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Conserved domains on  [gi|2545595587|ref|WP_301180715|]
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MULTISPECIES: AraC family transcriptional regulator [unclassified Thalassolituus]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12117664)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain and an N-terminal arabinose binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  12596232|10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 50-237 4.30e-32

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 118.90  E-value: 4.30e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587  50 GLEPSAMYARAGVDLGDEDGVGMFVSSRQVLNLVGQIIEALDMPYIGLPMGNLMTVSHHGMAGLAAVTQPTLWDCGQAVV 129
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 130 RYCRELFPPLEMSITLDGDEG-WFSIEENTSLAPYTHFFVELNMVSFYNIFRDLVanDPELMPVRVELGYPEPAWGHIYR 208
Cdd:pfam12625  81 RYLRLLSDALELRLEEGEGGLaRLRLDVRPIPGRRRDFLLELALAALLRLARWLL--GRRLPPLRVEFPHPAPADAAEYE 158

                         170       180
                  ....*....|....*....|....*....
gi 2545595587 209 RYFKCPVVFGCHQSRIIGKASLAeyELPL 237
Cdd:pfam12625 159 RLFGCPVRFGAPRNALVFDAADL--DRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
135-365 1.07e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.00  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 135 LFPPLEMSITLDGDEGWFSIEENTSLAPYTHFFVELNMVSFYNIFRDLVANDPELMPVRVELGYPEPAWGHIYRRYFKCP 214
Cdd:COG2207    26 LLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 215 VVFGCHQSRIIGKASLAEYELPLANRLMAMTAEKSLFENIPTRAMKYLPLRLRRLLIRYYGAFPSLENAASELGMSGRTM 294
Cdd:COG2207   106 LLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTL 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2545595587 295 RRKLKDD-GTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEYMASIQAR 365
Cdd:COG2207   186 SRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRAR 257
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 50-237 4.30e-32

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 118.90  E-value: 4.30e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587  50 GLEPSAMYARAGVDLGDEDGVGMFVSSRQVLNLVGQIIEALDMPYIGLPMGNLMTVSHHGMAGLAAVTQPTLWDCGQAVV 129
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 130 RYCRELFPPLEMSITLDGDEG-WFSIEENTSLAPYTHFFVELNMVSFYNIFRDLVanDPELMPVRVELGYPEPAWGHIYR 208
Cdd:pfam12625  81 RYLRLLSDALELRLEEGEGGLaRLRLDVRPIPGRRRDFLLELALAALLRLARWLL--GRRLPPLRVEFPHPAPADAAEYE 158

                         170       180
                  ....*....|....*....|....*....
gi 2545595587 209 RYFKCPVVFGCHQSRIIGKASLAeyELPL 237
Cdd:pfam12625 159 RLFGCPVRFGAPRNALVFDAADL--DRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
135-365 1.07e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.00  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 135 LFPPLEMSITLDGDEGWFSIEENTSLAPYTHFFVELNMVSFYNIFRDLVANDPELMPVRVELGYPEPAWGHIYRRYFKCP 214
Cdd:COG2207    26 LLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 215 VVFGCHQSRIIGKASLAEYELPLANRLMAMTAEKSLFENIPTRAMKYLPLRLRRLLIRYYGAFPSLENAASELGMSGRTM 294
Cdd:COG2207   106 LLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTL 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2545595587 295 RRKLKDD-GTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEYMASIQAR 365
Cdd:COG2207   186 SRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRAR 257
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
278-359 6.15e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 85.68  E-value: 6.15e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587  278 PSLENAASELGMSGRTMRRKLKDD-GTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPK 356
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 2545595587  357 EYM 359
Cdd:smart00342  82 EYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
284-361 4.88e-17

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 74.93  E-value: 4.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 284 ASELGMSGRTMRRKLKDD-GTSYQQELDFVRQKFAREYFAR-GGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEYMAS 361
Cdd:pfam12833   2 AAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRRR 81
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 281-361 2.54e-08

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 54.65  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 281 ENAASELGMSGRTMRRKLKDDGTS---Y--QQELDF----VRQKFAREyfarggdSITELAHLLGFADSSAFAKAFRRWT 351
Cdd:PRK09685  218 EWIAGELGISVRSLYRLFAEQGLVvaqYirNRRLDRcaddLRPAADDE-------KITSIAYKWGFSDSSHFSTAFKQRF 290

                          90
                  ....*....|
gi 2545595587 352 DMSPKEYMAS 361
Cdd:PRK09685  291 GVSPGEYRRK 300
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 280-358 1.33e-06

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 49.68  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 280 LENAASELGMSGRTMRRKLKDD-GTSYQQEldFVRQKF-AREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKE 357
Cdd:TIGR04094 304 VEEIAKQFFMSESKLRKLFKKEmGISIQEY--ISKRKIeEAKYLLRSQIPVSEVSNELGFYDLSHFSRTFKKHTGVSPKQ 381


                  .
gi 2545595587 358 Y 358
Cdd:TIGR04094 382 Y 382
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 50-237 4.30e-32

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 118.90  E-value: 4.30e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587  50 GLEPSAMYARAGVDLGDEDGVGMFVSSRQVLNLVGQIIEALDMPYIGLPMGNLMTVSHHGMAGLAAVTQPTLWDCGQAVV 129
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 130 RYCRELFPPLEMSITLDGDEG-WFSIEENTSLAPYTHFFVELNMVSFYNIFRDLVanDPELMPVRVELGYPEPAWGHIYR 208
Cdd:pfam12625  81 RYLRLLSDALELRLEEGEGGLaRLRLDVRPIPGRRRDFLLELALAALLRLARWLL--GRRLPPLRVEFPHPAPADAAEYE 158

