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Conserved domains on  [gi|2524716957|ref|WP_286738545|]
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NAD(P)/FAD-dependent oxidoreductase [Kocuria sp. UBA1838]

Protein Classification

dihydrolipoyl dehydrogenase family protein( domain architecture ID 11441193)

dihydrolipoyl dehydrogenase family protein belonging to the class-I pyridine nucleotide-disulfide oxidoreductase superfamily may function as a FAD/NAD(P)-dependent oxidoreductase, similar to dihydrolipoyl dehydrogenase which catalyzes the oxidation of dihydrolipoamide to lipoamide and is often a component of multienzyme 2-oxo-acid dehydrogenase complexes

CATH:  3.50.50.60|3.30.390.30
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0000166
PubMed:  34164859|2643922|37276180|38537870
SCOP:  4000121

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 8-456 2.72e-114

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


:

Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 343.99  E-value: 2.72e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   8 ESVDVIVIGGGAVGENAAQYAIEGtDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVTGLTDDLEG----VVPTRLDRD 83
Cdd:COG1249     2 KDYDLVVIGAGPGGYVAAIRAAQL-GLKVALVEKGRLGGTCLNVGCIPSKALLHAAEVAHEARHAAEfgisAGAPSVDWA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  84 GMLARRDSFVSDYDDSSQvEWAESAGIRVVRGHARLVGERSVRIEADdaaaRTLTARHAVIlATGSEPSIPS--EFDGAH 161
Cdd:COG1249    81 ALMARKDKVVDRLRGGVE-ELLKKNGVDVIRGRARFVDPHTVEVTGG----ETLTADHIVI-ATGSRPRVPPipGLDEVR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 162 PWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTK 241
Cdd:COG1249   155 VLTSDEALELEELPKSLVVIGGGYIGLEFAQIFARLGSEVTLVERGDRLLPGEDPEISEALEKALEKEGIDILTGAKVTS 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 242 CTRSdaedtglgrvhGGQVHLETSAG----TVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLH----EKL----PaWLH 309
Cdd:COG1249   235 VEKT-----------GDGVTVTLEDGggeeAVEADKVLVATGRRPNTDGLGLEAAGVELDERGGikvdEYLrtsvP-GIY 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 310 AVGDASGDVPLTHWGKYRARVIGARIkAAATGAPAPYEVenppVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYnG 389
Cdd:COG1249   303 AIGDVTGGPQLAHVASAEGRVAAENI-LGKKPRPVDYRA----IPSVVFTDPEIASVGLTEEEAREAGIDVKVGKFPF-A 376

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 390 AAGAALLRDTISGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:COG1249   377 ANGRALALGETEGFVKLIADAETGRILGAHIVGPHAGELIHEAALAMEMGLTVEDLADTIHAHPTLS 443
 
Name Accession Description Interval E-value
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 8-456 2.72e-114

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 343.99  E-value: 2.72e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   8 ESVDVIVIGGGAVGENAAQYAIEGtDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVTGLTDDLEG----VVPTRLDRD 83
Cdd:COG1249     2 KDYDLVVIGAGPGGYVAAIRAAQL-GLKVALVEKGRLGGTCLNVGCIPSKALLHAAEVAHEARHAAEfgisAGAPSVDWA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  84 GMLARRDSFVSDYDDSSQvEWAESAGIRVVRGHARLVGERSVRIEADdaaaRTLTARHAVIlATGSEPSIPS--EFDGAH 161
Cdd:COG1249    81 ALMARKDKVVDRLRGGVE-ELLKKNGVDVIRGRARFVDPHTVEVTGG----ETLTADHIVI-ATGSRPRVPPipGLDEVR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 162 PWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTK 241
Cdd:COG1249   155 VLTSDEALELEELPKSLVVIGGGYIGLEFAQIFARLGSEVTLVERGDRLLPGEDPEISEALEKALEKEGIDILTGAKVTS 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 242 CTRSdaedtglgrvhGGQVHLETSAG----TVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLH----EKL----PaWLH 309
Cdd:COG1249   235 VEKT-----------GDGVTVTLEDGggeeAVEADKVLVATGRRPNTDGLGLEAAGVELDERGGikvdEYLrtsvP-GIY 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 310 AVGDASGDVPLTHWGKYRARVIGARIkAAATGAPAPYEVenppVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYnG 389
Cdd:COG1249   303 AIGDVTGGPQLAHVASAEGRVAAENI-LGKKPRPVDYRA----IPSVVFTDPEIASVGLTEEEAREAGIDVKVGKFPF-A 376

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 390 AAGAALLRDTISGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:COG1249   377 ANGRALALGETEGFVKLIADAETGRILGAHIVGPHAGELIHEAALAMEMGLTVEDLADTIHAHPTLS 443
PRK06370 PRK06370
FAD-containing oxidoreductase;
7-456 2.76e-68

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 225.47  E-value: 2.76e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   7 QESVDVIVIGGGAVGENAAQYAiEGTDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVTGLTDDLE--GVV---PTRLD 81
Cdd:PRK06370    3 AQRYDAIVIGAGQAGPPLAARA-AGLGMKVALIERGLLGGTCVNTGCVPTKTLIASARAAHLARRAAeyGVSvggPVSVD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  82 RDGMLARRDSFVSDYDDSSQVEWAESAGIRVVRGHARLVGERSVRIeaddaAARTLTARHAVIlATGSEPSIPsEFDGAH 161
Cdd:PRK06370   82 FKAVMARKRRIRARSRHGSEQWLRGLEGVDVFRGHARFESPNTVRV-----GGETLRAKRIFI-NTGARAAIP-PIPGLD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 162 ---PWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDAS 238
Cdd:PRK06370  155 evgYLTNETIFSLDELPEHLVIIGGGYIGLEFAQMFRRFGSEVTVIERGPRLLPREDEDVAAAVREILEREGIDVRLNAE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 239 VTKCTRSDaedtglgrvHGGQVHLETSAG--TVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLHEKLPAWL-------H 309
Cdd:PRK06370  235 CIRVERDG---------DGIAVGLDCNGGapEITGSHILVAVGRVPNTDDLGLEAAGVETDARGYIKVDDQLrttnpgiY 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 310 AVGDASGDVPLTHwGKYRArvigARIKAAATGAPAPYEVENPPVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYNg 389
Cdd:PRK06370  306 AAGDCNGRGAFTH-TAYND----ARIVAANLLDGGRRKVSDRIVPYATYTDPPLARVGMTEAEARKSGRRVLVGTRPMT- 379

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 390 AAGAALLRDTISGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:PRK06370  380 RVGRAVEKGETQGFMKVVVDADTDRILGATILGVHGDEMIHEILDAMYAGAPYTTLSRAIHIHPTVS 446
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 11-294 2.71e-30

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 119.35  E-value: 2.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGAVGENAAQYAIEGTDLTAVIVeghlLGGECSYYACMPSKALLRPVDvtgltdDLEGVVPTRLDRDGMLARRD 90
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIE----DEGTCPYGGCVLSKALLGAAE------APEIASLWADLYKRKEEVVK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  91 SFVSDYDDSSQVEwaesaGIRVVRGHARLVGERSVrieadDAAARTLTARHaVILATGSEPSIPS-------EFDGAHPW 163
Cdd:pfam07992  72 KLNNGIEVLLGTE-----VVSIDPGAKKVVLEELV-----DGDGETITYDR-LVIATGARPRLPPipgvelnVGFLVRTL 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 164 TSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTKct 243
Cdd:pfam07992 141 DSAEALRLKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKE-- 218

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2524716957 244 rsdaedtglGRVHGGQVHLETSAGTVDVAE-VLVATGRTPrlRDVGLDAVGL 294
Cdd:pfam07992 219 ---------IIGDGDGVEVILKDGTEIDADlVVVAIGRRP--NTELLEAAGL 259
trypano_reduc TIGR01423
trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of ...
 11-454 1.50e-23

trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of spermidine, is (in its reduced form) an important antioxidant found in trypanosomatids (Crithidia, Leishmania, Trypanosoma). This model describes trypanothione reductase, a possible antitrypanosomal drug target closely related to some forms of glutathione reductase.


