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Conserved domains on  [gi|2486205827|ref|WP_278950312|]
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4Fe-4S binding protein [Anaerobutyricum hallii]

Protein Classification

PorD family protein( domain architecture ID 11439062)

PorD family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 18-98 7.40e-27

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


:

Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 93.96  E-value: 7.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  18 TPGCTIVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIMK 97
Cdd:COG1144     1 PQGGAITEPGGTAAYKTGGWRVERPVVDEDKCIGCGLCWIVCPDGAIRVDDGKYYGIDYDYCKGCGICAEVCPVKAIEMV 80


                  .
gi 2486205827  98 K 98
Cdd:COG1144    81 P 81
 
Name Accession Description Interval E-value
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 18-98 7.40e-27

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 93.96  E-value: 7.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  18 TPGCTIVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIMK 97
Cdd:COG1144     1 PQGGAITEPGGTAAYKTGGWRVERPVVDEDKCIGCGLCWIVCPDGAIRVDDGKYYGIDYDYCKGCGICAEVCPVKAIEMV 80


                  .
gi 2486205827  98 K 98
Cdd:COG1144    81 P 81
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 15-101 1.01e-20

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 79.30  E-value: 1.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  15 QNLTPGCTIVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:PRK09624   19 EKMTPGAIAYIPGSSVINKTGSWRVFMPEFNRDKCVRCYLCYIYCPEPAIYLDEEGYPVFDYDYCKGCGICANECPTKAI 98


                  ....*..
gi 2486205827  95 IMKKGVR 101
Cdd:PRK09624   99 EMVRETK 105
PorD_KorD TIGR02179
2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number ...
 28-96 1.17e-20

2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of delta subunits, representing mostly pyruvate, 2-ketoisovalerate, and 2-oxoglutarate specific enzymes. The delta subunit is the smallest and resembles ferredoxins.


Pssm-ID: 131234 [Multi-domain]  Cd Length: 78  Bit Score: 78.14  E-value: 1.17e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  28 TAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:TIGR02179   6 SSVANKTGDWRVFKPVVDKEKCIKCKNCWLYCPEGAIQEDEGGFVGIDYDYCKGCGICANVCPVKAIEM 74
PorD_Arch NF040684
pyruvate synthase subunit PorD;
18-96 8.66e-18

pyruvate synthase subunit PorD;


Pssm-ID: 468649 [Multi-domain]  Cd Length: 85  Bit Score: 71.34  E-value: 8.66e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  18 TPGCTIVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:NF040684    3 TIGAIVYKPGSTRKNKTGSWRTFRPILDKEKCIDCDNCYIFCPEGAIIQEENGMFEIDYDYCKGCGICANECPVKAIEM 81
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 42-98 9.31e-09

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 48.93  E-value: 9.31e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSI----PVKEGKRLDFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIelgpNGAIARGPEIDEDKCVFCGACVEVCPTGAIELTP 61
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 49-93 7.35e-06

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 39.82  E-value: 7.35e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  49 CKHCLLCVPVCP------DSSIPVKEGKRLDFDLDHCKGCGICEKACPFDA 93
Cdd:pfam12838   1 CIGCGACVAACPvgaitlDEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 77-99 6.71e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 39.84  E-value: 6.71e-05
                          10        20
                  ....*....|....*....|...
gi 2486205827  77 DHCKGCGICEKACPFDAIIMKKG 99
Cdd:NF038196  185 DKCIGCGICAKVCPVNNIEMEDG 207
FDH3_beta NF038355
formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the ...
 49-93 2.52e-03

formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the FDH3 type of formate dehydrogenase as found in Methylorubrum (Methylobacterium) extorquens.


Pssm-ID: 439648 [Multi-domain]  Cd Length: 180  Bit Score: 35.04  E-value: 2.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2486205827  49 CKHC--LLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDA 93
Cdd:NF038355   54 CMHCtdAPCAAVCPVDCFYIRADGIVLHDKDKCIGCGYCLYACPFGA 100
 
Name Accession Description Interval E-value
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 18-98 7.40e-27

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 93.96  E-value: 7.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  18 TPGCTIVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIMK 97
Cdd:COG1144     1 PQGGAITEPGGTAAYKTGGWRVERPVVDEDKCIGCGLCWIVCPDGAIRVDDGKYYGIDYDYCKGCGICAEVCPVKAIEMV 80


