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Conserved domains on  [gi|2534951727|ref|WP_291812050|]
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DNA-directed RNA polymerase [Limnobacter sp.]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA00452 super family cl42978
T3/T7-like RNA polymerase
3-794 0e+00

T3/T7-like RNA polymerase


The actual alignment was detected with superfamily member PHA00452:

Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 615.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727   3 QFDLEQEMLKMGQERYQAKVSRAKEMNLESTHPAGQKLLQHSVVSLADHFDNWIDHATTsAGKRHTALPYLNQVPTKVSA 82
Cdd:PHA00452    9 QLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKK-RGRAAKARGLLRLVDPEVLA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727  83 ALTARATLDAISNGR--KLISTAANIGGLIEDEVKYRTLKDDYAALWQQLNRVMDRYKS-AYTKKKFIEKSLRHH--DIV 157
Cdd:PHA00452   88 VITLKVTLDMLLSKEtpTAQAVATAIGRAIEDEIRFGRIEDLNPKYFKKVVEYLKRSRTgSVYHIAFMMVVEADMvlLGE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 158 IPRWSAQERIKVGLVCLELMRQSTGLIEINT-RKNQHGKAEQWVEPSNDLIEWLKNAHAHMEMLDPVFLPMIEQPVPWQD 236
Cdd:PHA00452  168 WDPWPKEDYIHVGKWLLEALIESTGLVELVRhTGGNGGKDHEYLELSEEAVELLQDIAAAAAGISPMYQPMVVPPKPWTS 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 237 YIVGGYSSGVFRRRPLVKTKDKGHLELVNASTMPKVYRALNAIQGTPFKVNTAVLEVMKHCWNKNiAIDGLVTAEDEPLP 316
Cdd:PHA00452  248 IVGGGYHTEGRRPLAPLVRKTKKALRRYRQKQMPEVYKAVNALQNTAWRINKDVLAVVNEVVNWG-PVGDVLGIPRRPLP 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 317 AKPTDIDTNRESRREWRRRAARQHFENERQRSKRLHAMRVMSLAEKFKD-ERIWFPHDLDFRGRAYPMPyFLQPQGPSFA 395
Cdd:PHA00452  327 PKPEFLDENEEAFKAWKRAAAAWYTKEKERVSKRRRLEFMLRVANKFADyKAIYFPYNMDWRGRVYAVS-MLNPQGSDLQ 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 396 RSLLTFDRTTVMTDVGEQWLRIHIANCWGMDKNNYDQRIQWTHENSGMLHQIGRDPMSNMDWTQADDPWRFLAACVEYAE 475
Cdd:PHA00452  406 KALLRFAEGKPLGKRGLYWLKVHGANCYGVDKVTFDERAAWVDENHDNILAAAEDPLNNTWWAEADSPLCFLAACFEYAA 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 476 MM-KGGQFHTSLPIGIDATNQGLQIYALALRDHTSAQATNCLPCELPNDIYQQVCDTV-------LDMIATDTHEYAKGW 547
Cdd:PHA00452  486 AVhSGTSYVSGLPVAMDGTCSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVneklerdAINGTDNTRALARLW 565
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 548 REFGLTRKTTKRQTMTLPYGSTFFSCKKYTAEwfyDELKKGKTNPFGD-QTYQPCGWLAEKIWEAIGQVVHAARVGMDWL 626
Cdd:PHA00452  566 LAYGITRSLTKRPVMTLPYGSTRFSCRDYILE---DLLQPGIDEGDGAmFTNQAASYMAKLIWDAISETVPAAVEAMNWL 642
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 627 QHVAETCLDNGVTP-QWVTPLGFPVYMHYEKQDHLNIKTNVFGVIRQTRiRTDSGDPSKRKSMNAMAPNFVHSIDgiGGL 705
Cdd:PHA00452  643 QQAAKLLAAKGAEAlHWTTPTGFPVWQEYRKPEEKRVRLRLMGVARVQL-YVNTDTIDARKHASGIAPNFVHSLD--ASH 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 706 LGETTNRALDRGVTDFLMVHDEYSVHAPCVPIVGEEVRNATVDLFSGN-ILKDLHTQINTLLPSGiqLDEPPPQGDLDIS 784
Cdd:PHA00452  720 LRLTVVACAEKGIESFAVIHDSFGTHAADADNLHRAIRETFVEMYEENdVLADFADQFGDQLQLK--MPELPEKGSLDLE 797
                         810
                  ....*....|
gi 2534951727 785 LINQAQYYFS 794
Cdd:PHA00452  798 EVLDSDFFFC 807
 
