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Conserved domains on  [gi|2530594339|ref|WP_289687509|]
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glycosyltransferase family 4 protein [Muribaculum intestinale]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
SCOP:  3001586

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
8-360 8.30e-54

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 181.58  E-value: 8.30e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339   8 TRGIPGVMGGVETHCEHLYPRLAAMGYDITVVrrdSYVAGDSRTRWQGVNLVDIATPRKKAFEAIVHTIR-AVVAARRAK 86
Cdd:cd03801     6 SPELPPPVGGAERHVRELARALAARGHDVTVL---TPADPGEPPEELEDGVIVPLLPSLAALLRARRLLReLRPLLRLRK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  87 ADLLHIHAVGPSLAV-PLAKLLGMRVVMTNHGPDYER-AKWGRLARTIIKmGESWGSRFSDDVIVISDAIRRNIASRYGR 164
Cdd:cd03801    83 FDVVHAHGLLAALLAaLLALLLGAPLVVTLHGAEPGRlLLLLAAERRLLA-RAEALLRRADAVIAVSEALRDELRALGGI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 165 TR-RVHLIYNGVPEPEIcsDDAYFSELGIKPGRYILGM-SRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDadfEDDYS 242
Cdd:cd03801   162 PPeKIVVIPNGVDLERF--SPPLRRKLGIPPDRPVLLFvGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGG---DGPLR 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 243 RSLKQKARDND--VVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVgLPAGDY---F 317
Cdd:cd03801   237 AELEELELGLGdrVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEV-VEDGEGglvV 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2530594339 318 PTGDIDTLASRIRSKIDNGPQRIDYS-------LGKYDWDNIAMQVASVY 360
Cdd:cd03801   316 PPDDVEALADALLRLLADPELRARLGraarervAERFSWERVAERLLDLY 365
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
8-360 8.30e-54

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 181.58  E-value: 8.30e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339   8 TRGIPGVMGGVETHCEHLYPRLAAMGYDITVVrrdSYVAGDSRTRWQGVNLVDIATPRKKAFEAIVHTIR-AVVAARRAK 86
Cdd:cd03801     6 SPELPPPVGGAERHVRELARALAARGHDVTVL---TPADPGEPPEELEDGVIVPLLPSLAALLRARRLLReLRPLLRLRK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  87 ADLLHIHAVGPSLAV-PLAKLLGMRVVMTNHGPDYER-AKWGRLARTIIKmGESWGSRFSDDVIVISDAIRRNIASRYGR 164
Cdd:cd03801    83 FDVVHAHGLLAALLAaLLALLLGAPLVVTLHGAEPGRlLLLLAAERRLLA-RAEALLRRADAVIAVSEALRDELRALGGI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 165 TR-RVHLIYNGVPEPEIcsDDAYFSELGIKPGRYILGM-SRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDadfEDDYS 242
Cdd:cd03801   162 PPeKIVVIPNGVDLERF--SPPLRRKLGIPPDRPVLLFvGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGG---DGPLR 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 243 RSLKQKARDND--VVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVgLPAGDY---F 317
Cdd:cd03801   237 AELEELELGLGdrVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEV-VEDGEGglvV 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2530594339 318 PTGDIDTLASRIRSKIDNGPQRIDYS-------LGKYDWDNIAMQVASVY 360
Cdd:cd03801   316 PPDDVEALADALLRLLADPELRARLGraarervAERFSWERVAERLLDLY 365
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
196-339 3.85e-26

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 102.35  E-value: 3.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 196 RYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFEDDYSRSLKQKARDNDVVLTGFIRGRRLHSLLSNAACF 275
Cdd:pfam00534   3 KIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVF 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2530594339 276 SLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVglpAGDY-----FPTGDIDTLASRIRSKIDNGPQR 339
Cdd:pfam00534  83 VLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEV---VKDGetgflVKPNNAEALAEAIDKLLEDEELR 148
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
265-360 1.40e-16

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 75.03  E-value: 1.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 265 LHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLP--AGDYFPTGDIDTLASRIRSKIDNGPQR--- 339
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDgeTGLLVPPGDPEALAEAILRLLEDPELRrrl 93
                          90       100
                  ....*....|....*....|....*
gi 2530594339 340 ----IDYSLGKYDWDNIAMQVASVY 360
Cdd:COG0438    94 geaaRERAEERFSWEAIAERLLALY 118
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
145-308 2.41e-12

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 67.42  E-value: 2.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 145 DDVIVISDAIRRNIASRYGRTRRVhlIYNGV------PEPEiCSDDAYFSELGIKPGRYILGMSRFVPEKNLHHLIDAFN 218
Cdd:TIGR04047 140 DAVLCVSAAWAAELRAEWGIDATV--VPNGVdaarfsPAAD-AADAALRRRLGLRGGPYVLAVGGIEPRKNTIDLLEAFA 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 219 RTGLAQYGYKLVLAGDADFED--DYSRSLKQKARDND-----VVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEA 291
Cdd:TIGR04047 217 LLRARRPQAQLVIAGGATLFDydAYRREFRARAAELGvdpgpVVITGPVPDADLPALYRCADAFAFPSLKEGFGLVVLEA 296
                         170
                  ....*....|....*..
gi 2530594339 292 MSYRLPVVVSDIPANLE 308
Cdd:TIGR04047 297 LASGIPVVASDIAPFTE 313
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
92-349 9.99e-12

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 65.89  E-value: 9.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  92 IHAVGPSL----AVPLAKLLGMRVVMTNH------GPDYE-----RAKWGrlartIIKmgesWGSRFSDDVIVISDAIRR 156
Cdd:PLN02871  148 IHASSPGImvfgALFYAKLLCVPLVMSYHthvpvyIPRYTfswlvKPMWD-----IIR----FLHRAADLTLVTSPALGK 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 157 NI-ASRYGRTRRVHLIYNGVP----EPEICSDDAYFSELGIKPGRYILG-MSRFVPEKNLHHLIDAFNRTGlaqyGYKLV 230
Cdd:PLN02871  219 ELeAAGVTAANRIRVWNKGVDsesfHPRFRSEEMRARLSGGEPEKPLIVyVGRLGAEKNLDFLKRVMERLP----GARLA 294
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 231 LAGDADFEDDysrsLKQKARDNDVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVV------VSDIP 304
Cdd:PLN02871  295 FVGDGPYREE----LEKMFAGTPTVFTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVaaraggIPDII 370
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2530594339 305 ANLEVGlPAGDYFPTGDIDTLASRIRSKIDNGPQRidYSLG--------KYDW 349
Cdd:PLN02871  371 PPDQEG-KTGFLYTPGDVDDCVEKLETLLADPELR--ERMGaaareeveKWDW 420
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
8-360 8.30e-54

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 181.58  E-value: 8.30e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339   8 TRGIPGVMGGVETHCEHLYPRLAAMGYDITVVrrdSYVAGDSRTRWQGVNLVDIATPRKKAFEAIVHTIR-AVVAARRAK 86
Cdd:cd03801     6 SPELPPPVGGAERHVRELARALAARGHDVTVL---TPADPGEPPEELEDGVIVPLLPSLAALLRARRLLReLRPLLRLRK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  87 ADLLHIHAVGPSLAV-PLAKLLGMRVVMTNHGPDYER-AKWGRLARTIIKmGESWGSRFSDDVIVISDAIRRNIASRYGR 164
Cdd:cd03801    83 FDVVHAHGLLAALLAaLLALLLGAPLVVTLHGAEPGRlLLLLAAERRLLA-RAEALLRRADAVIAVSEALRDELRALGGI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 165 TR-RVHLIYNGVPEPEIcsDDAYFSELGIKPGRYILGM-SRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDadfEDDYS 242
Cdd:cd03801   162 PPeKIVVIPNGVDLERF--SPPLRRKLGIPPDRPVLLFvGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGG---DGPLR 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 243 RSLKQKARDND--VVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVgLPAGDY---F 317
Cdd:cd03801   237 AELEELELGLGdrVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEV-VEDGEGglvV 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2530594339 318 PTGDIDTLASRIRSKIDNGPQRIDYS-------LGKYDWDNIAMQVASVY 360
Cdd:cd03801   316 PPDDVEALADALLRLLADPELRARLGraarervAERFSWERVAERLLDLY 365
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
9-353 7.20e-40

