Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPvyKHIPVIYFSA 84
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRD--PTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2536571873  85 NNDIKAL--AATAGAESYLSKPFDIDELEEMVA 115
Cdd:pfam00072  79 HGDEDDAveALEAGADDFLSKPFDPDELLAAIR 111

DNA-binding transcriptional activator KdpE; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKhpvYKHIPVIYFSA 84
Cdd:PRK10529    4 VLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQ---WSAIPVIVLSA 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2536571873  85 NND--IKALAATAGAESYLSKPFDIDELEEMVASLIRQ 120
Cdd:PRK10529   81 RSEesDKIAALDAGADDYLSKPFGIGELQARLRVALRR 118

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   4 KILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPVYKHIPVIYFS 83
Cdd:COG3706     3 RILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADIPIIFLT 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2536571873  84 ANNDI--KALAATAGAESYLSKPFDIDELEEMVASLIR 119
Cdd:COG3706    83 ALDDEedRARALEAGADDYLTKPFDPEELLARVDLVAR 120

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   3 KKILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHpvYKHIPVIYF 82
Cdd:COG2204     3 ARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRAL--DPDLPVILL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2536571873  83 SANNDIK-ALAAT-AGAESYLSKPFDIDELEEMVASLIRQQE 122
Cdd:COG2204    81 TGYGDVEtAVEAIkAGAFDYLTKPFDLEELLAAVERALERRR 122

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPvyKHIPVIYFSA 84
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRD--PTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2536571873  85 NNDIKAL--AATAGAESYLSKPFDIDELEEMVA 115
Cdd:pfam00072  79 HGDEDDAveALEAGADDFLSKPFDPDELLAAIR 111

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPVYKHIPVIYFSA 84
Cdd:cd19920     1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADPATRHIPVIFLTA 80

                          90       100
                  ....*....|....*....|....*
gi 2536571873  85 NNDI----KALAatAGAESYLSKPF 105
Cdd:cd19920    81 LTDTedkvKGFE--LGAVDYITKPF 103

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKhpVYKHIPVIYFSA 84
Cdd:cd17550     1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKE--KYPDLPVIMISG 78

                          90       100
                  ....*....|....*....|....*...
gi 2536571873  85 NNDIK-ALAAT-AGAESYLSKPFDIDEL 110
Cdd:cd17550    79 HGTIEtAVKATkLGAYDFIEKPLSLDRL 106

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   4 KILIFDDNKDILELCTLILEGAGYHTkasSTADN---IISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPVYKHIPVI 80
Cdd:cd17538     1 KILVVDDEPANRELLEALLSAEGYEV---LTADSgqeALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRHIPVI 77

                          90       100
                  ....*....|....*....|....*....
gi 2536571873  81 YFSANND----IKALAatAGAESYLSKPF 105
Cdd:cd17538    78 MITALDDredrIRGLE--AGADDFLSKPI 104

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   6 LIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPVYKHIPVIYFSAN 85
Cdd:cd19937     1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSIPIIMLTAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2536571873  86 ND--IKALAATAGAESYLSKPFDIDELEEMVASLIR 119
Cdd:cd19937    81 GEefDKVLGLELGADDYITKPFSPRELLARVKAVLR 116

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   4 KILIFDDNKDILELCTLILEGAGYHTkASSTAD--NIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPVYKHIPVIY 81
Cdd:cd17551     2 RILIVDDNPTNLLLLEALLRSAGYLE-VVSFTDprEALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDVPIVM 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2536571873  82 FSANND----IKALAatAGAESYLSKPFDIDEL 110
Cdd:cd17551    81 ITADTDrevrLRALE--AGATDFLTKPFDPVEL 111

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   6 LIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPvyKHIPVIYFSAN 85
Cdd:cd17574     1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKG--SDIPIIMLTAK 78

                          90       100
                  ....*....|....*....|...
gi 2536571873  86 ND----IKALaaTAGAESYLSKP 104
Cdd:cd17574    79 DEeedkVLGL--ELGADDYITKP 99

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   3 KKILIFDDNKDILELCTLILEGAGYH-TKASSTADNIISRVAEYEPNLILMDNWLP-DIGGIAATQELKKHpvyKHIPVI 80
Cdd:cd17534     1 KKILIVEDEAIIALDLKEILESLGYEvVGIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREK---FDIPVI 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2536571873  81 YFSANND--IKALAATAGAESYLSKPFDIDELE 111
Cdd:cd17534    78 FLTAYSDeeTLERAKETNPYGYLVKPFNERELK 110

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   4 KILIFDDNKDILELCTLILEGAGYHTKASSTAD-----NIISRVAEYE----PNLILMDNWLPDIGGIAATQELKKHPVY 74
Cdd:cd17557     1 TILLVEDNPGDAELIQEAFKEAGVPNELHVVRDgeealDFLRGEGEYAdaprPDLILLDLNMPRMDGFEVLREIKADPDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2536571873  75 KHIPVIYFS---ANNDIKAlAATAGAESYLSKPFDIDELEEMVASLIR 119
Cdd:cd17557    81 RRIPVVVLTtsdAEEDIER-AYELGANSYIVKPVDFEEFVEAIRSLGE 127

