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Conserved domains on  [gi|2527729465|ref|WP_288715023|]
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FtsX-like permease family protein [uncultured Bilophila sp.]

Protein Classification

ABC transporter permease family protein( domain architecture ID 1903414)

ABC transporter permease similar to cell division protein FtsX, bacitracin export permease protein BceB, and Buchnera aphidicola lipoprotein-releasing system transmembrane protein LolC

Gene Ontology:  GO:0140359|GO:0055085
TCDB:  3.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LolE super family cl44091
ABC-type transport system involved in lipoprotein release, permease component LolC [Cell wall ...
133-409 3.10e-11

ABC-type transport system involved in lipoprotein release, permease component LolC [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG4591:

Pssm-ID: 443648 [Multi-domain]  Cd Length: 283  Bit Score: 63.79  E-value: 3.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 133 AFAAQDEAVLGAGVP----LRLGEAFSpmhgqVSASHNEHGHVRYKAVGRLPETGTPWDN-AILIPIESVWAVHDALPda 207
Cdd:COG4591    29 VAKASDEVVLGEGLAkklgLKVGDTIT-----LISPDGSPKTRRFTVVGIFESGGYELDGsLVYVPLETAQELLGLGD-- 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 208 ghvlplghlfegkgsplpGVSAVVVKPESIAAAYRLRAFWQtATLPDADGRPVNmqgvftgEVLTELFATLGDMRDIMTG 287
Cdd:COG4591   102 ------------------QVSGILVKLKDGADAEAVAAALE-AALPGLEVKTWR-------ELNAALFSALKTEKLILLL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 288 MAYAAQFVALCGVMLVGGMAVSMRKRMLGTLRVLGAPRAYLVLSVWWVVSVSIAVGTLAGLLFGCGLSEGAALLMFRQTG 367
Cdd:COG4591   156 ILLLILLVAAFNIVNTLLMSVLERTREIGILKALGASRRQIRRIFLLEGLLLGLIGGLLGLLLGLLLALLLNALLGILLP 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2527729465 368 IMLSPQLTLAEGSFAAA---SFALGSLCALFPAYMVYRKTGAVAL 409
Cdd:COG4591   236 FIFALPVSLSPSDVLLAlllALLISLLASLYPARRAARLDPVEAL 280
 
Name Accession Description Interval E-value
LolE COG4591
ABC-type transport system involved in lipoprotein release, permease component LolC [Cell wall ...
133-409 3.10e-11

ABC-type transport system involved in lipoprotein release, permease component LolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443648 [Multi-domain]  Cd Length: 283  Bit Score: 63.79  E-value: 3.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 133 AFAAQDEAVLGAGVP----LRLGEAFSpmhgqVSASHNEHGHVRYKAVGRLPETGTPWDN-AILIPIESVWAVHDALPda 207
Cdd:COG4591    29 VAKASDEVVLGEGLAkklgLKVGDTIT-----LISPDGSPKTRRFTVVGIFESGGYELDGsLVYVPLETAQELLGLGD-- 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 208 ghvlplghlfegkgsplpGVSAVVVKPESIAAAYRLRAFWQtATLPDADGRPVNmqgvftgEVLTELFATLGDMRDIMTG 287
Cdd:COG4591   102 ------------------QVSGILVKLKDGADAEAVAAALE-AALPGLEVKTWR-------ELNAALFSALKTEKLILLL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 288 MAYAAQFVALCGVMLVGGMAVSMRKRMLGTLRVLGAPRAYLVLSVWWVVSVSIAVGTLAGLLFGCGLSEGAALLMFRQTG 367
Cdd:COG4591   156 ILLLILLVAAFNIVNTLLMSVLERTREIGILKALGASRRQIRRIFLLEGLLLGLIGGLLGLLLGLLLALLLNALLGILLP 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2527729465 368 IMLSPQLTLAEGSFAAA---SFALGSLCALFPAYMVYRKTGAVAL 409
Cdd:COG4591   236 FIFALPVSLSPSDVLLAlllALLISLLASLYPARRAARLDPVEAL 280
FtsX pfam02687
FtsX-like permease family; This is a family of predicted permeases and hypothetical ...
294-404 5.01e-05

FtsX-like permease family; This is a family of predicted permeases and hypothetical transmembrane proteins. Swiss:P57382 has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both Swiss:P57382 and Swiss:O54500 have been shown to require ATP. This region contains three transmembrane helices.


Pssm-ID: 460652 [Multi-domain]  Cd Length: 120  Bit Score: 42.62  E-value: 5.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 294 FVALCGVMLVGGMAVSMRKRMLGTLRVLGAPRAYLVLSVWWVVSVSIAVGTLAGLLFGCGLsegAALLMFRQTGIMLSPQ 373
Cdd:pfam02687   9 LLAVLIILLLLSISISERRREIGILRALGASRKQIFKLLLLEALLIGLIGLVIGLLLGLLL---AKLIAILLYSSGISLP 85
                          90       100       110
                  ....*....|....*....|....*....|....
gi 2527729465 374 LTLAEGSFAAA---SFALGSLCALFPAYMVYRKT 404
Cdd:pfam02687  86 ILVPPLSILIAlllALLIALLASLLPALRIRKIN 119
 
Name Accession Description Interval E-value
LolE COG4591
ABC-type transport system involved in lipoprotein release, permease component LolC [Cell wall ...
133-409 3.10e-11