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 144.43  E-value: 7.20e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339   9 RGIPGVMGGVETHCEHLYPRLAAMGYD---ITVVRRDSYVAGDSRTRWQGVNLVDIATPRKKAFEaivHTIRAVVAARRA 85
Cdd:cd03809     7 RSLAQRLTGIGRYTRELLKALAKNDPDesvLAVPPLPGELLRLLREYPELSLGVIKIKLWRELAL---LRWLQILLPKKD 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  86 KADLLHIhavgPSLAVPLaKLLGMRVVMTNH--GPDYERAKWGRLARTIIKMGESWGSRFSDDVIVISDAIRRNIASRYG 163
Cdd:cd03809    84 KPDLLHS----PHNTAPL-LLKGCPQVVTIHdlIPLRYPEFFPKRFRLYYRLLLPISLRRADAIITVSEATRDDIIKFYG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 164 -RTRRVHLIYNGV-PEPEICSDDAYFSELGIKPGRYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFEDDY 241
Cdd:cd03809   159 vPPEKIVVIPLGVdPSFFPPESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVGGKGWEDEE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 242 SRSLKQKARDND-VVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLPAGDYFPTG 320
Cdd:cd03809   239 LLDLVKKLGLGGrVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPEVAGDAALYFDPL 318
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2530594339 321 DIDTLASRIRSKIDNGPQRIDYS------LGKYDWDNIA 353
Cdd:cd03809   319 DPESIADAILRLLEDPSLREELIrkglerAKKFSWEKTA 357
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
15-348 4.32e-32

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 123.62  E-value: 4.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  15 MGGVETHCEHLYPRLAAMGYDITVV----RRDSYVAGDSRTRWQGV---NLVDIATPRKKAFEAIVHTIRAVVAarraka 87
Cdd:cd03811    11 GGGAERVLLNLANALDKRGYDVTLVllrdEGDLDKQLNGDVKLIRLlirVLKLIKLGLLKAILKLKRILKRAKP------ 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAVGPSLAVPLAKLLGMRVVMTNHGpDYERAKWGRLARTIIKMGeswgSRFSDDVIVISDAIRRNIASRYGRTR- 166
Cdd:cd03811    85 DVVISFLGFATYIVAKLAAARSKVIAWIHS-SLSKLYYLKKKLLLKLKL----YKKADKIVCVSKGIKEDLIRLGPSPPe 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 167 RVHLIYNGVPEPEICSDDAYFSELGIKPGRYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFEDDysrsLK 246
Cdd:cd03811   160 KIEVIYNPIDIDRIRALAKEPILNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILGDGPLREE----LE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 247 QKARDND----VVLTGFIRgrRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVgLPAGDY---FPT 319
Cdd:cd03811   236 KLAKELGlaerVIFLGFQS--NPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREI-LDDGENgllVPD 312
                         330       340
                  ....*....|....*....|....*....
gi 2530594339 320 GDIDTLASRIRSKIDNGPqriDYSLGKYD 348
Cdd:cd03811   313 GDAAALAGILAALLQKKL---DAALRERL 338
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
88-344 3.44e-31

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 121.16  E-value: 3.44e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAVGPS-LAVPLAKLLGM-RVVMTNHGPDYERAKwGRLARTIIKMGESWGSRFSDDVIVISDAIRRNIASRYGRT 165
Cdd:cd03808    83 DIVHCHTPKPGiLGRLAARLAGVpKVIYTVHGLGFVFTE-GKLLRLLYLLLEKLALLFTDKVIFVNEDDRDLAIKKGIIK 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 166 RRVHLIY--NGVPEPEICsddayFSELGIKPGRYILGM-SRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFEDDYS 242
Cdd:cd03808   162 KKKTVLIpgSGVDLDRFQ-----YSPESLPSEKVVFLFvARLLKDKGIDELIEAAKILKKKGPNVRFLLVGDGELENPSE 236
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 243 RSLKQKARDNDVVLTGFIRGrrLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEV------GLpagdY 316
Cdd:cd03808   237 ILIEKLGLEGRIEFLGFRSD--VPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELvidgvnGF----L 310
                         250       260
                  ....*....|....*....|....*...
gi 2530594339 317 FPTGDIDTLASRIRSKIDNGPQRIDYSL 344
Cdd:cd03808   311 VPPGDVEALADAIEKLIEDPELRKEMGE 338
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
14-335 8.01e-30

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 117.07  E-value: 8.01e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  14 VMGGVETHCEHLYPRLAAMGYDITVVRrdsyVAGDSRTRWQGVNLVDIATpRKKAFEAIVHTIRAVVAARRAKADLLHIH 93
Cdd:cd03819     9 EIGGAETYILDLARALAERGHRVLVVT----AGGPLLPRLRQIGIGLPGL-KVPLLRALLGNVRLARLIRRERIDLIHAH 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  94 AVGPSLAVPLA-KLLGMRVVMTNHGPDYERAKWGRLARTIIKMGeswgsrfsDDVIVISDAIRRNIASRYGRTR-RVHLI 171
Cdd:cd03819    84 SRAPAWLGWLAsRLTGVPLVTTVHGSYLATYHPKDFALAVRARG--------DRVIAVSELVRDHLIEALGVDPeRIRVI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 172 YNGV----PEPEicSDDAYFSELGIKPGRYILGM-SRFVPEKNLHHLIDAFNRTGlAQYGYKLVLAGDADFEDDYSRSLK 246
Cdd:cd03819   156 PNGVdtdrFPPE--AEAEERAQLGLPEGKPVVGYvGRLSPEKGWLLLVDAAAELK-DEPDFRLLVAGDGPERDEIRRLVE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 247 QKARDNDVVLTGFIRgrRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLP--AGDYFPTGDIDT 324
Cdd:cd03819   233 RLGLRDRVTFTGFRE--DVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHgrTGLLVPPGDAEA 310
                         330
                  ....*....|.
gi 2530594339 325 LASRIRSKIDN 335
Cdd:cd03819   311 LADAIRAAKLL 321
GT4-like cd04955
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
2-353 1.56e-29

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in certain bacteria and Archaea.