                  .
gi 2486205827  98 K 98
Cdd:COG1144    81 P 81
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 15-101 1.01e-20

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 79.30  E-value: 1.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  15 QNLTPGCTIVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:PRK09624   19 EKMTPGAIAYIPGSSVINKTGSWRVFMPEFNRDKCVRCYLCYIYCPEPAIYLDEEGYPVFDYDYCKGCGICANECPTKAI 98


                  ....*..
gi 2486205827  95 IMKKGVR 101
Cdd:PRK09624   99 EMVRETK 105
PorD_KorD TIGR02179
2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number ...
 28-96 1.17e-20

2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of delta subunits, representing mostly pyruvate, 2-ketoisovalerate, and 2-oxoglutarate specific enzymes. The delta subunit is the smallest and resembles ferredoxins.


Pssm-ID: 131234 [Multi-domain]  Cd Length: 78  Bit Score: 78.14  E-value: 1.17e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  28 TAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:TIGR02179   6 SSVANKTGDWRVFKPVVDKEKCIKCKNCWLYCPEGAIQEDEGGFVGIDYDYCKGCGICANVCPVKAIEM 74
PorD_Arch NF040684
pyruvate synthase subunit PorD;
18-96 8.66e-18

pyruvate synthase subunit PorD;


Pssm-ID: 468649 [Multi-domain]  Cd Length: 85  Bit Score: 71.34  E-value: 8.66e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  18 TPGCTIVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:NF040684    3 TIGAIVYKPGSTRKNKTGSWRTFRPILDKEKCIDCDNCYIFCPEGAIIQEENGMFEIDYDYCKGCGICANECPVKAIEM 81
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
34-98 3.49e-16

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 67.66  E-value: 3.49e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2486205827  34 TGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:PRK09623   38 TGDWRTFMPVVDESKCVKCYICWKFCPEPAIYIKEDGYVAIDYDYCKGCGICANECPTKAITMVK 102
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 34-90 4.96e-15

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 65.54  E-value: 4.96e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2486205827  34 TGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACP 90
Cdd:PRK09625   46 VAHWRVEKPVHNNEICINCFNCWVYCPDAAILSRDKKLKGVDYSHCKGCGVCVEVCP 102
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 12-96 9.25e-15

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 67.72  E-value: 9.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  12 VKWQNLTPGCTiVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSI----PVKEGKR--------LDFDLDHC 79
Cdd:PRK14028  213 VGWQEVNKAGA-VFPGSSFPYLTGGWRIDKPVIDHSKCIMCRKCWLYCPDDAIieawREAEGPRgrkfrmkmIDFDYQYC 291

                          90
                  ....*....|....*..
gi 2486205827  80 KGCGICEKACPFDAIIM 96
Cdd:PRK14028  292 KGCGVCAEVCPTGAIQM 308
flavo_MJ0208 TIGR02700
archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of ...
 32-95 1.00e-14

archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General]


Pssm-ID: 131747 [Multi-domain]  Cd Length: 234  Bit Score: 66.82  E-value: 1.00e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2486205827  32 FRTGEWRVDTPEFIE-EKCKHCLLCVPVCPDSSIPVKEGKrLDFDLDHCKGCGICEKACPFDAII 95
Cdd:TIGR02700 132 YEEGIIRTITPYMIDrKRCKGCGICVDACPRSAIDMVDGK-AFIRLLKCVGCGKCKEACPYNAIH 195
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
41-97 5.15e-13

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 62.96  E-value: 5.15e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2486205827  41 TPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIMK 97
Cdd:COG1148   490 VAEVDPEKCTGCGRCVEVCPYGAISIDEKGVAEVNPALCKGCGTCAAACPSGAISLK 546
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 38-98 1.68e-12

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 57.05  E-value: 1.68e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  38 RVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:COG1149     2 KRKIPVIDEEKCIGCGLCVEVCPEGAIKLDDGGAPVVDPDLCTGCGACVGVCPTGAITLEE 62
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
42-97 4.18e-11

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 53.97  E-value: 4.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSIPVKEGKrLDFDLDHCKGCGICEKACPFDAIIMK 97
Cdd:COG2768     6 PYVDEEKCIGCGACVKVCPVGAISIEDGK-AVIDPEKCIGCGACIEVCPVGAIKIE 60
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 46-98 2.63e-10

