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Conserved domains on  [gi|2536568968|ref|WP_293299574|]
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DeoR/GlpR family DNA-binding transcription regulator [Pedobacter sp. UBA4863]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-253 3.91e-110

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 317.46  E-value: 3.91e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   1 MTLAERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPYTVDRPVNEKEKMQSSEKN 80
Cdd:COG1349     1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  81 RIGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQV 160
Cdd:COG1349    81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 161 LQDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQMI 240
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 2536568968 241 NHLEGLGVTVTVV 253
Cdd:COG1349   241 EALEEAGVEVIVA 253
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-253 3.91e-110

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 317.46  E-value: 3.91e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   1 MTLAERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPYTVDRPVNEKEKMQSSEKN 80
Cdd:COG1349     1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  81 RIGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQV 160
Cdd:COG1349    81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 161 LQDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQMI 240
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 2536568968 241 NHLEGLGVTVTVV 253
Cdd:COG1349   241 EALEEAGVEVIVA 253
AgaR NF040755
transcriptional repressor AgaR;
4-253 4.33e-75

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 228.69  E-value: 4.33e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   4 AERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPYT--VDRPVNEKEKMQSSEKNR 81
Cdd:NF040755    5 SERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDGFIpgAEPSVEDKSRLNTAVKRL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  82 IGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQVL 161
Cdd:NF040755   85 IAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQAEQSL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 162 QDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQMIN 241
Cdd:NF040755  165 QNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQ 244

                         250
                  ....*....|..
gi 2536568968 242 HLEGLGVTVTVV 253
Cdd:NF040755  245 GLRKLGVEVILV 256
srlR PRK10434
DNA-binding transcriptional repressor;
1-253 6.68e-63

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 197.60  E-value: 6.68e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   1 MTLAERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLsNPYTVDRPVNEKEKMQSSEKN 80
Cdd:PRK10434    1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVL-NKEESDPPIDHKTLINTHKKE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  81 RIGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFL-RNPEVEVIQLGGLLRKSSSSVMGSYAEQ 159
Cdd:PRK10434   80 LIAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSeLDNEQTILMPGGTFRKKSASFHGQLAEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 160 VLQDFYFNTLFLGVDGIDLEHGFTTTNamEAH-LNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQ 238
Cdd:PRK10434  160 AFEHFTFDKLFIGTDGIDLNAGVTTFN--EVYtVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPA 237

                         250
                  ....*....|....*
gi 2536568968 239 MINHLEGLGVTVTVV 253
Cdd:PRK10434  238 FRQALEEKGIEVIIT 252
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 75-233 2.19e-62

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 192.73  E-value: 2.19e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  75 QSSEKNRIGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMG 154
Cdd:pfam00455   2 NAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVG 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2536568968 155 SYAEQVLQDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDK 233
Cdd:pfam00455  82 PLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
trans_reg_YciT NF040887
DNA-binding transcriptional regulator YciT; Involved in osmolarity control regulation
 6-253 5.33e-40

DNA-binding transcriptional regulator YciT; Involved in osmolarity control regulation


Pssm-ID: 468823 [Multi-domain]  Cd Length: 246  Bit Score: 138.47  E-value: 5.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   6 RHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPYTVDrpvnekEKMQS--SEKNRIG 83
Cdd:NF040887    4 RQQQILQLVNDRGRVSVSELAQLTGVSEVTIRQDLNLLEKQSYLKRVHGSAVALDSDDVD------TRMMTnfPLKQKLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  84 AAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISiEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQVLQD 163
Cdd:NF040887   78 EYAASLVEDGETVFIEGGSTNALLARYLAERKDITIITVSHYIA-HLLKDSACEVILLGGLYQKSSESVVGPLTRLCIQQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 164 FYFNTLFLGVDGIDLEHGFTTTNAMEAHL-NRQMIKVSQKVVvLADSTKFGK---RGFGKICGFEDVdyiITDKGISQQM 239
Cdd:NF040887  157 VHFSKAFIGIDGWHPETGFTGRDMMRADVvNAVLAKGAENIV-LTDSSKFGQihpYPLGPLHQFSRV---ITDDGLPADY 232

                         250
                  ....*....|....
gi 2536568968 240 INHLEGLGVTVTVV 253
Cdd:NF040887  233 RQQLEEQGIRVDLV 246
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-58 8.59e-13

