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Conserved domains on  [gi|2552837814|ref|WP_302966845|]
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3-isopropylmalate dehydrogenase [Intestinibacter bartlettii]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-356 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 641.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   1 MDFKIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  81 NIESSKRPEKGLLALRSGLGLFVNLRPATMHESIKEASPLRADIVEkGVDFVVVRELTGGIYFGE-RKTGVENGVEFAYD 159
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEpRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 160 VEKYDENEIRRIGKKAFETAMIRNKKLTCVDKANVLDSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVI 239
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 240 VTNNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLEEEAKAIE 319
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2552837814 320 TAVTNVLNAGYRTKDIYNGvGQVVGTKEMGDLIAKEI 356
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEG-GGKVSTSEMGDAILAAL 355
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-356 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 641.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   1 MDFKIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  81 NIESSKRPEKGLLALRSGLGLFVNLRPATMHESIKEASPLRADIVEkGVDFVVVRELTGGIYFGE-RKTGVENGVEFAYD 159
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEpRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 160 VEKYDENEIRRIGKKAFETAMIRNKKLTCVDKANVLDSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVI 239
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 240 VTNNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLEEEAKAIE 319
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2552837814 320 TAVTNVLNAGYRTKDIYNGvGQVVGTKEMGDLIAKEI 356
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEG-GGKVSTSEMGDAILAAL 355
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 3-356 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 558.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   3 FKIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDni 82
Cdd:COG0473     2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  83 eSSKRPEKGLLALRSGLGLFVNLRPATMHESIkeASPLRADIVEkGVDFVVVRELTGGIYFG-ERKTGVENGVEFAYDVE 161
Cdd:COG0473    80 -DGVRPESGLLALRKELDLYANLRPAKLYPGL--PSPLKPEIVE-GIDLVIVRENTEGLYFGiGGRIGTGTGEEVAIDTR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 162 KYDENEIRRIGKKAFETAMIRNKKLTCVDKANVL-DSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVIV 240
Cdd:COG0473   156 VYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 241 TNNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSfKLEEEAKAIET 320
Cdd:COG0473   236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADAIEA 314

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2552837814 321 AVTNVLNAGYRTKDIyngvGQVVGTKEMGDLIAKEI 356
Cdd:COG0473   315 AVEKVLAEGVRTPDL----GGKAGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 4-352 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 533.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   4 KIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNIE 83
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  84 SSKRPEKGLLALRSGLGLFVNLRPATMHESIKEASPLRADIVeKGVDFVVVRELTGGIYFGERKTgvENGVEFAYDVEKY 163
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKG--REGEGEAWDTEVY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 164 DENEIRRIGKKAFETAMIRNKKLTCVDKANVLDSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVIVTNN 243
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 244 IFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLEEEAKAIETAVT 323
Cdd:TIGR00169 238 LFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAVK 317

                         330       340
                  ....*....|....*....|....*....
gi 2552837814 324 NVLNAGYRTKDIYNGVGQVVGTKEMGDLI 352
Cdd:TIGR00169 318 KVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
4-352 1.58e-180

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 503.75  E-value: 1.58e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   4 KIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNie 83
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDP-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  84 SSKRPEKGLLALRSGLGLFVNLRPATMHESIKEASPLRADIveKGVDFVVVRELTGGIYFGERKTGVENGVEFAYDVEKY 163
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNEV--EGVDIVIVRELTGGIYFGIEKGIKGSGNEVAVDTKLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 164 DENEIRRIGKKAFETAMIRN-KKLTCVDKANVLDSSKLWRKVLNELAKD-YPEVELSYMYVDNAAMQLVKDPSQFDVIVT 241
Cdd:pfam00180 157 SRDEIERIARVAFELARKRGrKKVTSVDKANVLKSSDLWRKIVTEVAKAeYPDVELEHQLVDNAAMQLVKNPSQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 242 NNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLEEEAKAIETA 321
Cdd:pfam00180 237 PNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEAA 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2552837814 322 VTNVLNAGYRTKDIYnGVGQVVGTKEMGDLI 352
Cdd:pfam00180 317 VLKVLESGIRTGDLA-GSATYVSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-356 5.24e-86

