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Conserved domains on  [gi|2499904493|ref|WP_281070656|]
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universal stress protein [Pyrococcus horikoshii]

Protein Classification

UspA and USP_Like domain-containing protein( domain architecture ID 10001748)

UspA and USP_Like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-134 3.40e-27

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 102.69  E-value: 3.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   3 MVTILYPTDFSEVSKKALlECIPKIVSTFGedSKLILLHVVDITMVNIEAP-----ALMEVDKRDLDRLANFIREMGINV 77
Cdd:COG0589     2 YKRILVPTDGSEEAERAL-EYAAELAKALG--AELHLLHVVDPPPSAAAGPeeleeELREEAEEALEEAAERLEEAGVEV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2499904493  78 ETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLI 134
Cdd:COG0589    79 ETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 158-277 1.04e-18

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


:

Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 80.08  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 158 LVALDLSECSEKIIKNIRNLPEVKEA--ILFHVVD--------YGKVEELEANINNAKKALSEYGKLLPW---KIKVEIQ 224
Cdd:cd00293     3 LVAVDGSEESERALEWALELAKRPGAelTLLHVVDpppssslsGGLEELADELKEEAEELLEEAKKLAEEagvEVETIVV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2499904493 225 AGIASRGIIGAAINNVATLVVIGKKGKSILKELLLGSTAERVIRDCRLPTLLI 277
Cdd:cd00293    83 EGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-134 3.40e-27

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 102.69  E-value: 3.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   3 MVTILYPTDFSEVSKKALlECIPKIVSTFGedSKLILLHVVDITMVNIEAP-----ALMEVDKRDLDRLANFIREMGINV 77
Cdd:COG0589     2 YKRILVPTDGSEEAERAL-EYAAELAKALG--AELHLLHVVDPPPSAAAGPeeleeELREEAEEALEEAAERLEEAGVEV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2499904493  78 ETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLI 134
Cdd:COG0589    79 ETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 5-134 1.21e-24

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 95.88  E-value: 1.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   5 TILYPTDFSEVSKKALLECIPKIVStfgEDSKLILLHVVD-------ITMVNIEAPALMEVDKRDLDRLANFIREMGINV 77
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKR---PGAELTLLHVVDpppssslSGGLEELADELKEEAEELLEEAKKLAEEAGVEV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2499904493  78 ETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLI 134
Cdd:cd00293    78 ETIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 6-136 2.72e-21

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 87.08  E-value: 2.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   6 ILYPTDFSEVSKKALLECIpKIVSTFGedSKLILLHVVDIT---------MVNIEAPALMEVDKRDLDRLANFIREMGIN 76
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAA-ELAKARG--AELILLHVIDPPpsgaasladESAEEEELELELAEAEALAAAAAAEAGGVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493  77 VETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLILR 136
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 158-277 1.04e-18

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 80.08  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 158 LVALDLSECSEKIIKNIRNLPEVKEA--ILFHVVD--------YGKVEELEANINNAKKALSEYGKLLPW---KIKVEIQ 224
Cdd:cd00293     3 LVAVDGSEESERALEWALELAKRPGAelTLLHVVDpppssslsGGLEELADELKEEAEELLEEAKKLAEEagvEVETIVV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2499904493 225 AGIASRGIIGAAINNVATLVVIGKKGKSILKELLLGSTAERVIRDCRLPTLLI 277
Cdd:cd00293    83 EGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
154-277 9.46e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 77.65  E-value: 9.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 154 FERPLVALDLSECSEKIIKNIRNLPEVKEA--ILFHVVD------YGKVEELEANINNAKKALSEYGKLLP---WKIKVE 222
Cdd:COG0589     2 YKRILVPTDGSEEAERALEYAAELAKALGAelHLLHVVDpppsaaAGPEELEEELREEAEEALEEAAERLEeagVEVETV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2499904493 223 IQAGIASRGIIGAAINNVATLVVIGKKGKSILKELLLGSTAERVIRDCRLPTLLI 277
Cdd:COG0589    82 VREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 158-278 3.55e-11

