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Conserved domains on  [gi|2550865491|ref|WP_302236246|]
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tRNA1(Val) (adenine(37)-N6)-methyltransferase [Enterobacter vonholyi]

Protein Classification

tRNA1(Val) (adenine(37)-N6)-methyltransferase( domain architecture ID 11467886)

tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase is a class I SAM-dependent methyltransferase that specifically methylates the adenine in position 37 of tRNA(1)(Val)

CATH:  2.20.25.110
EC:  2.1.1.223
Gene Ontology:  GO:0016430|GO:1904047|GO:0008170|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.35e-88

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 262.00  E-value: 1.35e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491   9 RRDGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEEhVTIDAVELDAQAAEQANEN 88
Cdd:COG4123     2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSPG-ARITGVEIQPEAAELARRN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  89 MAESPWAARMKVECADVLAWAPE-QTARYDLIVSNPPYYAP--GVECGTPEREQARYTGSLDHKALLTSAAELISEEGFF 165
Cdd:COG4123    81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2550865491 166 CVVLPESTGNTFIGIAQEIGWTLRLRTDISDTEGRLPHRVLLALSPKEGECFN--DRMVIRGPDQRYSEDYTALTQAF 241
Cdd:COG4123   161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.35e-88

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 262.00  E-value: 1.35e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491   9 RRDGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEEhVTIDAVELDAQAAEQANEN 88
Cdd:COG4123     2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSPG-ARITGVEIQPEAAELARRN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  89 MAESPWAARMKVECADVLAWAPE-QTARYDLIVSNPPYYAP--GVECGTPEREQARYTGSLDHKALLTSAAELISEEGFF 165
Cdd:COG4123    81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2550865491 166 CVVLPESTGNTFIGIAQEIGWTLRLRTDISDTEGRLPHRVLLALSPKEGECFN--DRMVIRGPDQRYSEDYTALTQAF 241
Cdd:COG4123   161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-125 6.80e-16

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 74.81  E-value: 6.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSGLVALMLAQRTEeHVTIDAVELDAQAAEQANENmAESPWAARMKVECADVlaWAPEQTARYDLIVSNPPY 125
Cdd:PRK09328  110 LRVLDLGTGSGAIALALAKERP-DAEVTAVDISPEALAVARRN-AKHGLGARVEFLQGDW--FEPLPGGRFDLIVSNPPY 185
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 46-125 6.00e-14

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 69.03  E-value: 6.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSGLVALMLA-QRTEEHVTidAVELDAQAAEQANENmaespwAARMKVE-----CADVLAWAPEQtaRYDLI 119
Cdd:TIGR03534  88 PRVLDLGTGSGAIALALAkERPDARVT--AVDISPEALAVARKN------ARRLGLEnveflQGDWFEPLPSG--KFDLI 157


                  ....*.
gi 2550865491 120 VSNPPY 125
Cdd:TIGR03534 158 VSNPPY 163
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-127 5.43e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 5.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENMAEsPWAARMKVECADVLAWAPEQTARYDLIVSNPPYY 126
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVT--GVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEADESFDVIISDPPLH 77


                  .
gi 2550865491 127 A 127
Cdd:cd02440    78 H 78
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-122 7.39e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.88  E-value: 7.39e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2550865491  48 ILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENMAESPwaARMKVECADVLAWaPEQTARYDLIVSN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVT--GVDLSPEMLERARERAAEAG--LNVEFVQGDAEDL-PFPDGSFDLVVSS 70
rADc smart00650
Ribosomal RNA adenine dimethylases;
48-126 4.70e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 39.80  E-value: 4.70e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2550865491   48 ILDIGTGSGLVALMLAQRTEEhVTidAVELDAQAAEQANEnmaESPWAARMKVECADVLAWAPEQTARYdLIVSNPPYY 126
Cdd:smart00650  17 VLEIGPGKGALTEELLERAKR-VT--AIEIDPRLAPRLRE---KFAAADNLTVIHGDALKFDLPKLQPY-KVVGNLPYN 88
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.35e-88