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 51.67  E-value: 2.63e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2486205827  46 EEKCKHCLLCVPVCPDSSI---PVKEGKRLDFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:COG1143     1 EDKCIGCGLCVRVCPVDAItieDGEPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP 56
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 42-98 1.59e-09

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 49.66  E-value: 1.59e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSIPVkEGKRLDFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:COG2221    10 PKIDEEKCIGCGLCVAVCPTGAISL-DDGKLVIDEEKCIGCGACIRVCPTGAIKGEK 65
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 45-101 1.65e-09

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 49.66  E-value: 1.65e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2486205827  45 IEEKCKHCLLCVPVCPDSSIPVKEGKRLdFDLDHCKGCGICEKACPFDAIIMKKGVR 101
Cdd:COG4231    20 DEDKCTGCGACVKVCPADAIEEGDGKAV-IDPDLCIGCGSCVQVCPVDAIKLEKRVP 75
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 49-96 4.16e-09

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 51.80  E-value: 4.16e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2486205827  49 CKHCLLCVPVCPDSSI-PVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:PRK12771  512 CFECDNCYGACPQDAIiKLGPGRRYHFDYDKCTGCHICADVCPCGAIEM 560
NapF COG1145
Ferredoxin [Energy production and conversion];
1-98 6.47e-09

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 51.26  E-value: 6.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827   1 MVSDINKLGLDVKWQNLTPGCTIVGSCTAEVFRTGEWRVDTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKR-LDFDLDHC 79
Cdd:COG1145   136 AAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDGKPqIVVDPDKC 215

                          90
                  ....*....|....*....
gi 2486205827  80 KGCGICEKACPFDAIIMKK 98
Cdd:COG1145   216 IGCGACVKVCPVGAISLEP 234
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 42-98 9.31e-09

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 48.93  E-value: 9.31e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSI----PVKEGKRLDFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIelgpNGAIARGPEIDEDKCVFCGACVEVCPTGAIELTP 61
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 46-96 2.57e-08

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 47.80  E-value: 2.57e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  46 EEKCKHCLLCVPVCPDSSIPV---------KEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:TIGR01971  42 EEKCIGCTLCAAVCPADAIRVvpaegedgkRRLKFYEINFGRCIFCGLCEEACPTDAIVL 101
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 46-97 2.93e-08

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 47.78  E-value: 2.93e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2486205827  46 EEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIMK 97
Cdd:cd10549    77 EEKCIGCGLCVKVCPVDAITLEDELEIVIDKEKCIGCGICAEVCPVNAIKLV 128
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 42-100 4.44e-08

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 45.86  E-value: 4.44e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSI-PVKEGKR-LDFDLDHCKGCGICEKACPFDAIIMKKGV 100
Cdd:COG1146     3 PVIDTDKCIGCGACVEVCPVDVLeLDEEGKKaLVINPEECIGCGACELVCPVGAITVEDDE 63
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 45-94 8.65e-08

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 47.96  E-value: 8.65e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2486205827  45 IEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:PRK00783  167 VSEDCDECEKCVEACPRGVLELKEGKLVVTDLLNCSLCKLCERACPGKAI 216
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
48-94 1.03e-07

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 47.88  E-value: 1.03e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2486205827  48 KCKHclLCVPVCPdssiPVKEGKR---LDFDLDH-------CKGCGICEKACPFDAI 94
Cdd:PRK13409   16 KCNY--ECIKYCP----VVRTGEEtieIDEDDGKpviseelCIGCGICVKKCPFDAI 66
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 21-101 1.40e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 46.23  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  21 CTIVGSCTAEVFRTGEWRVDTPE----FIEEKCKHCL--LCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:cd04410    18 CKQEHGLRPGPDWSRIKVIEGGGleraFLPVSCMHCEdpPCVKACPTGAIYKDEDGIVLIDEDKCIGCGSCVEACPYGAI 97


                  ....*..
gi 2486205827  95 IMKKGVR 101
Cdd:cd04410    98 VFDPEPG 104
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
46-94 1.44e-07

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 47.36  E-value: 1.44e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2486205827  46 EEKCKHCLLCVPVCPdSSIPVKEGKRLDFDldhCKGCGICEKACPFDAI 94
Cdd:COG0348   209 RGDCIDCGLCVKVCP-MGIDIRKGEINQSE---CINCGRCIDACPKDAI 253
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
46-94 2.02e-07

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 46.94  E-value: 2.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2486205827  46 EEKCKHCLLCVPVCPDSSIPVKEGKRlDFDLDHCKGCGICEKACPFDAI 94
Cdd:COG4624    90 KEKCKNCYPCVRACPVKAIKVDDGKA-EIDEEKCISCGQCVAVCPFGAI 137
RNAP_D cd07030
D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is ...
 45-96 2.06e-07

D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The D subunit is equivalent to the RPB3 subunit of eukaryotic RNAP II. It contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer.