Pssm-ID: 200098 [Multi-domain]  Cd Length: 486  Bit Score: 103.13  E-value: 1.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGA----VGENAAqyAIEGTDLTAVIVEGH-------LLGGECSYYACMPSKAL---------LRPVDVTGLTD 70
Cdd:TIGR01423   5 DLVVIGAGSggleAGWNAA--TLYKKRVAVVDVQTHhgppfyaALGGTCVNVGCVPKKLMvtgaqymdtLRESAGFGWEF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  71 DLEGVVPtrlDRDGMLARRDSFVSDYDDSSQVEWAESAGIRVVRGHARLVGERSV--RIEADDAAA--RTLTARHaVILA 146
Cdd:TIGR01423  83 DRSSVKA---NWKALIAAKNKAVLDINKSYEGMFADTEGLTFFLGWGALEDKNVVlvRESADPKSAvkERLQAEH-ILLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 147 TGSEPSIPSEFDGAHPWTSADATGVVETPESIAIVGGGVVACEAAVWLNA---LGSRVTLLVRGSGLLSGNEPFAGDTVL 223
Cdd:TIGR01423 159 TGSWPQMLGIPGIEHCISSNEAFYLDEPPRRVLTVGGGFISVEFAGIFNAykpRGGKVTLCYRNNMILRGFDSTLRKELT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 224 DGLRASGVEVVLDASVTKCTRSDaedtglgrvhGGQVHLETSAG-TVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLHE 302
Cdd:TIGR01423 239 KQLRANGINIMTNENPAKVTLNA----------DGSKHVTFESGkTLDVDVVMMAIGRVPRTQTLQLDKVGVELTKKGAI 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 303 KLPAW-------LHAVGDASGDVPLTHwgkyRARVIGARIKAAATGApAPYEVENPPVPQVVFTQPQVAQTGLTEASARD 375
Cdd:TIGR01423 309 QVDEFsrtnvpnIYAIGDVTDRVMLTP----VAINEGAAFVDTVFGN-KPRKTDHTRVASAVFSIPPIGTCGLVEEDAAK 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 376 RGIDVVTAEVPYNGaagaalLRDTISGK------AKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAV 449
Cdd:TIGR01423 384 KFEKVAVYESSFTP------LMHNISGSkykkfvAKIVTNHADGTVLGVHLLGDSSPEIIQAVGICLKLNAKISDFYNTI 457


                  ....*
gi 2524716957 450 PSYPT 454
Cdd:TIGR01423 458 GVHPT 462
 
Name Accession Description Interval E-value
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 8-456 2.72e-114

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 343.99  E-value: 2.72e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   8 ESVDVIVIGGGAVGENAAQYAIEGtDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVTGLTDDLEG----VVPTRLDRD 83
Cdd:COG1249     2 KDYDLVVIGAGPGGYVAAIRAAQL-GLKVALVEKGRLGGTCLNVGCIPSKALLHAAEVAHEARHAAEfgisAGAPSVDWA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  84 GMLARRDSFVSDYDDSSQvEWAESAGIRVVRGHARLVGERSVRIEADdaaaRTLTARHAVIlATGSEPSIPS--EFDGAH 161
Cdd:COG1249    81 ALMARKDKVVDRLRGGVE-ELLKKNGVDVIRGRARFVDPHTVEVTGG----ETLTADHIVI-ATGSRPRVPPipGLDEVR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 162 PWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTK 241
Cdd:COG1249   155 VLTSDEALELEELPKSLVVIGGGYIGLEFAQIFARLGSEVTLVERGDRLLPGEDPEISEALEKALEKEGIDILTGAKVTS 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 242 CTRSdaedtglgrvhGGQVHLETSAG----TVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLH----EKL----PaWLH 309
Cdd:COG1249   235 VEKT-----------GDGVTVTLEDGggeeAVEADKVLVATGRRPNTDGLGLEAAGVELDERGGikvdEYLrtsvP-GIY 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 310 AVGDASGDVPLTHWGKYRARVIGARIkAAATGAPAPYEVenppVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYnG 389
Cdd:COG1249   303 AIGDVTGGPQLAHVASAEGRVAAENI-LGKKPRPVDYRA----IPSVVFTDPEIASVGLTEEEAREAGIDVKVGKFPF-A 376

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 390 AAGAALLRDTISGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:COG1249   377 ANGRALALGETEGFVKLIADAETGRILGAHIVGPHAGELIHEAALAMEMGLTVEDLADTIHAHPTLS 443
PRK06370 PRK06370
FAD-containing oxidoreductase;
7-456 2.76e-68

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 225.47  E-value: 2.76e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   7 QESVDVIVIGGGAVGENAAQYAiEGTDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVTGLTDDLE--GVV---PTRLD 81
Cdd:PRK06370    3 AQRYDAIVIGAGQAGPPLAARA-AGLGMKVALIERGLLGGTCVNTGCVPTKTLIASARAAHLARRAAeyGVSvggPVSVD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  82 RDGMLARRDSFVSDYDDSSQVEWAESAGIRVVRGHARLVGERSVRIeaddaAARTLTARHAVIlATGSEPSIPsEFDGAH 161
Cdd:PRK06370   82 FKAVMARKRRIRARSRHGSEQWLRGLEGVDVFRGHARFESPNTVRV-----GGETLRAKRIFI-NTGARAAIP-PIPGLD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 162 ---PWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDAS 238
Cdd:PRK06370  155 evgYLTNETIFSLDELPEHLVIIGGGYIGLEFAQMFRRFGSEVTVIERGPRLLPREDEDVAAAVREILEREGIDVRLNAE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 239 VTKCTRSDaedtglgrvHGGQVHLETSAG--TVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLHEKLPAWL-------H 309
Cdd:PRK06370  235 CIRVERDG---------DGIAVGLDCNGGapEITGSHILVAVGRVPNTDDLGLEAAGVETDARGYIKVDDQLrttnpgiY 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 310 AVGDASGDVPLTHwGKYRArvigARIKAAATGAPAPYEVENPPVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYNg 389
Cdd:PRK06370  306 AAGDCNGRGAFTH-TAYND----ARIVAANLLDGGRRKVSDRIVPYATYTDPPLARVGMTEAEARKSGRRVLVGTRPMT- 379

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 390 AAGAALLRDTISGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:PRK06370  380 RVGRAVEKGETQGFMKVVVDADTDRILGATILGVHGDEMIHEILDAMYAGAPYTTLSRAIHIHPTVS 446
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 8-456 6.01e-66

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 219.28  E-value: 6.01e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   8 ESVDVIVIGGGAVGENAAQYAIEGTDLTAVIVEGHLlGGECSYYACMPSKALLRPVDVTGLTDDLE--GVVPTRLDRDG- 84
Cdd:PRK06292    2 EKYDVIVIGAGPAGYVAARRAAKLGKKVALIEKGPL-GGTCLNVGCIPSKALIAAAEAFHEAKHAEefGIHADGPKIDFk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  85 -MLARRDSFVSDYDDSSQVEWAESAGIRVVRGHARLVGERsvRIEADDaaaRTLTARHaVILATGSE-PSIPSEF--DGA 160
Cdd:PRK06292   81 kVMARVRRERDRFVGGVVEGLEKKPKIDKIKGTARFVDPN--TVEVNG---ERIEAKN-IVIATGSRvPPIPGVWliLGD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 161 HPWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASgVEVVLDASVT 240
Cdd:PRK06292  155 RLLTSDDAFELDKLPKSLAVIGGGVIGLELGQALSRLGVKVTVFERGDRILPLEDPEVSKQAQKILSKE-FKIKLGAKVT 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 241 KCTRSDAEDTGLGRVHGGQVhletsagTVDVAEVLVATGRTPRLRDVGLDAVGLSADD----VLHEKL-----PAWlhAV 311
Cdd:PRK06292  234 SVEKSGDEKVEELEKGGKTE-------TIEADYVLVATGRRPNTDGLGLENTGIELDErgrpVVDEHTqtsvpGIY--AA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 312 GDASGDVPLTHWGKYRARVIGarikAAATGAPAPYeVENPPVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPY--NG 389
Cdd:PRK06292  305 GDVNGKPPLLHEAADEGRIAA----ENAAGDVAGG-VRYHPIPSVVFTDPQIASVGLTEEELKAAGIDYVVGEVPFeaQG 379

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 390 AAGAALLRDtisGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:PRK06292  380 RARVMGKND---GFVKVYADKKTGRLLGAHIIGPDAEHLIHLLAWAMQQGLTVEDLLRMPFYHPTLS 443
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 6-456 1.55e-65