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 262.00  E-value: 1.35e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491   9 RRDGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEEhVTIDAVELDAQAAEQANEN 88
Cdd:COG4123     2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRSPG-ARITGVEIQPEAAELARRN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  89 MAESPWAARMKVECADVLAWAPE-QTARYDLIVSNPPYYAP--GVECGTPEREQARYTGSLDHKALLTSAAELISEEGFF 165
Cdd:COG4123    81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2550865491 166 CVVLPESTGNTFIGIAQEIGWTLRLRTDISDTEGRLPHRVLLALSPKEGECFN--DRMVIRGPDQRYSEDYTALTQAF 241
Cdd:COG4123   161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 38-125 4.13e-17

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 78.27  E-value: 4.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  38 AWAPVAGVKRILDIGTGSGLVALMLAQRtEEHVTIDAVELDAQAAEQANENMAESPWAARMKVECADVLAWAPEQtARYD 117
Cdd:COG2890   106 ALLPAGAPPRVLDLGTGSGAIALALAKE-RPDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGD-GRFD 183


                  ....*...
gi 2550865491 118 LIVSNPPY 125
Cdd:COG2890   184 LIVSNPPY 191
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-125 6.80e-16

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 74.81  E-value: 6.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSGLVALMLAQRTEeHVTIDAVELDAQAAEQANENmAESPWAARMKVECADVlaWAPEQTARYDLIVSNPPY 125
Cdd:PRK09328  110 LRVLDLGTGSGAIALALAKERP-DAEVTAVDISPEALAVARRN-AKHGLGARVEFLQGDW--FEPLPGGRFDLIVSNPPY 185
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 46-125 6.00e-14

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 69.03  E-value: 6.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSGLVALMLA-QRTEEHVTidAVELDAQAAEQANENmaespwAARMKVE-----CADVLAWAPEQtaRYDLI 119
Cdd:TIGR03534  88 PRVLDLGTGSGAIALALAkERPDARVT--AVDISPEALAVARKN------ARRLGLEnveflQGDWFEPLPSG--KFDLI 157


                  ....*.
gi 2550865491 120 VSNPPY 125
Cdd:TIGR03534 158 VSNPPY 163
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 39-125 1.42e-13

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 68.31  E-value: 1.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  39 WAPVAGVKRILDIGTGSGLVALMLAQRTEEhVTIDAVELDAQAAEQANENMAESPWAARMKVECADVLAWAPEQtaRYDL 118
Cdd:TIGR03533 116 WLEPEPVKRILDLCTGSGCIAIACAYAFPE-AEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFAALPGR--KYDL 192


                  ....*..
gi 2550865491 119 IVSNPPY 125
Cdd:TIGR03533 193 IVSNPPY 199
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-127 5.43e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 5.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENMAEsPWAARMKVECADVLAWAPEQTARYDLIVSNPPYY 126
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVT--GVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEADESFDVIISDPPLH 77


                  .
gi 2550865491 127 A 127
Cdd:cd02440    78 H 78
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 41-127 5.74e-12

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 62.51  E-value: 5.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  41 PVAGVKRILDIGTGSGLVALMLAQRTEEhVTIDAVELDAQAAEQANENmaespwAARMKVECADVL---AWAPEQTARYD 117
Cdd:COG2813    46 PEPLGGRVLDLGCGYGVIGLALAKRNPE-ARVTLVDVNARAVELARAN------AAANGLENVEVLwsdGLSGVPDGSFD 118