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 59.73  E-value: 3.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 158 LVALDLSECSEKIIKNIRNLPEVKEA--ILFHVVDYG----------------KVEELEANINNAKKALSEYGKLlpwKI 219
Cdd:pfam00582   2 LVAVDGSEESKRALEWAAELAKARGAelILLHVIDPPpsgaasladesaeeeeLELELAEAEALAAAAAAEAGGV---KV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2499904493 220 KVEIQAGIASRGIIGAAINNVATLVVIGKKGKSILKELLLGSTAERVIRDCRLPTLLIP 278
Cdd:pfam00582  79 EVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
PRK15456 PRK15456
universal stress protein UspG; Provisional
 77-136 2.19e-04

universal stress protein UspG; Provisional


Pssm-ID: 185353  Cd Length: 142  Bit Score: 40.69  E-value: 2.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493  77 VETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQmLLGSTASNLARITRKPVLILR 136
Cdd:PRK15456   84 IKQHVRFGSVRDEVNELAEELGADVVVIGSRNPSISTH-LLGSNASSVIRHANLPVLVVR 142
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-134 3.40e-27

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 102.69  E-value: 3.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   3 MVTILYPTDFSEVSKKALlECIPKIVSTFGedSKLILLHVVDITMVNIEAP-----ALMEVDKRDLDRLANFIREMGINV 77
Cdd:COG0589     2 YKRILVPTDGSEEAERAL-EYAAELAKALG--AELHLLHVVDPPPSAAAGPeeleeELREEAEEALEEAAERLEEAGVEV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2499904493  78 ETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLI 134
Cdd:COG0589    79 ETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 5-134 1.21e-24

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 95.88  E-value: 1.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   5 TILYPTDFSEVSKKALLECIPKIVStfgEDSKLILLHVVD-------ITMVNIEAPALMEVDKRDLDRLANFIREMGINV 77
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKR---PGAELTLLHVVDpppssslSGGLEELADELKEEAEELLEEAKKLAEEAGVEV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2499904493  78 ETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLI 134
Cdd:cd00293    78 ETIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 6-136 2.72e-21

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 87.08  E-value: 2.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   6 ILYPTDFSEVSKKALLECIpKIVSTFGedSKLILLHVVDIT---------MVNIEAPALMEVDKRDLDRLANFIREMGIN 76
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAA-ELAKARG--AELILLHVIDPPpsgaasladESAEEEELELELAEAEALAAAAAAEAGGVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493  77 VETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLILR 136
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 158-277 1.04e-18

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 80.08  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 158 LVALDLSECSEKIIKNIRNLPEVKEA--ILFHVVD--------YGKVEELEANINNAKKALSEYGKLLPW---KIKVEIQ 224
Cdd:cd00293     3 LVAVDGSEESERALEWALELAKRPGAelTLLHVVDpppssslsGGLEELADELKEEAEELLEEAKKLAEEagvEVETIVV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2499904493 225 AGIASRGIIGAAINNVATLVVIGKKGKSILKELLLGSTAERVIRDCRLPTLLI 277
Cdd:cd00293    83 EGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
154-277 9.46e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 77.65  E-value: 9.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 154 FERPLVALDLSECSEKIIKNIRNLPEVKEA--ILFHVVD------YGKVEELEANINNAKKALSEYGKLLP---WKIKVE 222
Cdd:COG0589     2 YKRILVPTDGSEEAERALEYAAELAKALGAelHLLHVVDpppsaaAGPEELEEELREEAEEALEEAAERLEeagVEVETV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2499904493 223 IQAGIASRGIIGAAINNVATLVVIGKKGKSILKELLLGSTAERVIRDCRLPTLLI 277
Cdd:COG0589    82 VREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 5-136 3.15e-14

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 68.03  E-value: 3.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   5 TILYPTDFSEVSKKALLECIPKIVStfgEDSKLILLHVVDITMVNIEAPALMEVDKRD------------LDRLANFIRE 72
Cdd:cd23659     2 KVLIAVDGSEESEYALEWALENLHR---PGDEVVLLHVIEPPSLPAASLGSGSEEWEAleeearekaeklLEKYEKKLKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2499904493  73 M-GINVETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLILR 136
Cdd:cd23659    79 EkGIKVKVEVVAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 158-278 3.55e-11

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 59.73  E-value: 3.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 158 LVALDLSECSEKIIKNIRNLPEVKEA--ILFHVVDYG----------------KVEELEANINNAKKALSEYGKLlpwKI 219
Cdd:pfam00582   2 LVAVDGSEESKRALEWAAELAKARGAelILLHVIDPPpsgaasladesaeeeeLELELAEAEALAAAAAAEAGGV---KV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2499904493 220 KVEIQAGIASRGIIGAAINNVATLVVIGKKGKSILKELLLGSTAERVIRDCRLPTLLIP 278
Cdd:pfam00582  79 EVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 158-278 6.89e-09

