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Conserved domains on  [gi|2502261908|ref|WP_281664876|]
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NAD(P)/FAD-dependent oxidoreductase [Paraburkholderia fungorum]

Protein Classification

flavin-containing monooxygenase( domain architecture ID 11449697)

flavin-containing monooxygenase (FMO) catalyses the flavin-dependent oxidation of ketones and cyclic ketones to esters and lactones, by using molecular oxygen and NAD(P)H.

CATH:  3.50.50.60
Gene Ontology:  GO:0016709|GO:0004497|GO:0050660
PubMed:  20015679|33588053

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 6-453 2.06e-169

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


:

Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 483.98  E-value: 2.06e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908   6 SAQPAAPRIAIVGSGFAGIGMAIRLLQMGItSFTIYETAGDIGGTWRDNTYPGAACDVPSHLYSFSFEPNPAWSRAFGGQ 85
Cdd:COG2072     1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGI-DFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  86 AEIFAYLKHCVRKYGVDRYVRCNAGVVSARFDEARQTWQVGIDSNGTrenIEADVVIAASGPLSRPAMPQIAGLERFEGK 165
Cdd:COG2072    80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGET---LTARFVVVATGPLSRPKIPDIPGLEDFAGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 166 LFHSARWDHHYPLEGKRVAVIGTGASAIQFVPQIQPRVARLELFQRTAPWIMPKPDkpvgprarwlfrhlpFTQRFVRNA 245
Cdd:COG2072   157 QLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRPN---------------YDPERGRPA 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 246 IYWQLESRavafvvnPKLMKLP-MKFGMSYLERRVKDPALRaRLTPNYRLGCKRVLLSSDYYPALCQPNVDVVTTGIREI 324
Cdd:COG2072   222 NYLGLEAP-------PALNRRDaRAWLRRLLRAQVKDPELG-LLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERI 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 325 VADGIVTDDGAHHPVDAIICGTGFQVNDVG-APFEVSGLDGadlgatwlRDGPQAYLGTSIANFPNFFMiVGPNTGLGHN 403
Cdd:COG2072   294 TEDGVVFADGTEHEVDVIVWATGFRADLPWlAPLDVRGRDG--------RSGPRAYLGVVVPGFPNLFF-LGPNSPSGHS 364

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2502261908 404 SMIYMIESQVQYIADCLRVLRRRKARTMNLRADVQREFNERLQKQMQHSV 453
Cdd:COG2072   365 SLTLGAERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 6-453 2.06e-169

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 483.98  E-value: 2.06e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908   6 SAQPAAPRIAIVGSGFAGIGMAIRLLQMGItSFTIYETAGDIGGTWRDNTYPGAACDVPSHLYSFSFEPNPAWSRAFGGQ 85
Cdd:COG2072     1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGI-DFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  86 AEIFAYLKHCVRKYGVDRYVRCNAGVVSARFDEARQTWQVGIDSNGTrenIEADVVIAASGPLSRPAMPQIAGLERFEGK 165
Cdd:COG2072    80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGET---LTARFVVVATGPLSRPKIPDIPGLEDFAGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 166 LFHSARWDHHYPLEGKRVAVIGTGASAIQFVPQIQPRVARLELFQRTAPWIMPKPDkpvgprarwlfrhlpFTQRFVRNA 245
Cdd:COG2072   157 QLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRPN---------------YDPERGRPA 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 246 IYWQLESRavafvvnPKLMKLP-MKFGMSYLERRVKDPALRaRLTPNYRLGCKRVLLSSDYYPALCQPNVDVVTTGIREI 324
Cdd:COG2072   222 NYLGLEAP-------PALNRRDaRAWLRRLLRAQVKDPELG-LLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERI 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 325 VADGIVTDDGAHHPVDAIICGTGFQVNDVG-APFEVSGLDGadlgatwlRDGPQAYLGTSIANFPNFFMiVGPNTGLGHN 403
Cdd:COG2072   294 TEDGVVFADGTEHEVDVIVWATGFRADLPWlAPLDVRGRDG--------RSGPRAYLGVVVPGFPNLFF-LGPNSPSGHS 364

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2502261908 404 SMIYMIESQVQYIADCLRVLRRRKARTMNLRADVQREFNERLQKQMQHSV 453
Cdd:COG2072   365 SLTLGAERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 11-217 4.27e-17

