLgleEGLSAEEIYRELREDLRPepkdqlcGSPADGHD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 154 NPTEqKMDIIEHEGDTqvAEEELDALIIQAMGAARKQGNIPASLLEMFDEITKPSIDLHTLLHTYMSESFFDkESDFSH- 232
Cdd:COG3864   159 RQWE-LPDLSPEEREE--LREEWARAIAQALEAARGRGKLPGGLRRLLAALLQPPLPWRRLLRRFLARALRD-EPDYSYa 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 233 -PNRRFIHQgLYLPGYRYDRnRLSFFIFLDRSMSITGDVFSRFLGIIDSIVRLSHDFEVSVIPFDERVYSEEKksYDAQG 311
Cdd:COG3864   235 rPSRRQGAR-LILPGLRRRR-RPRVVVAIDTSGSISDEELGRFLGEVAAILRALGAVRITVLQCDAAVQRVGK--FEPEG 310
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2555830609 312 ILPQIEFaKGNGGTQFSPVLEFLNSHAGEKNLAVILSDGYFTV-DKAPAMQTLFLLSEKQnLKRFERYGDVVYFD 385
Cdd:COG3864   311 LLREIRL-KGGGGTDFRPVFEYAERAGPRPDLLVYFTDGEGPFpERPPPYPVLWLLPGEG-LSAPPPWGRVVRLG 383
DUF2201_N pfam13203
Putative metallopeptidase domain; This domain, found in various hypothetical bacterial ...
13-248 8.61e-21

Putative metallopeptidase domain; This domain, found in various hypothetical bacterial proteins, has no known function. However, it is related to pfam01435.


Pssm-ID: 404152  Cd Length: 271  Bit Score: 91.03  E-value: 8.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  13 RLEKIRVQFLFDHPFLSVLALSIPHKYQNNPHMLfETDGVSIRVDESKMLGYDDARLKYLYAHVLLHILLKHPFRMKDRD 92
Cdd:pfam13203   5 RLTKAIARMVEDAPFLASLALWLRHRDKDGLGTA-ATDGRTIRYNPGFLESLLLEEQVGVLAHEVLHVALRHPQRRGAFD 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  93 KPTWNRSCDIVIG--LLLRDFQRVGQA--DEEAMVIESFRDKSVEEVYHALYRESDEGEGQQSEENPTE----------- 157
Cdd:pfam13203  84 PQLFNLAADALINetLILAGHALPRSAvtLESLLREGALDNWDAEQLYTALGGAARDGEGDGREAAKQSrsdspgsarcg 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 158 -----QKMDIIEH-------EGDTQVAEEELDAlIIQAMGAARKQGNIPASLLEMFDEITKPSIDLHTLLHTYMSESFFD 225
Cdd:pfam13203 164 ggaggFEADLEPSpkgksgpERETPEAREWRER-IQQALEAGKAQGKLPGMLARLLADIPKPVTPWEVMLRTFLDRTLAD 242
                         250       260
                  ....*....|....*....|....*....
gi 2555830609 226 K-ESDFSHPNRRFI-----HQGLYLPGYR 248
Cdd:pfam13203 243 TpDYSWSRPNRRWIaaaggRRPVYLPSFR 271
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
260-355 3.77e-03

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 37.82  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  260 LDRSMSITGDVFSRFLGIIDSIVRL----SHDFEVSVIPFDE--RVYSEEKKSYDAQGILPQIEFA--KGNGGTQFSPVL 331
Cdd:smart00327   6 LDGSGSMGGNRFELAKEFVLKLVEQldigPDGDRVGLVTFSDdaRVLFPLNDSRSKDALLEALASLsyKLGGGTNLGAAL 85
                           90       100       110
                   ....*....|....*....|....*....|...
gi 2555830609  332 EFL---------NSHAGEKNLAVILSDGYFTVD 355
Cdd:smart00327  86 QYAlenlfsksaGSRRGAPKVVILITDGESNDG 118
 
Name Accession Description Interval E-value
COG3864 COG3864
Predicted metal-dependent peptidase [General function prediction only];
5-385 4.99e-86

Predicted metal-dependent peptidase [General function prediction only];