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 53.39  E-value: 6.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 158 LVALDLSECSEKI----IKNIrnlpeVK---EAILFHVVDYGKV-------------EELEANINNAKKALSEYGKLLPW 217
Cdd:cd23659     4 LIAVDGSEESEYAlewaLENL-----HRpgdEVVLLHVIEPPSLpaaslgsgseeweALEEEAREKAEKLLEKYEKKLKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2499904493 218 ----KIKVEIQAGIASRGIIGAAINNVATLVVIGKKGKSILKELLLGSTAERVIRDCRLPTLLIP 278
Cdd:cd23659    79 ekgiKVKVEVVAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 10-136 1.65e-04

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 40.57  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493  10 TDFSEVSKKALlecipkiVSTFGEDSK----LILLHV-VDITMVNIEAPALMEVDKRDLDRLANFI-----REMGINVET 79
Cdd:cd23661     6 VDGSPASELAT-------EIAFDEASRrgvdLVALHAwSDMGPGGFLGIDWRESEQDQERMLAERLagwqeRYPDVHVHK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2499904493  80 VVRIGIPSLEISEVAkeENVNLIVIPSKGQNILRQMLLGSTASNLARITRKPVLILR 136
Cdd:cd23661    79 VVVRDRPARVLLEAS--ERAQLVVVGSHGRGGFAGMLLGSVSRAVLHSAPCPVIVVR 133
USP_Rv2623_repeat1 cd23944
universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis ...
 74-136 2.14e-04

universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467509  Cd Length: 140  Bit Score: 40.47  E-value: 2.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2499904493  74 GINVETVVRIG--IPSL-EISEVAKeenvnLIVIPSKGQNILRQMLLGSTASNLARITRKPVLILR 136
Cdd:cd23944    80 PVKVETEIVPGspVPTLvEASRDAT-----MVVVGSRGIGALAGLLLGSVSTSLVRHAHCPVAVIH 140
PRK15456 PRK15456
universal stress protein UspG; Provisional
 77-136 2.19e-04

universal stress protein UspG; Provisional


Pssm-ID: 185353  Cd Length: 142  Bit Score: 40.69  E-value: 2.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493  77 VETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRQmLLGSTASNLARITRKPVLILR 136
Cdd:PRK15456   84 IKQHVRFGSVRDEVNELAEELGADVVVIGSRNPSISTH-LLGSNASSVIRHANLPVLVVR 142
USP_Rv2623_repeat1 cd23944
universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis ...
 194-278 1.38e-03

universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467509  Cd Length: 140  Bit Score: 38.15  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493 194 VEELEANINNAKKALSE-YGKLLPWKIKVEIQAGIASRGIIGAAinNVATLVVIGKKGKSILKELLLGSTAERVIRDCRL 272
Cdd:cd23944    57 QDEARQVIEQARKVAEEaSGEGPPVKVETEIVPGSPVPTLVEAS--RDATMVVVGSRGIGALAGLLLGSVSTSLVRHAHC 134


                  ....*.
gi 2499904493 273 PTLLIP 278
Cdd:cd23944   135 PVAVIH 140
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 6-136 1.64e-03

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 38.06  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493   6 ILYPTDFSEVSKKaLLECIPKIVSTFgeDSKLILLHVV-DITMVN---IEAPALMEVDKRDLDR---LANFIREMGINVE 78
Cdd:cd23657     4 ILVAVDLSPESQS-LVDKAVEIAREN--DAKLSLIHVDeDISEYYtglIDVDIAALQDLESTMLeeaLKNLSELAGYPVD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2499904493  79 -TVVRIGIPSLEISEVAKEENVNLIVIPSKGQNILRqmLLGSTASNLARITRKPVLILR 136
Cdd:cd23657    81 hTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLS--LLGSSARAVLNSAPCDVLIVP 137
PRK15005 PRK15005
universal stress protein UspF;
51-136 6.11e-03

universal stress protein UspF;


Pssm-ID: 184967 [Multi-domain]  Cd Length: 144  Bit Score: 36.32  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499904493  51 EAPALMEVDKRDLDRLANFIREMGI---NVETVVRIGIPSLEISEVAKEENVNLIVIPSKGQNIlRQMLLGSTASNLARI 127
Cdd:PRK15005   57 ELPAMDDLKAEAKSQLEEIIKKFKLptdRVHVHVEEGSPKDRILELAKKIPADMIIIASHRPDI-TTYLLGSNAAAVVRH 135


                  ....*....
gi 2499904493 128 TRKPVLILR 136
Cdd:PRK15005  136 AECSVLVVR 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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