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Conserved domains on  [gi|2519076326|ref|WP_284783998|]
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GNAT family N-acetyltransferase [Corynebacterium imitans]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-142 2.50e-36

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 123.18  E-value: 2.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   1 MTKIREAVEADTPVIYEMIKE-----LALYEKEPDSVTSTEEDVRTHLfgeNPSVFALVADNDGVLEGMAlWFLSYSTWE 75
Cdd:COG1247     1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSEEEREAWFAAIL---APGRPVLVAEEDGEVVGFA-SLGPFRPRP 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2519076326  76 GRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNTPSIGFYEAMGAGDMGEW 142
Cdd:COG1247    77 AYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTL 143
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-142 2.50e-36

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 123.18  E-value: 2.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   1 MTKIREAVEADTPVIYEMIKE-----LALYEKEPDSVTSTEEDVRTHLfgeNPSVFALVADNDGVLEGMAlWFLSYSTWE 75
Cdd:COG1247     1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSEEEREAWFAAIL---APGRPVLVAEEDGEVVGFA-SLGPFRPRP 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2519076326  76 GRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNTPSIGFYEAMGAGDMGEW 142
Cdd:COG1247    77 AYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTL 143
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 24-135 1.62e-18

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 76.02  E-value: 1.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  24 LYEKEPDSVTSTEEDVRTHLFGENPSVFALVADNDGVLEGMALwflSYSTWEGRHGIWLEDLYVREAHRGKGLGTALLQE 103
Cdd:pfam00583   7 LLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFAS---LSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQA 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2519076326 104 LARIAVDNDYRRVEWTVLKWNTPSIGFYEAMG 135
Cdd:pfam00583  84 LLEWARERGCERIFLEVAADNLAAIALYEKLG 115
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 53-119 2.66e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.43  E-value: 2.66e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2519076326  53 LVADNDGVLEGMALWflsYSTWEGRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWT 119
Cdd:cd04301     2 LVAEDDGEIVGFASL---SPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 48-135 1.91e-04

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 39.14  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  48 PSVFaLVADNDGVLEG--MAlwflsysTWEGRHGiWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNT 125
Cdd:PRK03624   44 PSLF-LVAEVGGEVVGtvMG-------GYDGHRG-WAYYLAVHPDFRGRGIGRALVARLEKKLIARGCPKINLQVREDND 114

                          90
                  ....*....|
gi 2519076326 126 PSIGFYEAMG 135
Cdd:PRK03624  115 AVLGFYEALG 124
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 87-135 2.11e-03

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 36.15  E-value: 2.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2519076326  87 VREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNTPSIGFYEAMG 135
Cdd:TIGR01575  62 VKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKLG 110
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-142 2.50e-36

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 123.18  E-value: 2.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   1 MTKIREAVEADTPVIYEMIKE-----LALYEKEPDSVTSTEEDVRTHLfgeNPSVFALVADNDGVLEGMAlWFLSYSTWE 75
Cdd:COG1247     1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSEEEREAWFAAIL---APGRPVLVAEEDGEVVGFA-SLGPFRPRP 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2519076326  76 GRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNTPSIGFYEAMGAGDMGEW 142
Cdd:COG1247    77 AYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTL 143
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 68-150 3.26e-19

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 77.00  E-value: 3.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  68 FLSYSTWEGRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNTPSIGFYEAMGAGDMGEWSTMRL 147
Cdd:COG0456     2 FALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYG 81


                  ...
gi 2519076326 148 DGD 150
Cdd:COG0456    82 DDA 84
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 24-135 1.62e-18

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 76.02  E-value: 1.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  24 LYEKEPDSVTSTEEDVRTHLFGENPSVFALVADNDGVLEGMALwflSYSTWEGRHGIWLEDLYVREAHRGKGLGTALLQE 103
Cdd:pfam00583   7 LLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFAS---LSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQA 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2519076326 104 LARIAVDNDYRRVEWTVLKWNTPSIGFYEAMG 135
Cdd:pfam00583  84 LLEWARERGCERIFLEVAADNLAAIALYEKLG 115
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 45-157 1.04e-16

