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Conserved domains on  [gi|2468800260|ref|WP_276922300|]
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beta-ketoacyl synthase [Frischella perrara]

Protein Classification

beta-ketoacyl-[acyl-carrier-protein] synthase family protein( domain architecture ID 11416750)

beta-ketoacyl-[acyl-carrier-protein] synthase family protein similar to nodulation protein E (nodE), which is involved in the synthesis of a highly unsaturated fatty acid moiety that is part of a lipo-oligosaccharide responsible for host specificity, and to polyketide beta-ketoacyl synthases, which are involved in the synthesis of polyketide antibiotics and related compounds

CATH:  3.40.47.10
EC:  2.3.1.-
Gene Ontology:  GO:0006633|GO:0004315
PubMed:  25456814|11969206
SCOP:  3000122

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FabB COG0304
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...
 9-417 1.29e-173

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440073 [Multi-domain]  Cd Length: 409  Bit Score: 491.15  E-value: 1.29e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   9 RVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIP-FELNlSPFSKRILKNTPRFGRLGLIAAD 86
Cdd:COG0304     2 RVVITGLGAVSPLGNGVEEFWEALLAGRSGIRPITRFDASgLPVRIAGEVKdFDPE-EYLDRKELRRMDRFTQYALAAAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  87 EALKMAfGDDLSELDKHyppfsR-GVIFGTGWGGADALAQNSLSYNTEGFA--SPLTNILSMNNVGSAIMSMNWNLRGYQ 163
Cdd:COG0304    81 EALADA-GLDLDEVDPD-----RtGVIIGSGIGGLDTLEEAYRALLEKGPRrvSPFFVPMMMPNMAAGHVSIRFGLKGPN 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 164 NTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSEGAA 243
Cdd:COG0304   155 YTVSTACASGAHAIGEAYRLIRRGRADVMIAGGAEAAITPLGLAGFDALGALSTRNDDPEKASRPFDKDRDGFVLGEGAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 244 VLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNETE 321
Cdd:COG0304   235 VLVLEELEHAKARGAKIYAEVVGYGASSDAYHITAPAPDGEGAARAMRAALKDAGLspEDIDYINAHGTSTPLGDAAETK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 322 MLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSVLNV 401
Cdd:COG0304   315 AIKRVFGDHAYKVPVSSTKSMTGHLLGAAGAIEAIASVLALRDGVIPPTINLENPDPECDLDYVPNEAREAK-IDYALSN 393

                         410
                  ....*....|....*.
gi 2468800260 402 NYGFGGSNSALIFERY 417
Cdd:COG0304   394 SFGFGGHNASLVFKRY 409
 
Name Accession Description Interval E-value
FabB COG0304
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...
 9-417 1.29e-173

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440073 [Multi-domain]  Cd Length: 409  Bit Score: 491.15  E-value: 1.29e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   9 RVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIP-FELNlSPFSKRILKNTPRFGRLGLIAAD 86
Cdd:COG0304     2 RVVITGLGAVSPLGNGVEEFWEALLAGRSGIRPITRFDASgLPVRIAGEVKdFDPE-EYLDRKELRRMDRFTQYALAAAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  87 EALKMAfGDDLSELDKHyppfsR-GVIFGTGWGGADALAQNSLSYNTEGFA--SPLTNILSMNNVGSAIMSMNWNLRGYQ 163
Cdd:COG0304    81 EALADA-GLDLDEVDPD-----RtGVIIGSGIGGLDTLEEAYRALLEKGPRrvSPFFVPMMMPNMAAGHVSIRFGLKGPN 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 164 NTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSEGAA 243
Cdd:COG0304   155 YTVSTACASGAHAIGEAYRLIRRGRADVMIAGGAEAAITPLGLAGFDALGALSTRNDDPEKASRPFDKDRDGFVLGEGAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 244 VLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNETE 321
Cdd:COG0304   235 VLVLEELEHAKARGAKIYAEVVGYGASSDAYHITAPAPDGEGAARAMRAALKDAGLspEDIDYINAHGTSTPLGDAAETK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 322 MLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSVLNV 401
Cdd:COG0304   315 AIKRVFGDHAYKVPVSSTKSMTGHLLGAAGAIEAIASVLALRDGVIPPTINLENPDPECDLDYVPNEAREAK-IDYALSN 393

                         410
                  ....*....|....*.
gi 2468800260 402 NYGFGGSNSALIFERY 417
Cdd:COG0304   394 SFGFGGHNASLVFKRY 409
KAS_I_II cd00834
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ...
 8-414 4.28e-173

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.


Pssm-ID: 238430 [Multi-domain]  Cd Length: 406  Bit Score: 489.74  E-value: 4.28e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   8 QRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIPFELNLSPFSKRILKNTPRFGRLGLIAAD 86
Cdd:cd00834     1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGIRPITRFDASgFPSRIAGEVPDFDPEDYLDRKELRRMDRFAQFALAAAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  87 EALKMAFGDDlseldKHYPPFSRGVIFGTGWGGADALAQNSLSYNTEG--FASPLTNILSMNNVGSAIMSMNWNLRGYQN 164
Cdd:cd00834    81 EALADAGLDP-----EELDPERIGVVIGSGIGGLATIEEAYRALLEKGprRVSPFFVPMALPNMAAGQVAIRLGLRGPNY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 165 TPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSEGAAV 244
Cdd:cd00834   156 TVSTACASGAHAIGDAARLIRLGRADVVIAGGAEALITPLTLAGFAALRALSTRNDDPEKASRPFDKDRDGFVLGEGAGV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 245 LCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADIEL--VDYVNAHGTSTQLNDFNETEM 322
Cdd:cd00834   236 LVLESLEHAKARGAKIYAEILGYGASSDAYHITAPDPDGEGAARAMRAALADAGLSPedIDYINAHGTSTPLNDAAESKA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 323 LKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSVLNVN 402
Cdd:cd00834   316 IKRVFGEHAKKVPVSSTKSMTGHLLGAAGAVEAIATLLALRDGVLPPTINLEEPDPECDLDYVPNEAREAP-IRYALSNS 394

                         410
                  ....*....|..
gi 2468800260 403 YGFGGSNSALIF 414
Cdd:cd00834   395 FGFGGHNASLVF 406
fabF TIGR03150
beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 ...
 8-414 7.10e-138

beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 274452 [Multi-domain]  Cd Length: 407  Bit Score: 400.32  E-value: 7.10e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   8 QRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIPfelNLSP---FSKRILKNTPRFGRLGLI 83
Cdd:TIGR03150   1 RRVVVTGLGAVTPLGNGVEEFWENLLAGKSGIGPITRFDASdLPVKIAGEVK---DFDPedyIDKKEARRMDRFIQYALA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  84 AADEALKMAfGDDLSELDKhyppfSR-GVIFGTGWGGADALAQNSLSYNTEGF--ASPLTNILSMNNVGSAIMSMNWNLR 160
Cdd:TIGR03150  78 AAKEAVEDS-GLDIEEEDA-----ERvGVIIGSGIGGLETIEEQHIVLLEKGPrrVSPFFIPMSIINMAAGQISIRYGAK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 161 GYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSE 240
Cdd:TIGR03150 152 GPNHAVVTACATGTHAIGDAFRLIQRGDADVMIAGGAEAAITPLGIAGFAAMKALSTRNDDPEKASRPFDKDRDGFVMGE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 241 GAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFN 318
Cdd:TIGR03150 232 GAGVLVLEELEHAKARGAKIYAEIVGYGMSGDAYHITAPAPEGEGAARAMRAALKDAGInpEDVDYINAHGTSTPLGDKA 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 319 ETEMLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSV 398
Cdd:TIGR03150 312 ETKAIKKVFGDHAYKLAVSSTKSMTGHLLGAAGAIEAIFTVLAIRDGIVPPTINLDNPDPECDLDYVPNEAREAK-IDYA 390

                         410
                  ....*....|....*.
gi 2468800260 399 LNVNYGFGGSNSALIF 414
Cdd:TIGR03150 391 LSNSFGFGGTNASLVF 406
PRK07314 PRK07314
beta-ketoacyl-ACP synthase II;
7-418 3.16e-136

beta-ketoacyl-ACP synthase II;