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 218.09  E-value: 1.55e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   6 TQESVDVIVIGGGAVGENAAQYAIEgTDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVTGLTDDLEG----VVPTRLD 81
Cdd:PRK06416    1 FAFEYDVIVIGAGPGGYVAAIRAAQ-LGLKVAIVEKEKLGGTCLNRGCIPSKALLHAAERADEARHSEDfgikAENVGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  82 RDGMLARRDSFVSDYddSSQVEW-AESAGIRVVRGHARLVGERSVRIEADDAAaRTLTARHaVILATGSEP-SIPS-EFD 158
Cdd:PRK06416   80 FKKVQEWKNGVVNRL--TGGVEGlLKKNKVDIIRGEAKLVDPNTVRVMTEDGE-QTYTAKN-IILATGSRPrELPGiEID 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 159 GAHPWTSADATGVVETPESIAIVGGGVVACE-AAVWlNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDA 237
Cdd:PRK06416  156 GRVIWTSDEALNLDEVPKSLVVIGGGYIGVEfASAY-ASLGAEVTIVEALPRILPGEDKEISKLAERALKKRGIKIKTGA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 238 SVTKCTRSDAEDTglgrvhggqVHLETSAG--TVDVAEVLVATGRTPRLRDVGLDAVGLS-------ADDVLHEKLPAwL 308
Cdd:PRK06416  235 KAKKVEQTDDGVT---------VTLEDGGKeeTLEADYVLVAVGRRPNTENLGLEELGVKtdrgfieVDEQLRTNVPN-I 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 309 HAVGDASGDVPLTHWGKYRARVIGARIKaaatGAPAPyeVENPPVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYN 388
Cdd:PRK06416  305 YAIGDIVGGPMLAHKASAEGIIAAEAIA----GNPHP--IDYRGIPAVTYTHPEVASVGLTEAKAKEEGFDVKVVKFPFA 378

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2524716957 389 GAAGAALLRDTiSGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:PRK06416  379 GNGKALALGET-DGFVKLIFDKKDGEVLGAHMVGARASELIQEAQLAINWEATPEDLALTIHPHPTLS 445
PRK07846 PRK07846
mycothione reductase; Reviewed
 11-425 2.10e-47

mycothione reductase; Reviewed


Pssm-ID: 181142 [Multi-domain]  Cd Length: 451  Bit Score: 169.75  E-value: 2.10e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGA----VGENAAqyaiegtDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVT---------GLTDDLEGVVP 77
Cdd:PRK07846    3 DLIIIGTGSgnsiLDERFA-------DKRIAIVEKGTFGGTCLNVGCIPTKMFVYAADVArtireaarlGVDAELDGVRW 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  78 TRLdRDGMLARRDSFVSDyddSSQVEWAESAGIRVVRGHARLVGERSVRIEADDaaarTLTARHAVIlATGSEPSIPSEF 157
Cdd:PRK07846   76 PDI-VSRVFGRIDPIAAG---GEEYRGRDTPNIDVYRGHARFIGPKTLRTGDGE----EITADQVVI-AAGSRPVIPPVI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 158 --DGAHPWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSgnepFAGDTVLD---GLRASGVE 232
Cdd:PRK07846  147 adSGVRYHTSDTIMRLPELPESLVIVGGGFIAAEFAHVFSALGVRVTVVNRSGRLLR----HLDDDISErftELASKRWD 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 233 VVLDASVTKCTRSDaedtglgrvhgGQVHLETSAGTVDVAEV-LVATGRTPRLRDVGLDAVGLSADDVLHEKLPAW---- 307
Cdd:PRK07846  223 VRLGRNVVGVSQDG-----------SGVTLRLDDGSTVEADVlLVATGRVPNGDLLDAAAAGVDVDEDGRVVVDEYqrts 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 308 ---LHAVGDASGDVPLTHWGKYRARVIGARIKAAATGAPAPYEvenpPVPQVVFTQPQVAQTGLTEASARDRGIDVVTAE 384
Cdd:PRK07846  292 aegVFALGDVSSPYQLKHVANHEARVVQHNLLHPDDLIASDHR----FVPAAVFTHPQIASVGLTENEARAAGLDITVKV 367

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2524716957 385 VPYNGAAGAALLRDTiSGKAKIVVDRETRCLVGATFVGPDA 425
Cdd:PRK07846  368 QNYGDVAYGWAMEDT-TGFVKLIADRDTGRLLGAHIIGPQA 407
PRK13748 PRK13748
putative mercuric reductase; Provisional
 8-445 1.38e-46

putative mercuric reductase; Provisional


Pssm-ID: 184298 [Multi-domain]  Cd Length: 561  Bit Score: 169.56  E-value: 1.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   8 ESVDVIVIGGGAVGENAAQYAIE-GTDLTavIVEGHLLGGECSYYACMPSKALLRPVDVTGL------TDDLEGVVPTrL 80
Cdd:PRK13748   97 RPLHVAVIGSGGAAMAAALKAVEqGARVT--LIERGTIGGTCVNVGCVPSKIMIRAAHIAHLrrespfDGGIAATVPT-I 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  81 DRDGMLARRDSFVSDYDDSSQVEWAES-AGIRVVRGHARLVGERSVRIEADDAAARTLTARHAVIlATGSEPSIP--SEF 157
Cdd:PRK13748  174 DRSRLLAQQQARVDELRHAKYEGILDGnPAITVLHGEARFKDDQTLIVRLNDGGERVVAFDRCLI-ATGASPAVPpiPGL 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 158 DGAHPWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSgLLSGNEPFAGDTVLDGLRASGVEVVLDA 237
Cdd:PRK13748  253 KETPYWTSTEALVSDTIPERLAVIGSSVVALELAQAFARLGSKVTILARST-LFFREDPAIGEAVTAAFRAEGIEVLEHT 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 238 SVTKCTRSDaedtglgrvhgGQVHLETSAGTVDVAEVLVATGRTPRLRDVGLDAVGLSA--------DDVLHEKLPAwLH 309
Cdd:PRK13748  332 QASQVAHVD-----------GEFVLTTGHGELRADKLLVATGRAPNTRSLALDAAGVTVnaqgaiviDQGMRTSVPH-IY 399

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 310 AVGDASgDVPLThwgKYRARVIGARIKAAATGAPAPYEVEnpPVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYNG 389
Cdd:PRK13748  400 AAGDCT-DQPQF---VYVAAAAGTRAAINMTGGDAALDLT--AMPAVVFTDPQVATVGYSEAEAHHDGIETDSRTLTLDN 473

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2524716957 390 AAGAALLRDTiSGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVL 445
Cdd:PRK13748  474 VPRALANFDT-RGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTVQEL 528
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
11-430 6.59e-39

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 146.84  E-value: 6.59e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGAVGENAAqyaIEGTDL---TAVIVEGHLLGGECSYYACMPSKALLRPV-DVTGL-TDDL--EGVVPTRLDRD 83
Cdd:PRK05249    7 DLVVIGSGPAGEGAA---MQAAKLgkrVAVIERYRNVGGGCTHTGTIPSKALREAVlRLIGFnQNPLysSYRVKLRITFA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  84 GMLARRDSFVsdyddSSQVEWAESA----GIRVVRGHARLVGERSVRIEADDAAARTLTARHAVIlATGSEPSIPSEFDG 159
Cdd:PRK05249   84 DLLARADHVI-----NKQVEVRRGQyernRVDLIQGRARFVDPHTVEVECPDGEVETLTADKIVI-ATGSRPYRPPDVDF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 160 AHPwTSADATGVVE---TPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSgnepFAGDTVLDGL----RASGVE 232
Cdd:PRK05249  158 DHP-RIYDSDSILSldhLPRSLIIYGAGVIGCEYASIFAALGVKVTLINTRDRLLS----FLDDEISDALsyhlRDSGVT 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 233 VVLDASVTKCTRSDAedtglGRVhggqVHLETsaGTVDVAE-VLVATGRTPRLRDVGLDAVGLSADD------------- 298
Cdd:PRK05249  233 IRHNEEVEKVEGGDD-----GVI----VHLKS--GKKIKADcLLYANGRTGNTDGLNLENAGLEADSrgqlkvnenyqta 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 299 VLHeklpawLHAVGDasgdvplthwgkyrarVIG-----------ARIKA-AATGAPAPYEVENppVPQVVFTQPQVAQT 366
Cdd:PRK05249  302 VPH------IYAVGD----------------VIGfpslasasmdqGRIAAqHAVGEATAHLIED--IPTGIYTIPEISSV 357

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2524716957 367 GLTEASARDRGidvvtaeVPYngAAGAALLRDT----ISGKA----KIVVDRETRCLVGATFVGPDAGEQLH 430
Cdd:PRK05249  358 GKTEQELTAAK-------VPY--EVGRARFKELaraqIAGDNvgmlKILFHRETLEILGVHCFGERATEIIH 420
PRK07251 PRK07251
FAD-containing oxidoreductase;
8-456 1.07e-37