                          90
                  ....*....|
gi 2550865491 118 LIVSNPPYYA 127
Cdd:COG2813   119 LILSNPPFHA 128
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-122 7.39e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.88  E-value: 7.39e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2550865491  48 ILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENMAESPwaARMKVECADVLAWaPEQTARYDLIVSN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVT--GVDLSPEMLERARERAAEAG--LNVEFVQGDAEDL-PFPDGSFDLVVSS 70
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 47-121 1.07e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 61.10  E-value: 1.07e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2550865491  47 RILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENMAESPWAARMKVECADVLAWAPEQtaRYDLIVS 121
Cdd:COG2230    54 RVLDIGCGWGGLALYLARRYGVRVT--GVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADG--QFDAIVS 124
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-122 2.73e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 58.30  E-value: 2.73e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2550865491  47 RILDIGTGSGLVALMLAQRTEEHvTIDAVELDAQAAEQANENmaespwAARMKVECADVLAWAPEQtaRYDLIVSN 122
Cdd:COG4106     4 RVLDLGCGTGRLTALLAERFPGA-RVTGVDLSPEMLARARAR------LPNVRFVVADLRDLDPPE--PFDLVVSN 70
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-130 4.36e-11

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 59.53  E-value: 4.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSGLVALMLAQRTeEHVTIDAVELDAQAAEQANENmAESPWAARMKVECADVLAWAPEqtARYDLIVSNPPY 125
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKES-PDAELTMVDINARALESAREN-LAANGLENGEVVASDVYSGVED--GKFDLIISNPPF 108


                  ....*
gi 2550865491 126 YAPGV 130
Cdd:pfam05175 109 HAGLA 113
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 44-119 1.03e-09

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 55.96  E-value: 1.03e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2550865491  44 GVKRILDIGTGSGLVALMLAQRTEEHVTIDAVELDAQAAEQANENMAESPWAARMKVECADVLAWAPE-QTARYDLI 119
Cdd:COG4122    16 GAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEVLPRlADGPFDLV 92
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 46-122 1.29e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 54.64  E-value: 1.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2550865491  46 KRILDIGTGSGLVALMLAQRtEEHVTidAVELDAQAAEQANENMAEspwaARMKVECADVLAWAPEQtARYDLIVSN 122
Cdd:COG2227    26 GRVLDVGCGTGRLALALARR-GADVT--GVDISPEALEIARERAAE----LNVDFVQGDLEDLPLED-GSFDLVICS 94
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 44-152 1.31e-09

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 56.98  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  44 GVKRILDIGTGSGLVALMLAQrTEEHVTIDAVELDAQAAEQANENMAESPWAARMKVECADVlaWAPEQTARYDLIVSNP 123
Cdd:TIGR00536 114 PILHILDLGTGSGCIALALAY-EFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNL--FEPLAGQKIDIIVSNP 190

                          90       100
                  ....*....|....*....|....*....
gi 2550865491 124 PYyapgvecgTPEREQARYTGSLDHKALL 152
Cdd:TIGR00536 191 PY--------IDEEDLADLPNVVRFEPLL 211
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
46-121 5.72e-09

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 54.66  E-value: 5.72e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2550865491  46 KRILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENMAESPWAARMKVECADVLAWAPEQTAryDLIVS 121
Cdd:COG4076    37 DVVLDIGTGSGLLSMLAARAGAKKVY--AVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEKA--DVIIS 108
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
46-122 1.03e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 54.41  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSG---LVALML-AQRteehvtIDAVELDAQAAEQANENMAESPWAARMKVECADVLAwapeqTARYDLIVS 121
Cdd:COG2264   150 KTVLDVGCGSGilaIAAAKLgAKR------VLAVDIDPVAVEAARENAELNGVEDRIEVVLGDLLE-----DGPYDLVVA 218


                  .
gi 2550865491 122 N 122
Cdd:COG2264   219 N 219
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 38-124 1.89e-08

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 54.03  E-value: 1.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  38 AWAPVAGVKRILDIGTGSGLVALMLAQRTEEhvtIDAVELDAQAAEQANENMAESPWaARMKVECADVLAWAPEQ--TAR 115
Cdd:COG2265   227 EWLDLTGGERVLDLYCGVGTFALPLARRAKK---VIGVEIVPEAVEDARENARLNGL-KNVEFVAGDLEEVLPELlwGGR 302


