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Conserved domains on  [gi|2470340391|ref|WP_277346074|]
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MULTISPECIES: glycoside hydrolase family 2 TIM barrel-domain containing protein, partial [Bacteria]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Bgal_small_N super family cl46900
Beta galactosidase small chain; This domain comprises the small chain of dimeric ...
12-166 1.71e-142

Beta galactosidase small chain; This domain comprises the small chain of dimeric beta-galactosidases EC:3.2.1.23. This domain is also found in single chain beta-galactosidase.


The actual alignment was detected with superfamily member PRK09525:

Pssm-ID: 481240 [Multi-domain]  Cd Length: 1027  Bit Score: 420.88  E-value: 1.71e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391   12 IRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPMNRLTDDP 91
Cdd:PRK09525   352 IRGVNRHEHHPEHGQVMDEETMVQDILLMKQHNFNAVRCSHYPNHPLWYELCDRYGLYVVDEANIETHGMVPMNRLSDDP 431
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2470340391   92 RWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYAR 166
Cdd:PRK09525   432 RWLPAMSERVTRMVQRDRNHPSIIIWSLGNESGHGANHDALYRWIKSNDPSRPVQYEGGGADTAATDIICPMYAR 506
 
Name Accession Description Interval E-value
lacZ PRK09525
beta-galactosidase;
12-166 1.71e-142

beta-galactosidase;


Pssm-ID: 236548 [Multi-domain]  Cd Length: 1027  Bit Score: 420.88  E-value: 1.71e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391   12 IRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPMNRLTDDP 91
Cdd:PRK09525   352 IRGVNRHEHHPEHGQVMDEETMVQDILLMKQHNFNAVRCSHYPNHPLWYELCDRYGLYVVDEANIETHGMVPMNRLSDDP 431
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2470340391   92 RWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYAR 166
Cdd:PRK09525   432 RWLPAMSERVTRMVQRDRNHPSIIIWSLGNESGHGANHDALYRWIKSNDPSRPVQYEGGGADTAATDIICPMYAR 506
Glyco_hydro_2_C pfam02836
Glycosyl hydrolases family 2, TIM barrel domain; This family contains beta-galactosidase, ...
12-166 2.21e-91

Glycosyl hydrolases family 2, TIM barrel domain; This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.


Pssm-ID: 397119 [Multi-domain]  Cd Length: 302  Bit Score: 268.16  E-value: 2.21e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391  12 IRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPM------- 84
Cdd:pfam02836  17 FRGVNRHEDHDRRGRGFDMDLMVKDIQLMKQNNINAVRTSHYPNHPEWYQLCDEYGIYVIDEANLETHGLWQKfgeieps 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391  85 -NRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPM 163
Cdd:pfam02836  97 ySELTDNPEWLPAHLERAEELVQRDKNHPSVIIWSLGNESGAGENIAAMYAATKSLDPTRPVHYEGVGIDPEVDDIILDI 176

                  ...
gi 2470340391 164 YAR 166
Cdd:pfam02836 177 YSR 179
LacZ COG3250
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
12-145 1.76e-68

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 218.86  E-value: 1.76e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391  12 IRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMvpmnrLTDDP 91
Cdd:COG3250   277 LKGVNRHEDWPDDGRAVTDEAMRRDLELMKEAGFNAVRTSHYPEDPEFYDLCDELGLLVWDEAPFEWHGM-----LGDDP 351
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2470340391  92 RWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPV 145
Cdd:COG3250   352 EFLEAVEAELREMVRRDRNHPSIILWSGGNESGGGPNFAALYEWVKELDPTRPV 405
 
Name Accession Description Interval E-value
lacZ PRK09525
beta-galactosidase;
12-166 1.71e-142

beta-galactosidase;