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 142.97  E-value: 1.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   8 ESVDVIVIGGGAVGEN-AAQYAIEGTDLTAVIVEGHLLGGECSYYACMPSKALLRPVDvtgltddlegvvpTRLDRDGML 86
Cdd:PRK07251    2 LTYDLIVIGFGKAGKTlAAKLASAGKKVALVEESKAMYGGTCINIGCIPTKTLLVAAE-------------KNLSFEQVM 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  87 ARRDSFVSDYDDSSQVEWAeSAGIRVVRGHARLVGERSVRIEADDAAaRTLTARHAVIL--ATGSEPSIPSEFDGAHPWT 164
Cdd:PRK07251   69 ATKNTVTSRLRGKNYAMLA-GSGVDLYDAEAHFVSNKVIEVQAGDEK-IELTAETIVINtgAVSNVLPIPGLADSKHVYD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 165 SADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTKCTR 244
Cdd:PRK07251  147 STGIQSLETLPERLGIIGGGNIGLEFAGLYNKLGSKVTVLDAASTILPREEPSVAALAKQYMEEDGITFLLNAHTTEVKN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 245 SdaedtglgrvhGGQVHLETSAGTVDVAEVLVATGRTPRLRDVGL--------DAVGLSADDVLHEKLPAwLHAVGDASG 316
Cdd:PRK07251  227 D-----------GDQVLVVTEDETYRFDALLYATGRKPNTEPLGLentdieltERGAIKVDDYCQTSVPG-VFAVGDVNG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 317 DVPLTHWGKYRARVIGARIKAAATgapapYEVEN-PPVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYnGAAGAAL 395
Cdd:PRK07251  295 GPQFTYISLDDFRIVFGYLTGDGS-----YTLEDrGNVPTTMFITPPLSQVGLTEKEAKEAGLPYAVKELLV-AAMPRAH 368

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2524716957 396 LRDTISGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:PRK07251  369 VNNDLRGAFKVVVNTETKEILGATLFGEGSQEIINLITMAMDNKIPYTYFKKQIFTHPTMA 429
PRK06116 PRK06116
glutathione reductase; Validated
 11-436 2.30e-37

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 142.22  E-value: 2.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGAVGENAAQYAIEGTDLTAVIvEGHLLGGECSYYACMPSKALlrpvdVTG------LTDDLEG----VVPTRL 80
Cdd:PRK06116    6 DLIVIGGGSGGIASANRAAMYGAKVALI-EAKRLGGTCVNVGCVPKKLM-----WYGaqiaeaFHDYAPGygfdVTENKF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  81 DRDGMLARRDSFVSDYDDSSQvEWAESAGIRVVRGHARLVGERSVRIeaddaAARTLTARHAVIlATGSEPSIPsEFDGA 160
Cdd:PRK06116   80 DWAKLIANRDAYIDRLHGSYR-NGLENNGVDLIEGFARFVDAHTVEV-----NGERYTADHILI-ATGGRPSIP-DIPGA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 161 -HPWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASV 239
Cdd:PRK06116  152 eYGITSDGFFALEELPKRVAVVGAGYIAVEFAGVLNGLGSETHLFVRGDAPLRGFDPDIRETLVEEMEKKGIRLHTNAVP 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 240 TKCTRSDaeDTGLgrvhggQVHLEtSAGTVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLHEKLPAW-------LHAVG 312
Cdd:PRK06116  232 KAVEKNA--DGSL------TLTLE-DGETLTVDCLIWAIGREPNTDGLGLENAGVKLNEKGYIIVDEYqntnvpgIYAVG 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 313 DASGDVPLTHWGKYRARVIGARIKAAATGAPAPYEVenppVPQVVFTQPQVAQTGLTEASARDRG----IDVVTAEVpyn 388
Cdd:PRK06116  303 DVTGRVELTPVAIAAGRRLSERLFNNKPDEKLDYSN----IPTVVFSHPPIGTVGLTEEEAREQYgednVKVYRSSF--- 375

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2524716957 389 gaagaALLRDTISG-----KAKIVVDRETRCLVGATFVGPDAGEQLHAATIAI 436
Cdd:PRK06116  376 -----TPMYTALTGhrqpcLMKLVVVGKEEKVVGLHGIGFGADEMIQGFAVAI 423
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 7-456 4.14e-35

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 136.21  E-value: 4.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   7 QESVDVIVIGGGAVGENAAQYAIEGTDLTAVIVE------GHLLGGECSYYACMPSKALLRP---------------VDV 65
Cdd:PRK06327    2 SKQFDVVVIGAGPGGYVAAIRAAQLGLKVACIEAwknpkgKPALGGTCLNVGCIPSKALLASseefenaghhfadhgIHV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  66 TGLTDDlegvVPTrldrdgMLARRDSFVSDYDDSSQVEWAeSAGIRVVRGHARLVG--ERSVRIEADDAAARTLTARHaV 143
Cdd:PRK06327   82 DGVKID----VAK------MIARKDKVVKKMTGGIEGLFK-KNKITVLKGRGSFVGktDAGYEIKVTGEDETVITAKH-V 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 144 ILATGSE----PSIPseFDGAHPWTSADATGVVETPESIAIVGGGVVACE-AAVWlNALGSRVTLLVRGSGLLSGNEPFA 218
Cdd:PRK06327  150 IIATGSEprhlPGVP--FDNKIILDNTGALNFTEVPKKLAVIGAGVIGLElGSVW-RRLGAEVTILEALPAFLAAADEQV 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 219 GDTVLDGLRASGVEVVLDASVtkctrSDAEDTGLGrVHGGQVHLETSAGTVDVAEVLVATGRTPRLRDVGLDAVGLSA-- 296
Cdd:PRK06327  227 AKEAAKAFTKQGLDIHLGVKI-----GEIKTGGKG-VSVAYTDADGEAQTLEVDKLIVSIGRVPNTDGLGLEAVGLKLde 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 297 ------DDVLHEKLPAwLHAVGDASGDVPLTHWGKYRARVIGARIkaaatgAPAPYEVENPPVPQVVFTQPQVAQTGLTE 370
Cdd:PRK06327  301 rgfipvDDHCRTNVPN-VYAIGDVVRGPMLAHKAEEEGVAVAERI------AGQKGHIDYNTIPWVIYTSPEIAWVGKTE 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 371 ASARDRGIDVVTAEVPYnGAAGAALLRDTISGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVP 450
Cdd:PRK06327  374 QQLKAEGVEYKAGKFPF-MANGRALAMGEPDGFVKIIADAKTDEILGVHVIGPNASELIAEAVVAMEFKASSEDIARICH 452


                  ....*.
gi 2524716957 451 SYPTVS 456
Cdd:PRK06327  453 AHPTLS 458
PRK08010 PRK08010
pyridine nucleotide-disulfide oxidoreductase; Provisional
 13-456 7.55e-31

pyridine nucleotide-disulfide oxidoreductase; Provisional


Pssm-ID: 181196 [Multi-domain]  Cd Length: 441  Bit Score: 123.97  E-value: 7.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  13 IVIGGGAVGEN-AAQYAIEGTDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVTGltddlegvvptrlDRDGMLARRDS 91
Cdd:PRK08010    7 VIIGFGKAGKTlAVTLAKAGWRVALIEQSNAMYGGTCINIGCIPTKTLVHDAQQHT-------------DFVRAIQRKNE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  92 FVSDYDDSSQVEWAESAGIRVVRGHARLVGERSVRIEADDaaaRTLTAR-HAVILATGSE---PSIPSEFDGAHPWTSAD 167
Cdd:PRK08010   74 VVNFLRNKNFHNLADMPNIDVIDGQAEFINNHSLRVHRPE---GNLEIHgEKIFINTGAQtvvPPIPGITTTPGVYDSTG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 168 ATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTKCTRsda 247
Cdd:PRK08010  151 LLNLKELPGHLGILGGGYIGVEFASMFANFGSKVTILEAASLFLPREDRDIADNIATILRDQGVDIILNAHVERISH--- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 248 edtglgrvHGGQVHLETSAGTVDVAEVLVATGRTPRLRDVGLDAVGLS--------ADDVLHEKLPAwLHAVGDASGDVP 319
Cdd:PRK08010  228 --------HENQVQVHSEHAQLAVDALLIASGRQPATASLHPENAGIAvnergaivVDKYLHTTADN-IWAMGDVTGGLQ 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 320 LTHWGKYRARVIgaRIKAAATGAPAPYEVENppVPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYNGAAGAALLRDT 399
Cdd:PRK08010  299 FTYISLDDYRIV--RDELLGEGKRSTDDRKN--VPYSVFMTPPLSRVGMTEEQARESGADIQVVTLPVAAIPRARVMNDT 374