Pssm-ID: 340858 [Multi-domain]  Cd Length: 379  Bit Score: 117.22  E-value: 1.56e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339   2 KVFVTGTRGIPGVMGGVETHCEHLYPRLAAMGYDITVVRRdSYVAGDSRTRWQGVNLVDIATPRKKAFEAIVHTIRAVVA 81
Cdd:cd04955     1 HIFIIGSRGLPAKYGGFETFVEKLTERQQSDNIKYHVACL-SENSKQQHFEYNGADCFYVKVPKIGPARAIAYDIAALNY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  82 ARRAKAD------LLHIHA--VGPSLA--VPLAKLLGMRVVMTNHGPDYERAKWGRLARTIIKMGESWGSRFSDDVIVIS 151
Cdd:cd04955    80 ALKYIKEqniknpIFYILAcrIGPFIApyIKKIHKLGGKLFVNPDGLEWKRAKWSLPVRKYWKFSESLMVKHADLLICDS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 152 DAIRRNIASRYGRTRRVHLIYnGVPE-PEICSDDA-----YFSELGIKPGRYILGMSRFVPEKNLHHLIDAFNRTGLaqy 225
Cdd:cd04955   160 KNIEKYIRKEYGKSNTTFIAY-GTDTlKSSLSDEDekvreWYKEKGVKPGKYYLIVGRFVPENNYETMIREFMKSST--- 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 226 GYKLVLAGDADFEDDYSRSLKQKARDND--VVLTGFIRGRRLHSLLSNaACFSLPSSHE--GLPISLLEAMSYRLPVVVS 301
Cdd:cd04955   236 KRDLVIITNVEGNAYYELLLKKTAFDHDerIKFVGTVYDQELLKYIRE-NAFAYLHGHEvgGTNPSLLEALGSTDLNLLL 314
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2530594339 302 DIPANLEVGLPAGDYFptgDIDTLASRIRSKIDNGP-----------QRIdysLGKYDWDNIA 353
Cdd:cd04955   315 DVGFNREVAEDAALYW---KKEPLASLIDEVDNLNPdeisdlgkkakQRI---EEAYTWEKIV 371
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
16-339 1.76e-29

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 116.65  E-value: 1.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  16 GGVETHCEHLYPRLAAMGYDITVVR--RDSYVAGDSRTRWqgvnlVDIATPRKKAFEAIVHTIRAVVAARRAKADLLHIH 93
Cdd:cd03807    12 GGAETMLLRLLEHMDKSRFEHVVISltGDGVLGEELLAAG-----VPVVCLGLSSGKDPGVLLRLAKLIRKRNPDVVHTW 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  94 AVGPSLAVPLAKLL--GMRVVMTNHGPDYerakWGRLARTIIKMgESWGSRFSDDVIVISDAIRRNIASRYGRTRRVHLI 171
Cdd:cd03807    87 MYHADLIGGLAAKLagGVKVIWSVRSSNI----PQRLTRLVRKL-CLLLSKFSPATVANSSAVAEFHQEQGYAKNKIVVI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 172 YNGV------PEPEICSDDAyfSELGIKPGRYILG-MSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFEDDYSRS 244
Cdd:cd03807   162 YNGIdlfklsPDDASRARAR--RRLGLAEDRRVIGiVGRLHPVKDHSDLLRAAALLVETHPDLRLLLVGRGPERPNLERL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 245 LKQKARDNDVVLTGFIRgrRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLE-VGLPAGDYFPTGDID 323
Cdd:cd03807   240 LLELGLEDRVHLLGERS--DVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAElVDDGTGFLVPAGDPQ 317
                         330
                  ....*....|....*.
gi 2530594339 324 TLASRIRSKIDNGPQR 339
Cdd:cd03807   318 ALADAIRALLEDPEKR 333
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
88-360 4.38e-29

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 115.55  E-value: 4.38e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAVGPS--LAVPLAKLLGMRVVMTNHGPDYERAKWGRLARTIIKmgesWGSRFSDDVIVISDAIRRNIASRYGRT 165
Cdd:cd03798    97 DLIHAHFAYPAgfAAALLARLYGVPYVVTEHGSDINVFPPRSLLRKLLR----WALRRAARVIAVSKALAEELVALGVPR 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 166 RRVHLIYNGVpepeicsDDAYFSELG---IKP--GRYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFEDD 240
Cdd:cd03798   173 DRVDVIPNGV-------DPARFQPEDrglGLPldAFVILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVGDGPLREA 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 241 YSRSLKQKARDNDVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDI--PANLEVGLPAGDYFP 318
Cdd:cd03798   246 LRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVggIPEVVGDPETGLLVP 325
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2530594339 319 TGDIDTLASRIRSKID------NGPQRIDYSLGKYDWDNIAMQVASVY 360
Cdd:cd03798   326 PGDADALAAALRRALAepylreLGEAARARVAERFSWVKAADRIAAAY 373
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
13-355 1.10e-27

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 111.56  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  13 GVMGGVE----THCEHLyprlAAMGYDITVV-----RRDSYVAGDSRtrwqgVNLVDIATPRKKAFEAIVHTIRAVVA-- 81
Cdd:cd03820    10 SNAGGAErvaiNLANHL----AKKGYDVTIIsldsaEKPPFYELDDN-----IKIKNLGDRKYSHFKLLLKYFKKVRRlr 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  82 ARRAKADLLHIHAVGPSLAVPLAKL-LGMRVVMTNHG-PDYERAKWGRlartiiKMGESWGSRFSDDVIVISDAIRRNIA 159
Cdd:cd03820    81 KYLKNNKPDVVISFRTSLLTFLALIgLKSKLIVWEHNnYEAYNKGLRR------LLLRRLLYKRADKIVVLTEADKLKKY 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 160 SRYGRtrRVHLIYNGVPEPEicsddayFSELGIKPGRYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFED 239
Cdd:cd03820   155 KQPNS--NVVVIPNPLSFPS-------EEPSTNLKSKRILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGDGPERE 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 240 dysrSLKQKARDND----VVLTGFIRGrrLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPA-------NLE 308
Cdd:cd03820   226 ----ELEKLIDKLGledrVKLLGPTKN--IAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCPTgpseiieDGE 299
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2530594339 309 VGLpagdYFPTGDIDTLASRIRSKIDNGPQRIDYS------LGKYDWDNIAMQ 355
Cdd:cd03820   300 NGL----LVPNGDVDALAEALLRLMEDEELRKKMGknarknAERFSIEKIIKQ 348
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
196-339 3.85e-26

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 102.35  E-value: 3.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 196 RYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFEDDYSRSLKQKARDNDVVLTGFIRGRRLHSLLSNAACF 275
Cdd:pfam00534   3 KIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVF 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2530594339 276 SLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVglpAGDY-----FPTGDIDTLASRIRSKIDNGPQR 339
Cdd:pfam00534  83 VLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEV---VKDGetgflVKPNNAEALAEAIDKLLEDEELR 148
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
88-355 5.89e-23

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 98.60  E-value: 5.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAV--GPSLAV-PLAKLLGMRVVMTNHGP------DYERAKWgRLARTIIkmgESWGSRFSDDVIVISDAIRRNI 158
Cdd:cd03821    92 DVVHIHGVwtYTSLAAcKLARRRGIPYVVSPHGMldpwalQQKHWKK-RIALHLI---ERRNLNNAALVHFTSEQEADEL 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 159 aSRYGRTRRVHLIYNGVPEPEICSDDAYFSELGIKPG-RYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADf 237
Cdd:cd03821   168 -RRFGLEPPIAVIPNGVDIPEFDPGLRDRRKHNGLEDrRIILFLGRIHPKKGLDLLIRAARKLAEQGRDWHLVIAGPDD- 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 238 eDDYSRSLKQKAR---DNDVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLPAG 314
Cdd:cd03821   246 -GAYPAFLQLQSSlglGDRVTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCGLSELVEAGC 324
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2530594339 315 DYFPTGDIDTLASRIRSKIDNGP---------QRIDYSLGKYDWDNIAMQ 355
Cdd:cd03821   325 GVVVDPNVSSLAEALAEALRDPAdrkrlgemaRRARQVEENFSWEAVAGQ 374
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
195-330 2.10e-21

