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Conserved domains on  [gi|2468165452|ref|WP_276618706|]
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MULTISPECIES: shikimate kinase [Alistipes]

Protein Classification

shikimate kinase( domain architecture ID 11431165)

shikimate kinase catalyzes the specific phosphorylation of the 3-hydroxylgroup of shikimic acid using ATP as a cosubstrate

CATH:  3.40.50.300
EC:  2.7.1.71
Gene Ontology:  GO:0009073|GO:0004765|GO:0000287|GO:0005524|GO:0008652
PubMed:  2279393|7870841
SCOP:  4003925

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 3-172 4.42e-58

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 178.78  E-value: 4.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIAsGDDLVVSTGGGLP 82
Cdd:COG0703     1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLE-EENAVIATGGGAV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  83 VWADNMARMNGAGLTVYIRRSAEQIAARLSphGRWKRPKLRGLDDRelvEFMSRNMAEREPFYGQAA-LTIDGGAMNDDE 161
Cdd:COG0703    80 LSPENRELLKEHGTVVYLDASPETLLERLR--RDDNRPLLQGEDPR---ERLEELLAEREPLYREVAdITVDTDGRSPEE 154

                         170
                  ....*....|.
gi 2468165452 162 ILEFITEKLKE 172
Cdd:COG0703   155 VVDEILEALEE 165
 
Name Accession Description Interval E-value
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 3-172 4.42e-58

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 178.78  E-value: 4.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIAsGDDLVVSTGGGLP 82
Cdd:COG0703     1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLE-EENAVIATGGGAV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  83 VWADNMARMNGAGLTVYIRRSAEQIAARLSphGRWKRPKLRGLDDRelvEFMSRNMAEREPFYGQAA-LTIDGGAMNDDE 161
Cdd:COG0703    80 LSPENRELLKEHGTVVYLDASPETLLERLR--RDDNRPLLQGEDPR---ERLEELLAEREPLYREVAdITVDTDGRSPEE 154

                         170
                  ....*....|.
gi 2468165452 162 ILEFITEKLKE 172
Cdd:COG0703   155 VVDEILEALEE 165
aroK PRK00131
shikimate kinase; Reviewed
 1-171 2.85e-48

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 154.58  E-value: 2.85e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   1 MIVFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASgDDLVVSTGGG 80
Cdd:PRK00131    5 PNIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLAR-HNLVISTGGG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  81 LPVWADNMARMNGAGLTVYIRRSAEQIAARLSpHGRwKRPKLRGLDDRELVEFMsrnMAEREPFYGQAA-LTIDGGAMND 159
Cdd:PRK00131   84 AVLREENRALLRERGTVVYLDASFEELLRRLR-RDR-NRPLLQTNDPKEKLRDL---YEERDPLYEEVAdITVETDGRSP 158

                         170
                  ....*....|..
gi 2468165452 160 DEILEFITEKLK 171
Cdd:PRK00131  159 EEVVNEILEKLE 170
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 2-161 6.40e-44

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 142.69  E-value: 6.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   2 IVFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLiASGDDLVVSTGGGL 81
Cdd:cd00464     1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLL-LTKENAVIATGGGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  82 PVWADNMARMNGAGLTVYIRRSAEQIAARLSphGRWKRPKLRGLDDRELVEFmsrnMAEREPFYGQAA-LTIDGGAMNDD 160
Cdd:cd00464    80 VLREENRRLLLENGIVVWLDASPEELLERLA--RDKTRPLLQDEDPERLREL----LEEREPLYREVAdLTIDTDELSPE 153


                  .
gi 2468165452 161 E 161
Cdd:cd00464   154 E 154
SKI pfam01202
Shikimate kinase;
9-171 1.55e-41

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 136.56  E-value: 1.55e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   9 MGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASgDDLVVSTGGGLPVWADNM 88
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAE-HGLVIATGGGAVLSEENR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  89 ARMNGAGLTVYIRRSAEQIAARLSphGRWKRPKLRGLD-DRELVEFMsrnMAEREPFYGQAA-LTIDGGAMNDDEILEFI 166
Cdd:pfam01202  80 DLLKERGIVIYLDAPLEVLLERLK--RDKTRPLLQNKDpEEELLELL---FEERDPLYEEAAdIVIDTDESSPEEVATEI 154