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 61.47  E-value: 8.59e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2536568968    6 RHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATL 58
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
hrcA TIGR00331
heat shock gene repressor HrcA; HrcA represses the class I heat shock operons groE and dnaK; ...
 5-145 8.11e-05

heat shock gene repressor HrcA; HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions]


Pssm-ID: 273017 [Multi-domain]  Cd Length: 337  Bit Score: 43.04  E-value: 8.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   5 ERHQFILNRIQQDqYIN---------VVELCkQLKVSSVTIRKDLKLLEDKHLLFRTH--GG---ATLSNPYTVDRPVnE 70
Cdd:TIGR00331   2 ERQRKILKAIVEE-YIKtgqpvgsktLLEKY-NLGLSSATIRNDMADLEDLGFIEKPHtsSGripTDKGYRYYVDHLL-K 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2536568968  71 KEKMQSSEKNRIGAAAAKLLKENDSIvvasgttLLYFVKSIPNGLNLTVVTSSLNISIEFLRNpeVEVIQLGGLL 145
Cdd:TIGR00331  79 VDSLTEEEKRRIQNQFLQRRFYLEKV-------LQLAASLLSELTNYTAVVLGPRLSQDKLKH--IELIPLDPNL 144
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-57 1.05e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 39.35  E-value: 1.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2536568968  10 ILNRIQQDQY------INVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGAT 57
Cdd:cd07377    10 LREAILSGELkpgdrlPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGT 63
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-253 3.91e-110

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 317.46  E-value: 3.91e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   1 MTLAERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPYTVDRPVNEKEKMQSSEKN 80
Cdd:COG1349     1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  81 RIGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQV 160
Cdd:COG1349    81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 161 LQDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQMI 240
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 2536568968 241 NHLEGLGVTVTVV 253
Cdd:COG1349   241 EALEEAGVEVIVA 253
AgaR NF040755
transcriptional repressor AgaR;
4-253 4.33e-75

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 228.69  E-value: 4.33e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   4 AERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPYT--VDRPVNEKEKMQSSEKNR 81
Cdd:NF040755    5 SERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDGFIpgAEPSVEDKSRLNTAVKRL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  82 IGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQVL 161
Cdd:NF040755   85 IAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQAEQSL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 162 QDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQMIN 241
Cdd:NF040755  165 QNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQ 244

                         250
                  ....*....|..
gi 2536568968 242 HLEGLGVTVTVV 253
Cdd:NF040755  245 GLRKLGVEVILV 256
srlR PRK10434
DNA-binding transcriptional repressor;
1-253 6.68e-63

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 197.60  E-value: 6.68e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   1 MTLAERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLsNPYTVDRPVNEKEKMQSSEKN 80
Cdd:PRK10434    1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVL-NKEESDPPIDHKTLINTHKKE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  81 RIGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFL-RNPEVEVIQLGGLLRKSSSSVMGSYAEQ 159
Cdd:PRK10434   80 LIAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSeLDNEQTILMPGGTFRKKSASFHGQLAEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 160 VLQDFYFNTLFLGVDGIDLEHGFTTTNamEAH-LNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQ 238
Cdd:PRK10434  160 AFEHFTFDKLFIGTDGIDLNAGVTTFN--EVYtVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPA 237

                         250
                  ....*....|....*
gi 2536568968 239 MINHLEGLGVTVTVV 253
Cdd:PRK10434  238 FRQALEEKGIEVIIT 252
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 75-233 2.19e-62

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 192.73  E-value: 2.19e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  75 QSSEKNRIGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMG 154
Cdd:pfam00455   2 NAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVG 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2536568968 155 SYAEQVLQDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDK 233
Cdd:pfam00455  82 PLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
PRK09802 PRK09802
DeoR family transcriptional regulator;
4-253 7.61e-62

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 195.46  E-value: 7.61e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   4 AERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATL--SNPYTVDRPVNEKEKMQSSEKNR 81
Cdd:PRK09802   16 SERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALIcdSTTPSVEPSVEDKSALNTAMKRS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  82 IGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQVL 161
Cdd:PRK09802   96 VAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 162 QDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQMIN 241
Cdd:PRK09802  176 QNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSLE 255

                         250
                  ....*....|..
gi 2536568968 242 HLEGLGVTVTVV 253
Cdd:PRK09802  256 GLRKAGVEVILV 267
trans_reg_YciT NF040887
DNA-binding transcriptional regulator YciT; Involved in osmolarity control regulation
 6-253 5.33e-40