                  ....*....
gi 2550865491 116 YDLIVSNPP 124
Cdd:COG2265   303 PDVVVLDPP 311
PRK14968 PRK14968
putative methyltransferase; Provisional
 46-125 5.06e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 51.44  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSGLVALMLAQRTEEHVtidAVELDAQAAEQANENMAESPWAAR-MKVECADVLawAPEQTARYDLIVSNPP 124
Cdd:PRK14968   25 DRVLEVGTGSGIVAIVAAKNGKKVV---GVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLF--EPFRGDKFDVILFNPP 99


                  .
gi 2550865491 125 Y 125
Cdd:PRK14968  100 Y 100
PRK14967 PRK14967
putative methyltransferase; Provisional
 47-168 6.02e-08

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 51.59  E-value: 6.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENMAESpwAARMKVECADVLAWAPEqtARYDLIVSNPPyY 126
Cdd:PRK14967   39 RVLDLCTGSGALAVAAAAAGAGSVT--AVDISRRAVRSARLNALLA--GVDVDVRRGDWARAVEF--RPFDVVVSNPP-Y 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2550865491 127 APGVECGTPEREQAR-YTGSLDHKALL----TSAAELISEEGFFCVV 168
Cdd:PRK14967  112 VPAPPDAPPSRGPARaWDAGPDGRAVLdrlcDAAPALLAPGGSLLLV 158
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 68-166 6.20e-08

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 52.49  E-value: 6.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  68 EHVTidAVELDAQAAEQANENMAESPWAARMKVECADVLAW---APEQTARYDLIVSNPPYYAPgvecgtpeREQARYTG 144
Cdd:COG1092   240 KSVT--SVDLSATALEWAKENAALNGLDDRHEFVQADAFDWlreLAREGERFDLIILDPPAFAK--------SKKDLFDA 309

                          90       100
                  ....*....|....*....|....
gi 2550865491 145 SLDHKALLTSAAELISEEG--FFC 166
Cdd:COG1092   310 QRDYKDLNRLALKLLAPGGilVTS 333
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-122 6.50e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.46  E-value: 6.50e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2550865491  47 RILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENmAESPWAARMKVECADVLAWAPEQTARYDLIVSN 122
Cdd:COG0500    29 RVLDLGCGTGRNLLALAARFGGRVI--GIDLSPEAIALARAR-AAKAGLGNVEFLVADLAELDPLPAESFDLVVAF 101
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
38-208 1.06e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 50.38  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  38 AWAPVAGVKRILDIGTGSGLVALMLAQRTEEhvtIDAVELDAQAAEQANENMAESpwaarmKVECADVLAWaPEQTARYD 117
Cdd:COG4976    40 ARLPPGPFGRVLDLGCGTGLLGEALRPRGYR---LTGVDLSEEMLAKAREKGVYD------RLLVADLADL-AEPDGRFD 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491 118 LIVSnppyyapgvecgtpereqaryTGSLDH----KALLTSAAELISEEGFFCVVLPESTGNTFIGIAQEigwtlRLRTD 193
Cdd:COG4976   110 LIVA---------------------ADVLTYlgdlAAVFAGVARALKPGGLFIFSVEDADGSGRYAHSLD-----YVRDL 163

                         170
                  ....*....|....*
gi 2550865491 194 ISDTEGRLPHRVLLA 208
Cdd:COG4976   164 LAAAGFEVPGLLVVA 178
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 35-122 2.92e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.45  E-value: 2.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  35 LLGAWAPVAGvKRILDIGTGSGLVALMLAQRTEEhvtIDAVELDAQAAEQANENMAESPWaaRMKVECADVLAWaPEQTA 114
Cdd:COG2226    14 LLAALGLRPG-ARVLDLGCGTGRLALALAERGAR---VTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDL-PFPDG 86


