|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
13-419 |
7.15e-166 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 473.05 E-value: 7.15e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 13 RISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPslpntrPDKADRLIVVDDALQTLQALAREHRRELG 92
Cdd:COG0770 26 GVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRP------LPADLPLIVVDDTLKALQQLAAAHRARFN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 93 LPILAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEPNYG 172
Cdd:COG0770 100 IPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMGMNHPGEIAYLARIARPDIA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 173 IVTNIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDPVLMSMA--AEHETL------AAECYPTTLADGVEH- 243
Cdd:COG0770 180 VITNIGPAHLEGFGSLEGIARAKGEIFEGL-PPGGVAVLNADDPLLAALAerAKARVLtfglseDADVRAEDIELDEDGt 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 244 ---------------HLEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRT-GQNTLILDCYNANPSSM 307
Cdd:COG0770 259 rftlhtpggelevtlPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGaGGVTLIDDSYNANPDSM 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 308 QASLVNFRQEPLEGctRKILILGDMLELGDWSDAEHRHIISLAAEIPDARILLVGPHFAKAYRSLESRPAdtTLYPSQEV 387
Cdd:COG0770 339 KAALDVLAQLPGGG--RRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAIAEAAGGERA--EHFEDKEE 414
|
410 420 430
....*....|....*....|....*....|..
gi 2485994068 388 LAAELRKHPVSQALILVKGSHSIGLERLADLL 419
Cdd:COG0770 415 LLAALKALLRPGDVVLVKGSRGMGLERVVEAL 446
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
16-419 |
8.71e-120 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 354.65 E-value: 8.71e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 16 TDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPSLPntrpDKADRLIVVDDALQTLQALAREHRRELGLPI 95
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGP----DNGLPQILVDDTLEALQALARAKRAKFSGKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 96 LAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEPNYGIVT 175
Cdd:TIGR01143 77 IGITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVIT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 176 NIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDPVLMSMAAE----------HETLAAECYPTTL-ADGVEHH 244
Cdd:TIGR01143 157 NIGPAHLEGFGSLEGIAEAKGEILQGL-KENGIAVINADDPAFADLAKRlpnrnilsfgFEGGDFVAKDISYsALGSTSF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 245 --------------LEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRsQKIRTGQN-TLILDCYNANPSSMQA 309
Cdd:TIGR01143 236 tlvapggefevslpLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGR-FEVQTKNGlTLIDDTYNANPDSMRA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 310 SLvnfrqEPLEGCT-RKILILGDMLELGDWSDAEHRHIISLAAEIPDARILLVGPHFAKAYRSL-ESRPADTTLYPSQEV 387
Cdd:TIGR01143 315 AL-----DALARFPgKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFgKQGKHFADKDELLAF 389
|
410 420 430
....*....|....*....|....*....|..
gi 2485994068 388 LAAELRKHPVsqalILVKGSHSIGLERLADLL 419
Cdd:TIGR01143 390 LKTLVRKGDV----VLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
13-419 |
3.13e-103 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 327.43 E-value: 3.13e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 13 RISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPslpntRPDKADRLIVVDDALQTLQALAREHRRELG 92
Cdd:PRK11929 528 AVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQ-----VADVDLPQIVVDDTRAALGRLATAWRARFS 602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 93 LPILAITGSNGKTTTKELVSRVLAE---KYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEP 169
Cdd:PRK11929 603 LPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAP 682
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 170 NYGIVTNIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDP-------------VLMSMAAEHETLAAECYPTT 236
Cdd:PRK11929 683 TVALVTNAQREHQEFMHSVEAVARAKGEIIAAL-PEDGVAVVNGDDPytaiwaklagarrVLRFGLQPGADVYAEKIAKD 761
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 237 LADGVEH-----------------HLEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRTGQNTLIL-D 298
Cdd:PRK11929 762 ISVGEAGgtrcqvvtpagsaevylPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIdD 841
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 299 CYNANPSSMQASLVNFRQEPLEgctRKILILGDMLELGDWSDAEHRHIISLAAEIPDARILLVGPHFAKAYRSL-ESRPA 377
Cdd:PRK11929 842 TYNANPDSMRAAIDVLAELPNG---PRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAARDAAAAFgAGARG 918
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2485994068 378 DttlYPSQEVLAAELRKHPVSQALILVKGSHSIGLERLADLL 419
Cdd:PRK11929 919 V---CASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDAL 957