Pssm-ID: 235987 [Multi-domain]  Cd Length: 411  Bit Score: 396.47  E-value: 3.16e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   7 RQRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIPfELNLSPF-SKRILKNTPRFGRLGLIA 84
Cdd:PRK07314    1 KRRVVVTGLGAVSPLGNDVESTWKNLLAGKSGIGPITHFDTSdLAVKIAGEVK-DFNPDDYmSRKEARRMDRFIQYGIAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  85 ADEALKMAfGDDLSELDKhyppfSR-GVIFGTGWGGADALAQNSLSYNTEGFA--SPLTNILSMNNVGSAIMSMNWNLRG 161
Cdd:PRK07314   80 AKQAVEDA-GLEITEENA-----DRiGVIIGSGIGGLETIEEQHITLLEKGPRrvSPFFVPMAIINMAAGHVSIRYGAKG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 162 YQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSEG 241
Cdd:PRK07314  154 PNHSIVTACATGAHAIGDAARLIAYGDADVMVAGGAEAAITPLGIAGFAAARALSTRNDDPERASRPFDKDRDGFVMGEG 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 242 AAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNE 319
Cdd:PRK07314  234 AGILVLEELEHAKARGAKIYAEVVGYGMTGDAYHMTAPAPDGEGAARAMKLALKDAGInpEDIDYINAHGTSTPAGDKAE 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 320 TEMLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSVL 399
Cdd:PRK07314  314 TQAIKRVFGEHAYKVAVSSTKSMTGHLLGAAGAVEAIFSVLAIRDQVIPPTINLDNPDEECDLDYVPNEARERK-IDYAL 392

                         410
                  ....*....|....*....
gi 2468800260 400 NVNYGFGGSNSALIFERYK 418
Cdd:PRK07314  393 SNSFGFGGTNASLVFKRYE 411
Ketoacyl-synt_C pfam02801
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar ...
 261-374 3.79e-35

Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.


Pssm-ID: 426989  Cd Length: 118  Bit Score: 125.76  E-value: 3.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 261 LAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNETEMLKMVFGDSVYS--LPI 336
Cdd:pfam02801   1 YAVIKGSAVNHDGRHNGLTAPNGEGQARAIRRALADAGVdpEDVDYVEAHGTGTPLGDPIEAEALKRVFGSGARKqpLAI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2468800260 337 SSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLN 374
Cdd:pfam02801  81 GSVKSNIGHLEGAAGAAGLIKVVLALRHGVIPPTLNLE 118
PKS_KS smart00825
Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the ...
 169-415 9.00e-15

Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the thiolase family and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.


Pssm-ID: 214836 [Multi-domain]  Cd Length: 298  Bit Score: 74.29  E-value: 9.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  169 ACATGGIAIGDAVEIIRSGRAEMMIAGGGeSLNSDLNIW-SIDILNALSKEQEnvetaCCPFDRNRNGFVLSEGAAVLCL 247
Cdd:smart00825  96 ACSSSLVALHLACQSLRSGECDMALAGGV-NLILSPDTFvGLSRAGMLSPDGR-----CKTFDASADGYVRGEGVGVVVL 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  248 EKYETALTRGATILAEVTGYGNCSDAYDV--TTPapdcggryhavkyalkqadielvdyvNAHGtstQlndfnetemlkm 325
Cdd:smart00825 170 KRLSDALRDGDPILAVIRGSAVNQDGRSNgiTAP--------------------------SGPA---Q------------ 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  326 vfgdsvysLPISSTKSYTGHLIAAAGaLESIlsIK---SIETNIIPATIHLNNPDPGCNLD----YVPNKHRQVENIQSV 398
Cdd:smart00825 209 --------LLIGSVKSNIGHLEAAAG-VAGL--IKvvlALKHGVIPPTLHFETPNPHIDLEesplRVPTELTPWPPPGRP 277

                          250       260
                   ....*....|....*....|
gi 2468800260  399 LNV---NYGFGGSNSALIFE 415
Cdd:smart00825 278 RRAgvsSFGFGGTNAHVILE 297
 
Name Accession Description Interval E-value
FabB COG0304
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...
 9-417 1.29e-173

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440073 [Multi-domain]  Cd Length: 409  Bit Score: 491.15  E-value: 1.29e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   9 RVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIP-FELNlSPFSKRILKNTPRFGRLGLIAAD 86
Cdd:COG0304     2 RVVITGLGAVSPLGNGVEEFWEALLAGRSGIRPITRFDASgLPVRIAGEVKdFDPE-EYLDRKELRRMDRFTQYALAAAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  87 EALKMAfGDDLSELDKHyppfsR-GVIFGTGWGGADALAQNSLSYNTEGFA--SPLTNILSMNNVGSAIMSMNWNLRGYQ 163
Cdd:COG0304    81 EALADA-GLDLDEVDPD-----RtGVIIGSGIGGLDTLEEAYRALLEKGPRrvSPFFVPMMMPNMAAGHVSIRFGLKGPN 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 164 NTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSEGAA 243
Cdd:COG0304   155 YTVSTACASGAHAIGEAYRLIRRGRADVMIAGGAEAAITPLGLAGFDALGALSTRNDDPEKASRPFDKDRDGFVLGEGAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 244 VLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNETE 321
Cdd:COG0304   235 VLVLEELEHAKARGAKIYAEVVGYGASSDAYHITAPAPDGEGAARAMRAALKDAGLspEDIDYINAHGTSTPLGDAAETK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 322 MLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSVLNV 401
Cdd:COG0304   315 AIKRVFGDHAYKVPVSSTKSMTGHLLGAAGAIEAIASVLALRDGVIPPTINLENPDPECDLDYVPNEAREAK-IDYALSN 393

                         410
                  ....*....|....*.
gi 2468800260 402 NYGFGGSNSALIFERY 417
Cdd:COG0304   394 SFGFGGHNASLVFKRY 409
KAS_I_II cd00834
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ...
 8-414 4.28e-173

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.


Pssm-ID: 238430 [Multi-domain]  Cd Length: 406  Bit Score: 489.74  E-value: 4.28e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   8 QRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIPFELNLSPFSKRILKNTPRFGRLGLIAAD 86
Cdd:cd00834     1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGIRPITRFDASgFPSRIAGEVPDFDPEDYLDRKELRRMDRFAQFALAAAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  87 EALKMAFGDDlseldKHYPPFSRGVIFGTGWGGADALAQNSLSYNTEG--FASPLTNILSMNNVGSAIMSMNWNLRGYQN 164
Cdd:cd00834    81 EALADAGLDP-----EELDPERIGVVIGSGIGGLATIEEAYRALLEKGprRVSPFFVPMALPNMAAGQVAIRLGLRGPNY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 165 TPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSEGAAV 244
Cdd:cd00834   156 TVSTACASGAHAIGDAARLIRLGRADVVIAGGAEALITPLTLAGFAALRALSTRNDDPEKASRPFDKDRDGFVLGEGAGV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 245 LCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADIEL--VDYVNAHGTSTQLNDFNETEM 322
Cdd:cd00834   236 LVLESLEHAKARGAKIYAEILGYGASSDAYHITAPDPDGEGAARAMRAALADAGLSPedIDYINAHGTSTPLNDAAESKA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 323 LKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSVLNVN 402
Cdd:cd00834   316 IKRVFGEHAKKVPVSSTKSMTGHLLGAAGAVEAIATLLALRDGVLPPTINLEEPDPECDLDYVPNEAREAP-IRYALSNS 394

                         410
                  ....*....|..
gi 2468800260 403 YGFGGSNSALIF 414
Cdd:cd00834   395 FGFGGHNASLVF 406
fabF TIGR03150
beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 ...
 8-414 7.10e-138

beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 274452 [Multi-domain]  Cd Length: 407  Bit Score: 400.32  E-value: 7.10e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   8 QRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIPfelNLSP---FSKRILKNTPRFGRLGLI 83
Cdd:TIGR03150   1 RRVVVTGLGAVTPLGNGVEEFWENLLAGKSGIGPITRFDASdLPVKIAGEVK---DFDPedyIDKKEARRMDRFIQYALA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  84 AADEALKMAfGDDLSELDKhyppfSR-GVIFGTGWGGADALAQNSLSYNTEGF--ASPLTNILSMNNVGSAIMSMNWNLR 160
Cdd:TIGR03150  78 AAKEAVEDS-GLDIEEEDA-----ERvGVIIGSGIGGLETIEEQHIVLLEKGPrrVSPFFIPMSIINMAAGQISIRYGAK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 161 GYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSE 240
Cdd:TIGR03150 152 GPNHAVVTACATGTHAIGDAFRLIQRGDADVMIAGGAEAAITPLGIAGFAAMKALSTRNDDPEKASRPFDKDRDGFVMGE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 241 GAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFN 318
Cdd:TIGR03150 232 GAGVLVLEELEHAKARGAKIYAEIVGYGMSGDAYHITAPAPEGEGAARAMRAALKDAGInpEDVDYINAHGTSTPLGDKA 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 319 ETEMLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSV 398
Cdd:TIGR03150 312 ETKAIKKVFGDHAYKLAVSSTKSMTGHLLGAAGAIEAIFTVLAIRDGIVPPTINLDNPDPECDLDYVPNEAREAK-IDYA 390

