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Conserved domains on  [gi|2507268757|ref|WP_282995398|]
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ABC transporter permease subunit, partial [Serratia sp. Se-RSBMAAmG]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM super family cl43263
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-102 1.43e-25

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG0765:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 94.76  E-value: 1.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:COG0765   116 KGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALI 195

                          90       100
                  ....*....|....*....|..
gi 2507268757  81 YVGINLVIMLIMSLVERKIRLP 102
Cdd:COG0765   196 YLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-102 1.43e-25

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 94.76  E-value: 1.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:COG0765   116 KGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALI 195

                          90       100
                  ....*....|....*....|..
gi 2507268757  81 YVGINLVIMLIMSLVERKIRLP 102
Cdd:COG0765   196 YLVLTLPLSLLARRLERRLARG 217
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 1-101 1.15e-10

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 55.83  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:PRK09494  118 KGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVI 197

                          90       100
                  ....*....|....*....|.
gi 2507268757  81 YVGINLVIMLIMSLVERKIRL 101
Cdd:PRK09494  198 YLIITLVLSFILRRLERRMKI 218
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 1-100 6.61e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 50.76  E-value: 6.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTI----GLVYMAAQAGKLLDYSAhAYESFTA 76
Cdd:pfam00528  80 SDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYPE-IQGPVLA 158

                          90       100
                  ....*....|....*....|....
gi 2507268757  77 ITLAYVGINLVIMLIMSLVERKIR 100
Cdd:pfam00528 159 AALILLLLNLLVDILQRLLDPRVR 182
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 1-99 1.17e-07

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 47.54  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:TIGR03003 114 RGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMNQAKSIGNSTFRYLEPMTLVGVF 193

                          90
                  ....*....|....*....
gi 2507268757  81 YVGINLVIMLIMSLVERKI 99
Cdd:TIGR03003 194 FLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 1-90 1.50e-04

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 38.80  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:cd06261   101 KDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLGVAAA 180

                          90
                  ....*....|
gi 2507268757  81 YVGINLVIML 90
Cdd:cd06261   181 VALILLLLSL 190
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-102 1.43e-25

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 94.76  E-value: 1.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:COG0765   116 KGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALI 195

                          90       100
                  ....*....|....*....|..
gi 2507268757  81 YVGINLVIMLIMSLVERKIRLP 102
Cdd:COG0765   196 YLVLTLPLSLLARRLERRLARG 217
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-101 5.48e-20

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 82.89  E-value: 5.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGlvYM---AAQAGKLLDYSAHAYESFTAI 77
Cdd:COG4597   293 KGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIG--YPdlvSVFAGTTLNQTGQAIEIIAIT 370

                          90       100
                  ....*....|....*....|....
gi 2507268757  78 TLAYVGINLVIMLIMSLVERKIRL 101
Cdd:COG4597   371 MAVYLTISLLISLLMNWYNRRVAL 394
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 1-101 1.15e-10

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 55.83  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:PRK09494  118 KGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVI 197

                          90       100
                  ....*....|....*....|.
gi 2507268757  81 YVGINLVIMLIMSLVERKIRL 101
Cdd:PRK09494  198 YLIITLVLSFILRRLERRMKI 218
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 1-100 6.61e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 50.76  E-value: 6.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTI----GLVYMAAQAGKLLDYSAhAYESFTA 76
Cdd:pfam00528  80 SDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYPE-IQGPVLA 158

                          90       100
                  ....*....|....*....|....
gi 2507268757  77 ITLAYVGINLVIMLIMSLVERKIR 100
Cdd:pfam00528 159 AALILLLLNLLVDILQRLLDPRVR 182
PRK15100 PRK15100
cystine ABC transporter permease;
1-75 6.67e-08

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 48.21  E-value: 6.67e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLldySAHAYESFT 75
Cdd:PRK15100  116 KGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQLI---TSRTLEVFT 187
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 1-99 1.17e-07

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 47.54  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:TIGR03003 114 RGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMNQAKSIGNSTFRYLEPMTLVGVF 193

                          90
                  ....*....|....*....
gi 2507268757  81 YVGINLVIMLIMSLVERKI 99
Cdd:TIGR03003 194 FLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 1-90 1.50e-04

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 38.80  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLLDYSAHAYESFTAITLA 80
Cdd:cd06261   101 KDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLGVAAA 180

                          90
                  ....*....|
gi 2507268757  81 YVGINLVIML 90
Cdd:cd06261   181 VALILLLLSL 190
artM PRK11122
arginine ABC transporter permease ArtM;
2-99 4.48e-04

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 37.63  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507268757   2 GQKNAGLAMGLTLPQTYRyVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGLVYMAAQAGKLL--DYSAHAyesFTAITL 79
Cdd:PRK11122  120 GQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTSLAYTITLMDVMGYSQLLYgrTYDVMV---FGAAGI 195

                          90       100
                  ....*....|....*....|
gi 2507268757  80 AYVGINLVIMLIMSLVERKI 99
Cdd:PRK11122  196 IYLVVNGLLTLLMRLIERKA 215
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
1-53 4.53e-04

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 37.50  E-value: 4.53e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2507268757   1 RGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMLNLVKNSAIASTIGL 53
Cdd:PRK15107  125 RGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSL 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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