Pssm-ID: 236548 [Multi-domain]  Cd Length: 1027  Bit Score: 420.88  E-value: 1.71e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391   12 IRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPMNRLTDDP 91
Cdd:PRK09525   352 IRGVNRHEHHPEHGQVMDEETMVQDILLMKQHNFNAVRCSHYPNHPLWYELCDRYGLYVVDEANIETHGMVPMNRLSDDP 431
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2470340391   92 RWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYAR 166
Cdd:PRK09525   432 RWLPAMSERVTRMVQRDRNHPSIIIWSLGNESGHGANHDALYRWIKSNDPSRPVQYEGGGADTAATDIICPMYAR 506
Glyco_hydro_2_C pfam02836
Glycosyl hydrolases family 2, TIM barrel domain; This family contains beta-galactosidase, ...
12-166 2.21e-91

Glycosyl hydrolases family 2, TIM barrel domain; This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.


Pssm-ID: 397119 [Multi-domain]  Cd Length: 302  Bit Score: 268.16  E-value: 2.21e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391  12 IRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPM------- 84
Cdd:pfam02836  17 FRGVNRHEDHDRRGRGFDMDLMVKDIQLMKQNNINAVRTSHYPNHPEWYQLCDEYGIYVIDEANLETHGLWQKfgeieps 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391  85 -NRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPM 163
Cdd:pfam02836  97 ySELTDNPEWLPAHLERAEELVQRDKNHPSVIIWSLGNESGAGENIAAMYAATKSLDPTRPVHYEGVGIDPEVDDIILDI 176

                  ...
gi 2470340391 164 YAR 166
Cdd:pfam02836 177 YSR 179
LacZ COG3250
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
12-145 1.76e-68

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 218.86  E-value: 1.76e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391  12 IRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMvpmnrLTDDP 91
Cdd:COG3250   277 LKGVNRHEDWPDDGRAVTDEAMRRDLELMKEAGFNAVRTSHYPEDPEFYDLCDELGLLVWDEAPFEWHGM-----LGDDP 351
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2470340391  92 RWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPV 145
Cdd:COG3250   352 EFLEAVEAELREMVRRDRNHPSIILWSGGNESGGGPNFAALYEWVKELDPTRPV 405
ebgA PRK10340
cryptic beta-D-galactosidase subunit alpha; Reviewed
12-166 2.92e-63

cryptic beta-D-galactosidase subunit alpha; Reviewed


Pssm-ID: 236673 [Multi-domain]  Cd Length: 1021  Bit Score: 209.15  E-value: 2.92e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391   12 IRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMV---PMNRLT 88
Cdd:PRK10340   336 LHGVNRHDNDHRKGRAVGMDRVEKDIQLMKQHNINSVRTAHYPNDPRFYELCDIYGLFVMAETDVESHGFAnvgDISRIT 415
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2470340391   89 DDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEgGGADTTATDIICPMYAR 166
Cdd:PRK10340   416 DDPQWEKVYVDRIVRHIHAQKNHPSIIIWSLGNESGYGCNIRAMYHAAKALDDTRLVHYE-EDRDAEVVDVISTMYTR 492
PRK10150 PRK10150
beta-D-glucuronidase; Provisional
13-145 2.99e-19

beta-D-glucuronidase; Provisional


Pssm-ID: 236657 [Multi-domain]  Cd Length: 604  Bit Score: 83.52  E-value: 2.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470340391  13 RGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEA------------------ 74
Cdd:PRK10150  295 KGFGKHEDADIRGKGLDEVLNVHDHNLMKWIGANSFRTSHYPYSEEMLDLADRHGIVVIDETpavglnlsfgagleagnk 374
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2470340391  75 NIETHGMVPMNRLTDDPRwLPAMSErvtrMVQRDRNHPSVIIWSLGNESghgANHDA--------LYRWIKSVDPSRPV 145
Cdd:PRK10150  375 PKETYSEEAVNGETQQAH-LQAIRE----LIARDKNHPSVVMWSIANEP---ASREQgareyfapLAELTRKLDPTRPV 445
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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