                  ....*
gi 2468165452 167 TEKLK 171
Cdd:pfam01202 155 LEALE 159
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 2-75 2.18e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.58  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452    2 IVFLVGYMGCGKTTIGRRLARRLGYD------FADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASGDDLVV 75
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPgggviyIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLI 83
 
Name Accession Description Interval E-value
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 3-172 4.42e-58

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 178.78  E-value: 4.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIAsGDDLVVSTGGGLP 82
Cdd:COG0703     1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLE-EENAVIATGGGAV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  83 VWADNMARMNGAGLTVYIRRSAEQIAARLSphGRWKRPKLRGLDDRelvEFMSRNMAEREPFYGQAA-LTIDGGAMNDDE 161
Cdd:COG0703    80 LSPENRELLKEHGTVVYLDASPETLLERLR--RDDNRPLLQGEDPR---ERLEELLAEREPLYREVAdITVDTDGRSPEE 154

                         170
                  ....*....|.
gi 2468165452 162 ILEFITEKLKE 172
Cdd:COG0703   155 VVDEILEALEE 165
aroK PRK00131
shikimate kinase; Reviewed
 1-171 2.85e-48

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 154.58  E-value: 2.85e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   1 MIVFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASgDDLVVSTGGG 80
Cdd:PRK00131    5 PNIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLAR-HNLVISTGGG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  81 LPVWADNMARMNGAGLTVYIRRSAEQIAARLSpHGRwKRPKLRGLDDRELVEFMsrnMAEREPFYGQAA-LTIDGGAMND 159
Cdd:PRK00131   84 AVLREENRALLRERGTVVYLDASFEELLRRLR-RDR-NRPLLQTNDPKEKLRDL---YEERDPLYEEVAdITVETDGRSP 158

                         170
                  ....*....|..
gi 2468165452 160 DEILEFITEKLK 171
Cdd:PRK00131  159 EEVVNEILEKLE 170
PRK13949 PRK13949
shikimate kinase; Provisional
 3-170 1.90e-46

shikimate kinase; Provisional


Pssm-ID: 140006 [Multi-domain]  Cd Length: 169  Bit Score: 149.49  E-value: 1.90e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQlIASGDDLVVSTGGGLP 82
Cdd:PRK13949    4 IFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHE-VAEFEDVVISTGGGAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  83 VWADNMARMNGAGLTVYIRRSAEQIAARLSPHGRwKRPKLRGLDDRELVEFMSRNMAEREPFYGQAALTIDGGAMNDDEI 162
Cdd:PRK13949   83 CFFDNMELMNASGTTVYLKVSPEVLFVRLRLAKQ-QRPLLKGKSDEELLDFIIEALEKRAPFYRQAKIIFNADKLEDESQ 161


                  ....*...
gi 2468165452 163 LEFITEKL 170
Cdd:PRK13949  162 IEQLVQRL 169
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 2-161 6.40e-44

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 142.69  E-value: 6.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   2 IVFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLiASGDDLVVSTGGGL 81
Cdd:cd00464     1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLL-LTKENAVIATGGGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  82 PVWADNMARMNGAGLTVYIRRSAEQIAARLSphGRWKRPKLRGLDDRELVEFmsrnMAEREPFYGQAA-LTIDGGAMNDD 160
Cdd:cd00464    80 VLREENRRLLLENGIVVWLDASPEELLERLA--RDKTRPLLQDEDPERLREL----LEEREPLYREVAdLTIDTDELSPE 153


                  .
gi 2468165452 161 E 161
Cdd:cd00464   154 E 154
SKI pfam01202
Shikimate kinase;
9-171 1.55e-41

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 136.56  E-value: 1.55e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   9 MGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASgDDLVVSTGGGLPVWADNM 88
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAE-HGLVIATGGGAVLSEENR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  89 ARMNGAGLTVYIRRSAEQIAARLSphGRWKRPKLRGLD-DRELVEFMsrnMAEREPFYGQAA-LTIDGGAMNDDEILEFI 166
Cdd:pfam01202  80 DLLKERGIVIYLDAPLEVLLERLK--RDKTRPLLQNKDpEEELLELL---FEERDPLYEEAAdIVIDTDESSPEEVATEI 154