Pssm-ID: 443073 [Multi-domain]  Cd Length: 384  Bit Score: 266.07  E-value: 4.99e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609   5 PKDTPIKNRLEKIRVQFLFDHPFLSVLALSIPHKYQNNPHMlFETDGV-SIRVDESKMLGYDDARLKYLYAHVLLHILLK 83
Cdd:COG3864     2 SGPADAETKLEAARLRLLLEDPFLGALLLALRHVEDDAVPT-AAVDGRwTLYYNPAFFARLSLEELAFVLAHEVLHLALR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  84 HPFRMKDRDKPTWNRSCDIVIGLLLRDfQRVGQAdEEAMVIESF---RDKSVEEVYHALYRESDE-------GEGQQSEE 153
Cdd:COG3864    81 HLARRKGRDPLLWNLACDYAINDYLDE-AGLGLP-PGAVTLERLgleEGLSAEEIYRELREDLRPepkdqlcGSPADGHD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 154 NPTEqKMDIIEHEGDTqvAEEELDALIIQAMGAARKQGNIPASLLEMFDEITKPSIDLHTLLHTYMSESFFDkESDFSH- 232
Cdd:COG3864   159 RQWE-LPDLSPEEREE--LREEWARAIAQALEAARGRGKLPGGLRRLLAALLQPPLPWRRLLRRFLARALRD-EPDYSYa 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 233 -PNRRFIHQgLYLPGYRYDRnRLSFFIFLDRSMSITGDVFSRFLGIIDSIVRLSHDFEVSVIPFDERVYSEEKksYDAQG 311
Cdd:COG3864   235 rPSRRQGAR-LILPGLRRRR-RPRVVVAIDTSGSISDEELGRFLGEVAAILRALGAVRITVLQCDAAVQRVGK--FEPEG 310
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2555830609 312 ILPQIEFaKGNGGTQFSPVLEFLNSHAGEKNLAVILSDGYFTV-DKAPAMQTLFLLSEKQnLKRFERYGDVVYFD 385
Cdd:COG3864   311 LLREIRL-KGGGGTDFRPVFEYAERAGPRPDLLVYFTDGEGPFpERPPPYPVLWLLPGEG-LSAPPPWGRVVRLG 383
DUF2201_N pfam13203
Putative metallopeptidase domain; This domain, found in various hypothetical bacterial ...
13-248 8.61e-21

Putative metallopeptidase domain; This domain, found in various hypothetical bacterial proteins, has no known function. However, it is related to pfam01435.


Pssm-ID: 404152  Cd Length: 271  Bit Score: 91.03  E-value: 8.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  13 RLEKIRVQFLFDHPFLSVLALSIPHKYQNNPHMLfETDGVSIRVDESKMLGYDDARLKYLYAHVLLHILLKHPFRMKDRD 92
Cdd:pfam13203   5 RLTKAIARMVEDAPFLASLALWLRHRDKDGLGTA-ATDGRTIRYNPGFLESLLLEEQVGVLAHEVLHVALRHPQRRGAFD 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  93 KPTWNRSCDIVIG--LLLRDFQRVGQA--DEEAMVIESFRDKSVEEVYHALYRESDEGEGQQSEENPTE----------- 157
Cdd:pfam13203  84 PQLFNLAADALINetLILAGHALPRSAvtLESLLREGALDNWDAEQLYTALGGAARDGEGDGREAAKQSrsdspgsarcg 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 158 -----QKMDIIEH-------EGDTQVAEEELDAlIIQAMGAARKQGNIPASLLEMFDEITKPSIDLHTLLHTYMSESFFD 225
Cdd:pfam13203 164 ggaggFEADLEPSpkgksgpERETPEAREWRER-IQQALEAGKAQGKLPGMLARLLADIPKPVTPWEVMLRTFLDRTLAD 242
                         250       260
                  ....*....|....*....|....*....
gi 2555830609 226 K-ESDFSHPNRRFI-----HQGLYLPGYR 248
Cdd:pfam13203 243 TpDYSWSRPNRRWIaaaggRRPVYLPSFR 271
DUF2201 pfam09967
VWA-like domain (DUF2201); This domain, found in various hypothetical bacterial proteins, has ...
258-349 3.89e-09

VWA-like domain (DUF2201); This domain, found in various hypothetical bacterial proteins, has no known function. However, it is clearly related to the VWA domain.


Pssm-ID: 401806  Cd Length: 123  Bit Score: 54.31  E-value: 3.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609 258 IFLDRSMSITGDVFSRFLGIIDSIVRlSHDFEVSVIPFDERVYSEEKKSYDAQgiLPQIEFaKGNGGTQFSPVLEFLNSH 337
Cdd:pfam09967   3 LAVDTSGSITDPLLARFAAEIAGILR-RYPAEVHVLAFDETVQSVQRIEPASY--LAELQF-TGGGGTDLVPVLEWASRL 78
                          90
                  ....*....|..
gi 2555830609 338 AgeKNLAVILSD 349
Cdd:pfam09967  79 R--PDAAVVLTD 88
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
260-355 3.77e-03

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 37.82  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2555830609  260 LDRSMSITGDVFSRFLGIIDSIVRL----SHDFEVSVIPFDE--RVYSEEKKSYDAQGILPQIEFA--KGNGGTQFSPVL 331
Cdd:smart00327   6 LDGSGSMGGNRFELAKEFVLKLVEQldigPDGDRVGLVTFSDdaRVLFPLNDSRSKDALLEALASLsyKLGGGTNLGAAL 85
                           90       100       110
                   ....*....|....*....|....*....|...
gi 2555830609  332 EFL---------NSHAGEKNLAVILSDGYFTVD 355
Cdd:smart00327  86 QYAlenlfsksaGSRRGAPKVVILITDGESNDG 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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