Pssm-ID: 132908 [Multi-domain]  Cd Length: 259  Bit Score: 46.88  E-value: 2.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2486205827  45 IEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:cd07030   167 IDEDCDGCGKCVEECPRGVLELEEGKVVVEDLEDCSLCKLCERACDAGAIRV 218
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 48-94 2.55e-07

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 46.70  E-value: 2.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2486205827  48 KCKHclLCVPVCPdssiPVKEGKR---LDFDLDH-------CKGCGICEKACPFDAI 94
Cdd:COG1245    16 KCNY--ECIKYCP----VNRTGKEaieIDEDDGKpviseelCIGCGICVKKCPFDAI 66
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
46-96 6.71e-07

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 44.87  E-value: 6.71e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  46 EEKCKHCLLCVPVCPDSSIPV---------KEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:PRK05888   57 EERCIACKLCAAICPADAITIeaaeredgrRRTTRYDINFGRCIFCGFCEEACPTDAIVE 116
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 44-92 9.10e-07

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 44.69  E-value: 9.10e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2486205827  44 FIEEKCKHCL--LCVPVCP-DSSIPVKEGKRLDFDLDHCKGCGICEKACPFD 92
Cdd:cd10558    65 IRKDGCMHCAdpGCLKACPsPGAIVQYANGIVDFQSDKCIGCGYCIKGCPFD 116
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 42-99 1.96e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 43.15  E-value: 1.96e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2486205827  42 PEFIEEKCKHCLLCVPVCP--------DSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIMKKG 99
Cdd:cd10549    35 PEIDEDKCVFCGACVEVCPtgaieltpEGKEYVPKEKEAEIDEEKCIGCGLCVKVCPVDAITLEDE 100
IOR_alpha TIGR03336
indolepyruvate ferredoxin oxidoreductase, alpha subunit; Indolepyruvate ferredoxin ...
 46-94 3.37e-06

indolepyruvate ferredoxin oxidoreductase, alpha subunit; Indolepyruvate ferredoxin oxidoreductase (IOR) is an alpha 2/beta 2 tetramer related to ketoacid oxidoreductases for pyruvate (1.2.7.1, POR), 2-ketoglutarate (1.2.7.3, KOR), and 2-oxoisovalerate (1.2.7.7, VOR). These multi-subunit enzymes typically are found in anaerobes and are inactiviated by oxygen. IOR in Pyrococcus acts in fermentation of all three aromatic amino acids, following removal of the amino group by transamination. In Methanococcus maripaludis, by contrast, IOR acts in the opposite direction, in pathways of amino acid biosynthesis from phenylacetate, indoleacetate, and p-hydroxyphenylacetate. In M. maripaludis and many other species, iorA and iorB are found next to an apparent phenylacetate-CoA ligase.


Pssm-ID: 274526 [Multi-domain]  Cd Length: 595  Bit Score: 43.56  E-value: 3.37e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  46 EEKCKHCLLCVPV--CPdsSIpVKEGKRLDFDlDHCKGCGICEKACPFDAI 94
Cdd:TIGR03336 549 QDKCIGCKKCIKElgCP--AI-EPEDKEAVID-PLCTGCGVCAQICPFDAI 595
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 44-94 3.94e-06

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 42.77  E-value: 3.94e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2486205827  44 FIEEKCKHCL--LCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:cd16366    65 FRKDQCMHCTdaGCLAACPTGAIIRTETGTVVVDPETCIGCGYCVNACPFDIP 117
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 49-101 5.56e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 41.91  E-value: 5.56e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2486205827  49 CKHCL--LCVPVCPDSSIPVKEGKRLDFDlDHCKGCGICEKACPFDAIIMKKGVR 101
Cdd:cd16367    57 CRHCVdpVCMIGCPTGAIHRDDGGEVVIS-DACCGCGNCASACPYGAIQMVRAVK 110
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 44-94 6.64e-06