                  ....*...
gi 2550865491 115 RYDLIVSN 122
Cdd:COG2226    87 SFDLVISS 94
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 47-140 4.54e-07

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 48.93  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDIGTGSGLVALMLAQRTeEHVTidAVELDAQAAEQANENMAESPWaARMKVECADVLAWAPEQtARYDLIVsnppyy 126
Cdd:COG2518    69 RVLEIGTGSGYQAAVLARLA-GRVY--SVERDPELAERARERLAALGY-DNVTVRVGDGALGWPEH-APFDRII------ 137

                          90
                  ....*....|....
gi 2550865491 127 apgVECGTPEREQA 140
Cdd:COG2518   138 ---VTAAAPEVPEA 148
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
46-122 4.76e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 49.38  E-value: 4.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSG---LVALML-AQRteehvtIDAVELDAQAAEQANENmaespwAARMKVEcadVLAWAPEQTARYDLIVS 121
Cdd:PRK00517  121 KTVLDVGCGSGilaIAAAKLgAKK------VLAVDIDPQAVEAAREN------AELNGVE---LNVYLPQGDLKADVIVA 185


                  .
gi 2550865491 122 N 122
Cdd:PRK00517  186 N 186
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 37-188 1.65e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 46.87  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  37 GAWAP--------VAGVK---RILD--IGTGSGLV-ALMLAqrteehVTIDAVELDAQAAEQANENMAespWAARM--KV 100
Cdd:COG1041     8 GSLDPrlaralvnLAGAKegdTVLDpfCGTGTILIeAGLLG------RRVIGSDIDPKMVEGARENLE---HYGYEdaDV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491 101 ECADVLAwAPEQTARYDLIVSNPPYyapGVECGTPEREQAR-YTGSldhkalLTSAAELISEEGFFCVVLPEstgnTFIG 179
Cdd:COG1041    79 IRGDARD-LPLADESVDAIVTDPPY---GRSSKISGEELLElYEKA------LEEAARVLKPGGRVVIVTPR----DIDE 144


                  ....*....
gi 2550865491 180 IAQEIGWTL 188
Cdd:COG1041   145 LLEEAGFKV 153
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 2-126 4.73e-06

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 45.95  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491   2 SQLKAQLRRdgFTFKqffvaHDRCAMKVGTD-GILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEEHVTIDAVELDAQ 80
Cdd:pfam01596   7 HEYLKELRE--ETAK-----LPLAPMQVSPDeGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPEDGKITAIDIDPE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2550865491  81 AAEQANENMAESPWAARMKVECADVLAWAPEQT-----ARYDLIV-----SNPPYY 126
Cdd:pfam01596  80 AYEIAKKFIQKAGVAHKISFILGPALKVLEQLTqdkplPEFDFIFidadkSNYPNY 135
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 43-172 1.50e-05

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 44.27  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  43 AGVK---RILD--IGTGSGLV--ALMLAQR------TEEHVTIDAVELDAQAAEQANENMAESPWAARMKVECADVLAwA 109
Cdd:pfam01170  24 AGWKpgdPLLDpmCGSGTILIeaALMGANIapgkfdARVRAPLYGSDIDRRMVQGARLNAENAGVGDLIEFVQADAAD-L 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2550865491 110 PEQTARYDLIVSNPPYyapGVECGTPEREQARYtgsldhKALLTSAAELISEEGFFCVVLPES 172
Cdd:pfam01170 103 PLLEGSVDVIVTNPPY---GIRLGSKGALEALY------PEFLREAKRVLRGGGWLVLLTAEN 156
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
46-124 1.51e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 44.51  E-value: 1.51e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2550865491  46 KRILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENmaESPWAARMKVECADVLAWAPEqtARYDLIVSNPP 124
Cdd:COG2263    47 KTVLDLGCGTGMLAIGAALLGAKKVV--GVDIDPEALEIAREN--AERLGVRVDFIRADVTRIPLG--GSVDTVVMNPP 119
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 32-125 8.11e-05