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
98-261 |
6.61e-33 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 122.80 E-value: 6.61e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 98 ITGSNGKTTTKELVSRVLAEKYEVYATRG--------NLNNHIGVPLTLLAMTR-DVEFGIVEMGASACGEiALLCSIAE 168
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 169 PNYGIVTNIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDP----------------VLMSMAAEHETLAAEC 232
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGL-PEDGIAVINADDPygafliaklkkagvrvITYGIEGEADLRAANI 158
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2485994068 233 YPTTlaDGVEHHLE--------------GDYNRFNVAAAVAVG 261
Cdd:pfam08245 159 ELSS--DGTSFDLFtvpggeleieipllGRHNVYNALAAIAAA 199
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
83-304 |
2.37e-08 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 55.79 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 83 LAREHRRELGLPILAITGSNGKTTTKELVSRVLAEKYEVYAT-RGNLNNHIGV--------PLTLLA--------MTRDV 145
Cdd:NF033197 82 ILKKKYGRIPKKFIEITGVKGKTTTAELLAHILSDEYVLLHTsRGTERYPEGElsnkgsitPASILNalelaeeiGIDDY 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 146 EFGIVE--MGASACGEIALLCSIAEpNYGIVTNIGRAHLE----------GFGGPEGVRRGKGELYDWLART-GGRVFVp 212
Cdd:NF033197 162 GFLIFEvsLGGTGAGDVGIITNILE-DYPIAGGKRSASAAklqslknakvGSINVADLGIYINGKNKLVITVaGVEILS- 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 213 ANDPVLMSMAAEHETlaaecypTTLADGvEHHLEgdynrfNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQkIRTGQ 292
Cdd:NF033197 240 KYPLRFKYGNTEFEF-------NPLLFG-PHYRE------NSLFAIEAALNLGVDPEDIISALKGFKGLPGRMA-VKKEG 304
|
250
....*....|..
gi 2485994068 293 NTLILDcyNANP 304
Cdd:NF033197 305 GVVIVD--NINP 314
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
13-419 |
7.15e-166 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 473.05 E-value: 7.15e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 13 RISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPslpntrPDKADRLIVVDDALQTLQALAREHRRELG 92
Cdd:COG0770 26 GVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRP------LPADLPLIVVDDTLKALQQLAAAHRARFN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 93 LPILAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEPNYG 172
Cdd:COG0770 100 IPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMGMNHPGEIAYLARIARPDIA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 173 IVTNIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDPVLMSMA--AEHETL------AAECYPTTLADGVEH- 243
Cdd:COG0770 180 VITNIGPAHLEGFGSLEGIARAKGEIFEGL-PPGGVAVLNADDPLLAALAerAKARVLtfglseDADVRAEDIELDEDGt 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 244 ---------------HLEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRT-GQNTLILDCYNANPSSM 307
Cdd:COG0770 259 rftlhtpggelevtlPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGaGGVTLIDDSYNANPDSM 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 308 QASLVNFRQEPLEGctRKILILGDMLELGDWSDAEHRHIISLAAEIPDARILLVGPHFAKAYRSLESRPAdtTLYPSQEV 387
Cdd:COG0770 339 KAALDVLAQLPGGG--RRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAIAEAAGGERA--EHFEDKEE 414
|
410 420 430
....*....|....*....|....*....|..
gi 2485994068 388 LAAELRKHPVSQALILVKGSHSIGLERLADLL 419
Cdd:COG0770 415 LLAALKALLRPGDVVLVKGSRGMGLERVVEAL 446
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
16-419 |
8.71e-120 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 354.65 E-value: 8.71e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 16 TDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPSLPntrpDKADRLIVVDDALQTLQALAREHRRELGLPI 95
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGP----DNGLPQILVDDTLEALQALARAKRAKFSGKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 96 LAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEPNYGIVT 175
Cdd:TIGR01143 77 IGITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVIT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 176 NIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDPVLMSMAAE----------HETLAAECYPTTL-ADGVEHH 244
Cdd:TIGR01143 157 NIGPAHLEGFGSLEGIAEAKGEILQGL-KENGIAVINADDPAFADLAKRlpnrnilsfgFEGGDFVAKDISYsALGSTSF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 245 --------------LEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRsQKIRTGQN-TLILDCYNANPSSMQA 309
Cdd:TIGR01143 236 tlvapggefevslpLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGR-FEVQTKNGlTLIDDTYNANPDSMRA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 310 SLvnfrqEPLEGCT-RKILILGDMLELGDWSDAEHRHIISLAAEIPDARILLVGPHFAKAYRSL-ESRPADTTLYPSQEV 387
Cdd:TIGR01143 315 AL-----DALARFPgKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFgKQGKHFADKDELLAF 389
|
410 420 430
....*....|....*....|....*....|..