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 88.72  E-value: 2.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 195 GRYILGMSRFVPE-KNLHHLIDAFNRTGLAQYGYKLVLAGDADfeddySRSLKQKAR--DNDVVLTGFIRgrRLHSLLSN 271
Cdd:pfam13692   1 RPVILFVGRLHPNvKGVDYLLEAVPLLRKRDNDVRLVIVGDGP-----EEELEELAAglEDRVIFTGFVE--DLAELLAA 73
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2530594339 272 AACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEV-----GLpagdYFPTGDIDTLASRIR 330
Cdd:pfam13692  74 ADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELvdgenGL----LVPPGDPEALAEAIL 133
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
15-309 2.72e-20

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 90.80  E-value: 2.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  15 MGGVETHCEHLYPRLAAMGYDITVV--RRD--SYVAGDSRTRWQGVNL---VDIATPRKKAFEAIvhtiravVAARRAKA 87
Cdd:cd03817    13 VNGVATSVRNLARALEKRGHEVYVItpSDPgaEDEEEVVRYRSFSIPIrkyHRQHIPFPFKKAVI-------DRIKELGP 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIH---AVGpSLAVPLAKLLGMRVVMTNHGP--DY--ERAKWGRLARTIIKMGESWGSRFSDDVIVISDAIRRNIAS 160
Cdd:cd03817    86 DIIHTHtpfSLG-KLGLRIARKLKIPIVHTYHTMyeDYlhYIPKGKLLVKAVVRKLVRRFYNHTDAVIAPSEKIKDTLRE 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 161 rYGRTRRVHLIYNGVPEP--EICSDDAYFSELGIKPGRYILGM-SRFVPEKNLHHLIDAFNRtGLAQYGYKLVLAGDADf 237
Cdd:cd03817   165 -YGVKGPIEVIPNGIDLDkfEKPLNTEERRKLGLPPDEPILLYvGRLAKEKNIDFLLRAFAE-LKKEPNIKLVIVGDGP- 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2530594339 238 eddYSRSLKQKARDN----DVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEV 309
Cdd:cd03817   242 ---EREELKELARELgladKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASEL 314
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
88-329 5.40e-19

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 87.12  E-value: 5.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIH-AVGPSLAVPLAKLLGMRVVMTNHGPDY----ERAKWGRLARTIIKMGESWGSRFSDDVIVISDAIRRNIASRY 162
Cdd:cd05844    83 ALVHAHfGRDGVYALPLARALGVPLVVTFHGFDIttsrAWLAASPGWPSQFQRHRRALQRPAALFVAVSGFIRDRLLARG 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 163 GRTRRVHLIYNGVpepeicsDDAYFSELGIK-PGRYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFeddy 241
Cdd:cd05844   163 LPAERIHVHYIGI-------DPAKFAPRDPAeRAPTILFVGRLVEKKGCDVLIEAFRRLAARHPTARLVIAGDGPL---- 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 242 SRSLKQKARDND-VVLTGFIRGRRLHSLLSNAACFSLPS------SHEGLPISLLEAMSYRLPVV---VSDIPANLEVGl 311
Cdd:cd05844   232 RPALQALAAALGrVRFLGALPHAEVQDWMRRAEIFCLPSvtaasgDSEGLGIVLLEAAACGVPVVssrHGGIPEAILDG- 310
                         250
                  ....*....|....*...
gi 2530594339 312 PAGDYFPTGDIDTLASRI 329
Cdd:cd05844   311 ETGFLVPEGDVDALADAL 328
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
88-361 4.58e-18

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 84.27  E-value: 4.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAVGPS--LAVPLAKLLGMRVVMTNHG--PDYERAKWGRLARTIIKMGESWGSRFSDDVIVISDAIRRNIASRyG 163
Cdd:cd03814    86 DIIHIATPGPLglAALRAARRLGLPVVTSYHTdfPEYLSYYTLGPLSWLAWAYLRWFHNPFDTTLVPSPSIARELEGH-G 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 164 RtRRVHLIYNGV------PEPeicSDDAYFSELGIKPGRYILGMSRFVPEKNLHHLIDAFnRTGLAQYGYKLVLAGD--- 234
Cdd:cd03814   165 F-ERVRLWPRGVdtelfhPSR---RDAALRRRLGPPGRPLLLYVGRLAPEKNLEALLDAD-LPLAASPPVRLVVVGDgpa 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 235 -ADFEddysrslkqkARDNDVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEV--GL 311
Cdd:cd03814   240 rAELE----------ARGPDVIFTGFLTGEELARAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIvrPG 309
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2530594339 312 PAGDYFPTGDIDTLASRIRSKIDNGPQRIDYSLG------KYDWDNIAMQVASVYG 361
Cdd:cd03814   310 GTGALVEPGDAAAFAAALRALLEDPELRRRMAARaraeaeRYSWEAFLDNLLDYYA 365
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
8-317 1.48e-17

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 80.91  E-value: 1.48e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339   8 TRGIPGVMGGVETHCEHLYPRLAAMGYDITVVrrdsyvagdsrtrwqgvnlvdiatprkkaFEAIVHTIRAVVAARRAKA 87
Cdd:cd01635     5 TGEYPPLRGGLELHVRALARALAALGHEVTVL-----------------------------ALLLLALRRILKKLLELKP 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHA--VGPSLAVPLAKLLGMRVVMTNHGPDYERAKWGRLARTIIkmgESWGSRFSDDVIVisdairrniasrygrt 165
Cdd:cd01635    56 DVVHAHSphAAALAALLAARLLGIPIVVTVHGPDSLESTRSELLALAR---LLVSLPLADKVSV---------------- 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 166 rrvhliyngvpepeicsddayfselgikpgryilgmSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDAD-FEDDYSRS 244
Cdd:cd01635   117 ------------------------------------GRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGeREEEEALA 160
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2530594339 245 LKQKARDNDVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLPAGDYF 317
Cdd:cd01635   161 AALGLLERVVIIGGLVDDEVLELLLAAADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGL 233
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
28-353 4.36e-17

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 81.62  E-value: 4.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  28 RLAAMGYDITVV------RRDSYVAGDSRTRwQGVNLVDIATPRKK----------AFEAIVHTIRAVVAARRAKaDLLH 91
Cdd:cd03794    26 ELVRRGHEVTVLtpspnyPLGRIFAGATETK-DGIRVIRVKLGPIKknglirrllnYLSFALAALLKLLVREERP-DVII 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  92 IHAVGPSLAVP---LAKLLGMRVVM------TNHGPDYERAKWGRLARTIIKMgESWGSRFSDDVIVISDAIRRNIASRY 162
Cdd:cd03794   104 AYSPPITLGLAallLKKLRGAPFILdvrdlwPESLIALGVLKKGSLLKLLKKL-ERKLYRLADAIIVLSPGLKEYLLRKG 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 163 GRTRRVHLIYNGVPEPEICSDDA-YFSELGIKPGRYILGMSRFVPEK-NLHHLIDAFNRtgLAQY-GYKLVLAGDADFED 239
Cdd:cd03794   183 VPKEKIIVIPNWADLEEFKPPPKdELRKKLGLDDKFVVVYAGNIGKAqGLETLLEAAER--LKRRpDIRFLFVGDGDEKE 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 240 DYSRSLKQKARDNdVVLTGFIRGRRLHSLLSNAAC--FSLPSSHE---GLPISLLEAMSYRLPVVVSDIPAN--LEVGLP 312
Cdd:cd03794   261 RLKELAKARGLDN-VTFLGRVPKEEVPELLSAADVglVPLKDNPAnrgSSPSKLFEYMAAGKPILASDDGGSdlAVEING 339
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2530594339 313 AGDYFPTGDIDTLASRIRSKIDNgPQRI--------DYSLGKYDWDNIA 353
Cdd:cd03794   340 CGLVVEPGDPEALADAILELLDD-PELRramgengrELAEEKFSREKLA 387
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
16-175 7.63e-17