                  ....*
gi 2468165452 167 TEKLK 171
Cdd:pfam01202 155 LEALE 159
aroL PRK03731
shikimate kinase AroL;
2-173 4.69e-34

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 118.12  E-value: 4.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   2 IVFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASGddLVVSTGGGL 81
Cdd:PRK03731    4 PLFLVGARGCGKTTVGMALAQALGYRFVDTDQWLQSTSNMTVAEIVEREGWAGFRARESAALEAVTAPS--TVIATGGGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  82 PVWADNMARMNGAGLTVYIRRSAEQIAARLSPHGR-WKRPKLRGlddRELVEFMSRNMAEREPFYGQAALTIDGGAMNDD 160
Cdd:PRK03731   82 ILTEENRHFMRNNGIVIYLCAPVSVLANRLEANPEeDQRPTLTG---KPISEEVAEVLAEREALYREVAHHIIDATQPPS 158

                         170
                  ....*....|...
gi 2468165452 161 EILEFITEKLKER 173
Cdd:PRK03731  159 QVVSEILSALAQS 171
PRK13947 PRK13947
shikimate kinase; Provisional
 3-175 4.83e-33

shikimate kinase; Provisional


Pssm-ID: 184412 [Multi-domain]  Cd Length: 171  Bit Score: 115.57  E-value: 4.83e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERgMLEQLIASGDDLVVSTGGGLP 82
Cdd:PRK13947    4 IVLIGFMGTGKTTVGKRVATTLSFGFIDTDKEIEKMTGMTVAEIFEKDGEVRFRSEEK-LLVKKLARLKNLVIATGGGVV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  83 VWADNMARMNGAGLTVYIRRSAEQIAARLSPHGrwKRPKLRGLDDRELVEFMsrnMAEREPFYGQAALTIDGGAMNDDEI 162
Cdd:PRK13947   83 LNPENVVQLRKNGVVICLKARPEVILRRVGKKK--SRPLLMVGDPEERIKEL---LKEREPFYDFADYTIDTGDMTIDEV 157

                         170
                  ....*....|....
gi 2468165452 163 LEFITEK-LKERNG 175
Cdd:PRK13947  158 AEEIIKAyLKLKNG 171
PRK13946 PRK13946
shikimate kinase; Provisional
 3-174 1.83e-31

shikimate kinase; Provisional


Pssm-ID: 184411 [Multi-domain]  Cd Length: 184  Bit Score: 111.94  E-value: 1.83e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASGdDLVVSTGGGLP 82
Cdd:PRK13946   13 VVLVGLMGAGKSTVGRRLATMLGLPFLDADTEIERAARMTIAEIFAAYGEPEFRDLERRVIARLLKGG-PLVLATGGGAF 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  83 VWADNMARMNGAGLTVYIRRSAEQIAARLSphGRWKRPKLRGLDDRELvefMSRNMAEREPFYGQAALTIDGGAMND--- 159
Cdd:PRK13946   92 MNEETRAAIAEKGISVWLKADLDVLWERVS--RRDTRPLLRTADPKET---LARLMEERYPVYAEADLTVASRDVPKevm 166

                         170
                  ....*....|....*.
gi 2468165452 160 -DEILEFITEKLKERN 174
Cdd:PRK13946  167 aDEVIEALAAYLEKEE 182
aroK PRK05057
shikimate kinase AroK;
3-149 7.29e-31

shikimate kinase AroK;