gi 2485994068 388 LAAELRKHPVsqalILVKGSHSIGLERLADLL 419
Cdd:TIGR01143 390 LKTLVRKGDV----VLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
13-419 |
3.13e-103 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 327.43 E-value: 3.13e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 13 RISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPslpntRPDKADRLIVVDDALQTLQALAREHRRELG 92
Cdd:PRK11929 528 AVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQ-----VADVDLPQIVVDDTRAALGRLATAWRARFS 602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 93 LPILAITGSNGKTTTKELVSRVLAE---KYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEP 169
Cdd:PRK11929 603 LPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAP 682
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 170 NYGIVTNIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDP-------------VLMSMAAEHETLAAECYPTT 236
Cdd:PRK11929 683 TVALVTNAQREHQEFMHSVEAVARAKGEIIAAL-PEDGVAVVNGDDPytaiwaklagarrVLRFGLQPGADVYAEKIAKD 761
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 237 LADGVEH-----------------HLEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRTGQNTLIL-D 298
Cdd:PRK11929 762 ISVGEAGgtrcqvvtpagsaevylPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIdD 841
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 299 CYNANPSSMQASLVNFRQEPLEgctRKILILGDMLELGDWSDAEHRHIISLAAEIPDARILLVGPHFAKAYRSL-ESRPA 377
Cdd:PRK11929 842 TYNANPDSMRAAIDVLAELPNG---PRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAARDAAAAFgAGARG 918
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2485994068 378 DttlYPSQEVLAAELRKHPVSQALILVKGSHSIGLERLADLL 419
Cdd:PRK11929 919 V---CASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDAL 957
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
14-419 |
6.63e-65 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 222.14 E-value: 6.63e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 14 ISTDSRRIE--PDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPSLPNTRPDKADrLIVVDDALQTLQALAREHRREL 91
Cdd:PRK11930 27 ILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHPEESYPDAN-FLKVKDPLKALQELAAYHRSQF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 92 GLPILAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEPNY 171
Cdd:PRK11930 106 DIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHELGIFEAGISQPGEMEALQKIIKPTI 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 172 GIVTNIGRAHLEGFGGPEGVRRGKGELYdwlARTGGRVFVPANDPVLMSMAAEHETLAAECYPTT---------LADGVE 242
Cdd:PRK11930 186 GILTNIGGAHQENFRSIKQKIMEKLKLF---KDCDVIIYNGDNELISSCITKSNLTLKLISWSRKdpeaplyipFVEKKE 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 243 HH-------LEGDYN---RFNVAAAV-------AVGRYFGVDDERIRYAVGSYRPDNHRSqKIRTGQN--TLILDCYNAN 303
Cdd:PRK11930 263 DHtvisytyKGEDFHfeiPFIDDASIenlihciAVLLYLGYSADQIQERMARLEPVAMRL-EVKEGINncTLINDSYNSD 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 304 PSSMQASL--VNFRQEPlegcTRKILILGDMLELGDWSDAEHRHIISLAAEIPDARILLVGPHFAKaYRSLESrPADTTL 381
Cdd:PRK11930 342 LQSLDIALdfLNRRSQS----KKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIGIGEEISS-EASKFE-GTEKEF 415
|
410 420 430
....*....|....*....|....*....|....*...