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 41.90  E-value: 6.64e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2486205827  44 FIEEKCKHCL--LCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:cd10562    65 FRKRQCMHCTdaACVKVCPTGALYKTENGAVVVDEDKCIGCGYCVAACPFDVP 117
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 49-93 7.35e-06

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 39.82  E-value: 7.35e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  49 CKHCLLCVPVCP------DSSIPVKEGKRLDFDLDHCKGCGICEKACPFDA 93
Cdd:pfam12838   1 CIGCGACVAACPvgaitlDEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 30-98 7.73e-06

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 42.37  E-value: 7.73e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  30 EVFRTGEwrvdTPEFIEEKCKHCLLCVPVCPDSSIpVKEGKRLDFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:cd03110    51 EDFVGGK----KAFIDQEKCIRCGNCERVCKFGAI-LEFFQKLIVDESLCEGCGACVIICPRGAIYLKD 114
PRK13795 PRK13795
hypothetical protein; Provisional
 48-90 1.44e-05

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 41.90  E-value: 1.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2486205827  48 KCKHCLLCVPVCPDSSIPVKEGKR-LDFDLDHCKGCGICEKACP 90
Cdd:PRK13795  582 ECVGCGVCVGACPTGAIRIEEGKRkISVDEEKCIHCGKCTEVCP 625
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 49-96 1.59e-05

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 40.71  E-value: 1.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2486205827  49 CKHCL--LCVPVCPDSSIpVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:cd10554    56 CRQCEdaPCANVCPVGAI-SQEDGVVQVDEERCIGCKLCVLACPFGAIEM 104
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 30-94 3.24e-05

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 40.31  E-value: 3.24e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2486205827  30 EVFRTGEWRVDTPEFIEEKCKHCL--LCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:COG0437    41 RRYEEGEFPNVEWLFVPVLCNHCDdpPCVKVCPTGATYKREDGIVLVDYDKCIGCRYCVAACPYGAP 107
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 32-94 4.82e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 39.47  E-value: 4.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2486205827  32 FRTGEWRVDTPEFIEEKCKHCL--LCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:cd16371    37 YEGGEFPEVFAYFLSMSCNHCEnpACVKVCPTGAITKREDGIVVVDQDKCIGCGYCVWACPYGAP 101
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 48-94 5.48e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 39.18  E-value: 5.48e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2486205827  48 KCKHC--LLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:cd16374    42 RCRHCedAPCMEVCPTGAIYRDEDGAVLVDPDKCIGCGMCAMACPFGVP 90
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
42-100 6.18e-05

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 39.92  E-value: 6.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDL--DH-------------CKGCGICEKACPFDAIIMKKGV 100
Cdd:PRK07118  163 PVVDEDKCTGCGACVKACPRNVIELIPKSARVFVAcnSKdkgkavkkvcevgCIGCGKCVKACPAGAITMENNL 236
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 77-99 6.71e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 39.84  E-value: 6.71e-05
                          10        20
                  ....*....|....*....|...
gi 2486205827  77 DHCKGCGICEKACPFDAIIMKKG 99
Cdd:NF038196  185 DKCIGCGICAKVCPVNNIEMEDG 207
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
49-93 6.83e-05

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 39.86  E-value: 6.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2486205827  49 CKHC--LLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDA 93
Cdd:PRK14993  100 CNHCdnPPCVPVCPVQATFQREDGIVVVDNKRCVGCAYCVQACPYDA 146
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 43-97 9.90e-05

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 39.31  E-value: 9.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2486205827  43 EFIEE--KCKHCLLCVPVCPDSsIPVKEG----KRLDF----DL-DHCKGCGICEKACPFDAIIMK 97
Cdd:cd01916   359 EFQELaaKCTDCGWCTRACPNS-LRIKEAmeaaKEGDFsglaDLfDQCVGCGRCEQECPKEIPIIN 423
PRK06991 PRK06991
electron transport complex subunit RsxB;
46-96 1.04e-04