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 77.19  E-value: 7.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  16 GGVETHCEHLYPRLAAMGYDITVV-RRDSYVAGDSRTRWQGVNLVDIATPRKKAFeAIVHTIRAVVAARRAKADLLHIHA 94
Cdd:pfam13439   1 GGVERYVLELARALARRGHEVTVVtPGGPGPLAEEVVRVVRVPRVPLPLPPRLLR-SLAFLRRLRRLLRRERPDVVHAHS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  95 VGPSLAVPLA--KLLGMRVVMTNHGPDYERAKWG---RLARTIIKMGESWGSRFSDDVIVISDAIRRNIASRYGRTR-RV 168
Cdd:pfam13439  80 PFPLGLAALAarLRLGIPLVVTYHGLFPDYKRLGarlSPLRRLLRRLERRLLRRADRVIAVSEAVADELRRLYGVPPeKI 159

                  ....*..
gi 2530594339 169 HLIYNGV 175
Cdd:pfam13439 160 RVIPNGV 166
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
265-360 1.40e-16

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 75.03  E-value: 1.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 265 LHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLP--AGDYFPTGDIDTLASRIRSKIDNGPQR--- 339
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDgeTGLLVPPGDPEALAEAILRLLEDPELRrrl 93
                          90       100
                  ....*....|....*....|....*
gi 2530594339 340 ----IDYSLGKYDWDNIAMQVASVY 360
Cdd:COG0438    94 geaaRERAEERFSWEAIAERLLALY 118
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
11-342 1.37e-15

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 76.94  E-value: 1.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  11 IPGVM--GGVETHCEHLYPRLAAMGYDITVV----RRDSYvagDSRTRWQGVNLVDIaTPRKKAFeaIVHTIRAVVAARR 84
Cdd:cd03812     5 IVGGMnvGGIETFLMNLYRKLDKSKIEFDFLatsdDKGEY---DEELEELGGKIFYI-PPKKKNI--IKYFIKLLKLIKK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  85 AKADLLHIHAVGPSLAVPL-AKLLGMRV-VMTNHGPDYERAKwgrlARTIIKMGESW-GSRFSDDVIVISDAIRRNIASR 161
Cdd:cd03812    79 EKYDIVHVHGSSSNGIILLlAAKAGVPVrIAHSHNTKDSSIK----LRKIRKNVLKKlIERLSTKYLACSEDAGEWLFGE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 162 YGRtRRVHLIYNGVP-EPEICSDDAYFS--ELGIKPGRYILG-MSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADF 237
Cdd:cd03812   155 VEN-GKFKVIPNGIDiEKYKFNKEKRRKrrKLLILEDKLVLGhVGRFNEQKNHSFLIDIFEELKKKNPNVKLVLVGEGEL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 238 EDDysrsLKQKARD----NDVVLTGFiRGRrLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLPA 313
Cdd:cd03812   234 KEK----IKEKVKElgleDKVIFLGF-RND-VSEILSAMDVFLFPSLYEGLPLVAVEAQASGLPCLLSDTITKECDITNN 307
                         330       340
                  ....*....|....*....|....*....
gi 2530594339 314 GDYFPtgdIDTLASRIRSKIDNGPQRIDY 342
Cdd:cd03812   308 VEFLP---LNETPSTWAEKILKLIKRKRR 333
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
88-331 3.99e-15

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 75.85  E-value: 3.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIH-AVGPSLAVPLAKLL---GMRVVMTNHGPD-----YERAkwgrLARTIikmgeSWGSRFSDDVIVISDAIRRNI 158
Cdd:cd04962    86 DVLHAHyAIPHASCAYLAREIlgeKIPIVTTLHGTDitlvgYDPS----LQPAV-----RFSINKSDRVTAVSSSLRQET 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 159 ASRYGRTRRVHLIYNGVPEPEICS--DDAYFSELGIKPG-RYILGMSRFVPEKNLHHLIDAFNRTGlAQYGYKLVLAGDA 235
Cdd:cd04962   157 YELFDVDKDIEVIHNFIDEDVFKRkpAGALKRRLLAPPDeKVVIHVSNFRPVKRIDDVVRVFARVR-RKIPAKLLLVGDG 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 236 DfedDYSRSlKQKARD----NDVVLTGfiRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPanlevGL 311
Cdd:cd04962   236 P---ERVPA-EELARElgveDRVLFLG--KQDDVEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAG-----GI 304
                         250       260
                  ....*....|....*....|....*..
gi 2530594339 312 P-------AGDYFPTGDIDTLASRIRS 331
Cdd:cd04962   305 PevvkhgeTGFLSDVGDVDAMAKSALS 331
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
12-330 5.36e-15

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 75.44  E-value: 5.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  12 PGVMGGVETHCEHLYPRLAAMGYDITVV---RRDSYVAGDSRT---RWQGVNLVDIATPRKKAFEAIVH-----TIRAVV 80
Cdd:cd03823    11 PQRVGGAEISVHDLAEALVAEGHEVAVLtagVGPPGQATVARSvvrYRRAPDETLPLALKRRGYELFETynpglRRLLAR 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  81 AARRAKADLLHIHA---VGPSLaVPLAKLLGMRVVMTNHgpDYErakWGRLARTIIKMGeswgsrfSDDVIVISdairRN 157
Cdd:cd03823    91 LLEDFRPDVVHTHNlsgLGASL-LDAARDLGIPVVHTLH--DYW---LLCPRQFLFKKG-------GDAVLAPS----RF 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 158 IASRYGR----TRRVHLIYNGVPEPEIcsddayfSELGIKPGR------YILGMSrfvPEKNLHHLIDAFNRtgLAQYGY 227
Cdd:cd03823   154 TANLHEAnglfSARISVIPNAVEPDLA-------PPPRRRPGTerlrfgYIGRLT---EEKGIDLLVEAFKR--LPREDI 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 228 KLVLAGDADFEDdysrsLKQKARDNDVVLTGFIRGRRLHSLLSNAACFSLPSS-HEGLPISLLEAMSYRLPVVVSDIPAN 306
Cdd:cd03823   222 ELVIAGHGPLSD-----ERQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIASDLGGI 296
                         330       340
                  ....*....|....*....|....*.
gi 2530594339 307 LE--VGLPAGDYFPTGDIDTLASRIR 330
Cdd:cd03823   297 AEliQPGVNGLLFAPGDAEDLAAAMR 322
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
12-299 8.14e-15

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 74.63  E-value: 8.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  12 PGVMGGVETHCEHLYPRLAAMGYDITVVrrdsyVAGDSRTRWQGVNLVDIAT-PRKKAFEAIV--HTIRAVVAARRAKAD 88
Cdd:cd03802    14 PGKYGGTELVVSALTEGLVRRGHEVTLF-----APGDSHTSAPLVAVIPRALrLDPIPQESKLaeLLEALEVQLRASDFD 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  89 LLHIHAVGPSLavPLAKLLGMRVVMTNHGPdyerakwgrlarTIIKMGESWGSRFSDDVIVISDAIRRNiasrYGRTRRV 168
Cdd:cd03802    89 VIHNHSYDWLP--PFAPLIGTPFVTTLHGP------------SIPPSLAIYAAEPPVNYVSISDAQRAA----TPPIDYL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 169 HLIYNGVPepeicSDDAYFSElgiKPGRYILGMSRFVPEKNLHHLIDAFNRTGLaqygyKLVLAGDADFEdDYSRSLKQK 248
Cdd:cd03802   151 TVVHNGLD-----PADYRFQP---DPEDYLAFLGRIAPEKGLEDAIRVARRAGL-----PLKIAGKVRDE-DYFYYLQEP 216
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2530594339 249 ARDNDVVLTGFIRGRRLHSLLSNAACFSLPSS-HEGLPISLLEAMSYRLPVV 299
Cdd:cd03802   217 LPGPRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVI 268
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
145-348 9.24e-15