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 400 iSGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:PRK08010  375 -RGVLKAIVDNKTQRILGASLLCVDSHEMINIVKMVMDAGLPYSILRDQIFTHPSMS 430
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 11-294 2.71e-30

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 119.35  E-value: 2.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGAVGENAAQYAIEGTDLTAVIVeghlLGGECSYYACMPSKALLRPVDvtgltdDLEGVVPTRLDRDGMLARRD 90
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIE----DEGTCPYGGCVLSKALLGAAE------APEIASLWADLYKRKEEVVK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  91 SFVSDYDDSSQVEwaesaGIRVVRGHARLVGERSVrieadDAAARTLTARHaVILATGSEPSIPS-------EFDGAHPW 163
Cdd:pfam07992  72 KLNNGIEVLLGTE-----VVSIDPGAKKVVLEELV-----DGDGETITYDR-LVIATGARPRLPPipgvelnVGFLVRTL 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 164 TSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTKct 243
Cdd:pfam07992 141 DSAEALRLKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKE-- 218

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2524716957 244 rsdaedtglGRVHGGQVHLETSAGTVDVAE-VLVATGRTPrlRDVGLDAVGL 294
Cdd:pfam07992 219 ---------IIGDGDGVEVILKDGTEIDADlVVVAIGRRP--NTELLEAAGL 259
PTZ00153 PTZ00153
lipoamide dehydrogenase; Provisional
 2-456 8.99e-29

lipoamide dehydrogenase; Provisional


Pssm-ID: 173442 [Multi-domain]  Cd Length: 659  Bit Score: 119.63  E-value: 8.99e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   2 TESATQ---ESVDVIVIGGGAVGENAAQYAIEgTDLTAVIVEG--HLLGGECSYYACMPSKALLRPVD------------ 64
Cdd:PTZ00153  106 TSQSMNfsdEEYDVGIIGCGVGGHAAAINAME-RGLKVIIFTGddDSIGGTCVNVGCIPSKALLYATGkyrelknlakly 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  65 VTGL-TDDLEGVVPTRLDRDGMLArrDSF------VSDYDDS------SQVEWA--------ESAGIRVVRGHARLVGER 123
Cdd:PTZ00153  185 TYGIyTNAFKNGKNDPVERNQLVA--DTVqiditkLKEYTQSvidklrGGIENGlkskkfckNSEHVQVIYERGHIVDKN 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 124 SVRIEADDAAARTltarHAVILATGSEPSIPS--EFDGAHPWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRV 201
Cdd:PTZ00153  263 TIKSEKSGKEFKV----KNIIIATGSTPNIPDniEVDQKSVFTSDTAVKLEGLQNYMGIVGMGIIGLEFMDIYTALGSEV 338

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 202 TLLVRGSGLLSG---------------NEP--FAGDTVLDGLRASGVEVVLDASVTKctRSDAEDTGLGRVHggqvhleT 264
Cdd:PTZ00153  339 VSFEYSPQLLPLldadvakyfervflkSKPvrVHLNTLIEYVRAGKGNQPVIIGHSE--RQTGESDGPKKNM-------N 409

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 265 SAGTVDVAEVLVATGRTPRLRDVGLDAVGL-------SADD---VLHEKLPAWLH--AVGDASGDVPLTHWGKYRA---- 328
Cdd:PTZ00153  410 DIKETYVDSCLVATGRKPNTNNLGLDKLKIqmkrgfvSVDEhlrVLREDQEVYDNifCIGDANGKQMLAHTASHQAlkvv 489

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 329 RVIGARIKAA-----ATGAPAPYEVENppVPQVVFTQPQVAQTGLTEASARDRGI-DVVTAEVPYNGAAGAALLRDTIS- 401
Cdd:PTZ00153  490 DWIEGKGKENvninvENWASKPIIYKN--IPSVCYTTPELAFIGLTEKEAKELYPpDNVGVEISFYKANSKVLCENNISf 567

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2524716957 402 ---------------------GKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:PTZ00153  568 pnnsknnsynkgkyntvdnteGMVKIVYLKDTKEILGMFIVGSYASILIHEGVLAINLKLSVKDLAHMVHSHPTIS 643
PLN02507 PLN02507
glutathione reductase
 3-438 3.45e-25

glutathione reductase


Pssm-ID: 215281 [Multi-domain]  Cd Length: 499  Bit Score: 107.98  E-value: 3.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957   3 ESATQESVDVIVIGGGAVGENAAQYAIE-GTDLTAVIVEGHLL--------GGECSYYACMPSKALLRPVDVTGLTDDLE 73
Cdd:PLN02507   19 ANATHYDFDLFVIGAGSGGVRAARFSANfGAKVGICELPFHPIssesiggvGGTCVIRGCVPKKILVYGATFGGEFEDAK 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  74 GV---VPTRLDRD--GMLARRDSFVSDYDDSSQvEWAESAGIRVVRGHARLVGERSVRIEADDAAARTLTARHaVILATG 148
Cdd:PLN02507   99 NYgweINEKVDFNwkKLLQKKTDEILRLNGIYK-RLLANAGVKLYEGEGKIVGPNEVEVTQLDGTKLRYTAKH-ILIATG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 149 SE---PSIPSEFDGAhpwTSADATGVVETPESIAIVGGGVVACE-AAVWlNALGSRVTLLVRGSGLLSGNEPFAGDTVLD 224
Cdd:PLN02507  177 SRaqrPNIPGKELAI---TSDEALSLEELPKRAVVLGGGYIAVEfASIW-RGMGATVDLFFRKELPLRGFDDEMRAVVAR 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 225 GLRASGVEVVLDASVTKCTRSdAEDTGLGRVHGGQVhletsagTVDVaeVLVATGRTPRLRDVGLDAVGLSADDVLHEKL 304
Cdd:PLN02507  253 NLEGRGINLHPRTNLTQLTKT-EGGIKVITDHGEEF-------VADV--VLFATGRAPNTKRLNLEAVGVELDKAGAVKV 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 305 PAW-------LHAVGDASGDVPLTHWGKYRARVIGariKAAATGAPAPYEVENppVPQVVFTQPQVAQTGLTEASARDRG 377
Cdd:PLN02507  323 DEYsrtnipsIWAIGDVTNRINLTPVALMEGTCFA---KTVFGGQPTKPDYEN--VACAVFCIPPLSVVGLSEEEAVEQA 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 378 I-DVVTAEVPYNGaagaalLRDTISGKA-----KIVVDRETRCLVGATFVGPDAGEQLHAATIAITG 438
Cdd:PLN02507  398 KgDILVFTSSFNP------MKNTISGRQektvmKLIVDAETDKVLGASMCGPDAPEIMQGIAVALKC 458
PLN02546 PLN02546
glutathione reductase
 108-436 8.20e-25

glutathione reductase


Pssm-ID: 215301 [Multi-domain]  Cd Length: 558  Bit Score: 107.27  E-value: 8.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 108 AGIRVVRGHARLVGERSVrieadDAAARTLTARHaVILATGSEPSIPSEFDGAHPWTSADATGVVETPESIAIVGGGVVA 187
Cdd:PLN02546  191 AGVTLIEGRGKIVDPHTV-----DVDGKLYTARN-ILIAVGGRPFIPDIPGIEHAIDSDAALDLPSKPEKIAIVGGGYIA 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 188 CEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTKCTRSDaedtglgrvhGGQVHLETSAG 267
Cdd:PLN02546  265 LEFAGIFNGLKSDVHVFIRQKKVLRGFDEEVRDFVAEQMSLRGIEFHTEESPQAIIKSA----------DGSLSLKTNKG 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 268 TVD-VAEVLVATGRTPRLRDVGLDAVG--------LSADDVLHEKLPA-WlhAVGDASGDVPLThwgkyrarvigaRIKA 337
Cdd:PLN02546  335 TVEgFSHVMFATGRKPNTKNLGLEEVGvkmdkngaIEVDEYSRTSVPSiW--AVGDVTDRINLT------------PVAL 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 338 AATGAPAPYEVENPP-------VPQVVFTQPQVAQTGLTEASARDR--GIDVVTAEVpyngaagaALLRDTISGKA---- 404
Cdd:PLN02546  401 MEGGALAKTLFGNEPtkpdyraVPSAVFSQPPIGQVGLTEEQAIEEygDVDVFTANF--------RPLKATLSGLPdrvf 472

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2524716957 405 -KIVVDRETRCLVGATFVGPDAGEQLHAATIAI 436
Cdd:PLN02546  473 mKLIVCAKTNKVLGVHMCGEDAPEIIQGFAVAV 505
Pyr_redox_dim pfam02852
Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both ...
 353-456 9.15e-25

Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.