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 39.39  E-value: 1.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2486205827  46 EEKCKHCLLCVPVCPDSSIpVKEGKRLDFDL-DHCKGCGICEKACPFDAIIM 96
Cdd:PRK06991   84 EQLCIGCTLCMQACPVDAI-VGAPKQMHTVLaDLCTGCDLCVPPCPVDCIDM 134
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 77-96 1.20e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 39.21  E-value: 1.20e-04
                          10        20
                  ....*....|....*....|
gi 2486205827  77 DHCKGCGICEKACPFDAIIM 96
Cdd:COG2878   137 YGCIGCGDCIKACPFDAIVG 156
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
74-100 1.44e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 39.07  E-value: 1.44e-04
                          10        20
                  ....*....|....*....|....*...
gi 2486205827  74 FDLDHCKGCGICEKACPFDAI-IMKKGV 100
Cdd:COG1148   493 VDPEKCTGCGRCVEVCPYGAIsIDEKGV 520
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 44-90 1.72e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 38.01  E-value: 1.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2486205827  44 FIEEKC------KHCLLCVPVCP---DSSIPVKEGKRLDFDLDHCKGCGICEKACP 90
Cdd:cd16373    88 IDKDRClawqggTDCGVCVEACPteaIAIVLEDDVLRPVVDEDKCVGCGLCEYVCP 143
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 74-99 2.70e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 36.24  E-value: 2.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 2486205827  74 FDLDHCKGCGICEKACPFDAIIMKKG 99
Cdd:COG1149     8 IDEEKCIGCGLCVEVCPEGAIKLDDG 33
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
49-96 3.16e-04

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 37.33  E-value: 3.16e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2486205827  49 CKHCLL--CVPVCPDSSIpVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:COG1142    52 CRHCEDapCAEVCPVGAI-TRDDGAVVVDEEKCIGCGLCVLACPFGAITM 100
PRK06991 PRK06991
electron transport complex subunit RsxB;
53-95 4.16e-04

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 37.47  E-value: 4.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2486205827  53 LLCVPVCP-DSSIPVKEGKRLDF-DLDHCKGCGICEKACPFDAII 95
Cdd:PRK06991   59 LLGKPVIPlDPANGVERPRAVAViDEQLCIGCTLCMQACPVDAIV 103
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 44-94 4.63e-04

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 37.37  E-value: 4.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2486205827  44 FIEEKCKHCLL--CVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:cd10560    73 FMSDVCKHCTDagCLEACPTGAIFRTEFGTVYIQPDICNGCGYCVAACPFGVI 125
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 40-90 6.32e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 37.04  E-value: 6.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  40 DTPEFIEEKCKHCLLCVPVCPDSSIPVK-----EGKRLD----FDLDHCKGCGICEKACP 90
Cdd:COG4656   357 EVPPPEEQPCIRCGRCVDACPMGLLPQQlywyaRAGDFDkaeeYNLMDCIECGCCSYVCP 416
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
49-98 8.19e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 36.83  E-value: 8.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2486205827  49 CKHCLLCVPVCPDSSIPVkEGKRLDFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:PRK07118  215 CIGCGKCVKACPAGAITM-ENNLAVIDQEKCTSCGKCVEKCPTKAIRILN 263
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 49-96 8.43e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 37.03  E-value: 8.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2486205827  49 CKHC--LLCVPVCPDSSIpVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:PRK12769   56 CHHCedAPCARSCPNGAI-SHVDDSIQVNQQKCIGCKSCVVACPFGTMQI 104
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 72-99 1.06e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 35.84  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*...
gi 2486205827  72 LDFDLDHCKGCGICEKACPFDAIIMKKG 99
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIELGPN 28
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
75-100 1.14e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 34.71  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 2486205827  75 DLDHCKGCGICEKACPFDAIIMKKGV 100
Cdd:COG2768     9 DEEKCIGCGACVKVCPVGAISIEDGK 34
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 31-96 1.15e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 35.63  E-value: 1.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  31 VFRTGEWRVDTPEFieekCKHCL--LCVPVCPDSSIPV-KEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:cd10550    35 VVRFEPEGLDVPVV----CRQCEdaPCVEACPVGAISRdEETGAVVVDEDKCIGCGMCVEACPFGAIRV 99
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
42-95 1.24e-03

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 36.46  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSS-----IPVKEGKRLDFDLDHCKGCGICEKACPFDAII 95
Cdd:PRK08318  337 ARIDQDKCIGCGRCYIACEDTShqaieWDEDGTRTPEVIEEECVGCNLCAHVCPVEGCI 395
PRK13984 PRK13984
putative oxidoreductase; Provisional
 75-96 1.24e-03