                         410
                  ....*....|....*.
gi 2468800260 399 LNVNYGFGGSNSALIF 414
Cdd:TIGR03150 391 LSNSFGFGGTNASLVF 406
PRK07314 PRK07314
beta-ketoacyl-ACP synthase II;
7-418 3.16e-136

beta-ketoacyl-ACP synthase II;


Pssm-ID: 235987 [Multi-domain]  Cd Length: 411  Bit Score: 396.47  E-value: 3.16e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   7 RQRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIPfELNLSPF-SKRILKNTPRFGRLGLIA 84
Cdd:PRK07314    1 KRRVVVTGLGAVSPLGNDVESTWKNLLAGKSGIGPITHFDTSdLAVKIAGEVK-DFNPDDYmSRKEARRMDRFIQYGIAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  85 ADEALKMAfGDDLSELDKhyppfSR-GVIFGTGWGGADALAQNSLSYNTEGFA--SPLTNILSMNNVGSAIMSMNWNLRG 161
Cdd:PRK07314   80 AKQAVEDA-GLEITEENA-----DRiGVIIGSGIGGLETIEEQHITLLEKGPRrvSPFFVPMAIINMAAGHVSIRYGAKG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 162 YQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSEG 241
Cdd:PRK07314  154 PNHSIVTACATGAHAIGDAARLIAYGDADVMVAGGAEAAITPLGIAGFAAARALSTRNDDPERASRPFDKDRDGFVMGEG 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 242 AAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNE 319
Cdd:PRK07314  234 AGILVLEELEHAKARGAKIYAEVVGYGMTGDAYHMTAPAPDGEGAARAMKLALKDAGInpEDIDYINAHGTSTPAGDKAE 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 320 TEMLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSVL 399
Cdd:PRK07314  314 TQAIKRVFGEHAYKVAVSSTKSMTGHLLGAAGAVEAIFSVLAIRDQVIPPTINLDNPDEECDLDYVPNEARERK-IDYAL 392

                         410
                  ....*....|....*....
gi 2468800260 400 NVNYGFGGSNSALIFERYK 418
Cdd:PRK07314  393 SNSFGFGGTNASLVFKRYE 411
PRK08439 PRK08439
3-oxoacyl-(acyl carrier protein) synthase II; Reviewed
 8-417 1.13e-108

3-oxoacyl-(acyl carrier protein) synthase II; Reviewed


Pssm-ID: 236265 [Multi-domain]  Cd Length: 406  Bit Score: 325.92  E-value: 1.13e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   8 QRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDdsiTAKFFGKIPFEL-NLSP---FSKRILKNTPRFGRLGLI 83
Cdd:PRK08439    2 KRVVVTGIGMINSLGLNKESSFKAICNGECGIKKITLFD---ASDFPVQIAGEItDFDPtevMDPKEVKKADRFIQLGLK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  84 AADEALKMAfGDDLSELDKHyppfSRGVIFGTGWGGADALAQNSLSYNTEG--------FASPLTNILSmnnvgsAIMSM 155
Cdd:PRK08439   79 AAREAMKDA-GFLPEELDAE----RFGVSSASGIGGLPNIEKNSIICFEKGprkispffIPSALVNMLG------GFISI 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 156 NWNLRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNG 235
Cdd:PRK08439  148 EHGLKGPNLSSVTACAAGTHAIIEAVKTIMLGGADKMLVVGAESAICPVGIGGFAAMKALSTRNDDPKKASRPFDKDRDG 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 236 FVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDcgGRYHAVKYALKQADIELVDYVNAHGTSTQLN 315
Cdd:PRK08439  228 FVMGEGAGALVLEEYESAKKRGAKIYAEIIGFGESGDANHITSPAPE--GPLRAMKAALEMAGNPKIDYINAHGTSTPYN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 316 DFNETEMLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnI 395
Cdd:PRK08439  306 DKNETAALKELFGSKEKVPPVSSTKGQIGHCLGAAGAIEAVISIMAMRDGILPPTINQETPDPECDLDYIPNVARKAE-L 384

                         410       420
                  ....*....|....*....|..
gi 2468800260 396 QSVLNVNYGFGGSNSALIFERY 417
Cdd:PRK08439  385 NVVMSNSFGFGGTNGVVIFKKV 406
PRK06333 PRK06333
beta-ketoacyl-ACP synthase;
5-418 4.04e-107

beta-ketoacyl-ACP synthase;


Pssm-ID: 235781 [Multi-domain]  Cd Length: 424  Bit Score: 322.72  E-value: 4.04e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   5 NSRQRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKY-EYSDDSITAKFFGKIPF-----ELNLSP---FSKRILKNTP 75
Cdd:PRK06333    1 MNKKRIVVTGMGAVSPLGCGVETFWQRLLAGQSGIRTLtDFPVGDLATKIGGQVPDlaedaEAGFDPdryLDPKDQRKMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  76 RFGRLGLIAADEALKMAFGDDLSELDKHyppfSRGVIFGTGWGGADALAQNSLSYNTEGF--ASPLTNILSMNNVGSAIM 153
Cdd:PRK06333   81 RFILFAMAAAKEALAQAGWDPDTLEDRE----RTATIIGSGVGGFPAIAEAVRTLDSRGPrrLSPFTIPSFLTNMAAGHV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 154 SMNWNLRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESlnsdlniwSIDILN--------ALSKE-QENVET 224
Cdd:PRK06333  157 SIRYGFKGPLGAPVTACAAGVQAIGDAARLIRSGEADVAVCGGTEA--------AIDRVSlagfaaarALSTRfNDAPEQ 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 225 ACCPFDRNRNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELV 302
Cdd:PRK06333  229 ASRPFDRDRDGFVMGEGAGILVIETLEHALARGAPPLAELVGYGTSADAYHMTAGPEDGEGARRAMLIALRQAGIppEEV 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 303 DYVNAHGTSTQLNDFNETEMLKMVFGdSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCN- 381
Cdd:PRK06333  309 QHLNAHATSTPVGDLGEVAAIKKVFG-HVSGLAVSSTKSATGHLLGAAGGVEAIFTILALRDQIAPPTLNLENPDPAAEg 387

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2468800260 382 LDYVPNKHRQVEnIQSVLNVNYGFGGSNSALIFERYK 418
Cdd:PRK06333  388 LDVVANKARPMD-MDYALSNGFGFGGVNASILFRRWE 423
PTZ00050 PTZ00050
3-oxoacyl-acyl carrier protein synthase; Provisional
 17-417 1.37e-101

3-oxoacyl-acyl carrier protein synthase; Provisional


Pssm-ID: 240245 [Multi-domain]  Cd Length: 421  Bit Score: 308.16  E-value: 1.37e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  17 AVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDSITAKFFGKIPFELNLSPFSKRI----------------LKNTPRFGRL 80
Cdd:PTZ00050    1 VVTPLGVGAESTWEALIAGKSGIRKLTEFPKFLPDCIPEQKALENLVAAMPCQIaaevdqsefdpsdfapTKRESRATHF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  81 GLIAADEALKMAFGDDLSELDKHyppfSRGVIFGTGWGGADALAQNSLSYNTEGFA--SPLTNILSMNNVGSAIMSMNWN 158
Cdd:PTZ00050   81 AMAAAREALADAKLDILSEKDQE----RIGVNIGSGIGSLADLTDEMKTLYEKGHSrvSPYFIPKILGNMAAGLVAIKHK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 159 LRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALS-KEQENVETACCPFDRNRNGFV 237
Cdd:PTZ00050  157 LKGPSGSAVTACATGAHCIGEAFRWIKYGEADIMICGGTEASITPVSFAGFSRMRALCtKYNDDPQRASRPFDKDRAGFV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 238 LSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQ-ADIEL--VDYVNAHGTSTQL 314
Cdd:PTZ00050  237 MGEGAGILVLEELEHALRRGAKIYAEIRGYGSSSDAHHITAPHPDGRGARRCMENALKDgANINIndVDYVNAHATSTPI 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 315 NDFNETEMLKMVFGDS-VYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQ-V 392
Cdd:PTZ00050  317 GDKIELKAIKKVFGDSgAPKLYVSSTKGGLGHLLGAAGAVESIVTILSLYEQIIPPTINLENPDAECDLNLVQGKTAHpL 396