Name Accession Description Interval E-value
PHA00452 PHA00452
T3/T7-like RNA polymerase
3-794 0e+00

T3/T7-like RNA polymerase


Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 615.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727   3 QFDLEQEMLKMGQERYQAKVSRAKEMNLESTHPAGQKLLQHSVVSLADHFDNWIDHATTsAGKRHTALPYLNQVPTKVSA 82
Cdd:PHA00452    9 QLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKK-RGRAAKARGLLRLVDPEVLA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727  83 ALTARATLDAISNGR--KLISTAANIGGLIEDEVKYRTLKDDYAALWQQLNRVMDRYKS-AYTKKKFIEKSLRHH--DIV 157
Cdd:PHA00452   88 VITLKVTLDMLLSKEtpTAQAVATAIGRAIEDEIRFGRIEDLNPKYFKKVVEYLKRSRTgSVYHIAFMMVVEADMvlLGE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 158 IPRWSAQERIKVGLVCLELMRQSTGLIEINT-RKNQHGKAEQWVEPSNDLIEWLKNAHAHMEMLDPVFLPMIEQPVPWQD 236
Cdd:PHA00452  168 WDPWPKEDYIHVGKWLLEALIESTGLVELVRhTGGNGGKDHEYLELSEEAVELLQDIAAAAAGISPMYQPMVVPPKPWTS 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 237 YIVGGYSSGVFRRRPLVKTKDKGHLELVNASTMPKVYRALNAIQGTPFKVNTAVLEVMKHCWNKNiAIDGLVTAEDEPLP 316
Cdd:PHA00452  248 IVGGGYHTEGRRPLAPLVRKTKKALRRYRQKQMPEVYKAVNALQNTAWRINKDVLAVVNEVVNWG-PVGDVLGIPRRPLP 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 317 AKPTDIDTNRESRREWRRRAARQHFENERQRSKRLHAMRVMSLAEKFKD-ERIWFPHDLDFRGRAYPMPyFLQPQGPSFA 395
Cdd:PHA00452  327 PKPEFLDENEEAFKAWKRAAAAWYTKEKERVSKRRRLEFMLRVANKFADyKAIYFPYNMDWRGRVYAVS-MLNPQGSDLQ 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 396 RSLLTFDRTTVMTDVGEQWLRIHIANCWGMDKNNYDQRIQWTHENSGMLHQIGRDPMSNMDWTQADDPWRFLAACVEYAE 475
Cdd:PHA00452  406 KALLRFAEGKPLGKRGLYWLKVHGANCYGVDKVTFDERAAWVDENHDNILAAAEDPLNNTWWAEADSPLCFLAACFEYAA 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 476 MM-KGGQFHTSLPIGIDATNQGLQIYALALRDHTSAQATNCLPCELPNDIYQQVCDTV-------LDMIATDTHEYAKGW 547
Cdd:PHA00452  486 AVhSGTSYVSGLPVAMDGTCSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVneklerdAINGTDNTRALARLW 565
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 548 REFGLTRKTTKRQTMTLPYGSTFFSCKKYTAEwfyDELKKGKTNPFGD-QTYQPCGWLAEKIWEAIGQVVHAARVGMDWL 626
Cdd:PHA00452  566 LAYGITRSLTKRPVMTLPYGSTRFSCRDYILE---DLLQPGIDEGDGAmFTNQAASYMAKLIWDAISETVPAAVEAMNWL 642
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 627 QHVAETCLDNGVTP-QWVTPLGFPVYMHYEKQDHLNIKTNVFGVIRQTRiRTDSGDPSKRKSMNAMAPNFVHSIDgiGGL 705
Cdd:PHA00452  643 QQAAKLLAAKGAEAlHWTTPTGFPVWQEYRKPEEKRVRLRLMGVARVQL-YVNTDTIDARKHASGIAPNFVHSLD--ASH 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 706 LGETTNRALDRGVTDFLMVHDEYSVHAPCVPIVGEEVRNATVDLFSGN-ILKDLHTQINTLLPSGiqLDEPPPQGDLDIS 784
Cdd:PHA00452  720 LRLTVVACAEKGIESFAVIHDSFGTHAADADNLHRAIRETFVEMYEENdVLADFADQFGDQLQLK--MPELPEKGSLDLE 797
                         810
                  ....*....|
gi 2534951727 785 LINQAQYYFS 794
Cdd:PHA00452  798 EVLDSDFFFC 807
RPO41 COG5108
Mitochondrial DNA-directed RNA polymerase [Transcription];
2-794 0e+00