gi 2485994068 382 YPSQEVLAAELRKHPVSQALILVKGSHSIGLERLADLL 419
Cdd:PRK11930 416 FKTTEAFLKSFAFLKFRNELILVKGARKFEFEQITELL 453
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
14-413 |
1.53e-55 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 189.86 E-value: 1.53e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 14 ISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPsLPNTRPDkadrlIVVDDALQTLQALAREHRRELGL 93
Cdd:PRK10773 27 VTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRP-LDIDLPQ-----LVVKDTRLAFGQLAAWVRQQVPA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 94 PILAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEPNYGI 173
Cdd:PRK10773 101 RVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELGANHQGEIAYTVSLTRPEAAL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 174 VTNIGRAHLEGFGGPEGVRRGKGELY----------------DWL-------ARTGGRVFVPANDPVLMSMAAEHETLAA 230
Cdd:PRK10773 181 VNNLAAAHLEGFGSLAGVAKAKGEIFsglpengiaimnadsnDWLnwqsvigSKTVWRFSPNAANSVDFTATNIHVTSHG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 231 E--CYPTTLAD-GVEHHLEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRTGQNTLIL-DCYNANPSS 306
Cdd:PRK10773 261 TefTLHTPTGSvDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFPIQLAEGQLLLdDSYNANVGS 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 307 MQASLVNFRQEPlegcTRKILILGDMLELGDWSDAEHRHIISLAAEIPDARILLVGP-------------HFA-KAyrSL 372
Cdd:PRK10773 341 MTAAAQVLAEMP----GYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKlshaiseasgvgeHFAdKT--AL 414
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 2485994068 373 ESRpadttlypsqevLAAELRKHPVsqALILVKGSHSIGLE 413
Cdd:PRK10773 415 IAR------------LKALLAEHQV--ITILVKGSRSAAME 441
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
14-363 |
1.08e-53 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 185.75 E-value: 1.08e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 14 ISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPSLPNTRPDKAdrLIVVDDALQTLQALAREHRRELGL 93
Cdd:PRK14093 31 ISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDKFAADAP--LLVVDDVLAALRDLGRAARARLEA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 94 PILAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIGVPLTLLAMTRDVEFGIVEMGASACGEIALLCSIAEPNYGI 173
Cdd:PRK14093 109 KVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVRPHVAI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 174 VTNIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDPVLMSMAA--------------EHE---------TLAA 230
Cdd:PRK14093 189 ITTVEPVHLEFFSGIEAIADAKAEIFTGL-EPGGAAVLNRDNPQFDRLAAsaraagiarivsfgADEkadarlldvALHA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 231 ECyPTTLADGVEHHLE------GDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHR----SQKIRTGQNTLILDCY 300
Cdd:PRK14093 268 DC-SAVHADILGHDVTyklgmpGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGRgvrhTLEVGGGEATLIDESY 346
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2485994068 301 NANPSSMQASLVNFRQEPLEGCTRKILILGDMLELGDWSDAEHRhiiSLAAEIPDARILLV---GP 363
Cdd:PRK14093 347 NANPASMAAALGVLGRAPVGPQGRRIAVLGDMLELGPRGPELHR---GLAEAIRANAIDLVfccGP 409
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
98-261 |
6.61e-33 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 122.80 E-value: 6.61e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 98 ITGSNGKTTTKELVSRVLAEKYEVYATRG--------NLNNHIGVPLTLLAMTR-DVEFGIVEMGASACGEiALLCSIAE 168
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 169 PNYGIVTNIGRAHLEGFGGPEGVRRGKGELYDWLaRTGGRVFVPANDP----------------VLMSMAAEHETLAAEC 232
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGL-PEDGIAVINADDPygafliaklkkagvrvITYGIEGEADLRAANI 158
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2485994068 233 YPTTlaDGVEHHLE--------------GDYNRFNVAAAVAVG 261
Cdd:pfam08245 159 ELSS--DGTSFDLFtvpggeleieipllGRHNVYNALAAIAAA 199
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
14-311 |
9.64e-23 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 99.77 E-value: 9.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 14 ISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAyAVVDDPSLPNTRPDKAdrLIVVDDALQTLQALARE-----HR 88
Cdd:COG0769 2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAV-AVVTEAPGALLAAGVP--VIVVPDPRAALALLAAAfyghpSQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 89 RelgLPILAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIG-----VPLT---------LLAMTRD--VEFGIVEm 152
Cdd:COG0769 79 K---LKLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGgelipSSLTtpealdlqrLLAEMVDagVTHVVME- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 153 gASacgeiallcSIA---------EPNYGIVTNIGRAHLEGFGGPEGVRRGKGELYDWLARTGGRVfVPANDPVLMSMAA 223
Cdd:COG0769 155 -VS---------SHAldqgrvdgvRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAV-INADDPYGRRLAA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 224 EHE----TLAAECYPTTLADGVEHHLE--------------------GDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYR 279
Cdd:COG0769 224 AAParviTYGLKADADLRATDIELSADgtrftlvtpggevevrlpliGRFNVYNALAAIAAALALGIDLEEILAALEKLK 303
|
330 340 350
....*....|....*....|....*....|..