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   3 KKILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHpvYKHIPVIYF 82
Cdd:cd19919     1 KTVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQR--HPDLPVIIM 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2536571873  83 SANNDIKALAAT--AGAESYLSKPFDIDELEEMV 114
Cdd:cd19919    79 TAHSDLDSAVSAyqGGAFEYLPKPFDIDEAVALV 112

nitrogen regulation protein NR(I); Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   4 KILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELK-KHPVykhIPVIYF 82
Cdd:PRK10923    5 IVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKqRHPM---LPVIIM 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2536571873  83 SANNDIKAL--AATAGAESYLSKPFDIDE---LEEMVASLIRQQE 122
Cdd:PRK10923   82 TAHSDLDAAvsAYQQGAFDYLPKPFDIDEavaLVERAISHYQEQQ 126

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   3 KKILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHpvYKHIPVIYF 82
Cdd:cd17554     1 KKILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREK--KPDLPVIIC 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2536571873  83 SANNDIKALAATAGAESYLSKPFDIDELEEMVASL 117
Cdd:cd17554    79 TAYSEYKSDFSSWAADAYVVKSSDLTELKETIKRL 113

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKhpvYKHIPVIYFSA 84
Cdd:cd17620     1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLRE---WSAVPVIVLSA 77

                          90       100
                  ....*....|....*....|....
gi 2536571873  85 NND----IKALaaTAGAESYLSKP 104
Cdd:cd17620    78 RDEesdkIAAL--DAGADDYLTKP 99

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   4 KILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHpvyKHIPVIYFS 83
Cdd:cd17626     2 RILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAE---SGVPIVMLT 78

                          90       100
                  ....*....|....*....|....*....
gi 2536571873  84 ANNDIK--ALAATAGAESYLSKPFDIDEL 110
Cdd:cd17626    79 AKSDTVdvVLGLESGADDYVAKPFKPKEL 107

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   1 MVKKILIFDDNKDILELCTLILEGAGYHTKAS-STADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPvykHIPV 79
Cdd:COG3707     2 RGLRVLVVDDEPLRRADLREGLREAGYEVVAEaADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEER---PAPV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2536571873  80 IYFSANND--IKALAATAGAESYLSKPFDIDELEEMVASLIRQQE 122
Cdd:COG3707    79 ILLTAYSDpeLIERALEAGVSAYLVKPLDPEDLLPALELALARFR 123

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPVykHIPVIYFSA 84
Cdd:COG4566     2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGS--PLPVIFLTG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2536571873  85 NNDIkALAATA---GAESYLSKPFDIDELEEMVASLIRQQE 122
Cdd:COG4566    80 HGDV-PMAVRAmkaGAVDFLEKPFDDQALLDAVRRALARDR 119

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHpvyKHIPVIYFSA 84
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKT---SNVPIIMLTA 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2536571873  85 NND--IKALAATAGAESYLSKPFDIDELEEMVASLIRQ 120
Cdd:cd17614    78 KDSevDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHpvYKHIPVIYFSA 84
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQ--GQSLPVLILTA 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2536571873  85 NND----IKALAAtaGAESYLSKPFDIDELEEMVASLIR 119
Cdd:cd17624    79 RDGvddrVAGLDA--GADDYLVKPFALEELLARLRALLR 115

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   3 KKILIFDDNKDILELCTLILEGAGYHT--KASSTADNIIsRVAEYEPNLILMDNWLPDIGGIAATQELKKhpVYKHIPVI 80
Cdd:cd17542     1 KKVLIVDDAAFMRMMLKDILTKAGYEVvgEAANGEEAVE-KYKELKPDLVTMDITMPEMDGIEALKEIKK--IDPNAKVI 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2536571873  81 YFSA--NNDIKALAATAGAESYLSKPFDIDELEEMVASL 117
Cdd:cd17542    78 MCSAmgQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKV 116

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   6 LIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHPVykHIPVIYFSAN 85
Cdd:cd17625     1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGI--ETPVLLLTAL 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2536571873  86 NDI--KALAATAGAESYLSKPFDIDELEEMVASLIRQ 120
Cdd:cd17625    79 DAVedRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   3 KKILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKhpVYKHIPVIYF 82
Cdd:cd17553     1 EKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKV--IDENIRVIIM 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2536571873  83 SANNDIKAL--AATAGAESYLSKPFDIDELEEMVASLI 118
Cdd:cd17553    79 TAYGELDMIqeSKELGALTHFAKPFDIDEIRDAVKKYL 116

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKhpVYKHIPVIYFSA 84
Cdd:cd19928     1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKK--ARPDLPIIVMSA 78

                          90       100
                  ....*....|....*....|..
gi 2536571873  85 NNDIKAL--AATAGAESYLSKP 104
Cdd:cd19928    79 QNTLMTAvkAAERGAFEYLPKP 100

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536571873   5 ILIFDDNKDILELCTLILEGAGYHTKASSTADNIISRVAEYEPNLILMDNWLPDIGGIAATQELKKHpvyKHIPVIYFSA 84
Cdd:cd17619     3 ILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQ---SEVGIILVTG 79

                          90       100
                  ....*....|....*....|....*...
gi 2536571873  85 -NNDI-KALAATAGAESYLSKPFDIDEL 110
Cdd:cd17619    80 rDDEVdRIVGLEIGADDYVTKPFNPREL 107