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 42.15  E-value: 8.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  32 DGILLGAWAPVAGVKRILDIGTGSGLVALMLAQRTEEHVTIDaveLDAQAAEQANENMAESpwAARMKVECADVlawAPE 111
Cdd:TIGR00537   7 DSLLLEANLRELKPDDVLEIGAGTGLVAIRLKGKGKCILTTD---INPFAVKELRENAKLN--NVGLDVVMTDL---FKG 78

                          90
                  ....*....|....
gi 2550865491 112 QTARYDLIVSNPPY 125
Cdd:TIGR00537  79 VRGKFDVILFNPPY 92
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
46-121 8.80e-05

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 42.12  E-value: 8.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSG-LVALMLAQRTEEHVtiDAVELDAQAAEQANENMAESPWA---ARMKVECADVLAWAPEQTARYDLIVS 121
Cdd:COG0421    39 KRVLIIGGGDGgLARELLKHPPVERV--DVVEIDPEVVELAREYFPLLAPAfddPRLRVVIGDGRAFLREAEESYDVIIV 116
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
47-184 1.46e-04

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 41.71  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDI--GTGSGLVALM-----LAQRTEEHVTIDAVELDAQAAEQANENMA----ESPwaarmKVECADVLAWAPEQTAR 115
Cdd:COG0286    46 TVYDPacGSGGFLVEAAeylkeHGGDERKKLSLYGQEINPTTYRLAKMNLLlhgiGDP-----NIELGDTLSNDGDELEK 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2550865491 116 YDLIVSNPPYYAPGVECGTPEREQARYTGSLDHK-----ALLTSAAELISEEGFFCVVLPESTgnTFIGIAQEI 184
Cdd:COG0286   121 FDVVLANPPFGGKWKKEELKDDLLGRFGYGLPPKsnadlLFLQHILSLLKPGGRAAVVLPDGV--LFRGAEKEI 192
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
47-126 2.54e-04

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 41.46  E-value: 2.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDIGTGSGLVALMLAQRTEEhVTIDAVELDAQAAEQANENMAESPWAARmkVECADVLAwapEQTARYDLIVSNPPYY 126
Cdd:PRK09489  199 KVLDVGCGAGVLSAVLARHSPK-IRLTLSDVSAAALESSRATLAANGLEGE--VFASNVFS---DIKGRFDMIISNPPFH 272
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-122 3.02e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.89  E-value: 3.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2550865491  49 LDIGTGSGLVALMLAQRTeEHVTIDAVELDAQAAEQANENMAESPW--AARMKVECADVLAWAPEQtarYDLIVSN 122
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL-PGLEYTGLDISPAALEAARERLAALGLlnAVRVELFQLDLGELDPGS---FDVVVAS 72
COG4262 COG4262
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ...
 40-124 3.97e-04

Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];


Pssm-ID: 443404 [Multi-domain]  Cd Length: 426  Bit Score: 41.00  E-value: 3.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  40 APVAGVKRILDIGTGSGLVALMLAqRTEEHVTIDAVELDAQAAE---------QANENMAESPwaaRMKVECADVLAWAP 110
Cdd:COG4262   282 AAHPRPRRVLVLGGGDGLAAREVL-KYPDVESVTLVDLDPEVTDlaktnpflrELNGGALNDP---RVTVVNADAFQFLR 357