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 74.26  E-value: 9.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 145 DDVIVISDAIRRNIASRYGRTRRVHLIYNGVpepeicSDDAYFSELGIKPGRY-ILGMSRFVPEKNLHHLIDAFNRTGLA 223
Cdd:cd04949   115 DAIIVSTEQQKQDLSERFNKYPPIFTIPVGY------VDQLDTAESNHERKSNkIITISRLAPEKQLDHLIEAVAKAVKK 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 224 QYGYKLVLAGDADFEDDYSRSLKQKARDNDVVLTGFIRGrrLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDI 303
Cdd:cd04949   189 VPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGYHSN--LDQEYQDAYLSLLTSQMEGFGLTLMEAIGHGLPVVSYDV 266
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2530594339 304 ---PANLEVGLPAGDYFPTGDIDTLASRIRSKIDNGPQRIDYSLGKYD 348
Cdd:cd04949   267 kygPSELIEDGENGYLIEKNNIDALADKIIELLNDPEKLQQFSEESYK 314
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
88-360 3.53e-13

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 69.78  E-value: 3.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAVGPSLAVPLAKLL--GMRVVMTNHGPDYErakwGRLARTIIKMgeswgSRFSDDVI--VISDAIRRNIASRYG 163
Cdd:cd04951    81 DVVHSHMFHANIFARFLRMLypIPLLICTAHNKNEG----GRIRMFIYRL-----TDFLCDITtnVSREALDEFIAKKAF 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 164 RTRRVHLIYNGVP----EPEICSDDAYFSELGIKPGRY-ILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFE 238
Cdd:cd04951   152 SKNKSVPVYNGIDlnkfKKDINVRLKIRNKLNLKNDEFvILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAGDGPLR 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 239 DDYSRSLKQKARDNDVVLTGFIRgrRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLPAGDYFP 318
Cdd:cd04951   232 NELERLICNLNLVDRVILLGQIS--NISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDHNYVVP 309
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2530594339 319 TGDIDTLASRIRSKIDNGPQ-------RIDYSLGKYDWDNIAMQVASVY 360
Cdd:cd04951   310 VSDPQLLAEKIKEIFDMSDEerdilgnKNEYIAKNFSINTIVNEWERLY 358
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
16-174 5.09e-13

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 66.27  E-value: 5.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  16 GGVETHCEHLYPRLAAMGYDITVVRRDSYVAGDSRTRWqGVNLVDIATPRK-KAFEAIVHTIRAVVAARRAKADLLHIHA 94
Cdd:pfam13579   1 GGIGVYVLELARALAALGHEVRVVTPGGPPGRPELVGD-GVRVHRLPVPPRpSPLADLAALRRLRRLLRAERPDVVHAHS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  95 VGPSLAVPLAK-LLGMRVVMTNHGPDYERAkwGRLARTIIKMGESWGSRFSDDVIVISDAIRRNIASRYGRTRRVHLIYN 173
Cdd:pfam13579  80 PTAGLAARLARrRRGVPLVVTVHGLALDYG--SGWKRRLARALERRLLRRADAVVVVSEAEAELLRALGVPAARVVVVPN 157

                  .
gi 2530594339 174 G 174
Cdd:pfam13579 158 G 158
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
145-308 2.41e-12

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 67.42  E-value: 2.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 145 DDVIVISDAIRRNIASRYGRTRRVhlIYNGV------PEPEiCSDDAYFSELGIKPGRYILGMSRFVPEKNLHHLIDAFN 218
Cdd:TIGR04047 140 DAVLCVSAAWAAELRAEWGIDATV--VPNGVdaarfsPAAD-AADAALRRRLGLRGGPYVLAVGGIEPRKNTIDLLEAFA 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 219 RTGLAQYGYKLVLAGDADFED--DYSRSLKQKARDND-----VVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEA 291
Cdd:TIGR04047 217 LLRARRPQAQLVIAGGATLFDydAYRREFRARAAELGvdpgpVVITGPVPDADLPALYRCADAFAFPSLKEGFGLVVLEA 296
                         170
                  ....*....|....*..
gi 2530594339 292 MSYRLPVVVSDIPANLE 308
Cdd:TIGR04047 297 LASGIPVVASDIAPFTE 313
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
126-325 9.12e-12

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 65.38  E-value: 9.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 126 GRLARTIIKMGESWGSRFS---DDVIVISDAIRRNIASRYGRTRRVhlIYNGV----PEPEICSDDayfselgikpgrYI 198
Cdd:cd03804   137 SLLASLFLHYLRLWDVRTAqrvDLFIANSQFVARRIKKFYGRESTV--IYPPVdtdaFAPAADKED------------YY 202
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 199 LGMSRFVPEKNLHHLIDAFNRTglaqyGYKLVLAGDAdfEDdySRSLKQKARDNdVVLTGFIRGRRLHSLLSNAACFSLP 278
Cdd:cd03804   203 LTASRLVPYKRIDLAVEAFNEL-----PKRLVVIGDG--PD--LDRLRAMASPN-VEFLGYQPDEVLKELLSKARAFVFA 272
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2530594339 279 SShEGLPISLLEAMSYRLPVVVSDIPANLEV--GLPAGDYFPTGDIDTL 325
Cdd:cd03804   273 AE-EDFGIVPVEAQACGTPVIAFGKGGALETvrPGPTGILFGEQTVESL 320
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
92-349 9.99e-12

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 65.89  E-value: 9.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  92 IHAVGPSL----AVPLAKLLGMRVVMTNH------GPDYE-----RAKWGrlartIIKmgesWGSRFSDDVIVISDAIRR 156
Cdd:PLN02871  148 IHASSPGImvfgALFYAKLLCVPLVMSYHthvpvyIPRYTfswlvKPMWD-----IIR----FLHRAADLTLVTSPALGK 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 157 NI-ASRYGRTRRVHLIYNGVP----EPEICSDDAYFSELGIKPGRYILG-MSRFVPEKNLHHLIDAFNRTGlaqyGYKLV 230
Cdd:PLN02871  219 ELeAAGVTAANRIRVWNKGVDsesfHPRFRSEEMRARLSGGEPEKPLIVyVGRLGAEKNLDFLKRVMERLP----GARLA 294
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 231 LAGDADFEDDysrsLKQKARDNDVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVV------VSDIP 304
Cdd:PLN02871  295 FVGDGPYREE----LEKMFAGTPTVFTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVaaraggIPDII 370
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2530594339 305 ANLEVGlPAGDYFPTGDIDTLASRIRSKIDNGPQRidYSLG--------KYDW 349
Cdd:PLN02871  371 PPDQEG-KTGFLYTPGDVDDCVEKLETLLADPELR--ERMGaaareeveKWDW 420
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
88-345 2.22e-11