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 36.28  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|..
gi 2486205827  75 DLDHCKGCGICEKACPFDAIIM 96
Cdd:PRK13984   43 DWEKCIGCGTCSKICPTDAITM 64
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 37-94 1.34e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 35.68  E-value: 1.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  37 WRVDTPEFIEeKCKHCLLCVPVCPDSSIPVKEGKR--LDFDLDHCKGCGICEKACPFDAI 94
Cdd:cd10564     4 WAVDEALFLD-LCTRCGDCVEACPEGIIVRGDGGFpeLDFSRGECTFCGACAEACPEGAL 62
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 55-96 1.43e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 35.33  E-value: 1.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2486205827  55 CVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:cd16370    61 CAEACPTGALEPRKGGGVVLDKEKCIGCGNCVKACIVGAIFW 102
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 40-94 1.56e-03

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 34.70  E-value: 1.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2486205827  40 DTPEFIEE-KCKHCLLCVPVCPDSSIPVKE------GKRLDF-DLDHCKGCGICEKACPFDAI 94
Cdd:PRK09626    8 NTPVWVDEsRCKACDICVSVCPAGVLAMRIdphavlGKMIKVvHPESCIGCRECELHCPDFAI 70
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 42-94 1.93e-03

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 35.39  E-value: 1.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSIPVK---EGKRLD--FDLDHCKGCGICEKACPFDAI 94
Cdd:PRK12387   33 PEYNPQQCIGCAACVNACPSNALTVEtdlATGELAweFNLGRCIFCGRCEEVCPTAAI 90
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
40-99 1.98e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 35.77  E-value: 1.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  40 DTPEFIEEKCKHCLLCVPVCPDSSIPVKEGKRLD---------FDLDHCKGCGICEKACPFDAIIMKKG 99
Cdd:COG4624    45 DSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIidkrgpsiiRDKEKCKNCYPCVRACPVKAIKVDDG 113
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 52-98 2.07e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 35.31  E-value: 2.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2486205827  52 CLLCVPVCPDSSIPVKEGKRLD-------FDLDHC------KGCGICEKACPFDAIIMKK 98
Cdd:cd16373    59 CDACVEVCPTGALRPLDLEEQKvkmgvavIDKDRClawqggTDCGVCVEACPTEAIAIVL 118
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 49-96 2.34e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 35.77  E-value: 2.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2486205827  49 CKHC--LLCVPVCPDSSIpVKEGKRLDFDLDHCKGCGICEKACPFDAIIM 96
Cdd:PRK12809   56 CHHCnnAPCVTACPVNAL-TFQSDSVQLDEQKCIGCKRCAIACPFGVVEM 104
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 47-92 2.40e-03

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 35.44  E-value: 2.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2486205827  47 EKCKHCLLCVPVCP-----------------------DSSIPVKEGKRLDFDLDHCKGCGICEKACPFD 92
Cdd:COG0247    78 DACVGCGFCRAMCPsykatgdekdsprgrinllrevlEGELPLDLSEEVYEVLDLCLTCKACETACPSG 146
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 42-90 2.43e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 33.38  E-value: 2.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSIPV------KEGKRLDFDLDHCKGCGICEKACP 90
Cdd:pfam13237   2 VVIDPDKCIGCGRCTAACPAGLTRVgaiverLEGEAVRIGVWKCIGCGACVEACP 56
PRK13795 PRK13795
hypothetical protein; Provisional
 79-101 2.47e-03

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 35.36  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|...
gi 2486205827  79 CKGCGICEKACPFDAIIMKKGVR 101
Cdd:PRK13795  583 CVGCGVCVGACPTGAIRIEEGKR 605
FDH3_beta NF038355
formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the ...
 49-93 2.52e-03

formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the FDH3 type of formate dehydrogenase as found in Methylorubrum (Methylobacterium) extorquens.