                          90
                  ....*....|....
gi 2550865491 111 EQTARYDLIVSNPP 124
Cdd:COG4262   358 ETDEKYDVIIVDLP 371
rADc smart00650
Ribosomal RNA adenine dimethylases;
48-126 4.70e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 39.80  E-value: 4.70e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2550865491   48 ILDIGTGSGLVALMLAQRTEEhVTidAVELDAQAAEQANEnmaESPWAARMKVECADVLAWAPEQTARYdLIVSNPPYY 126
Cdd:smart00650  17 VLEIGPGKGALTEELLERAKR-VT--AIEIDPRLAPRLRE---KFAAADNLTVIHGDALKFDLPKLQPY-KVVGNLPYN 88
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 46-131 4.79e-04

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 39.68  E-value: 4.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDI--GTGS-GLVALmlaQRTEEHVTidAVELDAQAAEQANENMAESPWAARMKVECADVLAWAP-EQTARYDLIVS 121
Cdd:COG0742    43 ARVLDLfaGSGAlGLEAL---SRGAASVV--FVEKDRKAAAVIRKNLEKLGLEDRARVIRGDALRFLKrLAGEPFDLVFL 117

                          90
                  ....*....|
gi 2550865491 122 NPPYYAPGVE 131
Cdd:COG0742   118 DPPYAKGLLE 127
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 47-126 7.34e-04

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 39.72  E-value: 7.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDIGTGSGlvAL--MLAQRTEeHVTidAVELDAQAAEQANENMAESPwaaRMKVECADVLAWAPEQTARYD--LIVSN 122
Cdd:COG0030    40 TVLEIGPGLG--ALtrALLERAA-RVT--AVEIDRRLAAILRETFAAYP---NLTVIEGDALKVDLPALAAGEplKVVGN 111


                  ....
gi 2550865491 123 PPYY 126
Cdd:COG0030   112 LPYN 115
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 48-127 9.05e-04

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 40.23  E-value: 9.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  48 ILDIGTGSGLVALML------AQRTEEHVTIDAVELdaqaaeqANENMAESPWAARMKVECADvlaWAPE-QTARYDLIV 120
Cdd:PRK01544  142 ILELGTGSGCIAISLlcelpnANVIATDISLDAIEV-------AKSNAIKYEVTDRIQIIHSN---WFENiEKQKFDFIV 211


                  ....*..
gi 2550865491 121 SNPPYYA 127
Cdd:PRK01544  212 SNPPYIS 218
PRK03612 PRK03612
polyamine aminopropyltransferase;
38-124 9.53e-04

polyamine aminopropyltransferase;


Pssm-ID: 235139 [Multi-domain]  Cd Length: 521  Bit Score: 39.82  E-value: 9.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  38 AWAPVAGVKRILDIGTGSGLvAL--MLAQRTEEHVTIdaVELDAQAAEQANENMA------ESPWAARMKVECADVLAWA 109
Cdd:PRK03612  291 AMAASARPRRVLVLGGGDGL-ALreVLKYPDVEQVTL--VDLDPAMTELARTSPAlralngGALDDPRVTVVNDDAFNWL 367

                          90
                  ....*....|....*
gi 2550865491 110 PEQTARYDLIVSNPP 124
Cdd:PRK03612  368 RKLAEKFDVIIVDLP 382
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 47-129 1.43e-03

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 39.29  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDIGTGSGLVALMLA-QRTEEHVTidAVELDAQAAEQANENMAEspWAARMKVECADVLAWAPEQTARYDLIVSNPPY 125
Cdd:PRK14966  254 RVWDLGTGSGAVAVTVAlERPDAFVR--ASDISPPALETARKNAAD--LGARVEFAHGSWFDTDMPSEGKWDIIVSNPPY 329


                  ....
gi 2550865491 126 YAPG 129
Cdd:PRK14966  330 IENG 333
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
47-173 1.66e-03