gi 2485994068 280 PDNHRSQKIRTGQNTLILDCYNANPSSMQASL 311
Cdd:COG0769 304 GVPGRMERVDGGQGPTVIVDYAHTPDALENVL 335
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
27-330 |
3.76e-22 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 97.84 E-value: 3.76e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 27 FFALRGAS---FDGN---RFAADALEK-GAAYAVVDDPSlpnTRPDKADRLIV---VDDALQTLQAlAREHR-------- 88
Cdd:COG0771 22 LLAKLGAEvtvSDDRpapELAAAELEApGVEVVLGEHPE---ELLDGADLVVKspgIPPDHPLLKA-ARAAGipvigeie 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 89 ---RELGLPILAITGSNGKTTTKELVSRVL-AEKYEVYATrGNlnnhIGVP-LTLLAMTRDVEFGIVE------MGASAC 157
Cdd:COG0771 98 layRLSPAPIIAITGTNGKTTTTTLIGHILkAAGLRVAVG-GN----IGTPlLDLLLEPEPPDVYVLElssfqlETTPSL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 158 geiallcsiaEPNYGIVTNIGRAHLEGFGGPEGVRRGKGELYDWlARTGGRVFVPANDPVLMSMAAEhetLAAECYPTTL 237
Cdd:COG0771 173 ----------RPDVAVILNITPDHLDRHGSMEAYAAAKARIFAN-QTPDDYAVLNADDPLTRALAEE---AKARVVPFSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 238 ADGVEH------------------------HLEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRTGQN 293
Cdd:COG0771 239 KEPLEGgagledgklvdrasgeellpvddlRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEING 318
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2485994068 294 TlilDCYN---A-NPSSMQASLVNFRQeplegctRKILILG 330
Cdd:COG0771 319 V---RFINdskAtNPDATLAALESFDG-------PVVLIAG 349
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
17-328 |
6.54e-22 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 98.62 E-value: 6.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 17 DSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPSLPNTRPDKAdRLIVVDDALQTLQALAREH--RRELGLP 94
Cdd:PRK11929 35 DSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAADA-LVLPVADLRKALGELAARWygRPSEQLS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 95 ILAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNH-----IGVPLT---------LLAMTRDVEFGIVEMGASACG-E 159
Cdd:PRK11929 114 LVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARldgrlIPGSLTtpdaiilhrILARMRAAGADAVAMEASSHGlE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 160 IALLCSIaEPNYGIVTNIGRAHLEGFGGPEGVRRGKGELYDWLARTGGRVfVPANDPVLMSMAAEHETLAAECYPT---- 235
Cdd:PRK11929 194 QGRLDGL-RIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAV-INADDPAAARLLAALPRGLKVGYSPqnag 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 236 -----------------TLADGVEHH-----LEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIR---T 290
Cdd:PRK11929 272 advqardlratahgqvfTLATPDGSYqlvtrLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERVGptaG 351
|
330 340 350
....*....|....*....|....*....|....*...
gi 2485994068 291 GQNTLILDCYNANPSSMQASLVNFRqePLEGCTRKILI 328
Cdd:PRK11929 352 AQGPLVVVDYAHTPDALAKALTALR--PVAQARNGRLV 387
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
14-296 |
1.67e-21 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 95.97 E-value: 1.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 14 ISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPslpnTRPDKADRLIVVDDALQTLQALARE--HRREL 91
Cdd:PRK00139 18 LTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEAD----GEAGTGVPVIIVPDLRKALALLAAAfyGHPSD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 92 GLPILAITGSNGKTTTKELVSRVLAEKYEVYATRGNLNNHIG-----------VPLTLLAMTRDvefgIVEMGASACgei 160
Cdd:PRK00139 94 KLKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGgelipsglttpDALDLQRLLAE----LVDAGVTYA--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 161 ALLCS--------IAEPNY--GIVTNIGRAHLEGFGGPEGVRRGKGELYDWLartGGRVFVPANDPVLMSMAAEHETLAA 230
Cdd:PRK00139 167 AMEVSshaldqgrVDGLKFdvAVFTNLSRDHLDYHGTMEDYLAAKARLFSEL---GLAAVINADDEVGRRLLALPDAYAV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 231 ECYPTTL-ADGVEHH---------------LEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRTGQNT 294
Cdd:PRK00139 244 SMAGADLrATDVEYTdsgqtftlvtevespLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVDAGQGP 323
|
..
