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Conserved domains on  [gi|2499904497|ref|WP_281070660|]
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hypothetical protein, partial [Pyrococcus horikoshii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 1-70 2.26e-14

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 65.70  E-value: 2.26e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2499904497   1 AAVCREAAMIAMRKALeKGIIKPGMKA--DEIKQKAKVTMKDFEEALKKIGPSVSKETMEYYRKIQEQFKQA 70
Cdd:TIGR01243 662 EAVCREAAMAALRESI-GSPAKEKLEVgeEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKELKRL 732
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 1-70 2.26e-14

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 65.70  E-value: 2.26e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2499904497   1 AAVCREAAMIAMRKALeKGIIKPGMKA--DEIKQKAKVTMKDFEEALKKIGPSVSKETMEYYRKIQEQFKQA 70
Cdd:TIGR01243 662 EAVCREAAMAALRESI-GSPAKEKLEVgeEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKELKRL 732
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 35-67 1.98e-06

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 40.56  E-value: 1.98e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 2499904497 35 KVTMKDFEEALKKIGPSVSKETMEYYRKIQEQF 67
Cdd:pfam09336 28 PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEF 60
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 1-57 4.49e-04

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 36.14  E-value: 4.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2499904497   1 AAVCREAAMIAMRKALEKgiikpgmkadeikqkakVTMKDFEEALKKIGPSVSKETM 57
Cdd:COG1222   287 KAIVTEAGMFAIREGRDT-----------------VTMEDLEKAIEKVKKKTETATN 326
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 1-70 2.26e-14

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 65.70  E-value: 2.26e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2499904497   1 AAVCREAAMIAMRKALeKGIIKPGMKA--DEIKQKAKVTMKDFEEALKKIGPSVSKETMEYYRKIQEQFKQA 70
Cdd:TIGR01243 662 EAVCREAAMAALRESI-GSPAKEKLEVgeEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKELKRL 732
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 1-57 1.47e-08

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 49.14  E-value: 1.47e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2499904497   1 AAVCREAAMIAMRKALEKGIIKPGMKA--DEIKQKAKVTMKDFEEALKKIGPSVSKETM 57
Cdd:TIGR01243 386 AALAKEAAMAALRRFIREGKINFEAEEipAEVLKELKVTMKDFMEALKMVEPSAIREVL 444
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 35-67 1.98e-06

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 40.56  E-value: 1.98e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 2499904497 35 KVTMKDFEEALKKIGPSVSKETMEYYRKIQEQF 67
Cdd:pfam09336 28 PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEF 60
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 1-57 4.49e-04

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 36.14  E-value: 4.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2499904497   1 AAVCREAAMIAMRKALEKgiikpgmkadeikqkakVTMKDFEEALKKIGPSVSKETM 57
Cdd:COG1222   287 KAIVTEAGMFAIREGRDT-----------------VTMEDLEKAIEKVKKKTETATN 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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