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 64.22  E-value: 2.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAvgPSlavPLAKLL----GMR--VVMTNHGpDYERAKwgrLARTIIKMGESWGSRFSDDVIVISDAIRRNIASR 161
Cdd:cd03795    85 DIIHYHF--PN---PLADLLlffsGAKkpVVVHWHS-DIVKQK---KLLKLYKPLMTRFLRRADRIIATSPNYVETSPTL 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 162 YGRTRRVHLIYNGVPEPEICSDDAYFSE--LGIKPGRYILGMSRFVPEKNLHHLIDAfnrtglAQY-GYKLVLAGDADFE 238
Cdd:cd03795   156 REFKNKVRVIPLGIDKNVYNIPRVDFENikREKKGKKIFLFIGRLVYYKGLDYLIEA------AQYlNYPIVIGGEGPLK 229
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 239 DDysrsLKQKARDN---DVVLTGFIRGRRLHSLLSNAACFSLPS--SHEGLPISLLEAMSYRLPVVVSDIPA-------N 306
Cdd:cd03795   230 PD----LEAQIELNlldNVKFLGRVDDEEKVIYLHLCDVFVFPSvlRSEAFGIVLLEAMMCGKPVISTNIGTgvpyvnnN 305
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2530594339 307 LEVGLPAgdyfPTGDIDTLASRIRSKIDNGPQRIDYSLG 345
Cdd:cd03795   306 GETGLVV----PPKDPDALAEAIDKLLSDEELRESYGEN 340
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
103-358 4.46e-11

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 63.80  E-value: 4.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 103 LAKLLGMRVVMTNHGpdYERAKWGRlartiikMGESWGSRFS-------------DDVIVISDAIRRNIASRYGRTR-RV 168
Cdd:cd03800   119 LARRLGVPLVHTFHS--LGRVKYRH-------LGAQDTYHPSlritaeeqileaaDRVIASTPQEADELISLYGADPsRI 189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 169 HLIYNGV------PEPEicsDDAYFSELGIKP-GRYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAG--DADFED 239
Cdd:cd03800   190 NVVPPGVdlerffPVDR---AEARRARLLLPPdKPVVLALGRLDPRKGIDTLVRAFAQLPELRELANLVLVGgpSDDPLS 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 240 DYSRSLKQKARDN----DVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVS------DIPANLEV 309
Cdd:cd03800   267 MDREELAELAEELglidRVRFPGRVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATavgglqDIVRDGRT 346
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2530594339 310 GLpagdYFPTGDIDTLASRIRSKIDNGPQRIDYSLG-------KYDWDNIAMQVAS 358
Cdd:cd03800   347 GL----LVDPHDPEALAAALRRLLDDPALWQRLSRAgleraraHYTWESVADQLLT 398
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
143-360 9.64e-09

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 56.26  E-value: 9.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 143 FSDDVIVISDAIRRNIASRYGRTRRVHLIYNGV-------PEPEICSDDAYFselgikpgrYIlGMSRFVPEKNLHHLID 215
Cdd:PRK09922  133 CADYHLAISSGIKEQMMARGISAQRISVIYNPVeiktiiiPPPERDKPAVFL---------YV-GRLKFEGQKNVKELFD 202
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 216 AFNRTglaQYGYKLVLAGDADFED---DYSRSLKQkarDNDVVLTG-------FIRGRrlhslLSNAACFSLPSSHEGLP 285
Cdd:PRK09922  203 GLSQT---TGEWQLHIIGDGSDFEkckAYSRELGI---EQRIIWHGwqsqpweVVQQK-----IKNVSALLLTSKFEGFP 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 286 ISLLEAMSYRLPVVVSDI---PANLEVGLPAGDYFPTGDIDTLASRIrskidngpqrIDYSLGK--YDWDNIAMQVASVY 360
Cdd:PRK09922  272 MTLLEAMSYGIPCISSDCmsgPRDIIKPGLNGELYTPGNIDEFVGKL----------NKVISGEvkYQHDAIPNSIERFY 341
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
167-360 4.10e-08

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 54.34  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 167 RVHLIYNGVPEPEICSDDAYFSELGIKPGRY-----ILGMSRFVPEKNLHHLIDAF----NRTGLAQYGYKLVLAGDADf 237
Cdd:TIGR03088 161 KIHQIYNGVDTERFHPSRGDRSPILPPDFFAdesvvVGTVGRLQAVKDQPTLVRAFallvRQLPEGAERLRLVIVGDGP- 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 238 eddySR-SLKQKARDNDVVLTGFIRGRR--LHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEVGLP-- 312
Cdd:TIGR03088 240 ----ARgACEQMVRAAGLAHLVWLPGERddVPALMQALDLFVLPSLAEGISNTILEAMASGLPVIATAVGGNPELVQHgv 315
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2530594339 313 AGDYFPTGDIDTLA----------SRIRSKIDNGPQRIDyslGKYDWDNIAMQVASVY 360
Cdd:TIGR03088 316 TGALVPPGDAVALAralqpyvsdpAARRAHGAAGRARAE---QQFSINAMVAAYAGLY 370
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
166-361 1.01e-07

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 53.10  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 166 RRVHLIYNGVPEPEICSDD--AYFSELGIKPGRYILGM---SRFVPEKNLHHLIDAfnrtgLAQYGYK----LVLAGdad 236
Cdd:cd03825   161 LPVVVIPNGIDTEIFAPVDkaKARKRLGIPQDKKVILFgaeSVTKPRKGFDELIEA-----LKLLATKddllLVVFG--- 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 237 feddYSRSLKQKArDNDVVLTGFIR-GRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEV------ 309
Cdd:cd03825   233 ----KNDPQIVIL-PFDIISLGYIDdDEQLVDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIvqhgvt 307
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2530594339 310 GLPAgdyfPTGDIDTLASRIRSKIDNGPQRidYSLGK---------YDWDNIAMQVASVYG 361
Cdd:cd03825   308 GYLV----PPGDVQALAEAIEWLLANPKER--ESLGEraralaenhFDQRVQAQRYLELYK 362
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
100-361 5.16e-07

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 50.85  E-value: 5.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 100 AVPLAKLLGMRVVMTNH------GPDYERAKWG-RLARTIIKmgeswgsRFSDDVIVISDAIRRNIASRygrtRRVHLIY 172
Cdd:cd03822    96 ALGLLLHLRIPVITTLHtvldlsDPGKQALKVLfRIATLSER-------VVVMAPISRFLLVRIKLIPA----VNIEVIP 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 173 NGVPEPEICSDDAYFSELGIKpGRYILGMSRFV-PEKNLHHLIDAFNRTgLAQYG--YKLVLAGDADFEDDYSRSLKQKA 249
Cdd:cd03822   165 HGVPEVPQDPTTALKRLLLPE-GKKVILTFGFIgPGKGLEILLEALPEL-KAEFPdvRLVIAGELHPSLARYEGERYRKA 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 250 R-------DNDVVLTGFIRGRRLHSLLSNAACFSLP--SSHEGLPISLLEAMSYRLPVVVSDIPANLEvgLPAGD---YF 317
Cdd:cd03822   243 AieelglqDHVDFHNNFLPEEEVPRYISAADVVVLPylNTEQSSSGTLSYAIACGKPVISTPLRHAEE--LLADGrgvLV 320
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2530594339 318 PTGDIDTLASRIRSKIDNGPQRIDYSLGKYD------WDNIAMQVASVYG 361
Cdd:cd03822   321 PFDDPSAIAEAILRLLEDDERRQAIAERAYAyaramtWESIADRYLRLFN 370
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
198-329 6.67e-07

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 50.53  E-value: 6.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 198 ILGMSRFVPEKNLHHLIDAFNRTgLAQYG---YKLVlaGDADFEDDYSRSLKQKARDNDVVLTGFIRGRRLHSLLSNAAC 274
Cdd:cd03799   177 ILTVGRLTEKKGLEYAIEAVAKL-AQKYPnieYQII--GDGDLKEQLQQLIQELNIGDCVKLLGWKPQEEIIEILDEADI 253
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2530594339 275 FSLPS------SHEGLPISLLEAMSYRLPVVV---SDIPANLEVGLpAGDYFPTGDIDTLASRI 329
Cdd:cd03799   254 FIAPSvtaadgDQDGPPNTLKEAMAMGLPVIStehGGIPELVEDGV-SGFLVPERDAEAIAEKL 316
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
88-301 3.05e-06