                         410       420
                  ....*....|....*....|....*
gi 2468800260 393 ENIQSVLNVNYGFGGSNSALIFERY 417
Cdd:PTZ00050  397 QSIDAVLSTSFGFGGVNTALLFTKY 421
PLN02836 PLN02836
3-oxoacyl-[acyl-carrier-protein] synthase
 9-414 3.80e-89

3-oxoacyl-[acyl-carrier-protein] synthase


Pssm-ID: 215449 [Multi-domain]  Cd Length: 437  Bit Score: 277.06  E-value: 3.80e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   9 RVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSD---------------DSITAKFFGKIPFELNLSPFSKRIL-- 71
Cdd:PLN02836    7 RVVVTGLGLVTPLGCGVETTWRRLIAGECGVRALTQDDlkmksedeetqlytlDQLPSRVAALVPRGTGPGDFDEELWln 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  72 -KNTPRFGRLGLIAADEALKMAFGDDLSELDKHyppfSRGVIFGTGWGG------ADALAQNSLSYNTEGFASPltNILS 144
Cdd:PLN02836   87 sRSSSRFIGYALCAADEALSDARWLPSEDEAKE----RTGVSIGGGIGSitdileAAQLICEKRLRRLSPFFVP--RILI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 145 mnNVGSAIMSMNWNLRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALS-KEQENVE 223
Cdd:PLN02836  161 --NMAAGHVSIRYGFQGPNHAAVTACATGAHSIGDAFRMIQFGDADVMVAGGTESSIDALSIAGFSRSRALStKFNSCPT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 224 TACCPFDRNRNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADIEL-- 301
Cdd:PLN02836  239 EASRPFDCDRDGFVIGEGAGVLVLEELEHAKRRGAKIYAEVRGYGMSGDAHHITQPHEDGRGAVLAMTRALQQSGLHPnq 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 302 VDYVNAHGTSTQLNDFNETEMLKMVFGDSVYS--LPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPG 379
Cdd:PLN02836  319 VDYVNAHATSTPLGDAVEARAIKTVFSEHATSggLAFSSTKGATGHLLGAAGAVEAIFSVLAIHHGIAPPTLNLERPDPI 398

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2468800260 380 CNLDYVPNKHRQVENIQSVLNVNYGFGGSNSALIF 414
Cdd:PLN02836  399 FDDGFVPLTASKAMLIRAALSNSFGFGGTNASLLF 433
PRK08722 PRK08722
beta-ketoacyl-ACP synthase II;
6-416 1.11e-83

beta-ketoacyl-ACP synthase II;


Pssm-ID: 181539 [Multi-domain]  Cd Length: 414  Bit Score: 262.25  E-value: 1.11e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   6 SRQRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDSITAKFFGKIPFELNLSPF-SKRILKNTPRFGRLGLIA 84
Cdd:PRK08722    2 SKRRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIEHFDTTNFSTRFAGLVKDFNCEEYmSKKDARKMDLFIQYGIAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  85 ADEALKMAfGDDLSELDKHyppfSRGVIFGTGWGGADALAQNSLSYNTEG--FASPLTNILSMNNVGSAIMSMNWNLRGY 162
Cdd:PRK08722   82 GIQALDDS-GLEVTEENAH----RIGVAIGSGIGGLGLIEAGHQALVEKGprKVSPFFVPSTIVNMIAGNLSIMRGLRGP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 163 QNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSEGA 242
Cdd:PRK08722  157 NIAISTACTTGLHNIGHAARMIAYGDADAMVAGGAEKASTPLGMAGFGAAKALSTRNDEPQKASRPWDKDRDGFVLGDGA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 243 AVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNET 320
Cdd:PRK08722  237 GMMVLEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGVtgEQIGYVNAHGTSTPAGDVAEI 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 321 EMLKMVFGDS-VYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVENIQSVL 399
Cdd:PRK08722  317 KGIKRALGEAgSKQVLVSSTKSMTGHLLGAAGSVEAIITVMSLVDQIVPPTINLDDPEEGLDIDLVPHTARKVESMEYAI 396

                         410
                  ....*....|....*..
gi 2468800260 400 NVNYGFGGSNSALIFER 416
Cdd:PRK08722  397 CNSFGFGGTNGSLIFKK 413
PRK09116 PRK09116
beta-ketoacyl-ACP synthase;
8-414 1.01e-78

beta-ketoacyl-ACP synthase;


Pssm-ID: 181657 [Multi-domain]  Cd Length: 405  Bit Score: 249.13  E-value: 1.01e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   8 QRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSD--DSITAKFFGKIP-FELNlSPFSKRILKNTPRFGRLGLIA 84
Cdd:PRK09116    2 RRVVVTGMGGVTALGEDWQTIAARLKAGRNAVRRMPEWDryDGLNTRLAAPIDdFELP-AHYTRKKIRSMGRVSLMATRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  85 ADEALKMA-FGDDLSELDKhyppfSRGVIFGTGWGGAD---ALAQNSLSYNTEGFASPlTNILSMNNVGSAIMSMNWNLR 160
Cdd:PRK09116   81 SELALEDAgLLGDPILTDG-----RMGIAYGSSTGSTDpigAFGTMLLEGSMSGITAT-TYVRMMPHTTAVNVGLFFGLK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 161 GYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLnSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVLSE 240
Cdd:PRK09116  155 GRVIPTSSACTSGSQGIGYAYEAIKYGYQTVMLAGGAEEL-CPTEAAVFDTLFATSTRNDAPELTPRPFDANRDGLVIGE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 241 GAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRyhAVKYALKQADI--ELVDYVNAHGTSTQLNDFN 318
Cdd:PRK09116  234 GAGTLVLEELEHAKARGATIYAEIVGFGTNSDGAHVTQPQAETMQI--AMELALKDAGLapEDIGYVNAHGTATDRGDIA 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 319 ETEMLKMVFGDSVyslPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGC-NLDYVPNKHRQVENiQS 397
Cdd:PRK09116  312 ESQATAAVFGARM---PISSLKSYFGHTLGACGALEAWMSIEMMNEGWFAPTLNLTQVDPACgALDYIMGEAREIDT-EY 387

                         410
                  ....*....|....*..
gi 2468800260 398 VLNVNYGFGGSNSALIF 414
Cdd:PRK09116  388 VMSNNFAFGGINTSLIF 404
PRK06501 PRK06501
beta-ketoacyl-ACP synthase;
7-418 3.92e-76

beta-ketoacyl-ACP synthase;


Pssm-ID: 235817 [Multi-domain]  Cd Length: 425  Bit Score: 243.00  E-value: 3.92e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   7 RQRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKY-EYSDDSITAKFFGKIPFeLNLSPFSKrilknTPRFGRLGLIAA 85
Cdd:PRK06501   10 RPIVAVTGMGVVTSLGQGKADNWAALTAGESGIHTItRFPTEGLRTRIAGTVDF-LPESPFGA-----SALSEALARLAA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  86 DEALKMA------FGDDL------SELD----------------------------KHYPPFSRGVIFGTGwggADALAQ 125
Cdd:PRK06501   84 EEALAQAgigkgdFPGPLflaappVELEwparfalaaavgdndapsydrllraargGRFDALHERFQFGSI---ADRLAD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 126 NslsYNTEGfaSPLTniLSmnnvgsaimsmnwnlrgyqntpvSACATGGIAIGDAVEIIRSGRAE--MMIAGGGeSLNSD 203
Cdd:PRK06501  161 R---FGTRG--LPIS--LS-----------------------TACASGATAIQLGVEAIRRGETDraLCIATDG-SVSAE 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 204 LNIwSIDILNALSKEQENVETACCPFDRNRNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDC 283
Cdd:PRK06501  210 ALI-RFSLLSALSTQNDPPEKASKPFSKDRDGFVMAEGAGALVLESLESAVARGAKILGIVAGCGEKADSFHRTRSSPDG 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 284 GGRYHAVKYALKQA--DIELVDYVNAHGTSTQLNDFNETEMLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKS 361
Cdd:PRK06501  289 SPAIGAIRAALADAglTPEQIDYINAHGTSTPENDKMEYLGLSAVFGERLASIPVSSNKSMIGHTLTAAGAVEAVFSLLT 368