gi 2485994068 295 LI 296
Cdd:PRK00139 324 LV 325
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
14-329 |
2.70e-20 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 92.38 E-value: 2.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 14 ISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPSLPNTRPDKadrLIVVDDALQTLQALARE---HRRE 90
Cdd:TIGR01085 7 LTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVAPVP---VIIVPDLRHALSSLAAAfygHPSK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 91 lGLPILAITGSNGKTTTKELVS---RVLAEKYEVYATRGN---LNNHIGVP--------LTLLAMTRD-----VEFGIVE 151
Cdd:TIGR01085 84 -KLKVIGVTGTNGKTTTTSLIAqllRLLGKKTGLIGTIGYrlgGNDLIKNPaalttpeaLTLQSTLAEmveagAQYAVME 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 152 mgASAcgeIAL-LCSIAEPNY--GIVTNIGRAHLEGFGGPEGVRRGKGELYDWLA-------------------RTGGRV 209
Cdd:TIGR01085 163 --VSS---HALaQGRVRGVRFdaAVFTNLSRDHLDFHGTMENYFAAKASLFTELGlkrfavinlddeygaqfvkRLPKDI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 210 FVPANDPVLMSMAAEHETLAAECYPTTLADGVEHH---------LEGDYNRFNVAAAVAVGRYFG-VDDERIRYAVGSYR 279
Cdd:TIGR01085 238 TVSAITQPADGRAQDIKITDSGYSFEGQQFTFETPageghlhtpLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKFR 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2485994068 280 PDNHRSQKIRTGQNTLILDCYNANPSSMQASLVNFRqeplEGCTRKILIL 329
Cdd:TIGR01085 318 GVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLR----KHKDGRLIVV 363
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
93-395 |
1.83e-17 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 83.93 E-value: 1.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 93 LPILAITGSNGKTTTKELVSRVLAEKYEVYATRGNlnnhIGVPLTLLAMTRDVEFGIVEMGASacgEIALLCSiAEPNYG 172
Cdd:TIGR01087 102 LPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLELSSF---QLETTES-LRPEIA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 173 IVTNIGRAHLEGFGGPEGVRRGKGELYDwLARTGGRVFVPANDPVLMSMA-----------AEHETLAAECYPT---TL- 237
Cdd:TIGR01087 174 LILNISEDHLDWHGSFEDYVAAKLKIFA-RQTEGDVAVLNADDPRFARLAqkskaqviwfsVEKDAERGLCIRDgglYLk 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 238 ADGVEHHLEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRTGQNTL-ILDCYNANPSSMQASLVNFRq 316
Cdd:TIGR01087 253 PNDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHfYNDSKATNVHATLAALSAFD- 331
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2485994068 317 EPLegctrkILILGDMLELGDWSDaehrhiISLAAEIPDARILLVGPHFAKAYRSLESRPADTTLYPSQEVLAAELRKH 395
Cdd:TIGR01087 332 NPV------ILIVGGDDKGADFSP------LAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVYLVESLEEAVQAAREV 398
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
14-88 |
2.12e-11 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 59.56 E-value: 2.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 14 ISTDSRRIEPDSVFFALRGASFDGNRFAADALEKGAAYAVVDDPSLpNTRPDKA------DRLIVVDDALQTLQALAREH 87
Cdd:pfam01225 5 VGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAAN-NISPDNPeleaakVPGIPVIDRREALAELAAAF 83
|
.