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 39.16  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  47 RILDIGTGSGLVALMLAQRTEEHVTIDAVELDAQAAE--QANENMAESPwaarMKVECADVLawAPEQTARYDLIVSNPP 124
Cdd:COG0827   118 RILDPAVGTGNLLTTVLNQLKKKVNAYGVEVDDLLIRlaAVLANLQGHP----VELFHQDAL--QPLLIDPVDVVISDLP 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2550865491 125 --YYapgvecgtPEREQA-RYTGSLD------HKALLTSAAELISEEGFFCVVLPEST 173
Cdd:COG0827   192 vgYY--------PNDERAkRFKLKADeghsyaHHLFIEQSLNYLKPGGYLFFLVPSNL 241
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 46-122 2.64e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 38.40  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  46 KRILDIGTGSG---LVALML-AQRteehvtIDAVELDAQAAEQANENMAESPWAARMKVEcadVLAWAPEQTAryDLIVS 121
Cdd:pfam06325 163 ESVLDVGCGSGilaIAALKLgAKK------VVGVDIDPVAVRAAKENAELNGVEARLEVY---LPGDLPKEKA--DVVVA 231


                  .
gi 2550865491 122 N 122
Cdd:pfam06325 232 N 232
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-122 3.47e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 35.72  E-value: 3.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2550865491  49 LDIGTGSGLVALMLAQRteeHVTIDAVELDAQAAEQANENMAESPWAARmkveCADV--LAWAPEQtarYDLIVSN 122
Cdd:pfam08241   1 LDVGCGTGLLTELLARL---GARVTGVDISPEMLELAREKAPREGLTFV----VGDAedLPFPDNS---FDLVLSS 66
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
48-127 4.46e-03

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 37.34  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  48 ILDIGTGSGLVALMLAQRTEEHVtidAVELDAQAAEQANENMAESPwaaRMKVECADVLAWAP----EQTARYDLIVSNP 123
Cdd:pfam00398  34 VLEIGPGKGALTVILAKRAKQVV---AIEIDPRLAKLLQKKLSLDE---NLTVIHQDFLKFEFpslvTHIHQEFLVVGNL 107


                  ....
gi 2550865491 124 PYYA 127
Cdd:pfam00398 108 PYNI 111
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 46-122 4.65e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 36.63  E-value: 4.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2550865491  46 KRILDIGTGSGLVALMLAQRTEEHVTIDAVELDAQAAEQANENmAESPWAARMKVECADVLAwAPEQTA--RYDLIVSN 122
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKAREN-AQKLGFDNVEFEQGDIEE-LPELLEddKFDVVISN 81
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
39-125 5.73e-03

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 36.45  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491  39 WAPVAGVKRILDIGTGSGLVALMLAQRTEEHVTidAVELDAQAAEQANENMAESPWAARMKVEcADVLAW--APEQTARY 116
Cdd:pfam03602  36 LAPYIEGARVLDLFAGSGALGLEALSRGAKRVT--LVEKDKRAVQILKENLQLLGLPGAVLVM-DALLALlrLAGKGPVF 112


                  ....*....
gi 2550865491 117 DLIVSNPPY 125
Cdd:pfam03602 113 DIVFLDPPY 121
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
102-189 5.79e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 36.82  E-value: 5.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2550865491 102 CADVLAWAPEQTAryDLIVSNPPY-----YAPGVECGTPEREQARYTGSLDhkALLTSAAELISEEGFFCVVLPESTGNT 176
Cdd:COG0863     7 CLEVLKELPDESV--DLIVTDPPYnlgkkYGLGRREIGNELSFEEYLEFLR--EWLAECYRVLKPGGSLYVNIGDRYISR 82

                          90
                  ....*....|...
gi 2550865491 177 FIGIAQEIGWTLR 189
Cdd:COG0863    83 LIAALRDAGFKLR 95
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 63-125 6.82e-03

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 37.00  E-value: 6.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2550865491  63 AQRTEEHVTIDAVELDAQAAEQANENMAESPWAARMKVECADVLAWAPEqtARYDLIVSNPPY 125
Cdd:COG0116   244 RIKRDPPLPIFGSDIDPRAIEAARENAERAGVADLIEFEQADFRDLEPP--AEPGLIITNPPY 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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