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2468800260 362 IETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnIQSVLNVNYGFGGSNSALIFERYK 418
Cdd:PRK06501  369 IQTGRLPPTINYDNPDPAIPLDVVPNVARDAR-VTAVLSNSFGFGGQNASLVLTAEP 424
PRK07967 PRK07967
beta-ketoacyl-ACP synthase I;
8-418 2.98e-68

beta-ketoacyl-ACP synthase I;


Pssm-ID: 181184 [Multi-domain]  Cd Length: 406  Bit Score: 221.85  E-value: 2.98e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   8 QRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKY-EYSDDSITAKFFGKIpfELNLSPF-SKRILkntpRFGRLGLIAA 85
Cdd:PRK07967    2 RRVVITGLGIVSSIGNNQQEVLASLREGRSGITFSpEFAEMGMRSQVWGNV--KLDPTGLiDRKVM----RFMGDASAYA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  86 DEALKMAFGDdlSELDKHYPPFSR-GVIFGTGWG-------GADALAQNSLSYNTEGFASPLTnilsMNNVGSAIMSMNW 157
Cdd:PRK07967   76 YLAMEQAIAD--AGLSEEQVSNPRtGLIAGSGGGstrnqveAADAMRGPRGPKRVGPYAVTKA----MASTVSACLATPF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 158 NLRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNsdlniWSI----DILNALS-KEQENVETACCPFDRN 232
Cdd:PRK07967  150 KIKGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELD-----WEMsclfDAMGALStKYNDTPEKASRAYDAN 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 233 RNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTtpAPDCGGRYHAVKYALKQADIElVDYVNAHGTST 312
Cdd:PRK07967  225 RDGFVIAGGGGVVVVEELEHALARGAKIYAEIVGYGATSDGYDMV--APSGEGAVRCMQMALATVDTP-IDYINTHGTST 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 313 QLNDFNETEMLKMVFGDSVysLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDP---GCNldyVPNKH 389
Cdd:PRK07967  302 PVGDVKELGAIREVFGDKS--PAISATKSLTGHSLGAAGVQEAIYSLLMMEHGFIAPSANIEELDPqaaGMP---IVTET 376

                         410       420
                  ....*....|....*....|....*....
gi 2468800260 390 RQVENIQSVLNVNYGFGGSNSALIFERYK 418
Cdd:PRK07967  377 TDNAELTTVMSNSFGFGGTNATLVFRRYK 405
elong_cond_enzymes cd00828
"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...
 8-412 3.30e-68

"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.


Pssm-ID: 238424 [Multi-domain]  Cd Length: 407  Bit Score: 221.93  E-value: 3.30e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   8 QRVVVTGYGAVTSLGQN---VEEIWKAIMDYKIGYSKYEYSDDSITAKFFGKIPFElnlsPFSKRILKNT---PRFGRLG 81
Cdd:cd00828     1 SRVVITGIGVVSPHGEGcdeVEEFWEALREGRSGIAPVARLKSRFDRGVAGQIPTG----DIPGWDAKRTgivDRTTLLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  82 LIAADEALKMAFGDDLSELDkhypPFSRGVIFGTGWGGADAL--AQNSLSYNTEGFASPLtNILSMNNVGSAIMSMNWNL 159
Cdd:cd00828    77 LVATEEALADAGITDPYEVH----PSEVGVVVGSGMGGLRFLrrGGKLDARAVNPYVSPK-WMLSPNTVAGWVNILLLSS 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 160 RGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDIlNALSKEQENVETACCPFDRNRNGFVLS 239
Cdd:cd00828   152 HGPIKTPVGACATALEALDLAVEAIRSGKADIVVVGGVEDPLEEGLSGFANM-GALSTAEEEPEEMSRPFDETRDGFVEA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 240 EGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDcGGRYHAVKYALKQA--DIELVDYVNAHGTSTQLNDF 317
Cdd:cd00828   231 EGAGVLVLERAELALARGAPIYGRVAGTASTTDGAGRSVPAGG-KGIARAIRTALAKAglSLDDLDVISAHGTSTPANDV 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 318 NETEMLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQ-VENIQ 396
Cdd:cd00828   310 AESRAIAEVAGALGAPLPVTAQKALFGHSKGAAGALQLIGALQSLEHGLIPPTANLDDVDPDVEHLSVVGLSRDlNLKVR 389

                         410
                  ....*....|....*.
gi 2468800260 397 SVLNVNYGFGGSNSAL 412
Cdd:cd00828   390 AALVNAFGFGGSNAAL 405
PLN02787 PLN02787
3-oxoacyl-[acyl-carrier-protein] synthase II
 7-418 3.29e-67

3-oxoacyl-[acyl-carrier-protein] synthase II


Pssm-ID: 215421 [Multi-domain]  Cd Length: 540  Bit Score: 222.93  E-value: 3.29e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   7 RQRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIPFELNLSPFSKRILKNTPRFGRLGLIAA 85
Cdd:PLN02787  128 QRRVVVTGMGVVSPLGHDPDVFYNNLLEGVSGISEIERFDCSqFPTRIAGEIKSFSTDGWVAPKLSKRMDKFMLYLLTAG 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  86 DEALKMA--FGDDLSELDKhyppfSR-GVIFGTGWGGA----DALAQNSLSYNTegfASPLTNILSMNNVGSAIMSMNWN 158
Cdd:PLN02787  208 KKALADGgiTEDVMKELDK-----TKcGVLIGSAMGGMkvfnDAIEALRISYRK---MNPFCVPFATTNMGSAMLAMDLG 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 159 LRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKEQENVETACCPFDRNRNGFVL 238
Cdd:PLN02787  280 WMGPNYSISTACATSNFCILNAANHIIRGEADVMLCGGSDAAIIPIGLGGFVACRALSQRNDDPTKASRPWDMNRDGFVM 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 239 SEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLND 316
Cdd:PLN02787  360 GEGAGVLLLEELEHAKKRGANIYAEFLGGSFTCDAYHMTEPHPEGAGVILCIEKALAQSGVskEDVNYINAHATSTKAGD 439

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 317 FNETEMLKMVFGDSVySLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVENIQ 396
Cdd:PLN02787  440 LKEYQALMRCFGQNP-ELRVNSTKSMIGHLLGAAGAVEAIATVQAIRTGWVHPNINLENPESGVDTKVLVGPKKERLDIK 518

                         410       420
                  ....*....|....*....|..
gi 2468800260 397 SVLNVNYGFGGSNSALIFERYK 418
Cdd:PLN02787  519 VALSNSFGFGGHNSSILFAPYK 540
PRK14691 PRK14691
3-oxoacyl-(acyl carrier protein) synthase II; Provisional
 91-417 7.81e-67

3-oxoacyl-(acyl carrier protein) synthase II; Provisional


Pssm-ID: 173154 [Multi-domain]  Cd Length: 342  Bit Score: 216.13  E-value: 7.81e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  91 MAFGDDLSELDKHYPPFSRGVIFGTGWGGADALAQNSLSYNTEG--FASPLTNILSMNNVGSAIMSMNWNLRGYQNTPVS 168
Cdd:PRK14691   10 ITFHPSLTHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGpkRLSPFTVPSFLVNLAAGHVSIKHHFKGPIGAPVT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 169 ACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKE-QENVETACCPFDRNRNGFVLSEGAAVLCL 247
Cdd:PRK14691   90 ACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHfNSTPEKASRPFDTARDGFVMGEGAGLLII 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 248 EKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNETEMLKM 325
Cdd:PRK14691  170 EELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGItpEQVQHLNAHATSTPVGDLGEINAIKH 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 326 VFGDSvYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVENIQSVLNVNYGF 405
Cdd:PRK14691  250 LFGES-NALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMTYALSNGFGF 328