Mitochondrial DNA-directed RNA polymerase [Transcription];


Pssm-ID: 444054 [Multi-domain]  Cd Length: 826  Bit Score: 573.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727   2 KQFDLEQEMLKMGQERYQAKVSRAKEMNLESTHPAGQKLLQHSVVSLADHFDNWID-HATTSAGKRHTALPYLNQVPTKV 80
Cdd:COG5108    13 RQIALEEEMAEAGRSRFVERIEKARKRGEESGTQYGRRIISDAVELLAEAIEATIDeSSSGGAGNWHTAYAYLRELDAEV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727  81 SAALTARATLDAISNGRKLISTAANIGGLIEDEVKYRTLKDDYAALWQQLNRVMD-RYKSAYTKKKFIEKSLRHHDIVIP 159
Cdd:COG5108    93 LAYLALRQCLDAVTQRHTLQAVAIRIASMVEDEVRGEAIREAFKDFYPRGKKKIEsRTSRAVRYKDDFERRVKNAVAKEE 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 160 RWSAQERIKVGLVCLELMRQSTGLIEINTRKNQHGKAEQWVEPSNDLIEWLKNAHAHMEMLDPVFLPMIEQPVPWQDYIV 239
Cdd:COG5108   173 DWPVSDKIHVGFKLIELVVESTGLVEIARDTEGINDTPVFVRPTETTLEWIAEANLRMAMLSPAYLPMVVPPRNWTTPFR 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 240 GGYSSGVFRRRPLVKTKDKGHLELVNASTMPKVYRALNAIQGTPFKVNTAVLEVMKHCWNKNIAIdGLVTAEDEPLPAKP 319
Cdd:COG5108   253 GGYLSGEVRRLPLVKTRNRKYLEELKNGDMPEVYAAVNALQQTPWTINRYVLAVMKWLWERDLDL-GLPQREPITPPIKP 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 320 T---DIDTNRESRREWRRRAARQHFENERQRSKRLHAMRVMSLAEKFKDER-IWFPHDLDFRGRAYPMPYFLQPQGPSFA 395
Cdd:COG5108   332 EnreDITTNQVARKRWKKAARKIYIANAKLCSKRVQFRRDLNEAERFSDYReFYFPYQLDFRGRVYAVPAFLNPQGQDHA 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 396 RSLLTFDRTTVMTDVGEQWLRIHIANCWGMDKNNYDQRIQWTHENSGMLHQIGRDpMSNMDWTQADDPWRFLAACVEYAE 475
Cdd:COG5108   412 KGLLMFADGKPIGDGGAKWLAIHGANVWGYDKASLEERVKWVEDNYEAILAAAAD-YVAEFWSKADKPWQFLAFCREWYG 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 476 MMKGGQ-FHTSLPIGIDATNQGLQIYALALRDHTSAQATNCLPCELPNDIYQQVCDTVLDMIA-------TDTHEYAKG- 546
Cdd:COG5108   491 YDQHGEgYVSGLPIAMDGSCSGLQHYSAMLRDEVGGAAVNLVPSDKPQDIYAFVAEVDINLAQrigcpdeLTTNEILNGi 570
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 547 ------WREFGLTRKTTKRQTMTLPYGSTFFSCKKYTAEWFYDELK--KGKTNPFGDQTYQPCGWLAEKIWEAIGQVVHA 618
Cdd:COG5108   571 mdmahnWLAFGITRKVTKRNVMTLPYGSTEYGFRDQVREDMITRKKeeEGEPFPFGGDGFSAAMWLAKLIWDAIGEVVVA 650
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 619 ARVGMDWLQHVAETCLDNGVTPQWVTPLGFPVYMHYEKQDHLNIKTNVFGVIRQTRIRTDSGDPSKRKSMNAMAPNFVHS 698
Cdd:COG5108   651 ARRGMDWLQDLAGIAAKEGLPVIWTTPLGFPVMQDYRSSKARRINTTTRKVRVRLTLREEQDTIDKRKQKQGIAPNFVHS 730
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 699 IDGIGGLLgeTTNRALDRGVTDFLMVHDEYSVHAPCVPIVGEEVRNATVDLFS-GNILKDLHTQINTLLP-SGIQLDEPP 776
Cdd:COG5108   731 MDATHLMM--TVNRSNEYGASSFALVHDSFGTDAGSAELMLDCLRKAFIELYEeSDVLEDFKSEIADMLSdDAYALPEVP 808
                         810
                  ....*....|....*...
gi 2534951727 777 PQGDLDISLINQAQYYFS 794
Cdd:COG5108   809 KKGSLDVSAVLESDFFFA 826
RNA_pol pfam00940
DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.
414-794 1.90e-92

DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.


Pssm-ID: 460006  Cd Length: 411  Bit Score: 295.57  E-value: 1.90e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 414 WLRIHIANCWGMDKNNYDQRIQWTHENsgmLHQI---GRDPMS-NMDWTQADDPWRFLAACVEYAEMMKGG---QFHTSL 486
Cdd:pfam00940  10 WLKIHLANLYGFDKASLDERVAFVEDN---LEDIldsAENPLDgRRWWLKAEDPWQCLAACFELANALRSPdpeEYVSHL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 487 PIGIDATNQGLQIYALALRDHTSAQATNCLPCELPNDIYQQVCDTVLDMIATD---THEYAKGWREFgLTRKTTKRQTMT 563
Cdd:pfam00940  87 PVHQDGSCNGLQHYAALGGDEEGAKQVNLVPSDRPQDVYSGVAELVEEKIEKDaakGNEIAKLLKGK-ITRKVVKQTVMT 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 564 LPYGSTFFSCKKYtaewFYDELKKGKTNPFGDQTYQPCGWLAEKIWEAIGQVVHAARVGMDWLQHVA-----ETCLDNGV 638
Cdd:pfam00940 166 NVYGVTFIGAREQ----IEKQLKEIGDFPGEEDLYKASSYLAKKIFDSIGELFTGAHEIQDWLGECAkriakSVPPEQSM 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 639 TP-QWVTPLGFPVYMHYEKQDHLNIKTNVFGVIRQTRIRTDSgdPSKRKSMNAMAPNFVHSIDGIGGLLgeTTNRALDRG 717
Cdd:pfam00940 242 SPvIWTTPLGLPVVQPYRKSKKKQVKTNLQSVSISDPNDTDP--VDKRKQLQAFPPNFIHSLDATHMML--TALACDEAG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 718 VTdFLMVHDEYSVHAPCVPIVGEEVRNATVDLFSGNILKDLHTQINTLLPSGIQLD------------------EPPPQG 779
Cdd:pfam00940 318 LT-FAAVHDSFWTHACDVDEMNKILREQFVKLHSEDILERLREEFKERYKGSLQLAkipkdspltpvwlpltfpEVPKKG 396
                         410
                  ....*....|....*
gi 2534951727 780 DLDISLINQAQYYFS 794
Cdd:pfam00940 397 DFDLNRVLDSKYFFS 411
 
Name Accession Description Interval E-value
PHA00452 PHA00452
T3/T7-like RNA polymerase
3-794 0e+00