gi 2485994068 88 R 88
Cdd:pfam01225 84 Y 84
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
83-304 |
2.37e-08 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 55.79 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 83 LAREHRRELGLPILAITGSNGKTTTKELVSRVLAEKYEVYAT-RGNLNNHIGV--------PLTLLA--------MTRDV 145
Cdd:NF033197 82 ILKKKYGRIPKKFIEITGVKGKTTTAELLAHILSDEYVLLHTsRGTERYPEGElsnkgsitPASILNalelaeeiGIDDY 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 146 EFGIVE--MGASACGEIALLCSIAEpNYGIVTNIGRAHLE----------GFGGPEGVRRGKGELYDWLART-GGRVFVp 212
Cdd:NF033197 162 GFLIFEvsLGGTGAGDVGIITNILE-DYPIAGGKRSASAAklqslknakvGSINVADLGIYINGKNKLVITVaGVEILS- 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 213 ANDPVLMSMAAEHETlaaecypTTLADGvEHHLEgdynrfNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQkIRTGQ 292
Cdd:NF033197 240 KYPLRFKYGNTEFEF-------NPLLFG-PHYRE------NSLFAIEAALNLGVDPEDIISALKGFKGLPGRMA-VKKEG 304
|
250
....*....|..
gi 2485994068 293 NTLILDcyNANP 304
Cdd:NF033197 305 GVVIVD--NINP 314
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
283-366 |
3.29e-08 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 50.81 E-value: 3.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 283 HRSQKIRTGQNTLILDCYNANPSSMQASLVNFRQEPLEgctRKILILGDMLELGDWSDAEhrhiISLAAEIPDARILLVG 362
Cdd:pfam02875 3 GRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPG---RLILVFGGMGDRDAEFHAL----LGRLAAALADVVILTG 75
|
....
gi 2485994068 363 PHFA 366
Cdd:pfam02875 76 DYPR 79
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
13-106 |
2.08e-07 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 52.73 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 13 RISTDSRRIEPDSVFFAlRGASFDgNRFAADALEKGAAYAVVD-DPSLPNTrpdkadrLIVVDDALQTLQALARE----- 86
Cdd:PRK14022 36 DISYDSRTADEGTLFFA-KGAYFK-HKFLQNAITQGLKLYVSEkDYEVGIP-------QVIVPDIKKAMSLIAMEfydnp 106
|
90 100
....*....|....*....|.
gi 2485994068 87 -HRrelgLPILAITGSNGKTT 106
Cdd:PRK14022 107 qHK----LKLLAFTGTKGKTT 123
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
94-290 |
4.11e-06 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 48.81 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 94 PILAITGSNGKTTTKELVSRVLAEKYEVYATRGNlnnhIGVPLTLLAMTRDVEFGIVemgasacGEIA--LLCSIAE--P 169
Cdd:PRK14106 109 PIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPLIDAVEEYGEDDIIV-------AEVSsfQLETIKEfkP 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 170 NYGIVTNIGRAHLEGFGGPEGVRRGKGELYDWLARTGGRVfVPANDPVLMSMAaehETLAAECYP----TTLADGV---- 241
Cdd:PRK14106 178 KVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTV-LNYDDPRTRSLA---KKAKARVIFfsrkSLLEEGVfvkn 253
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2485994068 242 ------------------EHHLEGDYNRFNVAAAVAVGRYFGVDDERIRYAVGSYRPDNHRSQKIRT 290
Cdd:PRK14106 254 gkivislggkeeevididEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAE 320
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
94-281 |
8.68e-05 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 44.76 E-value: 8.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 94 PILAITGSNGKTTTKELVSRVL--AEKYEVYATRGnlnnhiGVPL-----------------TLLaMTRDVEFGIVEmga 154
Cdd:PRK14016 481 PIVAVTGTNGKTTTTRLIAHILklSGKRVGMTTTD------GVYIdgrlidkgdctgpksarRVL-MNPDVEAAVLE--- 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 155 SACGEI---AL---LCSIaepnyGIVTNIGRAHLeGFGG-------------------PEGV--------------RRGK 195
Cdd:PRK14016 551 TARGGIlreGLaydRCDV-----GVVTNIGEDHL-GLGGintledlakvkrvvveavkPDGYavlnaddpmvaamaERCK 624
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2485994068 196 GE------------LYDWLARtGGR-VFVPANDPVLMSMAAEHETLAAECYPTTLADGVEHHLEgdynrfNVAAAVAVGR 262
Cdd:PRK14016 625 GKviffsmdpdnpvIAEHRAQ-GGRaVYVEGDYIVLAEGGWEIRIISLADIPLTLGGKAGFNIE------NALAAIAAAW 697
|
250
....*....|....*....
gi 2485994068 263 YFGVDDERIRYAVGSYRPD 281
Cdd:PRK14016 698 ALGIDIELIRAGLRTFVSD 716
|
|
| |