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 263.13  E-value: 5.24e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   3 FKIAVIKGDGVGPEIVDEGLKILDKIaqkyNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVggpkwdni 82
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLDAL----DLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV-------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  83 eSSKRPEK-GLLALRSGLGLFVNLRPATMHESIkeasplraDIVEKGVDFVVVRELTGGIYFGERKTGVENGVEfAYDVE 161
Cdd:NF040626   70 -TSTPGQKsPIITLRKELDLYANLRPIKSYEGI--------NCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAI-AERVI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 162 KYDENEirRIGKKAFETAMIRN-KKLTCVDKANVLDSSK-LWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVI 239
Cdd:NF040626  140 TRKASE--RICKFAFEYAIKLGrKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 240 VTNNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKAIE 319
Cdd:NF040626  218 VTTNLFGDILSDEAAGLVGGLGLAPSANI-GDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKLE 295

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2552837814 320 TAVTNVLNAG-YRTKDIyngvGQVVGTKEMGDLIAKEI 356
Cdd:NF040626  296 NALEKVLREGkVVTPDL----GGNAKTMEMANEIKKKI 329
AksF_Meth NF040619
homoisocitrate dehydrogenase;
4-352 2.41e-77

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 240.82  E-value: 2.41e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   4 KIAVIKGDGVGPEIVDEGLKILDKIaqkynHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNIE 83
Cdd:NF040619    3 KICVIEGDGIGKEVIPETVRVLKEL-----GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTELK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  84 SsKRPEKGLLALRSGLGLFVNLRPAtmhesikeaSPLRADIVEKGVDFVVVRELTGGIYFGERKTGVENGVEFAYDVEKY 163
Cdd:NF040619   78 N-KNYKSPILTLRKELDLYANVRPI---------NNFGDGQDVKNIDFVIIRENTEGLYVGREYYDEENEIAIAERIISK 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 164 DENEirRIGKKAFETAMIRN-KKLTCVDKANVLD-SSKLWRKVLNELAKDYPEVELSY--MYVDNAAMQLVKDPSQFDVI 239
Cdd:NF040619  148 KGSE--RIIKFAFEYAKKNNrKKVSCIHKANVLRvTDGLFLEIFNEIKKKYKNFNIEAddYLVDATAMYLIKNPEMFDVI 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 240 VTNNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKAIE 319
Cdd:NF040619  226 VTTNLFGDILSDEASGLIGGLGLAPSANI-GDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKGDLIR 303

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2552837814 320 TAVTNVLNAGYRTKDIyngvGQVVGTKEMGDLI 352
Cdd:NF040619  304 EAVKKCLENGKVTPDL----GGNLKTKEVTDKI 332
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-356 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 641.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   1 MDFKIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  81 NIESSKRPEKGLLALRSGLGLFVNLRPATMHESIKEASPLRADIVEkGVDFVVVRELTGGIYFGE-RKTGVENGVEFAYD 159
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEpRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 160 VEKYDENEIRRIGKKAFETAMIRNKKLTCVDKANVLDSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVI 239
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 240 VTNNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLEEEAKAIE 319
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2552837814 320 TAVTNVLNAGYRTKDIYNGvGQVVGTKEMGDLIAKEI 356
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEG-GGKVSTSEMGDAILAAL 355
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 3-356 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 558.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   3 FKIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDni 82
Cdd:COG0473     2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  83 eSSKRPEKGLLALRSGLGLFVNLRPATMHESIkeASPLRADIVEkGVDFVVVRELTGGIYFG-ERKTGVENGVEFAYDVE 161
Cdd:COG0473    80 -DGVRPESGLLALRKELDLYANLRPAKLYPGL--PSPLKPEIVE-GIDLVIVRENTEGLYFGiGGRIGTGTGEEVAIDTR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 162 KYDENEIRRIGKKAFETAMIRNKKLTCVDKANVL-DSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVIV 240
Cdd:COG0473   156 VYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 241 TNNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSfKLEEEAKAIET 320
Cdd:COG0473   236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADAIEA 314