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 84.06  E-value: 4.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  11 APRIAIVGSGFAGIGMAIRLLQMGITSfTIYETAGDIGGTWR--DNTYPGAA-------CDVPSHLYSFSFEPNPAWSRA 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEP-TCFERSDDIGGLWRftENVEEGRAsiyksviTNTSKEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  82 FGGQAEIFAYLKHCVRKYGVDRYVRCNAGVVSAR----FDEARQtWQVGIDSNGTRENIEADVVIAASGPLSRPAMP--Q 155
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKkrpdFSTSGQ-WEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPleS 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2502261908 156 IAGLERFEGKLFHSARWDHHYPLEGKRVAVIGTGASAIQFVPQIQPRVARLELFQRTAPWIM 217
Cdd:pfam00743 159 FPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVL 220
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 1-191 1.35e-08

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 57.18  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908   1 MTPASSaQPAAPRIAIVGSGFAGIGMAIRLLQMGITsFTIYETAGDIGGTWrdNTYPGAACD----------VPSHLYS- 69
Cdd:PLN02172    1 MAPAQN-PINSQHVAVIGAGAAGLVAARELRREGHT-VVVFEREKQVGGLW--VYTPKSESDplsldptrsiVHSSVYEs 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  70 --------------FSFEPNP----AWSRAFGGQAEIFAYLKHCVRKYGVDRYVRCNAGVVsaRFDEARQTWQVGIDSNG 131
Cdd:PLN02172   77 lrtnlprecmgyrdFPFVPRFddesRDSRRYPSHREVLAYLQDFAREFKIEEMVRFETEVV--RVEPVDGKWRVQSKNSG 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2502261908 132 TRENIEA-DVVIAASGPLSRPAMPQIAGLERFEGKLFHSarwdHHY----PLEGKRVAVIGTGAS 191
Cdd:PLN02172  155 GFSKDEIfDAVVVCNGHYTEPNVAHIPGIKSWPGKQIHS----HNYrvpdPFKNEVVVVIGNFAS 215
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 6-453 2.06e-169

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 483.98  E-value: 2.06e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908   6 SAQPAAPRIAIVGSGFAGIGMAIRLLQMGItSFTIYETAGDIGGTWRDNTYPGAACDVPSHLYSFSFEPNPAWSRAFGGQ 85
Cdd:COG2072     1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGI-DFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  86 AEIFAYLKHCVRKYGVDRYVRCNAGVVSARFDEARQTWQVGIDSNGTrenIEADVVIAASGPLSRPAMPQIAGLERFEGK 165
Cdd:COG2072    80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGET---LTARFVVVATGPLSRPKIPDIPGLEDFAGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 166 LFHSARWDHHYPLEGKRVAVIGTGASAIQFVPQIQPRVARLELFQRTAPWIMPKPDkpvgprarwlfrhlpFTQRFVRNA 245
Cdd:COG2072   157 QLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRPN---------------YDPERGRPA 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 246 IYWQLESRavafvvnPKLMKLP-MKFGMSYLERRVKDPALRaRLTPNYRLGCKRVLLSSDYYPALCQPNVDVVTTGIREI 324
Cdd:COG2072   222 NYLGLEAP-------PALNRRDaRAWLRRLLRAQVKDPELG-LLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERI 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 325 VADGIVTDDGAHHPVDAIICGTGFQVNDVG-APFEVSGLDGadlgatwlRDGPQAYLGTSIANFPNFFMiVGPNTGLGHN 403
Cdd:COG2072   294 TEDGVVFADGTEHEVDVIVWATGFRADLPWlAPLDVRGRDG--------RSGPRAYLGVVVPGFPNLFF-LGPNSPSGHS 364

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2502261908 404 SMIYMIESQVQYIADCLRVLRRRKARTMNLRADVQREFNERLQKQMQHSV 453
Cdd:COG2072   365 SLTLGAERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 11-217 4.27e-17

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 84.06  E-value: 4.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  11 APRIAIVGSGFAGIGMAIRLLQMGITSfTIYETAGDIGGTWR--DNTYPGAA-------CDVPSHLYSFSFEPNPAWSRA 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEP-TCFERSDDIGGLWRftENVEEGRAsiyksviTNTSKEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  82 FGGQAEIFAYLKHCVRKYGVDRYVRCNAGVVSAR----FDEARQtWQVGIDSNGTRENIEADVVIAASGPLSRPAMP--Q 155
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKkrpdFSTSGQ-WEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPleS 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2502261908 156 IAGLERFEGKLFHSARWDHHYPLEGKRVAVIGTGASAIQFVPQIQPRVARLELFQRTAPWIM 217
Cdd:pfam00743 159 FPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVL 220
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 12-235 3.11e-11