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 49.26  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAVGPSLAVPLAKLLG--------MRVVMTNHGPDYERAKWGRLARTIIKMgeswgsrfsDDVIVISDAIRrnIA 159
Cdd:PRK15179  402 SVVHIWQDGSIFACALAALLAgvprivlsVRTMPPVDRPDRYRVEYDIIYSELLKM---------RGVALSSNSQF--AA 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 160 SRYGR-----TRRVHLIYNGVPEPEICSDDA------YFSELGIKPGRYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYK 228
Cdd:PRK15179  471 HRYADwlgvdERRIPVVYNGLAPLKSVQDDActammaQFDARTSDARFTVGTVMRVDDNKRPFLWVEAAQRFAASHPKVR 550
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2530594339 229 LVLAGDADFEDDYsRSLKQKARDND-VVLTGFirGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVS 301
Cdd:PRK15179  551 FIMVGGGPLLESV-REFAQRLGMGErILFTGL--SRRVGYWLTQFNAFLLLSRFEGLPNVLIEAQFSGVPVVTT 621
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
98-302 1.82e-05

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 46.43  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  98 SLAVPLAKLL-GMRVVMTNHGPDYERAK----WGRLARTIIKMGESWGSRFSDDVIVisdairrNiaSRYgrTRRV---- 168
Cdd:cd03805   104 SACVPLLKLFrPSKILFYCHFPDQLLAQrkslLKRLYRKPFDWLEEFTTGMADQIVV-------N--SNF--TAGVfkkt 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 169 --HLIYNGVP---------EPEICSDDAYFSELGIKPGRYI-LGMSRFVPEKNLHHLIDAFNR---TGLAQYGYKLVLAG 233
Cdd:cd03805   173 fpSLAKNPPEvlypcvdtdSFDSTSEDPDPGDLIAKSNKKFfLSINRFERKKNIALAIEAFAKlkqKLPEFENVRLVIAG 252
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2530594339 234 DADF---ED-DYSRSLKQKA-----RDNDVVLTGFIRGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSD 302
Cdd:cd03805   253 GYDPrvaENvEYLEELQRLAeellnVEDQVLFLRSISDSQKEQLLSSALALLYTPSNEHFGIVPLEAMYAGKPVIACN 330
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
88-303 2.42e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 46.17  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  88 DLLHIHAVGPS--LAVPLAKLLGMRVVMTNHG----------------PDYERAKWGRLARTIIKMGeswgSRFSDDVIV 149
Cdd:cd03813   175 DLYHSVSTGYAglLGALARHRRGIPFLLTEHGiytrerkieilqstwiMGYIKKLWIRFFERLGKLA----YQQADKIIS 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 150 ISDAIRRnIASRYGRTR-RVHLIYNGVpEPEICSDDAYFSELGIKPgryILG-MSRFVPEKNLHHLIDAFNRTGLAQYGY 227
Cdd:cd03813   251 LYEGNRR-RQIRLGADPdKTRVIPNGI-DIQRFAPAREERPEKEPP---VVGlVGRVVPIKDVKTFIRAFKLVRRAMPDA 325
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 228 KLVLAGDADFEDDYSRSLKQKAR----DNDVVLTGFirgRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDI 303
Cdd:cd03813   326 EGWLIGPEDEDPEYAQECKRLVAslglENKVKFLGF---QNIKEYYPKLGLLVLTSISEGQPLVILEAMASGVPVVATDV 402
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
166-299 3.24e-04

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 42.76  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 166 RRVHLIYNGV--PEPEICSDDAY-----FSELGIKPGRYILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAGDADFE 238
Cdd:PRK15490  362 KHFQVVYNGVlpPSTEPSSEVPHkiwqqFTQKTQDADTTIGGVFRFVGDKNPFAWIDFAARYLQHHPATRFVLVGDGDLR 441
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2530594339 239 DDYSRSLKQKARDNDVVLTGFirGRRLHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVV 299
Cdd:PRK15490  442 AEAQKRAEQLGILERILFVGA--SRDVGYWLQKMNVFILFSRYEGLPNVLIEAQMVGVPVI 500
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
174-309 4.56e-04

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 42.06  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 174 GVPEPEIcsddayFSELGIKPGRYILGMSRFVPEKNLHHLIDAFNRTGLA--QYGYKLVLAGDADFEDDYSRSLKQKARD 251
Cdd:cd04946   209 GVSDKEQ------YSKVKKEGDLRLVSCSSIVPVKRIDLIIETLNSLCVAhpSICISWTHIGGGPLKERLEKLAENKLEN 282
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 252 NDVVLTGFIRGRRLHSLL--SNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDIPANLEV 309
Cdd:cd04946   283 VKVNFTGEVSNKEVKQLYkeNDVDVFVNVSESEGIPVSIMEAISFGIPVIATNVGGTREI 342
GT9_LPS_heptosyltransferase cd03789
lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide ...
91-275 5.53e-04

lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340821  Cd Length: 277  Bit Score: 41.18  E-value: 5.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339  91 HIHAVGPSLAVPLAKLLGM--RVVMTNHGPDYERAKWGRLARTIIKMGeswgsrfSDDVIVISDAIRRNIASRYGRTRRV 168
Cdd:cd03789    31 KITVVVGPGYAELLELNPYidEVIPDDKRRRAGLRGRRKLLRELRARK-------YDLVIDLHSSLRSALLLLLSGAPRR 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 169 hliyngvpepeICSDDAYFSELGIKPGRYILGM-------SRFVPEKNLHHLIDAfnrtgLAQYGYKLVLAGDADfEDDY 241
Cdd:cd03789   104 -----------IGFDREKRRFLLNHPVKPLVVIppgasgpAKRWPAERFAELADR-----LADEGYRVVLFGGPA-EEEL 166
                         170       180       190
                  ....*....|....*....|....*....|....
gi 2530594339 242 SRSLKQKARDNDVVLTGFIRGRRLHSLLSNAACF 275
Cdd:cd03789   167 AEEIAAALGARVVNLAGKTSLRELAALLARADLV 200
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
192-303 1.94e-03

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 40.00  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 192 IKPGR-YILGMSRFVPEKNLHHLIDAFNRTGLAQYGYKLVLAG-----DADFEDDYSRSLKQKARDNDV-VLTGFIRGRR 264
Cdd:cd03792   193 IDPERpYILQVARFDPSKDPLGVIDAYKLFKRRAEEPQLVICGhgavdDPEGSVVYEEVMEYAGDDHDIhVLRLPPSDQE 272
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2530594339 265 LHSLLSNAACFSLPSSHEGLPISLLEAMSYRLPVVVSDI 303
Cdd:cd03792   273 INALQRAATVVLQLSTREGFGLTVSEALWKGKPVIATPA 311
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
138-251 5.27e-03

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 38.74  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2530594339 138 SWGSRFSDDVIVISDAIRRNIASRYGRTRRVHLIYngvPePeiCSDDAyFSELGIKPGR---YILGMSRFVPEKNlHHL- 213
Cdd:cd03806   184 GLAGSFADVVMVNSTWTYNHIRQLWKRNIKPSIVY---P-P--CDTEE-LTKLPIDEKTrenQILSIAQFRPEKN-HPLq 255
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2530594339 214 IDAF-----NRTGLAQYGYKLVLAGDADFEDDYSR--SLKQKARD 251
Cdd:cd03806   256 LRAFaellkRLPESIRSNPKLVLIGSCRNEEDKERveALKLLAKE 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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