T3/T7-like RNA polymerase


Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 615.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727   3 QFDLEQEMLKMGQERYQAKVSRAKEMNLESTHPAGQKLLQHSVVSLADHFDNWIDHATTsAGKRHTALPYLNQVPTKVSA 82
Cdd:PHA00452    9 QLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKK-RGRAAKARGLLRLVDPEVLA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727  83 ALTARATLDAISNGR--KLISTAANIGGLIEDEVKYRTLKDDYAALWQQLNRVMDRYKS-AYTKKKFIEKSLRHH--DIV 157
Cdd:PHA00452   88 VITLKVTLDMLLSKEtpTAQAVATAIGRAIEDEIRFGRIEDLNPKYFKKVVEYLKRSRTgSVYHIAFMMVVEADMvlLGE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 158 IPRWSAQERIKVGLVCLELMRQSTGLIEINT-RKNQHGKAEQWVEPSNDLIEWLKNAHAHMEMLDPVFLPMIEQPVPWQD 236
Cdd:PHA00452  168 WDPWPKEDYIHVGKWLLEALIESTGLVELVRhTGGNGGKDHEYLELSEEAVELLQDIAAAAAGISPMYQPMVVPPKPWTS 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 237 YIVGGYSSGVFRRRPLVKTKDKGHLELVNASTMPKVYRALNAIQGTPFKVNTAVLEVMKHCWNKNiAIDGLVTAEDEPLP 316
Cdd:PHA00452  248 IVGGGYHTEGRRPLAPLVRKTKKALRRYRQKQMPEVYKAVNALQNTAWRINKDVLAVVNEVVNWG-PVGDVLGIPRRPLP 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 317 AKPTDIDTNRESRREWRRRAARQHFENERQRSKRLHAMRVMSLAEKFKD-ERIWFPHDLDFRGRAYPMPyFLQPQGPSFA 395
Cdd:PHA00452  327 PKPEFLDENEEAFKAWKRAAAAWYTKEKERVSKRRRLEFMLRVANKFADyKAIYFPYNMDWRGRVYAVS-MLNPQGSDLQ 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 396 RSLLTFDRTTVMTDVGEQWLRIHIANCWGMDKNNYDQRIQWTHENSGMLHQIGRDPMSNMDWTQADDPWRFLAACVEYAE 475
Cdd:PHA00452  406 KALLRFAEGKPLGKRGLYWLKVHGANCYGVDKVTFDERAAWVDENHDNILAAAEDPLNNTWWAEADSPLCFLAACFEYAA 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 476 MM-KGGQFHTSLPIGIDATNQGLQIYALALRDHTSAQATNCLPCELPNDIYQQVCDTV-------LDMIATDTHEYAKGW 547
Cdd:PHA00452  486 AVhSGTSYVSGLPVAMDGTCSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVneklerdAINGTDNTRALARLW 565
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 548 REFGLTRKTTKRQTMTLPYGSTFFSCKKYTAEwfyDELKKGKTNPFGD-QTYQPCGWLAEKIWEAIGQVVHAARVGMDWL 626
Cdd:PHA00452  566 LAYGITRSLTKRPVMTLPYGSTRFSCRDYILE---DLLQPGIDEGDGAmFTNQAASYMAKLIWDAISETVPAAVEAMNWL 642
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 627 QHVAETCLDNGVTP-QWVTPLGFPVYMHYEKQDHLNIKTNVFGVIRQTRiRTDSGDPSKRKSMNAMAPNFVHSIDgiGGL 705
Cdd:PHA00452  643 QQAAKLLAAKGAEAlHWTTPTGFPVWQEYRKPEEKRVRLRLMGVARVQL-YVNTDTIDARKHASGIAPNFVHSLD--ASH 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 706 LGETTNRALDRGVTDFLMVHDEYSVHAPCVPIVGEEVRNATVDLFSGN-ILKDLHTQINTLLPSGiqLDEPPPQGDLDIS 784
Cdd:PHA00452  720 LRLTVVACAEKGIESFAVIHDSFGTHAADADNLHRAIRETFVEMYEENdVLADFADQFGDQLQLK--MPELPEKGSLDLE 797
                         810
                  ....*....|
gi 2534951727 785 LINQAQYYFS 794
Cdd:PHA00452  798 EVLDSDFFFC 807
RPO41 COG5108
Mitochondrial DNA-directed RNA polymerase [Transcription];
2-794 0e+00

Mitochondrial DNA-directed RNA polymerase [Transcription];