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 64.26  E-value: 3.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  12 PRIAIVGSGFAGIGMAIRLLQMGItSFTIYETAGdiggtwrdnTYPGAACdVPSHLYSFSFEPNPawsrAFGGQAEIFAY 91
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGG-KVTLIEDEG---------TCPYGGC-VLSKALLGAAEAPE----IASLWADLYKR 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  92 LKHCVRKYGVDRYVRCNAGVVSarFDEARQTWQVGIDSNGTRENIEADVVIAASGplSRPAMPQIAGLERFEGKLFHSar 171
Cdd:pfam07992  66 KEEVVKKLNNGIEVLLGTEVVS--IDPGAKKVVLEELVDGDGETITYDRLVIATG--ARPRLPPIPGVELNVGFLVRT-- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2502261908 172 WDH----HYPLEGKRVAVIGTGASAIQFVPQIQPRVARLELFQRtAPWIMPKPDKPVGPRARWLFRHL 235
Cdd:pfam07992 140 LDSaealRLKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEA-LDRLLRAFDEEISAALEKALEKN 206
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
14-194 1.77e-09

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 58.98  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  14 IAIVGSGFAGIGMAI--RLLQMgitSFTIYEtAGDIGG----TWRDNTYPGAACDVPshlysfsfepnpawsrafgGQaE 87
Cdd:COG0492     3 VVIIGAGPAGLTAAIyaARAGL---KTLVIE-GGEPGGqlatTKEIENYPGFPEGIS-------------------GP-E 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  88 IFAYLKHCVRKYGVDrYVRCNagVVSARFDEarQTWQVGIDSNGTrenIEADVVIAASGplSRPAMPQIAGLERFEGK-L 166
Cdd:COG0492    59 LAERLREQAERFGAE-ILLEE--VTSVDKDD--GPFRVTTDDGTE---YEAKAVIIATG--AGPRKLGLPGEEEFEGRgV 128

                         170       180
                  ....*....|....*....|....*...
gi 2502261908 167 FHSARWDHHYpLEGKRVAVIGTGASAIQ 194
Cdd:COG0492   129 SYCATCDGFF-FRGKDVVVVGGGDSALE 155
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
8-235 7.73e-09

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 57.66  E-value: 7.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908   8 QPAAPRIAIVGSGFAGIGMAIRLLQMGITSF--TIYETAGDIG-GT---WRD-----NTYPG---AACDVPSHLYSFSFE 73
Cdd:COG4529     2 TGARKRIAIIGGGASGTALAIHLLRRAPEPLriTLFEPRPELGrGVaysTDSpehllNVPAGrmsAFPDDPDHFLRWLRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  74 PNPAWSRAFGGQAeiFA-------YLKHCVRKY-----GVDRYVRCNAGVVSARFDEARqtWQVGIDSNgtrENIEAD-V 140
Cdd:COG4529    82 NGARAAPAIDPDA--FVprrlfgeYLRERLAEAlarapAGVRLRHIRAEVVDLERDDGG--YRVTLADG---ETLRADaV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908 141 VIAASGPLSRPAMPQIAGLERFegklFHSArwdhhYPLE-------GKRVAVIGTGASAIQFV----------------- 196
Cdd:COG4529   155 VLATGHPPPAPPPGLAAGSPRY----IADP-----WPPGalarippDARVLIIGTGLTAIDVVlslaarghrgpitalsr 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2502261908 197 ----PQIQPRVARLELFQRTAPWIMPKPDKPVGPRARWLFRHL 235
Cdd:COG4529   226 rgllPRAHPPGAPLPLKFLTPEALEELPLFFAARTARDLLRAL 268
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 1-191 1.35e-08

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 57.18  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908   1 MTPASSaQPAAPRIAIVGSGFAGIGMAIRLLQMGITsFTIYETAGDIGGTWrdNTYPGAACD----------VPSHLYS- 69
Cdd:PLN02172    1 MAPAQN-PINSQHVAVIGAGAAGLVAARELRREGHT-VVVFEREKQVGGLW--VYTPKSESDplsldptrsiVHSSVYEs 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  70 --------------FSFEPNP----AWSRAFGGQAEIFAYLKHCVRKYGVDRYVRCNAGVVsaRFDEARQTWQVGIDSNG 131
Cdd:PLN02172   77 lrtnlprecmgyrdFPFVPRFddesRDSRRYPSHREVLAYLQDFAREFKIEEMVRFETEVV--RVEPVDGKWRVQSKNSG 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2502261908 132 TRENIEA-DVVIAASGPLSRPAMPQIAGLERFEGKLFHSarwdHHY----PLEGKRVAVIGTGAS 191
Cdd:PLN02172  155 GFSKDEIfDAVVVCNGHYTEPNVAHIPGIKSWPGKQIHS----HNYrvpdPFKNEVVVVIGNFAS 215
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
16-75 4.18e-08