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2552837814 321 AVTNVLNAGYRTKDIyngvGQVVGTKEMGDLIAKEI 356
Cdd:COG0473   315 AVEKVLAEGVRTPDL----GGKAGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 4-352 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 533.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   4 KIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNIE 83
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  84 SSKRPEKGLLALRSGLGLFVNLRPATMHESIKEASPLRADIVeKGVDFVVVRELTGGIYFGERKTgvENGVEFAYDVEKY 163
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKG--REGEGEAWDTEVY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 164 DENEIRRIGKKAFETAMIRNKKLTCVDKANVLDSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVIVTNN 243
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 244 IFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLEEEAKAIETAVT 323
Cdd:TIGR00169 238 LFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAVK 317

                         330       340
                  ....*....|....*....|....*....
gi 2552837814 324 NVLNAGYRTKDIYNGVGQVVGTKEMGDLI 352
Cdd:TIGR00169 318 KVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
4-352 1.58e-180

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 503.75  E-value: 1.58e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   4 KIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNie 83
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDP-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  84 SSKRPEKGLLALRSGLGLFVNLRPATMHESIKEASPLRADIveKGVDFVVVRELTGGIYFGERKTGVENGVEFAYDVEKY 163
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNEV--EGVDIVIVRELTGGIYFGIEKGIKGSGNEVAVDTKLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 164 DENEIRRIGKKAFETAMIRN-KKLTCVDKANVLDSSKLWRKVLNELAKD-YPEVELSYMYVDNAAMQLVKDPSQFDVIVT 241
Cdd:pfam00180 157 SRDEIERIARVAFELARKRGrKKVTSVDKANVLKSSDLWRKIVTEVAKAeYPDVELEHQLVDNAAMQLVKNPSQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 242 NNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLEEEAKAIETA 321
Cdd:pfam00180 237 PNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEAA 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2552837814 322 VTNVLNAGYRTKDIYnGVGQVVGTKEMGDLI 352
Cdd:pfam00180 317 VLKVLESGIRTGDLA-GSATYVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 3-356 1.24e-129

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 377.11  E-value: 1.24e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   3 FKIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNI 82
Cdd:PLN02329   47 YNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKN 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  83 ESSKRPEKGLLALRSGLGLFVNLRPATMHESIKEASPLRADIVEkGVDFVVVRELTGGIYFGERK--TGVENGVEFAYDV 160
Cdd:PLN02329  127 EKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAE-GVDMMIVRELTGGIYFGEPRgiTINENGEEVGVST 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 161 EKYDENEIRRIGKKAFETAMIRNKKLTCVDKANVLDSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVIV 240
Cdd:PLN02329  206 EIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIV 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 241 TNNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLEEEAKAIET 320
Cdd:PLN02329  286 TNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIED 365

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2552837814 321 AVTNVLNAGYRTKDIYNGVGQVVGTKEMGDLIAKEI 356
Cdd:PLN02329  366 AVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKSV 401
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-353 2.29e-99

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 297.61  E-value: 2.29e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   1 MDFKIAVIKGDGVGPEIVDEGLKILDKIAQKyNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPkwd 80
Cdd:PRK03437    3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDP--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  81 niesSKRP---EKG-LLALRSGLGLFVNLRPATMHESIkeASPLRADiveKGVDFVVVRELTGGIYFGER---KTGVENg 153
Cdd:PRK03437   79 ----SVPSgvlERGlLLKLRFALDHYVNLRPSKLYPGV--TSPLAGP---GDIDFVVVREGTEGPYTGNGgalRVGTPH- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 154 vEFAYDVEKYDENEIRRIGKKAFETAMIRN-KKLTCVDKANVL-DSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVK 231
Cdd:PRK03437  149 -EVATEVSVNTAFGVERVVRDAFERAQKRPrKHLTLVHKTNVLtFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVT 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 232 DPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASV--RGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsF 309
Cdd:PRK03437  228 DPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInpTGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH-L 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2552837814 310 KLEEEAKAIETAVtnvlnagyrTKDIYNGVGQVVGTKEMGDLIA 353
Cdd:PRK03437  307 GEEDAAARIEAAV---------EADLAERGKMGRSTAEVGDRIA 341
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 5-353 2.03e-93