DNA-binding transcriptional regulator YciT; Involved in osmolarity control regulation


Pssm-ID: 468823 [Multi-domain]  Cd Length: 246  Bit Score: 138.47  E-value: 5.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   6 RHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPYTVDrpvnekEKMQS--SEKNRIG 83
Cdd:NF040887    4 RQQQILQLVNDRGRVSVSELAQLTGVSEVTIRQDLNLLEKQSYLKRVHGSAVALDSDDVD------TRMMTnfPLKQKLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  84 AAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISiEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQVLQD 163
Cdd:NF040887   78 EYAASLVEDGETVFIEGGSTNALLARYLAERKDITIITVSHYIA-HLLKDSACEVILLGGLYQKSSESVVGPLTRLCIQQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 164 FYFNTLFLGVDGIDLEHGFTTTNAMEAHL-NRQMIKVSQKVVvLADSTKFGK---RGFGKICGFEDVdyiITDKGISQQM 239
Cdd:NF040887  157 VHFSKAFIGIDGWHPETGFTGRDMMRADVvNAVLAKGAENIV-LTDSSKFGQihpYPLGPLHQFSRV---ITDDGLPADY 232

                         250
                  ....*....|....
gi 2536568968 240 INHLEGLGVTVTVV 253
Cdd:NF040887  233 RQQLEEQGIRVDLV 246
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
1-233 2.63e-31

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 116.11  E-value: 2.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   1 MTLAERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPyTVDRPVNEKEKMQSSEKN 80
Cdd:PRK10906    1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSS-SVNTPWHDRKATQTEEKE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  81 RIGAAAAKLLKENDSIVVASGTTLLYFVKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQV 160
Cdd:PRK10906   80 RIARKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDF 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2536568968 161 LQDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDK 233
Cdd:PRK10906  160 ISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQ 232
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
1-253 1.46e-30

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 113.95  E-value: 1.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   1 MTLAERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGA-TLSNPYTVDRPVNEKEKMQSSEK 79
Cdd:PRK13509    1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeAITQQRPRWTPMNIHQAQNHDEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  80 NRIGAAAAKLLKENDSIVVASGTTLLYFVKSIPnGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSsVMGSYAEQ 159
Cdd:PRK13509   81 VRIAKAASQLCNPGESVVINCGSTAFLLGRELC-GKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQS-ITLSPQGS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 160 VLQDFYFNTLFLGVDGIDLEhGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQM 239
Cdd:PRK13509  159 ENSLYAGHWMFTSGKGLTAD-GLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNADPEV 237

                         250
                  ....*....|....
gi 2536568968 240 INHLEGLGVTVTVV 253
Cdd:PRK13509  238 LQQLEAQGVSILLV 251
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 29-250 5.03e-22

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 91.30  E-value: 5.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  29 LKVSSVTIRKDLKLLEDKHLLFrthGGATLSNPYTVDRP-VNEKEKMQSSEKNRIGAAAAKLLKENDSIVVASGTTLLYF 107
Cdd:PRK10681   31 LGVSEMTIRRDLNAHSAPVVLL---GGYIVLEPRSASHYlLSDQKSRLVEEKRRAAQLAATLVEPNQTLFFDCGTTTPWI 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968 108 VKSIPNGLNLTVVTSSLNISIEFLRNPEVEVIQLGGLLRKSSSSVMGSYAEQVLQDFYFNTLFLGVDGIDLEHGFTTTNA 187
Cdd:PRK10681  108 IEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEFHASNAIFKPLDFQQTLDNICPDIAFYSAAGVHVSKGATCFNL 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2536568968 188 MEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDKGISQQMINHLEGLGVTV 250
Cdd:PRK10681  188 EELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYAQAQRIKL 250
PRK10411 PRK10411
L-fucose operon activator;
4-233 1.98e-17