                         330
                  ....*....|..
gi 2468800260 406 GGSNSALIFERY 417
Cdd:PRK14691  329 AGVNASILLKRW 340
PRK05952 PRK05952
beta-ketoacyl-ACP synthase;
9-412 1.13e-65

beta-ketoacyl-ACP synthase;


Pssm-ID: 235653 [Multi-domain]  Cd Length: 381  Bit Score: 214.53  E-value: 1.13e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   9 RVVVTGYGAVTSLGqNVEEIWKAIMDYKIGYSKYEysddsitakffgkiPFElNLSPFSKRILKNTPRF-GRLGLIAADE 87
Cdd:PRK05952    3 KVVVTGIGLVSALG-DLEQSWQRLLQGKSGIKLHQ--------------PFP-ELPPLPLGLIGNQPSSlEDLTKTVVTA 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  88 ALKMAfgddlseldKHYPPF-SRGVIFGT--GWGGA--DALAQNSLSYNTEGFASPLTNILSMNNVGSAIMSMNwnLRGY 162
Cdd:PRK05952   67 ALKDA---------GLTPPLtDCGVVIGSsrGCQGQweKLARQMYQGDDSPDEELDLENWLDTLPHQAAIAAAR--QIGT 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 163 QNT---PVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKeqenveTACCPFDRNRNGFVLS 239
Cdd:PRK05952  136 QGPvlaPMAACATGLWAIAQGVELIQTGQCQRVIAGAVEAPITPLTLAGFQQMGALAK------TGAYPFDRQREGLVLG 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 240 EGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADIEL--VDYVNAHGTSTQLNDF 317
Cdd:PRK05952  210 EGGAILVLESAELAQKRGAKIYGQILGFGLTCDAYHMSAPEPDGKSAIAAIQQCLARSGLTPedIDYIHAHGTATRLNDQ 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 318 NETEMLKMVFGDSVyslPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDpgCNLDYVPNKHRQveNIQS 397
Cdd:PRK05952  290 REANLIQALFPHRV---AVSSTKGATGHTLGASGALGVAFSLLALRHQQLPPCVGLQEPE--FDLNFVRQAQQS--PLQN 362

                         410
                  ....*....|....*
gi 2468800260 398 VLNVNYGFGGSNSAL 412
Cdd:PRK05952  363 VLCLSFGFGGQNAAI 377
PRK07910 PRK07910
beta-ketoacyl-ACP synthase;
10-417 4.10e-65

beta-ketoacyl-ACP synthase;


Pssm-ID: 236129 [Multi-domain]  Cd Length: 418  Bit Score: 214.21  E-value: 4.10e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  10 VVVTGYGAVTSLGQNVEEIWKAIMDykiGYSKYEYSDDSITAKF-----FG---KIPFELNLSPFSKRilkNTPRFGRLG 81
Cdd:PRK07910   14 VVVTGIAMTTALATDAETTWKLLLD---GQSGIRTLDDPFVEEFdlpvrIGghlLEEFDHQLTRVELR---RMSYLQRMS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  82 LIAADEALKMAFGDDLSeldkhypPFSRGVIFGTGWGGADALAQNSLSYNTEGF--ASPLTNILSMNNVGSAIMSMNWNL 159
Cdd:PRK07910   88 TVLGRRVWENAGSPEVD-------TNRLMVSIGTGLGSAEELVFAYDDMRARGLraVSPLAVQMYMPNGPAAAVGLERHA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 160 RGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNA-LSKEQENVETACCPFDRNRNGFVL 238
Cdd:PRK07910  161 KAGVITPVSACASGSEAIAQAWRQIVLGEADIAICGGVETRIEAVPIAGFAQMRIvMSTNNDDPAGACRPFDKDRDGFVF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 239 SEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADIEL--VDYVNAHGTSTQLND 316
Cdd:PRK07910  241 GEGGALMVIETEEHAKARGANILARIMGASITSDGFHMVAPDPNGERAGHAMTRAIELAGLTPgdIDHVNAHATGTSVGD 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 317 FNETEMLKMVFGD---SVYslpisSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQvE 393
Cdd:PRK07910  321 VAEGKAINNALGGhrpAVY-----APKSALGHSVGAVGAVESILTVLALRDGVIPPTLNLENLDPEIDLDVVAGEPRP-G 394

                         410       420
                  ....*....|....*....|....
gi 2468800260 394 NIQSVLNVNYGFGGSNSALIFERY 417
Cdd:PRK07910  395 NYRYAINNSFGFGGHNVALAFGRY 418
PRK07103 PRK07103
polyketide beta-ketoacyl:acyl carrier protein synthase; Validated
 7-416 1.06e-49

polyketide beta-ketoacyl:acyl carrier protein synthase; Validated


Pssm-ID: 180839 [Multi-domain]  Cd Length: 410  Bit Score: 173.29  E-value: 1.06e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   7 RQRVVVTGYGAVTSLGQNVEEIWKAIMDYKIGY--------SKYEYSDDSITAKFFG-KIPFELNLSPFSKRILKNTPRF 77
Cdd:PRK07103    1 MDEVVVTGVGVVSAIGQGRPSFAAALLAGRHAFgvmrrpgrQVPDDAGAGLASAFIGaELDSLALPERLDAKLLRRASLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  78 GRLGLIAADEALKMAFGDDlseldkhYPPFSRGVIFGtgwggADALAQNSL-----SY-NTEGFASPlTNILS-MNNVGS 150
Cdd:PRK07103   81 AQAALAAAREAWRDAALGP-------VDPDRIGLVVG-----GSNLQQREQalvheTYrDRPAFLRP-SYGLSfMDTDLV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 151 AIMSMNWNLRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESlnsDLNIWSIDILNAL-----SKEQENVETA 225
Cdd:PRK07103  148 GLCSEQFGIRGEGFTVGGASASGQLAVIQAARLVQSGSVDACIAVGALM---DLSYWECQALRSLgamgsDRFADEPEAA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 226 CCPFDRNRNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYdvTTPAPDCGGRYHAVKYALKQADI--ELVD 303
Cdd:PRK07103  225 CRPFDQDRDGFIYGEACGAVVLESAESARRRGARPYAKLLGWSMRLDAN--RGPDPSLEGEMRVIRAALRRAGLgpEDID 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 304 YVNAHGTSTQLNDfnETEmLKMVFGDSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNP-DPGCNl 382
Cdd:PRK07103  303 YVNPHGTGSPLGD--ETE-LAALFASGLAHAWINATKSLTGHGLSAAGIVELIATLLQMRAGFLHPSRNLDEPiDERFR- 378

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2468800260 383 dYVpNKHRQVENIQSVLNVNYGFGGSNSALIFER 416
Cdd:PRK07103  379 -WV-GSTAESARIRYALSLSFGFGGINTALVLER 410
PRK09185 PRK09185
beta-ketoacyl-ACP synthase;
168-416 1.22e-45

beta-ketoacyl-ACP synthase;


Pssm-ID: 236398 [Multi-domain]  Cd Length: 392  Bit Score: 161.93  E-value: 1.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 168 SACATGGIAIGDAVEIIRSGRAEMMIAGGGESLnSDLNIWSIDILNALSKEQenvetaCCPFDRNRNGFVLSEGAAVLCL 247
Cdd:PRK09185  158 TACSSSAKVFASARRLLEAGLCDAAIVGGVDSL-CRLTLNGFNSLESLSPQP------CRPFSANRDGINIGEAAAFFLL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 248 EKyetalTRGATILaeVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADIEL--VDYVNAHGTSTQLNDFNETEMLKM 325
Cdd:PRK09185  231 ER-----EDDAAVA--LLGVGESSDAHHMSAPHPEGLGAILAMQQALADAGLAPadIGYINLHGTATPLNDAMESRAVAA 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 326 VFGDSVyslPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKhRQVENIQSVLNVNYGF 405
Cdd:PRK09185  304 VFGDGV---PCSSTKGLTGHTLGAAGAVEAAICWLALRHGLPPHGWNTGQPDPALPPLYLVEN-AQALAIRYVLSNSFAF 379

                         250
                  ....*....|.
gi 2468800260 406 GGSNSALIFER 416
Cdd:PRK09185  380 GGNNCSLIFGR 390
PKS cd00833
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different ...
 51-413 4.96e-44

polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.