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 281.65  E-value: 2.03e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   5 IAVIKGDGVGPEIVDEGLKILDKiaqkYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNIES 84
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNK----LGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  85 SkrpekgLLALRSGLGLFVNLRPATMHESIKEASPLradivekGVDFVVVRELTGGIYFGERKTGVENGVEFAYDVEKYD 164
Cdd:TIGR02088  77 V------IVTLRKELDLYANVRPAKSLPGIPDLYPN-------GKDIVIVRENTEGLYAGFEFGFSDRAIAIRVITREGS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 165 EneirRIGKKAFETAMIRNKKLTCVDKANVLDSS-KLWRKVLNELAKDYpEVELSYMYVDNAAMQLVKDPSQFDVIVTNN 243
Cdd:TIGR02088 144 E----RIARFAFNLAKERNRKVTCVHKANVLKGTdGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTN 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 244 IFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLeEEAKAIETAVT 323
Cdd:TIGR02088 219 MFGDILSDLASALAGSLGLAPSANI-GDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGEL-EKGKLVWEAVE 296

                         330       340       350
                  ....*....|....*....|....*....|
gi 2552837814 324 NVLNAGYRTKDiyngVGQVVGTKEMGDLIA 353
Cdd:TIGR02088 297 YYIIEGKKTPD----LGGTAKTKEVGDEIA 322
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-356 5.24e-86

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 263.13  E-value: 5.24e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   3 FKIAVIKGDGVGPEIVDEGLKILDKIaqkyNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVggpkwdni 82
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLDAL----DLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV-------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  83 eSSKRPEK-GLLALRSGLGLFVNLRPATMHESIkeasplraDIVEKGVDFVVVRELTGGIYFGERKTGVENGVEfAYDVE 161
Cdd:NF040626   70 -TSTPGQKsPIITLRKELDLYANLRPIKSYEGI--------NCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAI-AERVI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 162 KYDENEirRIGKKAFETAMIRN-KKLTCVDKANVLDSSK-LWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVI 239
Cdd:NF040626  140 TRKASE--RICKFAFEYAIKLGrKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 240 VTNNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKAIE 319
Cdd:NF040626  218 VTTNLFGDILSDEAAGLVGGLGLAPSANI-GDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKLE 295

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2552837814 320 TAVTNVLNAG-YRTKDIyngvGQVVGTKEMGDLIAKEI 356
Cdd:NF040626  296 NALEKVLREGkVVTPDL----GGNAKTMEMANEIKKKI 329
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 4-356 1.18e-84

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 259.68  E-value: 1.18e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   4 KIAVIKGDGVGPEIVDEGLKILdkiaQKYNHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNIe 83
Cdd:PRK14025    3 KICVIEGDGIGKEVVPAALHVL----EATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAADVI- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  84 sskrpekglLALRSGLGLFVNLRPATMHESIKEASPlradivekGVDFVVVRELTGGIYFGErKTGVENGVEFAYDVekY 163
Cdd:PRK14025   78 ---------VKLRRILDTYANVRPVKSYKGVKCLYP--------DIDYVIVRENTEGLYKGI-EAEIADGVTVATRV--I 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 164 DENEIRRIGKKAFETA-----MIRNKKLTCVDKANVLD-SSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFD 237
Cdd:PRK14025  138 TRKASERIFRFAFEMAkrrkkMGKEGKVTCAHKANVLKkTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFD 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 238 VIVTNNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKA 317
Cdd:PRK14025  218 VVVTSNLFGDILSDGAAGLVGGLGLAPSANI-GDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEEADK 295