Pssm-ID: 444054 [Multi-domain]  Cd Length: 826  Bit Score: 573.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727   2 KQFDLEQEMLKMGQERYQAKVSRAKEMNLESTHPAGQKLLQHSVVSLADHFDNWID-HATTSAGKRHTALPYLNQVPTKV 80
Cdd:COG5108    13 RQIALEEEMAEAGRSRFVERIEKARKRGEESGTQYGRRIISDAVELLAEAIEATIDeSSSGGAGNWHTAYAYLRELDAEV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727  81 SAALTARATLDAISNGRKLISTAANIGGLIEDEVKYRTLKDDYAALWQQLNRVMD-RYKSAYTKKKFIEKSLRHHDIVIP 159
Cdd:COG5108    93 LAYLALRQCLDAVTQRHTLQAVAIRIASMVEDEVRGEAIREAFKDFYPRGKKKIEsRTSRAVRYKDDFERRVKNAVAKEE 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 160 RWSAQERIKVGLVCLELMRQSTGLIEINTRKNQHGKAEQWVEPSNDLIEWLKNAHAHMEMLDPVFLPMIEQPVPWQDYIV 239
Cdd:COG5108   173 DWPVSDKIHVGFKLIELVVESTGLVEIARDTEGINDTPVFVRPTETTLEWIAEANLRMAMLSPAYLPMVVPPRNWTTPFR 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 240 GGYSSGVFRRRPLVKTKDKGHLELVNASTMPKVYRALNAIQGTPFKVNTAVLEVMKHCWNKNIAIdGLVTAEDEPLPAKP 319
Cdd:COG5108   253 GGYLSGEVRRLPLVKTRNRKYLEELKNGDMPEVYAAVNALQQTPWTINRYVLAVMKWLWERDLDL-GLPQREPITPPIKP 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 320 T---DIDTNRESRREWRRRAARQHFENERQRSKRLHAMRVMSLAEKFKDER-IWFPHDLDFRGRAYPMPYFLQPQGPSFA 395
Cdd:COG5108   332 EnreDITTNQVARKRWKKAARKIYIANAKLCSKRVQFRRDLNEAERFSDYReFYFPYQLDFRGRVYAVPAFLNPQGQDHA 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 396 RSLLTFDRTTVMTDVGEQWLRIHIANCWGMDKNNYDQRIQWTHENSGMLHQIGRDpMSNMDWTQADDPWRFLAACVEYAE 475
Cdd:COG5108   412 KGLLMFADGKPIGDGGAKWLAIHGANVWGYDKASLEERVKWVEDNYEAILAAAAD-YVAEFWSKADKPWQFLAFCREWYG 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 476 MMKGGQ-FHTSLPIGIDATNQGLQIYALALRDHTSAQATNCLPCELPNDIYQQVCDTVLDMIA-------TDTHEYAKG- 546
Cdd:COG5108   491 YDQHGEgYVSGLPIAMDGSCSGLQHYSAMLRDEVGGAAVNLVPSDKPQDIYAFVAEVDINLAQrigcpdeLTTNEILNGi 570
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 547 ------WREFGLTRKTTKRQTMTLPYGSTFFSCKKYTAEWFYDELK--KGKTNPFGDQTYQPCGWLAEKIWEAIGQVVHA 618
Cdd:COG5108   571 mdmahnWLAFGITRKVTKRNVMTLPYGSTEYGFRDQVREDMITRKKeeEGEPFPFGGDGFSAAMWLAKLIWDAIGEVVVA 650
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 619 ARVGMDWLQHVAETCLDNGVTPQWVTPLGFPVYMHYEKQDHLNIKTNVFGVIRQTRIRTDSGDPSKRKSMNAMAPNFVHS 698
Cdd:COG5108   651 ARRGMDWLQDLAGIAAKEGLPVIWTTPLGFPVMQDYRSSKARRINTTTRKVRVRLTLREEQDTIDKRKQKQGIAPNFVHS 730
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 699 IDGIGGLLgeTTNRALDRGVTDFLMVHDEYSVHAPCVPIVGEEVRNATVDLFS-GNILKDLHTQINTLLP-SGIQLDEPP 776
Cdd:COG5108   731 MDATHLMM--TVNRSNEYGASSFALVHDSFGTDAGSAELMLDCLRKAFIELYEeSDVLEDFKSEIADMLSdDAYALPEVP 808
                         810
                  ....*....|....*...
gi 2534951727 777 PQGDLDISLINQAQYYFS 794
Cdd:COG5108   809 KKGSLDVSAVLESDFFFA 826
RNA_pol pfam00940
DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.
414-794 1.90e-92

DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.