                         170       180
                  ....*....|....*....|....*....
gi 2545595587 209 RYFKCPVVFGCHQSRIIGKASLAeyELPL 237
Cdd:pfam12625 159 RLFGCPVRFGAPRNALVFDAADL--DRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
135-365 1.07e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.00  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 135 LFPPLEMSITLDGDEGWFSIEENTSLAPYTHFFVELNMVSFYNIFRDLVANDPELMPVRVELGYPEPAWGHIYRRYFKCP 214
Cdd:COG2207    26 LLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 215 VVFGCHQSRIIGKASLAEYELPLANRLMAMTAEKSLFENIPTRAMKYLPLRLRRLLIRYYGAFPSLENAASELGMSGRTM 294
Cdd:COG2207   106 LLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTL 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2545595587 295 RRKLKDD-GTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEYMASIQAR 365
Cdd:COG2207   186 SRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRAR 257
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
278-359 6.15e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 85.68  E-value: 6.15e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587  278 PSLENAASELGMSGRTMRRKLKDD-GTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPK 356
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 2545595587  357 EYM 359
Cdd:smart00342  82 EYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
284-361 4.88e-17

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 74.93  E-value: 4.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 284 ASELGMSGRTMRRKLKDD-GTSYQQELDFVRQKFAREYFAR-GGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEYMAS 361
Cdd:pfam12833   2 AAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRRR 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 279-358 2.62e-10

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 60.94  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 279 SLENAASELGMSGRTMRRKLKDD-GTS---YQQELdfvRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMS 354
Cdd:COG4977   228 SVDELARRAGMSPRTLERRFRAAtGTTparYLQRL---RLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVS 304


                  ....
gi 2545595587 355 PKEY 358
Cdd:COG4977   305 PSAY 308
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 281-361 2.54e-08

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 54.65  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 281 ENAASELGMSGRTMRRKLKDDGTS---Y--QQELDF----VRQKFAREyfarggdSITELAHLLGFADSSAFAKAFRRWT 351
Cdd:PRK09685  218 EWIAGELGISVRSLYRLFAEQGLVvaqYirNRRLDRcaddLRPAADDE-------KITSIAYKWGFSDSSHFSTAFKQRF 290

                          90
                  ....*....|
gi 2545595587 352 DMSPKEYMAS 361
Cdd:PRK09685  291 GVSPGEYRRK 300
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 278-358 1.13e-07

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 53.13  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 278 PSLENAASELGMSGRTMRRKLKDD-GTSYQQELDFVRQKFAREYFaRGGDSITELAHLLGFADSSAFAKAFRRWTDMSPK 356
Cdd:COG2169   101 PSLEDLAARLGLSPRHLRRLFKAHtGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMTPS 179


                  ..
gi 2545595587 357 EY 358
Cdd:COG2169   180 AY 181
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 279-358 1.46e-07

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 52.24  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 279 SLENAASELGMSGRTMRRKLKDDGTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEY 358
Cdd:PRK09978  160 TLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEY 239
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
281-357 3.65e-07

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 50.83  E-value: 3.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2545595587 281 ENAASELGMSGRTMRRKLKDD-GTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKE 357
Cdd:PRK13503  191 EALADQFSLSLRTLHRQLKQQtGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRD 268
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 280-358 1.33e-06

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 49.68  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 280 LENAASELGMSGRTMRRKLKDD-GTSYQQEldFVRQKF-AREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKE 357
Cdd:TIGR04094 304 VEEIAKQFFMSESKLRKLFKKEmGISIQEY--ISKRKIeEAKYLLRSQIPVSEVSNELGFYDLSHFSRTFKKHTGVSPKQ 381


                  .
gi 2545595587 358 Y 358
Cdd:TIGR04094 382 Y 382
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 280-362 6.01e-06

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 47.30  E-value: 6.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 280 LENAASELGMSGRTMRRKLKDDGTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEYM 359
Cdd:PRK15185  225 LTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFI 304


                  ...
gi 2545595587 360 ASI 362
Cdd:PRK15185  305 KMA 307
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 327-358 1.99e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 41.37  E-value: 1.99e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2545595587 327 SITELAHLLGFaDSSAFAKAFRRWTDMSPKEY 358
Cdd:pfam00165  10 TIADIADELGF-SRSYFSRLFKKYTGVTPSQY 40
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 279-360 7.78e-05

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 43.90  E-value: 7.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2545595587 279 SLENAASELGMSGRTMRRKLKDDGTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEY 358
Cdd:PRK15186  199 ALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEF 278


                  ..
gi 2545595587 359 MA 360
Cdd:PRK15186  279 LA 280
ftrA PRK09393
transcriptional activator FtrA; Provisional
 284-358 1.86e-04

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 43.03  E-value: 1.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2545595587 284 ASELGMSGRTMRRKLKD-DGTSYQQELDFVRQKFAREYFARGGDSITELAHLLGFADSSAFAKAFRRWTDMSPKEY 358
Cdd:PRK09393  241 AARAAMSPRTFLRRFEAaTGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAY 316
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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