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2552837814 318 IETAVTNVLNAGYRTKDIyngvGQVVGTKEMGDLIAKEI 356
Cdd:PRK14025  296 VEKALEEVLALGLTTPDL----GGNLSTMEMAEEVAKRV 330
AksF_Meth NF040619
homoisocitrate dehydrogenase;
4-352 2.41e-77

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 240.82  E-value: 2.41e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   4 KIAVIKGDGVGPEIVDEGLKILDKIaqkynHKFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWDNIE 83
Cdd:NF040619    3 KICVIEGDGIGKEVIPETVRVLKEL-----GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTELK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  84 SsKRPEKGLLALRSGLGLFVNLRPAtmhesikeaSPLRADIVEKGVDFVVVRELTGGIYFGERKTGVENGVEFAYDVEKY 163
Cdd:NF040619   78 N-KNYKSPILTLRKELDLYANVRPI---------NNFGDGQDVKNIDFVIIRENTEGLYVGREYYDEENEIAIAERIISK 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 164 DENEirRIGKKAFETAMIRN-KKLTCVDKANVLD-SSKLWRKVLNELAKDYPEVELSY--MYVDNAAMQLVKDPSQFDVI 239
Cdd:NF040619  148 KGSE--RIIKFAFEYAKKNNrKKVSCIHKANVLRvTDGLFLEIFNEIKKKYKNFNIEAddYLVDATAMYLIKNPEMFDVI 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 240 VTNNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKAIE 319
Cdd:NF040619  226 VTTNLFGDILSDEASGLIGGLGLAPSANI-GDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKGDLIR 303

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2552837814 320 TAVTNVLNAGYRTKDIyngvGQVVGTKEMGDLI 352
Cdd:NF040619  304 EAVKKCLENGKVTPDL----GGNLKTKEVTDKI 332
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 3-356 5.38e-76

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 238.08  E-value: 5.38e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   3 FKIAVIKGDGVGPEIVDEGLKILDKIAQKYNH-KFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKW-- 79
Cdd:PRK08194    4 FKIAVIPGDGVGKEVVPAAVRVLKAVAEVHGGlKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKLvp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  80 DNIESSkrpekGLL-ALRSGLGLFVNLRPATMHESIKeaSPLRAdivEKGVDFVVVRELTGG--------IYFGERKTGV 150
Cdd:PRK08194   84 DHISLW-----GLLiKIRREFEQVINIRPAKQLRGIK--SPLAN---PKDFDLLVVRENSEGeysevggrIHRGEDEIAI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 151 ENGVefaydvekYDENEIRRIGKKAFETAMIRNKKLTCVDKAN-VLDSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQL 229
Cdd:PRK08194  154 QNAV--------FTRKGTERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFF 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 230 VKDPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSAS--VRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRY 307
Cdd:PRK08194  226 VTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANinVNGKYPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH 305

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2552837814 308 sFKLEEEAKAIETAVTNVLNAGYRTKDIyngvGQVVGTKEMGDLIAKEI 356
Cdd:PRK08194  306 -FGEEELGSHLLDVIEDVTEDGIKTPDI----GGRATTDEVTDEIISRL 349
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 3-335 6.17e-76

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 237.81  E-value: 6.17e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   3 FKIAVIKGDGVGPEIVDEGLKILDKIAQKYNH-KFECTNVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKwdN 81
Cdd:TIGR02089   4 YRIAAIPGDGIGKEVVAAALQVLEAAAKRHGGfSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA--L 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  82 IESSKRPEKGLLALRSGLGLFVNLRPATMHESIKeaSPLRADiVEKGVDFVVVRELTGGIYF---GERKTGVENgvEFAY 158
Cdd:TIGR02089  82 VPDHISLWGLLLKIRREFDQYANVRPAKLLPGVT--SPLRNC-GPGDFDFVVVRENSEGEYSgvgGRIHRGTDE--EVAT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 159 DVEKYDENEIRRIGKKAFETAMIRNKKLTCVDKAN-VLDSSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFD 237
Cdd:TIGR02089 157 QNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNgIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 238 VIVTNNIFGDIISDEASMITGSIGMLPSASV--RGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEA 315
Cdd:TIGR02089 237 VIVASNLFGDILSDLGAALMGSLGVAPSANInpEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEKEAG 315