Pssm-ID: 439648 [Multi-domain]  Cd Length: 180  Bit Score: 35.04  E-value: 2.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2486205827  49 CKHC--LLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDA 93
Cdd:NF038355   54 CMHCtdAPCAAVCPVDCFYIRADGIVLHDKDKCIGCGYCLYACPFGA 100
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 74-94 2.97e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 32.61  E-value: 2.97e-03
                          10        20
                  ....*....|....*....|.
gi 2486205827  74 FDLDHCKGCGICEKACPFDAI 94
Cdd:pfam00037   3 IDEEKCIGCGACVEVCPVGAI 23
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 44-98 3.29e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 34.56  E-value: 3.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2486205827  44 FIEEKCKHCLLCVPVCPDSSIpvkegkRLDFDLDH---CKGCGICEKACPFDAIIMKK 98
Cdd:cd16370    80 LDKEKCIGCGNCVKACIVGAI------FWDEETNKpiiCIHCGYCARYCPHDVLAMEE 131
Fer4_9 pfam13187
4Fe-4S dicluster domain;
48-94 3.61e-03

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 32.91  E-value: 3.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2486205827  48 KCKHCLLCVPVCPDSSIPVKEGK---RLDFDLDHCKGCGICEKACPFDAI 94
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGqtiRGDIAGLACIGCGACVDACPRGAI 50
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 51-97 3.61e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 34.53  E-value: 3.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  51 HCLLCVPVCPDSSI---PVKEGK-RLDFDLDHCKGCGICEKACPFDAIIMK 97
Cdd:cd10564    87 ECRSCQDACPTQAIrfrPRLGGIaLPELDADACTGCGACVSVCPVGAITLT 137
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 46-94 4.19e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 34.23  E-value: 4.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2486205827  46 EEKCKHCLLCVPVCPDSSIPVKEGKRLDFDldhCKGCGICEKACPFDAI 94
Cdd:cd16372    76 KKLCVGCLMCVGFCPEGAMFKHEDYPEPFK---CIACGICVKACPTGAL 121
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 46-98 4.46e-03

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 34.39  E-value: 4.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2486205827  46 EEKCKHCLLCVPVCPDSSIpVKEGKRLDFDL-DHCKGCGICEKACPFDAIIMKK 98
Cdd:TIGR01944 112 EDNCIGCTKCIQACPVDAI-VGAAKAMHTVIaDECTGCDLCVEPCPTDCIEMIP 164
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 34-94 5.08e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 33.70  E-value: 5.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2486205827  34 TGEWRVDtpefiEEKCKHCLLCVPVCPDSSIPVKEGKRLDFDLDHCKGCGICEKACPFDAI 94
Cdd:cd10550    72 TGAVVVD-----EDKCIGCGMCVEACPFGAIRVDPETGKAIKCDLCGGDPACVKVCPTGAL 127
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 70-99 5.47e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 32.72  E-value: 5.47e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2486205827  70 KRLDFDLDHCKGCGICEKACPFDAIIMKKG 99
Cdd:COG2221     8 WPPKIDEEKCIGCGLCVAVCPTGAISLDDG 37
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 60-91 5.64e-03

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 34.28  E-value: 5.64e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2486205827  60 PDSSIPVKEGKRLDFDLDHCKGCGICEKACPF 91
Cdd:COG0247    61 HDKNLKTLPWKELLDALDACVGCGFCRAMCPS 92
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 38-98 5.99e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 34.20  E-value: 5.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2486205827  38 RVDTPEFIEEKCKHCLLCVPVCPDSSIpVKEGKRL-DFDLDHCKGCGICEKACPFDAIIMKK 98
Cdd:COG2878   128 VIGGPKGCEYGCIGCGDCIKACPFDAI-VGAAKGMhTVDEDKCTGCGLCVEACPVDCIEMVP 188
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
 49-94 6.50e-03

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 34.20  E-value: 6.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2486205827  49 CKHCL--LCVPVCPDSSIPVKE--GKRLdFDLDHCKGCGICEKACPFDAI 94
Cdd:cd10555   133 CNHCTnpACLAACPRKAIYKREedGIVL-VDQDRCRGYRYCVEACPYKKI 181
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 42-98 7.57e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 33.81  E-value: 7.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2486205827  42 PEFIEEKCKHCLLCVPVCPDSSI---PVKE-----GKRLDFDLDHCKGC-GICEKACPFDAIIMKK 98
Cdd:COG2878   162 HTVDEDKCTGCGLCVEACPVDCIemvPVSPtvvvsSWDKGKAVRKVVGCiGLCCKKCCPAAAITVN 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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