Pssm-ID: 238429 [Multi-domain]  Cd Length: 421  Bit Score: 158.49  E-value: 4.96e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  51 AKFFGKIPFELNLSpfskrilknTPRFgRLGLIAADEALKMAFGDDLSELDKHyppfsRGVIFGTGWGGADALAQNSLSY 130
Cdd:cd00833    71 AAFFGISPREAEAM---------DPQQ-RLLLEVAWEALEDAGYSPESLAGSR-----TGVFVGASSSDYLELLARDPDE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 131 ntegfASPLTNILSMNNVGSAIMSMNWNLRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGeSLNSDLNIW-SI 209
Cdd:cd00833   136 -----IDAYAATGTSRAFLANRISYFFDLRGPSLTVDTACSSSLVALHLACQSLRSGECDLALVGGV-NLILSPDMFvGF 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 210 DILNALSKEqenveTACCPFDRNRNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYD--VTTPAPDcgGRY 287
Cdd:cd00833   210 SKAGMLSPD-----GRCRPFDADADGYVRGEGVGVVVLKRLSDALRDGDRIYAVIRGSAVNQDGRTkgITAPSGE--AQA 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 288 HAVKYALKQADIEL--VDYVNAHGTSTQLNDFNETEMLKMVFG---DSVYSLPISSTKSYTGHLIAAAGALESILSIKSI 362
Cdd:cd00833   283 ALIRRAYARAGVDPsdIDYVEAHGTGTPLGDPIEVEALAKVFGgsrSADQPLLIGSVKSNIGHLEAAAGLAGLIKVVLAL 362

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2468800260 363 ETNIIPATIHLNNPDPGCNLD----YVP--NKHRQVENIQSVLNVN-YGFGGSNSALI 413
Cdd:cd00833   363 EHGVIPPNLHFETPNPKIDFEesplRVPteARPWPAPAGPRRAGVSsFGFGGTNAHVI 420
decarbox_cond_enzymes cd00825
decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new ...
 76-413 1.01e-42

decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new carbon-carbon bond by a decarboxylating Claisen-like condensation reaction. Members are involved in the synthesis of fatty acids and polyketides, a diverse group of natural products. Both pathways are an iterative series of additions of small carbon units, usually acetate, to a nascent acyl group. There are 2 classes of decarboxylating condensing enzymes, which can be distinguished by sequence similarity, type of active site residues and type of primer units (acetyl CoA or acyl carrier protein (ACP) linked units).


Pssm-ID: 238421 [Multi-domain]  Cd Length: 332  Bit Score: 152.79  E-value: 1.01e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  76 RFGRLGLIAADEALKMAfgddlsELDKHYPPFSR-GVIFGTGWG-------GADALAQNSLSYNTEGFASPLT-NILSMN 146
Cdd:cd00825    10 YVSILGFEAAERAIADA------GLSREYQKNPIvGVVVGTGGGsprfqvfGADAMRAVGPYVVTKAMFPGASgQIATPL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 147 NVGSAIMSMNwnlrgyqntpvSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLnsdlnIWSIDILNALSKEQENVETAC 226
Cdd:cd00825    84 GIHGPAYDVS-----------AACAGSLHALSLAADAVQNGKQDIVLAGGSEEL-----AAPMDCEFDAMGALSTPEKAS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 227 CPFDRNRNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDY 304
Cdd:cd00825   148 RTFDAAADGFVFGDGAGALVVEELEHALARGAHIYAEIVGTAATIDGAGMGAFAPSAEGLARAAKEALAVAGLtvWDIDY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 305 VNAHGTSTQLNDFNETEMLKMVFGDsvYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPgcNLDY 384
Cdd:cd00825   228 LVAHGTGTPIGDVKELKLLRSEFGD--KSPAVSATKAMTGNLSSAAVVLAVDEAVLMLEHGFIPPSIHIEELDE--AGLN 303

                         330       340
                  ....*....|....*....|....*....
gi 2468800260 385 VPNKHRQVEnIQSVLNVNYGFGGSNSALI 413
Cdd:cd00825   304 IVTETTPRE-LRTALLNGFGLGGTNATLV 331
CLF cd00832
Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic ...
 9-413 4.40e-40

Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein (ACP). CLFs are similar to other elongation ketosynthase domains, but their active site cysteine is replaced by a conserved glutamine.


Pssm-ID: 238428 [Multi-domain]  Cd Length: 399  Bit Score: 147.51  E-value: 4.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   9 RVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYSKYEYSDDS-ITAKFFGKIPFELNLSPFSKRILKNTPRFGRLGLIAADE 87
Cdd:cd00832     2 RAVVTGIGVVAPNGLGVEEYWKAVLDGRSGLGPITRFDPSgYPARLAGEVPDFDAAEHLPGRLLPQTDRMTRLALAAADW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  88 ALKMAfGDDLSELdkhyPPFSRGVIFGTGWGGADaLAQNSL-SYNTEG--FASPLTNILSMNNVGSAIMSMNWNLRGyqn 164
Cdd:cd00832    82 ALADA-GVDPAAL----PPYDMGVVTASAAGGFE-FGQRELqKLWSKGprHVSAYQSFAWFYAVNTGQISIRHGMRG--- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 165 tPVSACAT---GGI-AIGDAVEIIRSGrAEMMIAGGGESLNSDLNiWSIDILNALSKEQENVETACCPFDRNRNGFVLSE 240
Cdd:cd00832   153 -PSGVVVAeqaGGLdALAQARRLVRRG-TPLVVSGGVDSALCPWG-WVAQLSSGRLSTSDDPARAYLPFDAAAAGYVPGE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 241 GAAVLCLEKYETALTRGATILAEVTGYGNCSDaydvttPAPDCG---GRYHAVKYALKQADI--ELVDYVNAHGTSTQLN 315
Cdd:cd00832   230 GGAILVLEDAAAARERGARVYGEIAGYAATFD------PPPGSGrppGLARAIRLALADAGLtpEDVDVVFADAAGVPEL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 316 DFNETEMLKMVFGDsvYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDPGCNLDYVPNKHRQVEnI 395
Cdd:cd00832   304 DRAEAAALAAVFGP--RGVPVTAPKTMTGRLYAGGAPLDVATALLALRDGVIPPTVNVTDVPPAYGLDLVTGRPRPAA-L 380

                         410
                  ....*....|....*...
gi 2468800260 396 QSVLNVNYGFGGSNSALI 413
Cdd:cd00832   381 RTALVLARGRGGFNSALV 398
Ketoacyl-synt_C pfam02801
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar ...
 261-374 3.79e-35

Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.


Pssm-ID: 426989  Cd Length: 118  Bit Score: 125.76  E-value: 3.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 261 LAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNETEMLKMVFGDSVYS--LPI 336
Cdd:pfam02801   1 YAVIKGSAVNHDGRHNGLTAPNGEGQARAIRRALADAGVdpEDVDYVEAHGTGTPLGDPIEAEALKRVFGSGARKqpLAI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2468800260 337 SSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLN 374
Cdd:pfam02801  81 GSVKSNIGHLEGAAGAAGLIKVVLALRHGVIPPTLNLE 118
ketoacyl-synt pfam00109
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ...
 9-253 1.96e-31

Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.


Pssm-ID: 425468 [Multi-domain]  Cd Length: 251  Bit Score: 120.43  E-value: 1.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   9 RVVVTGYGAVTSLGQNVEEIWKAIMDYKIGYS--------KYEYSDDSitAKFFGKIP-----------FELNLSPFSKR 69
Cdd:pfam00109   2 PVAIVGMGCRFPGGNDPEEFWENLLEGRDGISeipadrwdPDKLYDPP--SRIAGKIYtkwgglddifdFDPLFFGISPR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  70 ILKNTPRFGRLGLIAADEALKMAfGDDLSELDKhyppfSR-GVIFGTGWGGADALaQNSLSYNTEGFASPLTnILSMNNV 148
Cdd:pfam00109  80 EAERMDPQQRLLLEAAWEALEDA-GITPDSLDG-----SRtGVFIGSGIGDYAAL-LLLDEDGGPRRGSPFA-VGTMPSV 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 149 GSAIMSMNWNLRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKeqenvETACCP 228
Cdd:pfam00109 152 IAGRISYFLGLRGPSVTVDTACSSSLVAIHAAVQSIRSGEADVALAGGVNLLLTPLGFAGFSAAGMLSP-----DGPCKA 226