                         330       340
                  ....*....|....*....|
gi 2552837814 316 KAIETAVTNVLNAGYRTKDI 335
Cdd:TIGR02089 316 AKIMDAIERVTAAGILTPDV 335
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 1-332 6.14e-75

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 234.61  E-value: 6.14e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   1 MDFKIAVIKGDGVGPEIVDEGLKILDKIAQKYNHKFectnVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPKWD 80
Cdd:PRK08997    1 MKQTITVIPGDGIGPSIIDATLKILDKLGCDFEYEF----ADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  81 NIESSKrpekglLALRSGLGLFVNLRPATMHESIKEasplRADivekGVDFVVVRELTGGIYFGERKTGVENGvEFAYDV 160
Cdd:PRK08997   77 GFTSIN------VTLRKKFDLYANVRPVLSFPGTKA----RYD----NIDIITVRENTEGMYSGEGQTVSEDG-ETAEAT 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 161 EKYDENEIRRIGKKAFETAMIRN-KKLTCVDKANVLDS-SKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDV 238
Cdd:PRK08997  142 SIITRKGAERIVRFAYELARKEGrKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDV 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 239 IVTNNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKAI 318
Cdd:PRK08997  222 IVTTNLFGDILSDLCAGLVGGLGMAPGANI-GRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKAERI 299

                         330
                  ....*....|....
gi 2552837814 319 ETAVTNVLNAGYRT 332
Cdd:PRK08997  300 RKAIVAVIEAGDRT 313
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
4-347 4.34e-63

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 208.59  E-value: 4.34e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   4 KIAVIKGDGVGPEIVDEGLKILDKiaqkynhkfectnvlgGGAAIDVT----GEPLPKESLDTCKASDAvllgavggpkW 79
Cdd:PRK09222    6 PITVAYGDGIGPEIMEAVLKILEA----------------AGAPLEIEtieiGEKVYKKGWTSGISPSA----------W 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  80 DNIESS----KRP--------EKGL-LALRSGLGLFVNLRPA-TMHESIKEASPlradivekGVDFVVVRE----LTGGI 141
Cdd:PRK09222   60 ESIRRTkvllKAPittpqgggYKSLnVTLRKTLGLYANVRPCvSYHPFVETKHP--------NLDVVIIREneedLYAGI 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 142 YFgeRKTG---------VENGVEfaydvekydeneirRIGKKAFETAMIRN-KKLTCVDKANVLD-SSKLWRKVLNELAK 210
Cdd:PRK09222  132 EH--RQTPdvyqclkliSRPGSE--------------KIIRYAFEYARANGrKKVTCLTKDNIMKlTDGLFHKVFDEIAK 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 211 DYPEVELSYMYVDNAAMQLVKDPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQN 290
Cdd:PRK09222  196 EYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANI-GEEYAMFEAVHGSAPDIAGKN 274

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2552837814 291 VVNPIATILSVAMMLRYsFKLEEEAKAIETAVTNVLNAGYRTKDIYN-GVGQV-VGTKE 347
Cdd:PRK09222  275 IANPSGLLNAAVMMLVH-IGQFDIAELIENAWLKTLEDGIHTADIYNeGVSKKkVGTKE 332
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 3-335 8.33e-46

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 160.43  E-value: 8.33e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   3 FKIAVIKGDGVGPEIVDEGLKILDkiAQKYNHKFECTNVlggGAAIDV-TGEPLPKESLDTCKASDAVLLGAVGGPKWDN 81
Cdd:PLN00118   42 ITATLFPGDGIGPEIAESVKQVFT--AAGVPIEWEEHYV---GTTVDPrTGSFLTWESLESVRRNKVGLKGPMATPIGKG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  82 IESSKrpekglLALRSGLGLFVNLRPATMHESIKEasplRADivekGVDFVVVRELTGGIYFGERKTGVENGVEfayDVE 161
Cdd:PLN00118  117 HRSLN------LTLRKELGLYANVRPCYSLPGYKT----RYD----DVDLVTIRENTEGEYSGLEHQVVRGVVE---SLK 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 162 KYDENEIRRIGKKAFETAMIRN-KKLTCVDKANVLDSSK-LWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVI 239
Cdd:PLN00118  180 IITRQASLRVAEYAFHYAKTHGrKRVSAIHKANIMKKTDgLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 240 VTNNIFGDIISDEASMITGSIGMLPSASVRGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKAIE 319
Cdd:PLN00118  260 VMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQIH 338