Pssm-ID: 427019 [Multi-domain]  Cd Length: 109  Bit Score: 98.39  E-value: 9.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 353 VPQVVFTQPQVAQTGLTEASARDRGIDVVTAEVPYNGAAGAALLRDTiSGKAKIVVDRETRCLVGATFVGPDAGEQLHAA 432
Cdd:pfam02852   1 IPSVVFTDPEIASVGLTEEEAKEKGGEVKVGKFPFAANGRALAYGDT-DGFVKLVADRETGKILGAHIVGPNAGELIQEA 79

                          90       100
                  ....*....|....*....|....
gi 2524716957 433 TIAITGKVPVHVLRHAVPSYPTVS 456
Cdd:pfam02852  80 ALAIKMGATVEDLANTIHIHPTLS 103
PTZ00058 PTZ00058
glutathione reductase; Provisional
 11-376 9.17e-24

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 104.31  E-value: 9.17e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGAVGENAAQYAIEgTDLTAVIVEGHLLGGECSYYACMPSKALLRPVDVTGLTDDLEGV---VPTRLDRDGMLA 87
Cdd:PTZ00058   50 DLIVIGGGSGGMAAARRAAR-NKAKVALVEKDYLGGTCVNVGCVPKKIMFNAASIHDILENSRHYgfdTQFSFNLPLLVE 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  88 RRDSFVSDYDDSSQVEWAEsAGIRVVRGHARLVGERSVRIE------------ADDAAA------------RTLTARHaV 143
Cdd:PTZ00058  129 RRDKYIRRLNDIYRQNLKK-DNVEYFEGKGSLLSENQVLIKkvsqvdgeadesDDDEVTivsagvsqlddgQVIEGKN-I 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 144 ILATGSEPSIPsEFDGAHPWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVL 223
Cdd:PTZ00058  207 LIAVGNKPIFP-DVKGKEFTISSDDFFKIKEAKRIGIAGSGYIAVELINVVNRLGAESYIFARGNRLLRKFDETIINELE 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 224 DGLRASGVEVVLDASVTKCTRsdAEDTGLgrvhggQVHLETSAGTVDVAEVLVATGRTPRLRDVGLDAVG-------LSA 296
Cdd:PTZ00058  286 NDMKKNNINIITHANVEEIEK--VKEKNL------TIYLSDGRKYEHFDYVIYCVGRSPNTEDLNLKALNiktpkgyIKV 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 297 DDVLHEKLPAwLHAVGDASGDVP------LTHWGKYRARVIGAriKAAATGAPAPYEVENPPV----------------- 353
Cdd:PTZ00058  358 DDNQRTSVKH-IYAVGDCCMVKKnqeiedLNLLKLYNEEPYLK--KKENTSGESYYNVQLTPVainagrlladrlfgpfs 434

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2524716957 354 --------PQVVFTQPQVAQTGLTEASARDR 376
Cdd:PTZ00058  435 rttnykliPSVIFSHPPIGTIGLSEQEAIDI 465
trypano_reduc TIGR01423
trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of ...
 11-454 1.50e-23

trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of spermidine, is (in its reduced form) an important antioxidant found in trypanosomatids (Crithidia, Leishmania, Trypanosoma). This model describes trypanothione reductase, a possible antitrypanosomal drug target closely related to some forms of glutathione reductase.


Pssm-ID: 200098 [Multi-domain]  Cd Length: 486  Bit Score: 103.13  E-value: 1.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGA----VGENAAqyAIEGTDLTAVIVEGH-------LLGGECSYYACMPSKAL---------LRPVDVTGLTD 70
Cdd:TIGR01423   5 DLVVIGAGSggleAGWNAA--TLYKKRVAVVDVQTHhgppfyaALGGTCVNVGCVPKKLMvtgaqymdtLRESAGFGWEF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  71 DLEGVVPtrlDRDGMLARRDSFVSDYDDSSQVEWAESAGIRVVRGHARLVGERSV--RIEADDAAA--RTLTARHaVILA 146
Cdd:TIGR01423  83 DRSSVKA---NWKALIAAKNKAVLDINKSYEGMFADTEGLTFFLGWGALEDKNVVlvRESADPKSAvkERLQAEH-ILLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 147 TGSEPSIPSEFDGAHPWTSADATGVVETPESIAIVGGGVVACEAAVWLNA---LGSRVTLLVRGSGLLSGNEPFAGDTVL 223
Cdd:TIGR01423 159 TGSWPQMLGIPGIEHCISSNEAFYLDEPPRRVLTVGGGFISVEFAGIFNAykpRGGKVTLCYRNNMILRGFDSTLRKELT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 224 DGLRASGVEVVLDASVTKCTRSDaedtglgrvhGGQVHLETSAG-TVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLHE 302
Cdd:TIGR01423 239 KQLRANGINIMTNENPAKVTLNA----------DGSKHVTFESGkTLDVDVVMMAIGRVPRTQTLQLDKVGVELTKKGAI 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 303 KLPAW-------LHAVGDASGDVPLTHwgkyRARVIGARIKAAATGApAPYEVENPPVPQVVFTQPQVAQTGLTEASARD 375
Cdd:TIGR01423 309 QVDEFsrtnvpnIYAIGDVTDRVMLTP----VAINEGAAFVDTVFGN-KPRKTDHTRVASAVFSIPPIGTCGLVEEDAAK 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 376 RGIDVVTAEVPYNGaagaalLRDTISGK------AKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAV 449
Cdd:TIGR01423 384 KFEKVAVYESSFTP------LMHNISGSkykkfvAKIVTNHADGTVLGVHLLGDSSPEIIQAVGICLKLNAKISDFYNTI 457


                  ....*
gi 2524716957 450 PSYPT 454
Cdd:TIGR01423 458 GVHPT 462
PRK07845 PRK07845
flavoprotein disulfide reductase; Reviewed
 12-456 1.82e-22

flavoprotein disulfide reductase; Reviewed


Pssm-ID: 236112 [Multi-domain]  Cd Length: 466  Bit Score: 99.55  E-value: 1.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  12 VIVIGGGAVGENAAQYAIE-GTDLTavIVEGHLLGGECSYYACMPSKAL-----------------LRPVDVTGLTDDLe 73
Cdd:PRK07845    4 IVIIGGGPGGYEAALVAAQlGADVT--VIERDGLGGAAVLTDCVPSKTLiataevrtelrraaelgIRFIDDGEARVDL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  74 GVVPTRLDRdgmLARRDSFvsdyDDSSQVEwaeSAGIRVVRGHARL----VGERSVRIEADDAAARTLTArHAVILATGS 149
Cdd:PRK07845   81 PAVNARVKA---LAAAQSA----DIRARLE---REGVRVIAGRGRLidpgLGPHRVKVTTADGGEETLDA-DVVLIATGA 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 150 EPSI-PS-EFDGAHPWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLR 227
Cdd:PRK07845  150 SPRIlPTaEPDGERILTWRQLYDLDELPEHLIVVGSGVTGAEFASAYTELGVKVTLVSSRDRVLPGEDADAAEVLEEVFA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 228 ASGVEVVLDASVTKCTRSDaedtglgrvHGGQVHLeTSAGTVDVAEVLVATGRTPRLRDVGLDAVGLSADDVLHEKLP-- 305
Cdd:PRK07845  230 RRGMTVLKRSRAESVERTG---------DGVVVTL-TDGRTVEGSHALMAVGSVPNTAGLGLEEAGVELTPSGHITVDrv 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 306 -----AWLHAVGDASGDVPLthwgkyrARVigarikAAATGAPAPY----EVENP----PVPQVVFTQPQVAQTGLTEAS 372
Cdd:PRK07845  300 srtsvPGIYAAGDCTGVLPL-------ASV------AAMQGRIAMYhalgEAVSPlrlkTVASNVFTRPEIATVGVSQAA 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 373 ARDRGIDVVTAEVPYNGAAGAAL--LRDtisGKAKIVVDRETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAVP 450
Cdd:PRK07845  367 IDSGEVPARTVMLPLATNPRAKMsgLRD---GFVKLFCRPGTGVVIGGVVVAPRASELILPIALAVQNRLTVDDLAQTFT 443


                  ....*.
gi 2524716957 451 SYPTVS 456
Cdd:PRK07845  444 VYPSLS 449
TGR TIGR01438
thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member ...
 11-456 4.29e-20

thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member of the pyridine nucleotide disulfide oxidoreductase family contains a C-terminal motif Cys-SeCys-Gly, where SeCys is selenocysteine encoded by TGA (in some sequence reports interpreted as a stop codon). In some members of this subfamily, Cys-SeCys-Gly is replaced by Cys-Cys-Gly. The reach of the selenium atom at the C-term arm of the protein is proposed to allow broad substrate specificity.