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 49.84  E-value: 4.18e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  16 IVGSGFAGIGMAIRLLQMGItSFTIYETAGDIGGTWRDNTYPGAACDVPSHLYSFSFEPN 75
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF-RVLVLEKRDRLGGNAYSYRVPGYVFDYGAHIFHGSDEPN 59
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 67-192 1.75e-04

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 43.73  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  67 LYSF----SFEPnpawSRAfggqaEIFAYLKHCVRkyGVDRYVRCNAGVVSARFDEARQTWQVGI---DSNGTRENIEAD 139
Cdd:pfam13434  81 LYSFynleTFFP----SRR-----EFNDYLQWAAS--HLPNRLRFGQEVESVEPDAERGEPLLRVrvrDADGEETTFLAR 149

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2502261908 140 VVIAASGPlsRPAMP-QIAGLERFegklFHSARWDHHYP--LEGKRVAVIGTGASA 192
Cdd:pfam13434 150 NLVLGTGG--EPYIPeCARGGERV----FHSSEYLERIDrlAAKKRIAVVGSGQSA 199
PRK07233 PRK07233
hypothetical protein; Provisional
 13-57 3.25e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 42.95  E-value: 3.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2502261908  13 RIAIVGSGFAGIGMAIRLLQMGItSFTIYETAGDIGG---TWRDNTYP 57
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGH-EVTVFEADDQLGGlaaSFEFGGLP 47
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 13-217 7.49e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 41.46  E-value: 7.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  13 RIAIVGSGFAGIGMAIRLLQMGItSFTIYETAGDIG-------------------GTW---RDNTYPGAACDV-----PS 65
Cdd:COG0654     5 DVLIVGGGPAGLALALALARAGI-RVTVVERAPPPRpdgrgialsprslellrrlGLWdrlLARGAPIRGIRVrdgsdGR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  66 HLYSFSFEPNPAWSRAFGGQAEIFAYLKHCVRKYGVDryVRCNAGVVSARFDEARQTWQVgidSNGTRenIEADVVIAAS 145
Cdd:COG0654    84 VLARFDAAETGLPAGLVVPRADLERALLEAARALGVE--LRFGTEVTGLEQDADGVTVTL---ADGRT--LRADLVVGAD 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2502261908 146 GPLSRpaMPQIAGLErFEGKLFhsarwdhhypleGKRVAVIGTGASAIQFVPQIQPRVARLELFQRTAPWIM 217
Cdd:COG0654   157 GARSA--VRRLLGIG-FTGRDY------------PQRALWAGVRTELRARLAAAGPRLGELLELSPRSAFPL 213
PLN02676 PLN02676
polyamine oxidase
 3-58 1.27e-03

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 41.24  E-value: 1.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2502261908   3 PASSAQPAAPRIAIVGSGFAGIGMAIRLLQMGITSFTIYETAGDIGGTWRDNTYPG 58
Cdd:PLN02676   18 VAAMDAKPSPSVIIVGAGMSGISAAKTLSEAGIEDILILEATDRIGGRMRKANFAG 73
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 8-49 6.67e-03

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 39.01  E-value: 6.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2502261908   8 QPAAP---RIAIVGSGFAGIGMAIRLLQMGItSFTIYETAGDIGG 49
Cdd:PRK11749  134 KRAPKtgkKVAVIGAGPAGLTAAHRLARKGY-DVTIFEARDKAGG 177
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 2-49 7.45e-03

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 38.61  E-value: 7.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2502261908   2 TPASSAQPAAPRIAIVGSGFAGIGMAIRLLQMGITSfTIYETAGDIGG 49
Cdd:PRK12810  134 KPDPPVKRTGKKVAVVGSGPAGLAAADQLARAGHKV-TVFERADRIGG 180
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
15-146 8.27e-03

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 36.87  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  15 AIVGSGFAGIGMAIRLLQMGIT---SFTIYETAGD-IGGTWRD--------NTYPGA--------------ACDVPSHLY 68
Cdd:pfam13454   1 AIVGGGPSGLALLERLLARAPKrplEITLFDPSPPgAGGVYRTdqspehllNVPASRmslfpddpphflewLRARGALDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502261908  69 SFSFEPNPAWSRAFGGQaeifaYLKHCVRKY-----GVDRYVRCNAGVVSARFDEARQTWqvgIDSNGTRenIEADVVIA 143
Cdd:pfam13454  81 APGLDPDDFPPRALYGR-----YLRDRFEEAlarapAGVTVRVHRARVTDLRPRGDGYRV---LLADGRT--LAADAVVL 150


                  ...
gi 2502261908 144 ASG 146
Cdd:pfam13454 151 ATG 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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