                         330
                  ....*....|....*..
gi 2552837814 320 TAVTNVLNAG-YRTKDI 335
Cdd:PLN00118  339 NAILNTIAEGkYRTADL 355
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 5-356 8.87e-44

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 155.65  E-value: 8.87e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   5 IAVIKGDGVGPEIVDEGLKILDKIAQK-YNHK-----FEctnVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGPK 78
Cdd:COG0538    21 IPFIEGDGIGPEITRAIWKVIDAAVEKaYGGKrdiewKE---VDAGEKARDETGDWLPDETAEAIKEYGVGIKGPLTTPV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  79 WDNIESskrpekglL--ALRSGLGLFVNLRPATMHESIKeaSPLRADivEKgVDFVVVRELTGGIY-------------- 142
Cdd:COG0538    98 GGGWRS--------LnvTIRQILDLYVCRRPVRYFKGVP--SPVKHP--EK-VDIVIFRENTEDIYagiewkagspealk 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 143 ---FGERKTGVENgVEFAYD----VEKYDENEIRRIGKKAFETAmIRNKK--LTCVDKANVL------------------ 195
Cdd:COG0538   165 lifFLEDEMGVTV-IRFPEDsgigIKPVSDEGTERLVRAAIQYA-LDNKRksVTLVHKGNIMkftegafkdwgyevaeee 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 196 -----DSSKLWRKVLNELAKDypEVELSYMYVDNAAMQLVKDPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASVRG 270
Cdd:COG0538   243 fgdkfITEGPWEKYKGPKPAG--KIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGD 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 271 DDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYSFKLeEEAKAIETAVTNVLNAGYRTKDIYNGV--GQVVGTKEM 348
Cdd:COG0538   321 DGGAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWL-EAADLIEKAVEKTIESGKVTYDLARLMegATELSTSEF 399


                  ....*...
gi 2552837814 349 GDLIAKEI 356
Cdd:COG0538   400 GDAIIENL 407
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 5-335 4.50e-43

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 152.71  E-value: 4.50e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   5 IAVIKGDGVGPEIVDEGLKILDKI-AQKYNHKFEctnVLGGGaaidvtgEPLPKESLDTCKASDAVLLGAVGGPKWDNIE 83
Cdd:PLN00123   33 VTLIPGDGIGPLVTGAVEQVMEAMhAPVYFERYE---VHGDM-------KKVPEEVLESIRRNKVCLKGGLATPVGGGVS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  84 SSKrpekglLALRSGLGLFVNLrpatMHESIKEASPLRADivekGVDFVVVRELTGGIYFGERKTGVENGVEfAYDVEKY 163
Cdd:PLN00123  103 SLN------VQLRKELDLFASL----VNCFNLPGLPTRHE----NVDIVVIRENTEGEYSGLEHEVVPGVVE-SLKVITK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 164 DENEirRIGKKAFETAMIRN-KKLTCVDKANVLD-SSKLWRKVLNELAKDYPEVELSYMYVDNAAMQLVKDPSQFDVIVT 241
Cdd:PLN00123  168 FCSE--RIAKYAFEYAYLNNrKKVTAVHKANIMKlADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVT 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 242 NNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSA----PDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKA 317
Cdd:PLN00123  246 PNLYGNLVANTAAGIAGGTGVMPGGNV-GADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRH-LQFPSFADR 323