ABC-type transport system involved in lipoprotein release, permease component LolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443648 [Multi-domain]  Cd Length: 283  Bit Score: 63.79  E-value: 3.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 133 AFAAQDEAVLGAGVP----LRLGEAFSpmhgqVSASHNEHGHVRYKAVGRLPETGTPWDN-AILIPIESVWAVHDALPda 207
Cdd:COG4591    29 VAKASDEVVLGEGLAkklgLKVGDTIT-----LISPDGSPKTRRFTVVGIFESGGYELDGsLVYVPLETAQELLGLGD-- 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 208 ghvlplghlfegkgsplpGVSAVVVKPESIAAAYRLRAFWQtATLPDADGRPVNmqgvftgEVLTELFATLGDMRDIMTG 287
Cdd:COG4591   102 ------------------QVSGILVKLKDGADAEAVAAALE-AALPGLEVKTWR-------ELNAALFSALKTEKLILLL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 288 MAYAAQFVALCGVMLVGGMAVSMRKRMLGTLRVLGAPRAYLVLSVWWVVSVSIAVGTLAGLLFGCGLSEGAALLMFRQTG 367
Cdd:COG4591   156 ILLLILLVAAFNIVNTLLMSVLERTREIGILKALGASRRQIRRIFLLEGLLLGLIGGLLGLLLGLLLALLLNALLGILLP 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2527729465 368 IMLSPQLTLAEGSFAAA---SFALGSLCALFPAYMVYRKTGAVAL 409
Cdd:COG4591   236 FIFALPVSLSPSDVLLAlllALLISLLASLYPARRAARLDPVEAL 280
FtsX pfam02687
FtsX-like permease family; This is a family of predicted permeases and hypothetical ...
294-404 5.01e-05

FtsX-like permease family; This is a family of predicted permeases and hypothetical transmembrane proteins. Swiss:P57382 has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both Swiss:P57382 and Swiss:O54500 have been shown to require ATP. This region contains three transmembrane helices.


Pssm-ID: 460652 [Multi-domain]  Cd Length: 120  Bit Score: 42.62  E-value: 5.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 294 FVALCGVMLVGGMAVSMRKRMLGTLRVLGAPRAYLVLSVWWVVSVSIAVGTLAGLLFGCGLsegAALLMFRQTGIMLSPQ 373
Cdd:pfam02687   9 LLAVLIILLLLSISISERRREIGILRALGASRKQIFKLLLLEALLIGLIGLVIGLLLGLLL---AKLIAILLYSSGISLP 85
                          90       100       110
                  ....*....|....*....|....*....|....
gi 2527729465 374 LTLAEGSFAAA---SFALGSLCALFPAYMVYRKT 404
Cdd:pfam02687  86 ILVPPLSILIAlllALLIALLASLLPALRIRKIN 119
SalY COG0577
ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms];
257-409 2.43e-04

ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms];


Pssm-ID: 440342 [Multi-domain]  Cd Length: 339  Bit Score: 42.96  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 257 GRPVNMQGVFTGEVLTELFATLGDMRDIMTGMAYAAQFVALCGVMLVGGMAVSMRKRMLGTLRVLGAPRAYLVLSVWWVV 336
Cdd:COG0577   189 DPGDDFEVQTLDEILAALYGVLRTLTLLLGAIAGLALLVACIGIMNLMLASVTERTREIGIRKALGASRRDILRQFLTEA 268
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2527729465 337 svsiAVGTLAGLLFGCGLSEGAALLMFRQTGIMLSPQLTLAEGSFaAASFALGSLCALFPAYMVYRKTGAVAL 409
Cdd:COG0577   269 ----LLLALLGGLLGLLLALLLLRLLAALLGLPVSLDPWVLLLAL-ALSLLVGLLAGLYPARRAARLDPVEAL 336
YbbP COG3127
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease ...
291-407 3.23e-03

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442361 [Multi-domain]  Cd Length: 830  Bit Score: 39.78  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 291 AAQFVALCGV--MLVGGMAVSM--------RKRMLGTLRVLGAPRAYLVLSVWWVVSVSIAVGTLAGLLFGCGLSEGAAL 360
Cdd:COG3127   252 AEQFLLLVALlaLLLAGVAVANaarryvarRLDTIALLRCLGASRRQIFRIYLLQLLLLGLLGSLLGLLLGALLQALLAA 331
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2527729465 361 LMFRQTGIMLSPQLTLAEgsfAAASFALGSLCALFPAYMVYRKTGAV 407
Cdd:COG3127   332 LLADLLPVPLEPALSPLP---LLLGLLVGLLVLLLFALPPLLRLRRV 375
YbbP COG3127
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease ...
276-409 9.86e-03

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442361 [Multi-domain]  Cd Length: 830  Bit Score: 38.24  E-value: 9.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527729465 276 ATLGDMRDIMTGMAYAAQFVA----LCGVM-LVGGMAVSMRKRM--LGTLRVLGAPRAylvLSVWWVVSVSIAVGTLAGL 348
Cdd:COG3127   691 AILDQVRDILDQVSLAVEFLAgfalLAGLLvLAAALAASRDERTreAALLRTLGASRR---QLRRALALEFALLGLLAGL 767
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2527729465 349 LfGCGLSEGAALLMFRQ---TGIMLSPQLTLAegsFAAASFALGSLCALFPAYMVYRKTGAVAL 409
Cdd:COG3127   768 L-AALLAELAGWALARFvfdLPFSPPWWLWLA---GLLGGALLVLLAGLLGARRVLRQPPLEVL 827
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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