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 78.69  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   4 AERHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNPYTVDR--PVNEKEKMQSSEKNR 81
Cdd:PRK10411    3 AARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSgdPFHIRLKSHYAHKAD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968  82 IGAAAAKLLKENDSIVVASGTTLLYFVKSIPNgLNLTVVTSSLNISIEFLRNPEVEVIQLGGLL-RKSSSSVMGSYAEQv 160
Cdd:PRK10411   83 IAREALAWIEEGMVIALDASSTCWYLARQLPD-INIQVFTNSHPICQELGKRERIQLISSGGTLeRKYGCYVNPSLISQ- 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2536568968 161 LQDFYFNTLFLGVDGIDLEHGFTTTNAMEAHLNRQMIKVSQKVVVLADSTKFGKRGFGKICGFEDVDYIITDK 233
Cdd:PRK10411  161 LKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDE 233
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-58 8.59e-13

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 61.47  E-value: 8.59e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2536568968    6 RHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATL 58
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
6-61 8.88e-12

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 58.81  E-value: 8.88e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2536568968   6 RHQFILNRIQQDQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGATLSNP 61
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSS 56
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-54 8.01e-05

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 42.54  E-value: 8.01e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2536568968   8 QFILNRIQQDQYI------NVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHG 54
Cdd:COG2188    12 DALRERIESGELPpgdrlpSERELAEEFGVSRMTVRKALDELVEEGLLERRQG 64
hrcA TIGR00331
heat shock gene repressor HrcA; HrcA represses the class I heat shock operons groE and dnaK; ...
 5-145 8.11e-05

heat shock gene repressor HrcA; HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions]


Pssm-ID: 273017 [Multi-domain]  Cd Length: 337  Bit Score: 43.04  E-value: 8.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   5 ERHQFILNRIQQDqYIN---------VVELCkQLKVSSVTIRKDLKLLEDKHLLFRTH--GG---ATLSNPYTVDRPVnE 70
Cdd:TIGR00331   2 ERQRKILKAIVEE-YIKtgqpvgsktLLEKY-NLGLSSATIRNDMADLEDLGFIEKPHtsSGripTDKGYRYYVDHLL-K 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2536568968  71 KEKMQSSEKNRIGAAAAKLLKENDSIvvasgttLLYFVKSIPNGLNLTVVTSSLNISIEFLRNpeVEVIQLGGLL 145
Cdd:TIGR00331  79 VDSLTEEEKRRIQNQFLQRRFYLEKV-------LQLAASLLSELTNYTAVVLGPRLSQDKLKH--IELIPLDPNL 144
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-57 1.05e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 39.35  E-value: 1.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2536568968  10 ILNRIQQDQY------INVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGAT 57
Cdd:cd07377    10 LREAILSGELkpgdrlPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGT 63
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
10-57 6.65e-04

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 37.17  E-value: 6.65e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2536568968   10 ILNRIQQ------DQYINVVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGAT 57
Cdd:smart00345   5 LREDIVSgelrpgDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGT 58
PRK13029 PRK13029
indolepyruvate ferredoxin oxidoreductase family protein;
80-172 2.78e-03

indolepyruvate ferredoxin oxidoreductase family protein;


Pssm-ID: 237278 [Multi-domain]  Cd Length: 1186  Bit Score: 39.00  E-value: 2.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2536568968   80 NRIGAAAAKLLKENDSIVVASGTTLlyfvKSIPNGLNLTVVTSSLNISIEFLRNPE--VEVIQLGGLLRKSS--SSVMGS 155
Cdd:PRK13029   806 TRIDTGEADLVIACDLVVAASGEAL----AAMRPGRTRAAANSHETPTAAFVRNPDwsFPVDQTVALLRDSIgaDQCAFF 881

                           90       100
                   ....*....|....*....|..
gi 2536568968  156 YAEQVL-----QDFYFNTLFLG 172
Cdd:PRK13029   882 DANALAlallgDSIYANPLLLG 903
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 1-56 3.44e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 37.59  E-value: 3.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2536568968   1 MTLAERHQFILNRIQQdqYIN-------VVELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGA 56
Cdd:COG1974     2 KKLTKRQREILDFIKE--YIRergyppsQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKS 62
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 14-46 6.04e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 33.95  E-value: 6.04e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2536568968  14 IQQDQYINVVELCKQLKVSSVTIRKDLKLLEDK 46
Cdd:pfam08279   8 LEARGPISGQELAEKLGVSRRTIRRDIKILEEL 40
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 24-57 8.94e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 34.13  E-value: 8.94e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2536568968  24 ELCKQLKVSSVTIRKDLKLLEDKHLLFRTHGGAT 57
Cdd:pfam00392  29 ELAAEFGVSRTTVREALRRLEAEGLVERRQGRGT 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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