                         330
                  ....*....|....*....
gi 2552837814 318 IETAVTNVLNAG-YRTKDI 335
Cdd:PLN00123  324 LETAVKRVIAEGkYRTKDL 342
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
5-350 4.30e-41

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 148.83  E-value: 4.30e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   5 IAVIKGDGVGPEIVDEGLKILDKIAQK-YNHKFECT--NVLGGGAAIDVTGEPLPKESLDTCKASDAVLLGAVGGP---K 78
Cdd:PRK06451   26 ILYVEGDGIGPEITHAAMKVINKAVEKaYGSDREIKwvEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  79 WDNIEsskrpekglLALRSGLGLFVNLRPATMHESIKeaSPLRADivEKgVDFVVVRELTGGIYfgerktgveNGVEFAY 158
Cdd:PRK06451  106 WKSIN---------VAIRLMLDLYANIRPVKYIPGIE--SPLKNP--EK-IDLIIFRENTDDLY---------RGIEYPY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 159 DVE------KYDENEIR--------------------RIGKKAFETAMIRN-KKLTCVDKANVLDSSK-LWRKVLNELA- 209
Cdd:PRK06451  163 DSEeakkirDFLRKELGveveddtgigikliskfktqRIARMAIKYAIDHKrKKVTIMHKGNVMKYTEgAFREWAYEVAl 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 210 ---KDY--PEVELSYMY---------------VDNAAMQLVKDPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASVr 269
Cdd:PRK06451  243 kefRDYvvTEEEVTKNYngvppsgkviindriADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANI- 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 270 GDDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRYsFKLEEEAKAIETAVTNVLNAGYRTKDI--YNGVgQVVGTKE 347
Cdd:PRK06451  322 GDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLarFMGV-RALSTTE 399


                  ...
gi 2552837814 348 MGD 350
Cdd:PRK06451  400 YTD 402
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 5-307 5.06e-30

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 118.63  E-value: 5.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814   5 IAVIKGDGVGPEIVDEGLKILDKIAQK-YN--HKFECTNVLGGGAAIDVTGEP--LPKESLDTCKASDAVLLGAVGGPKW 79
Cdd:PRK07006   22 IPFIEGDGIGPDITPAMLKVVDAAVEKaYKgeRKISWMEIYAGEKATKVYGEDvwLPEETLDLIREYRVAIKGPLTTPVG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814  80 DNIESSKrpekglLALRSGLGLFVNLRPATMHESIkeASPLRADivEKgVDFVVVRELTGGIYFG-ERKTGVENgvefAY 158
Cdd:PRK07006  102 GGIRSLN------VALRQELDLYVCLRPVRYFKGV--PSPVKRP--ED-TDMVIFRENSEDIYAGiEWKAGSAE----AK 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 159 DVEKYDENE-----IR------------------RIGKKAFETAMIRNKK-LTCVDKANVLD----SSKLWRKvlnELAK 210
Cdd:PRK07006  167 KVIKFLQEEmgvkkIRfpetsgigikpvseegteRLVRAAIEYAIDNDRKsVTLVHKGNIMKftegAFKDWGY---QLAE 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 211 DYPEVEL----SYMYVDNAAMQ---LVKD-------------PSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASVrG 270
Cdd:PRK07006  244 EEFGDELidggPWDKIKNPETGkeiIVKDsiadaflqqillrPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANI-N 322

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2552837814 271 DDFGMYEPIHGSAPDIAGQNVVNPIATILSVAMMLRY 307
Cdd:PRK07006  323 DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH 359
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
223-335 7.34e-14

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 72.44  E-value: 7.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552837814 223 DNAAMQLVKDPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASVrGDDFGMYEPIHGSAPDIAGQNVVNPIATILSVA 302
Cdd:PRK07362  340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANI-GDNAAIFEATHGTAPKHAGLDRINPGSVILSGV 418

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2552837814 303 MMLRYsFKLEEEAKAIETAVTNVLNAGYRTKDI 335
Cdd:PRK07362  419 MMLEY-LGWQEAADLITKGLSAAIANKQVTYDL 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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