Pssm-ID: 460006  Cd Length: 411  Bit Score: 295.57  E-value: 1.90e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 414 WLRIHIANCWGMDKNNYDQRIQWTHENsgmLHQI---GRDPMS-NMDWTQADDPWRFLAACVEYAEMMKGG---QFHTSL 486
Cdd:pfam00940  10 WLKIHLANLYGFDKASLDERVAFVEDN---LEDIldsAENPLDgRRWWLKAEDPWQCLAACFELANALRSPdpeEYVSHL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 487 PIGIDATNQGLQIYALALRDHTSAQATNCLPCELPNDIYQQVCDTVLDMIATD---THEYAKGWREFgLTRKTTKRQTMT 563
Cdd:pfam00940  87 PVHQDGSCNGLQHYAALGGDEEGAKQVNLVPSDRPQDVYSGVAELVEEKIEKDaakGNEIAKLLKGK-ITRKVVKQTVMT 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 564 LPYGSTFFSCKKYtaewFYDELKKGKTNPFGDQTYQPCGWLAEKIWEAIGQVVHAARVGMDWLQHVA-----ETCLDNGV 638
Cdd:pfam00940 166 NVYGVTFIGAREQ----IEKQLKEIGDFPGEEDLYKASSYLAKKIFDSIGELFTGAHEIQDWLGECAkriakSVPPEQSM 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 639 TP-QWVTPLGFPVYMHYEKQDHLNIKTNVFGVIRQTRIRTDSgdPSKRKSMNAMAPNFVHSIDGIGGLLgeTTNRALDRG 717
Cdd:pfam00940 242 SPvIWTTPLGLPVVQPYRKSKKKQVKTNLQSVSISDPNDTDP--VDKRKQLQAFPPNFIHSLDATHMML--TALACDEAG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 718 VTdFLMVHDEYSVHAPCVPIVGEEVRNATVDLFSGNILKDLHTQINTLLPSGIQLD------------------EPPPQG 779
Cdd:pfam00940 318 LT-FAAVHDSFWTHACDVDEMNKILREQFVKLHSEDILERLREEFKERYKGSLQLAkipkdspltpvwlpltfpEVPKKG 396
                         410
                  ....*....|....*
gi 2534951727 780 DLDISLINQAQYYFS 794
Cdd:pfam00940 397 DFDLNRVLDSKYFFS 411
RPOL_N pfam14700
DNA-directed RNA polymerase N-terminal; This is the N-terminal domain of DNA-directed RNA ...
3-278 5.73e-16

DNA-directed RNA polymerase N-terminal; This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme. In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex.


Pssm-ID: 464270  Cd Length: 286  Bit Score: 79.19  E-value: 5.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727   3 QFDLEQEMLKMGQERYQAKVSRAKEMNLestHPAGQKLLQhsvvslaDHFDNW--------------IDHAT-----TSA 63
Cdd:pfam14700   2 QLRLERDSVEAAVERWREEFEELQKRGL---NTNLPKSLN-------ALLWQWyeallpaikeeielLKAAEakpkkTKD 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727  64 GKRHTALPYLNQVPTKVSAALTARATLDAISNGR-----KLISTAANIGGLIEDEVKYRTLKddyaalwqqlnrvmdryk 138
Cdd:pfam14700  72 KERCEYGPYLRLLPPEKLAAITILELLSLLSTGGvdkgmKVSRLAISIGKAVEDEYRAQQLL------------------ 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 139 saytkkkfiEKSLRHHDIVIPRWSAQERIKVGLVCLELMRQStglIEIN-TRKNQHGK------------AEQW------ 199
Cdd:pfam14700 134 ---------KKEKKKIKKKKIPWPQEVRAKVGAVLLSLLIET---AKVPvTAEDPETGekviqpqpafyhSYQYkrgkkv 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2534951727 200 --VEPSNDLIEWLKNAHAHmEMLDPVFLPMIEQPVPWQDYIVGGYssgVFRRRPLVKTKD--KGHLELVNAS---TMPKV 272
Cdd:pfam14700 202 gvIKPHPELVKLLLREPAR-DTLTPRHLPMLVPPKPWTSYNKGGY---LLSPSKLMRTKDgdEQRAYLKAASergDLDQV 277

                  ....*.
gi 2534951727 273 YRALNA 278
Cdd:pfam14700 278 FDGLDV 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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