Pssm-ID: 273624 [Multi-domain]  Cd Length: 484  Bit Score: 92.61  E-value: 4.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGAVGENAAQYAIEGTDLTAVI--VE----GHL--LGGECSYYACMPSKaLLRPVDVTG--LTDD----LEGVV 76
Cdd:TIGR01438   4 DLIVIGGGSGGLAAAKEAAAYGAKVMLLdfVTptplGTRwgIGGTCVNVGCIPKK-LMHQAALLGqaLKDSrnygWKVEE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  77 PTRLDRDGMLARRDSFVSDYDDSSQVEWAESAgIRVVRGHARLVGERSVRIEADDAAARTLTARHAVIlATGSEPSIPS- 155
Cdd:TIGR01438  83 TVKHDWKRLVEAVQNHIGSLNWGYRVALREKK-VKYENAYAEFVDKHRIKATNKKGKEKIYSAERFLI-ATGERPRYPGi 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 156 EFDGAHPWTSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRgSGLLSGNEPFAGDTVLDGLRASGVEVVL 235
Cdd:TIGR01438 161 PGAKELCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVR-SILLRGFDQDCANKVGEHMEEHGVKFKR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 236 DASVTKCTRSDAedtglgrvhggQVHLETSAGTVDVAE----VLVATGRTPRLRDVGLDAVGLSADDVlHEKLPA----- 306
Cdd:TIGR01438 240 QFVPIKVEQIEA-----------KVLVEFTDSTNGIEEeydtVLLAIGRDACTRKLNLENVGVKINKK-TGKIPAdeeeq 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 307 ----WLHAVGDASGDVP-LTHWGKYRARVIGARIKAAATgapapYEVENPPVPQVVFTQPQVAQTGLTEASARDR----G 377
Cdd:TIGR01438 308 tnvpYIYAVGDILEDKPeLTPVAIQAGRLLAQRLFKGST-----VICDYENVPTTVFTPLEYGACGLSEEKAVEKfgeeN 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 378 IDVVTAE-------VPYNGAAGAALlrdtisgkAKIVVDR-ETRCLVGATFVGPDAGEQLHAATIAITGKVPVHVLRHAV 449
Cdd:TIGR01438 383 VEVFHSYfwplewtIPSRDNHNKCY--------AKLVCNKkENERVVGFHVVGPNAGEVTQGFAAALRCGLTKKDLDNTI 454


                  ....*..
gi 2524716957 450 PSYPTVS 456
Cdd:TIGR01438 455 GIHPVCA 461
PTZ00052 PTZ00052
thioredoxin reductase; Provisional
 11-436 7.64e-17

thioredoxin reductase; Provisional


Pssm-ID: 185416 [Multi-domain]  Cd Length: 499  Bit Score: 82.95  E-value: 7.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGAVGENAAQYA------IEGTDLTAVIVEGHL--LGGECSYYACMPSKALLRPVDVtgltddlegvvptrldr 82
Cdd:PTZ00052    7 DLVVIGGGSGGMAAAKEAaahgkkVALFDYVKPSTQGTKwgLGGTCVNVGCVPKKLMHYAANI----------------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  83 dGMLARRDSFVSDYDDSSQVEWAE---------------------SAGIRVVRGHARLVGERSVRIEaDDAAARTLTARH 141
Cdd:PTZ00052   70 -GSIFHHDSQMYGWKTSSSFNWGKlvttvqnhirslnfsyrtglrSSKVEYINGLAKLKDEHTVSYG-DNSQEETITAKY 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 142 aVILATGSEPSIPSEFDGAHPW--TSADATGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRgSGLLSGNEPFAG 219
Cdd:PTZ00052  148 -ILIATGGRPSIPEDVPGAKEYsiTSDDIFSLSKDPGKTLIVGASYIGLETAGFLNELGFDVTVAVR-SIPLRGFDRQCS 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 220 DTVLDGLRASGV---EVVLDASVTKctrsdAEDtglgrvhggQVHLETSAGTVDVAE-VLVATGRTPRLRDVGLDAVGLS 295
Cdd:PTZ00052  226 EKVVEYMKEQGTlflEGVVPINIEK-----MDD---------KIKVLFSDGTTELFDtVLYATGRKPDIKGLNLNAIGVH 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 296 ADDVLHEKLP------AWLHAVGDASGDVPLTHWGKYRARVIGARIKAAATGAPAPYEVenppVPQVVFTQPQVAQTGLT 369
Cdd:PTZ00052  292 VNKSNKIIAPndctniPNIFAVGDVVEGRPELTPVAIKAGILLARRLFKQSNEFIDYTF----IPTTIFTPIEYGACGYS 367

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 370 EASARDR----GIDVVTAEvpYNGAAGAALLRDTISGKAK---------------IVVDRETRCLVGATFVGPDAGEQLH 430
Cdd:PTZ00052  368 SEAAIAKygedDIEEYLQE--FNTLEIAAVHREKHERARKdeydfdvssnclaklVCVKSEDNKVVGFHFVGPNAGEITQ 445


                  ....*.
gi 2524716957 431 AATIAI 436
Cdd:PTZ00052  446 GFSLAL 451
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
103-422 5.76e-16

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 79.42  E-value: 5.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 103 EWAESAGIRVVRGharlvgersVRIEADDAAARTLTARH-------AVILATGSEPSIP----SEFDGAHP-WTSADA-- 168
Cdd:COG1251    64 DFYEENGIDLRLG---------TRVTAIDRAARTVTLADgetlpydKLVLATGSRPRVPpipgADLPGVFTlRTLDDAda 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 169 -TGVVETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGN-EPFAGDTVLDGLRASGVEVVLDASVTKCTRSD 246
Cdd:COG1251   135 lRAALAPGKRVVVIGGGLIGLEAAAALRKRGLEVTVVERAPRLLPRQlDEEAGALLQRLLEALGVEVRLGTGVTEIEGDD 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 247 aedtglgRVHGgqvhLETSAGT-VDVAEVLVATGRTPR---LRDVGLD-AVGLSADDVLHEKLPAwLHAVGD-------A 314
Cdd:COG1251   215 -------RVTG----VRLADGEeLPADLVVVAIGVRPNtelARAAGLAvDRGIVVDDYLRTSDPD-IYAAGDcaehpgpV 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 315 SGDVPLTHW--GKYRARVIGARIkaaaTGAPAPYEvenPPVPQVVFTQPqvaqtglteasardrGIDVVTAEVPyNGAAG 392
Cdd:COG1251   283 YGRRVLELVapAYEQARVAAANL----AGGPAAYE---GSVPSTKLKVF---------------GVDVASAGDA-EGDEE 339

                         330       340       350
                  ....*....|....*....|....*....|
gi 2524716957 393 AALLRDTISGKAKIVVDRETRcLVGATFVG 422
Cdd:COG1251   340 VVVRGDPARGVYKKLVLRDGR-LVGAVLVG 368
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 177-241 1.90e-12

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 62.61  E-value: 1.90e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2524716957 177 SIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTK 241
Cdd:pfam00070   1 RVVVVGGGYIGLELAGALARLGSKVTVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEA 65
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
11-290 2.36e-11

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 64.37  E-value: 2.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  11 DVIVIGGGAVGENAAQYA-IEGtdLTAVIVEGHLLGGECSYYACMPskallrpvDVTGLTDDLEGvvPTRLDRdgMLARr 89
Cdd:COG0492     2 DVVIIGAGPAGLTAAIYAaRAG--LKTLVIEGGEPGGQLATTKEIE--------NYPGFPEGISG--PELAER--LREQ- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  90 dsfvsdyddssqvewAESAGIRVVRGHARLV--GERSVRIEADDAaaRTLTARhAVILATGSEPSIPsEFDGAHPWTSAD 167
Cdd:COG0492    67 ---------------AERFGAEILLEEVTSVdkDDGPFRVTTDDG--TEYEAK-AVIIATGAGPRKL-GLPGEEEFEGRG 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 168 --ATGVVETP----ESIAIVGGGVVACEAAVWLNALGSRVTLLVRgsgllsGNEPFAGDTVLDGLRAS-GVEVVLDASVT 240
Cdd:COG0492   128 vsYCATCDGFffrgKDVVVVGGGDSALEEALYLTKFASKVTLIHR------RDELRASKILVERLRANpKIEVLWNTEVT 201