                         250       260
                  ....*....|....*....|....*
gi 2468800260 229 FDRNRNGFVLSEGAAVLCLEKYETA 253
Cdd:pfam00109 227 FDPFADGFVRGEGVGAVVLKRLSDA 251
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 79-417 2.58e-24

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 106.11  E-value: 2.58e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260   79 RLGLIAADEALkmafgddlsElDKHYPP--FSR---GVIFGTGWGG-ADALAQNSlsynteGFASPLTNILSMNNVGSAI 152
Cdd:COG3321     93 RLLLEVAWEAL---------E-DAGYDPesLAGsrtGVFVGASSNDyALLLLADP------EAIDAYALTGNAKSVLAGR 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  153 MSMNWNLRGyqntP-VS---ACATGGIAIGDAVEIIRSGRAEMMIAGGgeslnsdlniwsIDILN------------ALS 216
Cdd:COG3321    157 ISYKLDLRG----PsVTvdtACSSSLVAVHLACQSLRSGECDLALAGG------------VNLMLtpesfilfskggMLS 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  217 KEQEnvetaCCPFDRNRNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYG-NcSD----AYdvTTPAPDcgGRYHAVK 291
Cdd:COG3321    221 PDGR-----CRAFDADADGYVRGEGVGVVVLKRLSDALRDGDRIYAVIRGSAvN-QDgrsnGL--TAPNGP--AQAAVIR 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  292 YALKQADIEL--VDYVNAHGTSTQLNDFNETEMLKMVFG---DSVYSLPISSTKSYTGHLIAAAGA--LesilsIK---S 361
Cdd:COG3321    291 RALADAGVDPatVDYVEAHGTGTPLGDPIEAAALTAAFGqgrPADQPCAIGSVKSNIGHLEAAAGVagL-----IKavlA 365

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2468800260  362 IETNIIPATIHLNNPDPGCNLD----YVPNKHR--QVENIQSVLNVN-YGFGGSNSALIFERY 417
Cdd:COG3321    366 LRHGVLPPTLHFETPNPHIDFEnspfYVNTELRpwPAGGGPRRAGVSsFGFGGTNAHVVLEEA 428
omega_3_PfaA TIGR02813
polyketide-type polyunsaturated fatty acid synthase PfaA; Members of the seed for this ...
 144-418 9.35e-23

polyketide-type polyunsaturated fatty acid synthase PfaA; Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.


Pssm-ID: 274311 [Multi-domain]  Cd Length: 2582  Bit Score: 101.24  E-value: 9.35e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  144 SMNNVGSAIMSMNWNLRGYQNTPVSACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNSDLNIWSIDILNALSKeQENVE 223
Cdd:TIGR02813  180 SLGNVISGRIANRFDLGGMNCVVDAACAGSLAAIRMALSELLEGRSEMMITGGVCTDNSPFMYMSFSKTPAFTT-NEDIQ 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  224 taccPFDRNRNGFVLSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCGGRYHAVKYALKQA--DIEL 301
Cdd:TIGR02813  259 ----PFDIDSKGMMIGEGIGMMALKRLEDAERDGDRIYAVIKGVGASSDGKFKSIYAPRPEGQAKALKRAYDDAgfAPHT 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  302 VDYVNAHGTSTQLNDFNETEMLKMVFG---DSVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATIHLNNPDP 378
Cdd:TIGR02813  335 CGLIEAHGTGTAAGDVAEFGGLVSVFSqdnDQKQHIALGSVKSQIGHTKSTAGTAGMIKAVLALHHKVLPPTINVDQPNP 414

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2468800260  379 GCNLD----YVPNKHR----QVENIQSVLNV-NYGFGGSNSALIFERYK 418
Cdd:TIGR02813  415 KLDIEnspfYLNTETRpwmqREDGTPRRAGIsSFGFGGTNFHMVLEEYS 463
cond_enzymes cd00327
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...
 168-413 3.43e-22

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.


Pssm-ID: 238201 [Multi-domain]  Cd Length: 254  Bit Score: 94.82  E-value: 3.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 168 SACATGGIAIGDAVEIIRSGRAEMMIAGGGESlnsdlniwsidilnalskeqenvetaccpfdrnrngFVLSEGAAVLCL 247
Cdd:cd00327    66 QACATGLTALALAVQQVQNGKADIVLAGGSEE------------------------------------FVFGDGAAAAVV 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 248 EKYETALTRGATILAEVTGYGNCSD-AYDVTTPAPDcgGRYHAVKYALKQADI--ELVDYVNAHGTSTQLNDFNETEMLK 324
Cdd:cd00327   110 ESEEHALRRGAHPQAEIVSTAATFDgASMVPAVSGE--GLARAARKALEGAGLtpSDIDYVEAHGTGTPIGDAVELALGL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260 325 MVFGdsVYSLPISSTKSYTGHLIAAAGALESILSIKSIETNIIPATihlnnPDPGcnldyvpnkhrqveniQSVLNVNYG 404
Cdd:cd00327   188 DPDG--VRSPAVSATLIMTGHPLGAAGLAILDELLLMLEHEFIPPT-----PREP----------------RTVLLLGFG 244


                  ....*....
gi 2468800260 405 FGGSNSALI 413
Cdd:cd00327   245 LGGTNAAVV 253
PKS_KS smart00825
Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the ...
 169-415 9.00e-15

Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the thiolase family and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.


Pssm-ID: 214836 [Multi-domain]  Cd Length: 298  Bit Score: 74.29  E-value: 9.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  169 ACATGGIAIGDAVEIIRSGRAEMMIAGGGeSLNSDLNIW-SIDILNALSKEQEnvetaCCPFDRNRNGFVLSEGAAVLCL 247
Cdd:smart00825  96 ACSSSLVALHLACQSLRSGECDMALAGGV-NLILSPDTFvGLSRAGMLSPDGR-----CKTFDASADGYVRGEGVGVVVL 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  248 EKYETALTRGATILAEVTGYGNCSDAYDV--TTPapdcggryhavkyalkqadielvdyvNAHGtstQlndfnetemlkm 325
Cdd:smart00825 170 KRLSDALRDGDPILAVIRGSAVNQDGRSNgiTAP--------------------------SGPA---Q------------ 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468800260  326 vfgdsvysLPISSTKSYTGHLIAAAGaLESIlsIK---SIETNIIPATIHLNNPDPGCNLD----YVPNKHRQVENIQSV 398
Cdd:smart00825 209 --------LLIGSVKSNIGHLEAAAG-VAGL--IKvvlALKHGVIPPTLHFETPNPHIDLEesplRVPTELTPWPPPGRP 277

                          250       260
                   ....*....|....*....|
gi 2468800260  399 LNV---NYGFGGSNSALIFE 415
Cdd:smart00825 278 RRAgvsSFGFGGTNAHVILE 297
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
 169-200 3.31e-04

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 41.90  E-value: 3.31e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2468800260 169 ACATGGIAIGDAVEIIRSGRAEMMIAGGGESL 200
Cdd:pfam00108  84 VCGSGLKAVYLAAQSIASGDADVVLAGGVESM 115
PLN02644 PLN02644
acetyl-CoA C-acetyltransferase
 238-304 3.93e-04

acetyl-CoA C-acetyltransferase


Pssm-ID: 215347 [Multi-domain]  Cd Length: 394  Bit Score: 42.39  E-value: 3.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2468800260 238 LSEGAAVLCLEKYETALTRGATILAEVTGYGNCSDAYDVTTPAPDCggryhAVKYALKQADIEL--VDY 304
Cdd:PLN02644  250 ISDGAAALVLVSGEKALELGLQVIAKIRGYADAAQAPELFTTAPAL-----AIPKALKHAGLEAsqVDY 313
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
 169-199 1.49e-03

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 40.43  E-value: 1.49e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2468800260 169 ACATGGIAIGDAVEIIRSGRAEMMIAGGGES 199
Cdd:COG0183    87 VCGSGLQAVALAAQAIAAGDADVVIAGGVES 117
PRK06064 PRK06064
thiolase domain-containing protein;
169-216 5.60e-03

thiolase domain-containing protein;


Pssm-ID: 235688 [Multi-domain]  Cd Length: 389  Bit Score: 38.72  E-value: 5.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2468800260 169 ACATGGIAIGDAVEIIRSGRAEMMIAGGGESLNsdlNIWSIDILNALS 216
Cdd:PRK06064   84 ACASGGAALRQAYLAVASGEADVVLAAGVEKMT---DVPTPDATEAIA 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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