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 72.01  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  45 GENPSVFALVADNDGVLEGmalwFLSYSTWEGRHGIwLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWN 124
Cdd:COG0454    29 GSLAGAEFIAVDDKGEPIG----FAGLRRLDDKVLE-LKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGN 103

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2519076326 125 TPSIGFYEAMGAGDMGEWSTMRLDGDALRVLGS 157
Cdd:COG0454   104 PAAIRFYERLGFKEIERYVAYVGGEFEKELSLS 136
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
73-148 3.57e-15

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 66.47  E-value: 3.57e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2519076326  73 TWEGRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNTPSIGFYEAMGAGDMGEWSTMRLD 148
Cdd:COG3393     9 RAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATVLFR 84
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 3-135 6.23e-15

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 67.32  E-value: 6.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   3 KIREAVEADTPVIYEMIKELALYEkepdsvtsteedvrthlfgenPSVFALVADNDGVLEGMAlwflSYSTWEGRHGiWL 82
Cdd:COG1246     2 TIRPATPDDVPAILELIRPYALEE---------------------EIGEFWVAEEDGEIVGCA----ALHPLDEDLA-EL 55

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2519076326  83 EDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVlkwNTPSIGFYEAMG 135
Cdd:COG1246    56 RSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLT---TSAAIHFYEKLG 105
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
4-135 1.75e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 66.26  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   4 IREAVEADTPVIYEMIKELALYEKEPDSVTSTEEDVRTHLFgenpsvfaLVADNDGVLEGMALwfLSYSTWEGRHGI-WL 82
Cdd:COG3153     1 IRPATPEDAEAIAALLRAAFGPGREAELVDRLREDPAAGLS--------LVAEDDGEIVGHVA--LSPVDIDGEGPAlLL 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2519076326  83 EDLYVREAHRGKGLGTALLQELARIAVDNDYRRVewtVLKWNTPSIGFYEAMG 135
Cdd:COG3153    71 GPLAVDPEYRGQGIGRALMRAALEAARERGARAV---VLLGDPSLLPFYERFG 120
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 53-135 9.20e-12

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 9.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  53 LVADNDGVLEGmalwFLSYSTWEGRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEwtvLKWNTPSIGFYE 132
Cdd:pfam13508   6 FVAEDDGKIVG----FAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLE---LETTNRAAAFYE 78


                  ...
gi 2519076326 133 AMG 135
Cdd:pfam13508  79 KLG 81
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 4-160 7.91e-11

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 57.32  E-value: 7.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   4 IREAVEADTPVIYEMIKELALYE---KEPDSVTSTEEDVRTHLFGENPS---VFALVADNDGVLEGMA-LWFLSYSTWEG 76
Cdd:COG1670    10 LRPLRPEDAEALAELLNDPEVARylpGPPYSLEEARAWLERLLADWADGgalPFAIEDKEDGELIGVVgLYDIDRANRSA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  77 RHGIWLedlyvREAHRGKGLGTALLQELARIAVDN-DYRRVEWTVLKWNTPSIGFYEAMGagdmgewstMRLDG---DAL 152
Cdd:COG1670    90 EIGYWL-----APAYWGKGYATEALRALLDYAFEElGLHRVEAEVDPDNTASIRVLEKLG---------FRLEGtlrDAL 155


                  ....*...
gi 2519076326 153 RVLGSTRD 160
Cdd:COG1670   156 VIDGRYRD 163
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 53-119 2.66e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.43  E-value: 2.66e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2519076326  53 LVADNDGVLEGMALWflsYSTWEGRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWT 119
Cdd:cd04301     2 LVAEDDGEIVGFASL---SPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 46-135 2.64e-08

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 49.58  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  46 ENPSVFALVADNDGVLEGMAlwflsySTWEGRHgiwLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVlKWNT 125
Cdd:pfam13673  27 DQGEYFFFVAFEGGQIVGVI------ALRDRGH---ISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTV-NASP 96

                          90
                  ....*....|
gi 2519076326 126 PSIGFYEAMG 135
Cdd:pfam13673  97 YAVPFYEKLG 106
COG3818 COG3818
Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];
3-141 8.21e-08

Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 443030 [Multi-domain]  Cd Length: 168  Bit Score: 49.16  E-value: 8.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   3 KIREAVEADTPVIyemikeLALYEKEPDSVTSTEEDVRTHLFGEnpSVFALVADNDGVLEGMALWFLSYSTWEGRHGIWL 82
Cdd:COG3818     6 VIRDAREHDLDAV------LALNNAAVPAVSPLDAARLARLHEQ--AAYARVAEVDGEVAGFLLAFGPGADYDSPNYRWF 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2519076326  83 EDLY----------VREAHRGKGLGTALLQELARIAVDNDYRRV--EWTVLKWNTPSIGFYEAMGAGDMGE 141
Cdd:COG3818    78 AERYdnflyidrivVAPSARGRGLGRALYADVFSYARARGVPRVtcEVNLEPPNPGSLAFHARLGFREVGQ 148
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 85-135 2.69e-05

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 40.39  E-value: 2.69e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2519076326  85 LYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKwNTPSIGFYEAMG 135
Cdd:pfam08445  27 LQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAG-NTPSRRLYEKLG 76
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
75-135 2.79e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 41.32  E-value: 2.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2519076326  75 EGRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVewtVLKWNTPSIGFYEAMG 135
Cdd:COG2153    54 PGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRI---VLSAQAHAVGFYEKLG 111
PRK03624 PRK03624
putative acetyltransferase; Provisional
 48-135 1.91e-04

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 39.14  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326  48 PSVFaLVADNDGVLEG--MAlwflsysTWEGRHGiWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNT 125
Cdd:PRK03624   44 PSLF-LVAEVGGEVVGtvMG-------GYDGHRG-WAYYLAVHPDFRGRGIGRALVARLEKKLIARGCPKINLQVREDND 114

                          90
                  ....*....|
gi 2519076326 126 PSIGFYEAMG 135
Cdd:PRK03624  115 AVLGFYEALG 124
PRK07757 PRK07757
N-acetyltransferase;
1-135 3.72e-04

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 38.64  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   1 MTKIREAVEADTPVIYEMIKELAlyEKE---PDSVTSTEEDVRThlfgenpsvFALVADNDGVLEGMALWFLSYSTWEGR 77
Cdd:PRK07757    1 MMEIRKARLSDVKAIHALINVYA--KKGlmlPRSLDELYENIRD---------FYVAEEEGEIVGCCALHILWEDLAEIR 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2519076326  78 hgiwleDLYVREAHRGKGLGTALLQELARIAVDNDYRRVewTVLkwnTPSIGFYEAMG 135
Cdd:PRK07757   70 ------SLAVSEDYRGQGIGRMLVEACLEEARELGVKRV--FAL---TYQPEFFEKLG 116
COG3375 COG3375
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
51-119 5.55e-04

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 442602 [Multi-domain]  Cd Length: 271  Bit Score: 38.77  E-value: 5.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2519076326  51 FALVADNDGVLEGMALWFLSYStwEGRHGIWLEDLYVREAHRGKGLGTALLQELARIAVDNDYRRVEWT 119
Cdd:COG3375    49 YVLGAFDGGELVGFSFGFPGFR--PGGLYLHSHMAGVLPEYRGRGVGYALKLHQREWALERGVTLITWT 115
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 87-135 2.11e-03

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 36.15  E-value: 2.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2519076326  87 VREAHRGKGLGTALLQELARIAVDNDYRRVEWTVLKWNTPSIGFYEAMG 135
Cdd:TIGR01575  62 VKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKLG 110
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 4-136 4.69e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 35.40  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519076326   4 IREAVEADTPVIYEMIKE---LALYEKEPDSVTSTEEDVRTHLFGENPS---VFALVADNDGVLeGMAlWFLSYSTWEGR 77
Cdd:pfam13302   4 LRPLTEEDAEALFELLSDpevMRYGVPWPLTLEEAREWLARIWAADEAErgyGWAIELKDTGFI-GSI-GLYDIDGEPER 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2519076326  78 H--GIWLedlyvREAHRGKGLGTALLQELARIAVDN-DYRRVEWTVLKWNTPSIGFYEAMGA 136
Cdd:pfam13302  82 AelGYWL-----GPDYWGKGYATEAVRALLEYAFEElGLPRLVARIDPENTASRRVLEKLGF 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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