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2524716957 241 kctrsdaEDTGLGRVHGgqVHLETSAG----TVDVAEVLVATGRTPR---LRDVGLD 290
Cdd:COG0492   202 -------EIEGDGRVEG--VTLKNVKTgeekELEVDGVFVAIGLKPNtelLKGLGLE 249
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 103-346 2.87e-10

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 61.37  E-value: 2.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 103 EWAESAGIRVVRGHarlvgersvRIEADDAAARTLTARH-------AVILATGSEPSIPS----EFDGAHPWTSADATGV 171
Cdd:COG0446    44 ESFERKGIDVRTGT---------EVTAIDPEAKTVTLRDgetlsydKLVLATGARPRPPPipglDLPGVFTLRTLDDADA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 172 V------ETPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGNEPFAGDTVLDGLRASGVEVVLDASVTKctrs 245
Cdd:COG0446   115 LrealkeFKGKRAVVIGGGPIGLELAEALRKRGLKVTLVERAPRLLGVLDPEMAALLEEELREHGVELRLGETVVA---- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 246 dAEDTGLGRVHggqvhlETSAGTVDVAEVLVATGRTPR---LRDVGL---DAVGLSADDVLHEKLPAwLHAVGDASGdVP 319
Cdd:COG0446   191 -IDGDDKVAVT------LTDGEEIPADLVVVAPGVRPNtelAKDAGLalgERGWIKVDETLQTSDPD-VYAAGDCAE-VP 261

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2524716957 320 LTHWGKYR-----------ARVIGARIkaaaTGAPAPY 346
Cdd:COG0446   262 HPVTGKTVyiplasaankqGRVAAENI----LGGPAPF 295
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 92-445 3.38e-10

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 61.98  E-value: 3.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957  92 FVSD-YDDSSQV-----EWAESAGIRVVRGHarlvgersvRIEADDAAARTLTARH------------AVILATGSEPSI 153
Cdd:PRK09564   47 FVGGfFDDPNTMiartpEEFIKSGIDVKTEH---------EVVKVDAKNKTITVKNlktgsifndtydKLMIATGARPII 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 154 P--SEFDGAHPWT---SADATGVVE-----TPESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGN-EPFAGDTV 222
Cdd:PRK09564  118 PpiKNINLENVYTlksMEDGLALKEllkdeEIKNIVIIGAGFIGLEAVEAAKHLGKNVRIIQLEDRILPDSfDKEITDVM 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 223 LDGLRASGVEVVLDASVTkctrsdaEDTGLGRVHGgqvhLETSAGTVDVAEVLVATGRTPR---LRDVGLDAVGLSA--D 297
Cdd:PRK09564  198 EEELRENGVELHLNEFVK-------SLIGEDKVEG----VVTDKGEYEADVVIVATGVKPNtefLEDTGLKTLKNGAiiV 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 298 DVLHEKLPAWLHAVGD-------ASGD---VPLTHWGKYRARVIGARIkaaaTGAPAPYEVENPPVPQVVFTQpQVAQTG 367
Cdd:PRK09564  267 DEYGETSIENIYAAGDcatiyniVSNKnvyVPLATTANKLGRMVGENL----AGRHVSFKGTLGSACIKVLDL-EAARTG 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 368 LTEASARDRGIDVVTAevpyngaagaallrdTISGK-------------AKIVVDRETRCLVGATFVGP-DAGEQLHAAT 433
Cdd:PRK09564  342 LTEEEAKKLGIDYKTV---------------FIKDKnhtnyypgqedlyVKLIYEADTKVILGGQIIGKkGAVLRIDALA 406

                         410
                  ....*....|..
gi 2524716957 434 IAITGKVPVHVL 445
Cdd:PRK09564  407 VAIYAKLTTQEL 418
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
136-282 3.51e-07

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 51.84  E-value: 3.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 136 TLTARHaVILATGsEPSIP------------SEFDGAHPWTSADatgvvetpesIAIVGGGVVACEAAVWLNALGSRVTL 203
Cdd:pfam13738 116 TYQARY-VIIATG-EFDFPnklgvpelpkhySYVKDFHPYAGQK----------VVVIGGYNSAVDAALELVRKGARVTV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 204 LVRGSGLLSGNEPF----AGDTV--LDGLRASG-VEVVLDASVTKCTRsdaedtglgrvHGGQVHLETSAGTVDVAE--V 274
Cdd:pfam13738 184 LYRGSEWEDRDSDPsyslSPDTLnrLEELVKNGkIKAHFNAEVKEITE-----------VDVSYKVHTEDGRKVTSNddP 252


                  ....*...
gi 2524716957 275 LVATGRTP 282
Cdd:pfam13738 253 ILATGYHP 260
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 102-218 1.67e-06

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 49.89  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 102 VEWAESAGIRVVRgharlvgersVRIEADDAAARTLTARHaVILATGSEPSIPSEFDGAHP-WTSADAT---GVVETPES 177
Cdd:pfam13434 121 VEPDAERGEPLLR----------VRVRDADGEETTFLARN-LVLGTGGEPYIPECARGGERvFHSSEYLeriDRLAAKKR 189

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2524716957 178 IAIVGGGVVACEaaVWLNALGSR----VTLLVRGSGLL-SGNEPFA 218
Cdd:pfam13434 190 IAVVGSGQSAAE--IFRDLLRRGpayeLTWVTRSPNFFpLDDSPFV 233
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
105-243 6.27e-05

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 45.12  E-value: 6.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 105 AESAGIRVVRGHArlvgersVRIeadDAAARTLTARH-------AVILATGSEPS---IPSEFDGAHP-WTSADAT---- 169
Cdd:COG1252    66 LRRAGVRFIQGEV-------TGI---DPEARTVTLADgrtlsydYLVIATGSVTNffgIPGLAEHALPlKTLEDALalre 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 170 --------GVVETPESIAIVGGGV----VACEAAVWLNALGS---------RVTLLVRGSGLLSGNEPFAGDTVLDGLRA 228
Cdd:COG1252   136 rllaaferAERRRLLTIVVVGGGPtgveLAGELAELLRKLLRypgidpdkvRITLVEAGPRILPGLGEKLSEAAEKELEK 215

                         170
                  ....*....|....*
gi 2524716957 229 SGVEVVLDASVTKCT 243
Cdd:COG1252   216 RGVEVHTGTRVTEVD 230
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
126-282 6.48e-05

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 44.91  E-value: 6.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 126 RIEADDAAARTLTAR------HAVILATGSEPSIP--------------SEFDGAHpwtsadatGVVETPESIAIVGGGV 185
Cdd:PRK04965   80 WVTDIDAEAQVVKSQgnqwqyDKLVLATGASAFVPpipgrelmltlnsqQEYRAAE--------TQLRDAQRVLVVGGGL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 186 VACEAAVWLNALGSRVTLLVRGSGLLSGNEP-FAGDTVLDGLRASGVEVVLDASVTKCTRSDAedtglgrvhGGQVHLeT 264
Cdd:PRK04965  152 IGTELAMDLCRAGKAVTLVDNAASLLASLMPpEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDS---------GIRATL-D 221

                         170
                  ....*....|....*...
gi 2524716957 265 SAGTVDVAEVLVATGRTP 282
Cdd:PRK04965  222 SGRSIEVDAVIAAAGLRP 239
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 103-313 4.41e-04

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 42.89  E-value: 4.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 103 EWAESAGIRVvrgharLVGERSVRIEADD-----AAARTLTaRHAVILATGSEPSIP----SEFDGAHPWTSADATGVVE 173
Cdd:TIGR02374  62 DWYEKHGITL------YTGETVIQIDTDQkqvitDAGRTLS-YDKLILATGSYPFILpipgADKKGVYVFRTIEDLDAIM 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 174 T----PESIAIVGGGVVACEAAVWLNALGSRVTLLVRGSGLLSGN-EPFAGDTVLDGLRASGVEVVLDasvtKCTRSDAE 248
Cdd:TIGR02374 135 AmaqrFKKAAVIGGGLLGLEAAVGLQNLGMDVSVIHHAPGLMAKQlDQTAGRLLQRELEQKGLTFLLE----KDTVEIVG 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2524716957 249 DTGLGRVHggqvhleTSAGTVDVAEVLV-ATGRTPRL---RDVGLD-AVGLSADDVLHEKLPAwLHAVGD 313
Cdd:TIGR02374 211 ATKADRIR-------FKDGSSLEADLIVmAAGIRPNDelaVSAGIKvNRGIIVNDSMQTSDPD-IYAVGE 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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