Pssm-ID: 235335 [Multi-domain]  Cd Length: 172  Bit Score: 109.80  E-value: 7.29e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLiASGDDLVVSTGGGLP 82
Cdd:PRK05057    7 IFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADIGWVFDVEGEEGFRDREEKVINEL-TEKQGIVLATGGGSV 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2468165452  83 VWADNMARMNGAGLTVYIRRSAEQIAARLSPHGrwKRPKLRGLDDRELVEFMsrnMAEREPFYGQAA 149
Cdd:PRK05057   86 KSRETRNRLSARGVVVYLETTIEKQLARTQRDK--KRPLLQVDDPREVLEAL---ANERNPLYEEIA 147
PRK13948 PRK13948
shikimate kinase; Provisional
 3-170 2.32e-27

shikimate kinase; Provisional


Pssm-ID: 184413 [Multi-domain]  Cd Length: 182  Bit Score: 101.40  E-value: 2.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASgDDLVVSTGGGLP 82
Cdd:PRK13948   13 VALAGFMGTGKSRIGWELSRALMLHFIDTDRYIERVTGKSIPEIFRHLGEAYFRRCEAEVVRRLTRL-DYAVISLGGGTF 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  83 VWADNMARMNGAGLTVYIRRSAEQIAARLSPHgrwKRPKLRGLDDRELVEFMsrnMAEREPFYGQAALTIDGGAMNDDEI 162
Cdd:PRK13948   92 MHEENRRKLLSRGPVVVLWASPETIYERTRPG---DRPLLQVEDPLGRIRTL---LNEREPVYRQATIHVSTDGRRSEEV 165


                  ....*...
gi 2468165452 163 LEFITEKL 170
Cdd:PRK13948  166 VEEIVEKL 173
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
1-169 1.58e-24

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 98.82  E-value: 1.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   1 MIVFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLiASGDDLVVSTGGG 80
Cdd:PRK13951    1 MRIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIERREGRSVRRIFEEDGEEYFRLKEKELLREL-VERDNVVVATGGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  81 LPVWADNMARMNGAGlTVYIRRSAEQIAARLSPHgrwKRPKLRGLDDReLVEFMSRnmaeREPFYGQAAlTIDGGAMNDD 160
Cdd:PRK13951   80 VVIDPENRELLKKEK-TLFLYAPPEVLMERVTTE---NRPLLREGKER-IREIWER----RKQFYTEFR-GIDTSKLNEW 149

                         170
                  ....*....|....
gi 2468165452 161 E-----ILEFITEK 169
Cdd:PRK13951  150 EttalvVLEALDEK 163
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 5-153 2.54e-21

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 88.09  E-value: 2.54e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   5 LVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASGDDLVVSTGGGLPVW 84
Cdd:PRK08154  138 LIGLRGAGKSTLGRMLAARLGVPFVELNREIEREAGLSVSEIFALYGQEGYRRLERRALERLIAEHEEMVLATGGGIVSE 217

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  85 ADNMARMNGAGLTVYIRRSAEQIAARLSPHGrwkrpKLRGL-DDRELVEFMSRNMAEREPFYGQAALTID 153
Cdd:PRK08154  218 PATFDLLLSHCYTVWLKASPEEHMARVRAQG-----DLRPMaDNREAMEDLRRILASREPLYARADAVVD 282
PLN02199 PLN02199
shikimate kinase
 3-122 6.03e-20

shikimate kinase


Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 84.36  E-value: 6.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEK-QEGADVCDIFHYAGEEYFRKAERGMLEQLiASGDDLVVSTGGGL 81
Cdd:PLN02199  105 MYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQaMNGTSVAEIFVHHGENFFRGKETDALKKL-SSRYQVVVSTGGGA 183

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2468165452  82 PVWADNMARMNgAGLTVYIRRSAEQIAARLSPHGRWKRPKL 122
Cdd:PLN02199  184 VIRPINWKYMH-KGISIWLDVPLEALAHRIAAVGTDSRPLL 223
PRK14021 PRK14021
bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional
 5-149 5.08e-12

bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional


Pssm-ID: 184458 [Multi-domain]  Cd Length: 542  Bit Score: 62.96  E-value: 5.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   5 LVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASGDDlVVSTGGGLP-- 82
Cdd:PRK14021   11 IIGMMGAGKTRVGKEVAQMMRLPFADADVEIEREIGMSIPSYFEEYGEPAFREVEADVVADMLEDFDG-IFSLGGGAPmt 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2468165452  83 -----VWADNMARmngAGLTVYIRRSAEQIAARLSPHGrwKRPKLRGLDDRELVEFMSrnmaEREPFYGQAA 149
Cdd:PRK14021   90 pstqhALASYIAH---GGRVVYLDADPKEAMERANRGG--GRPMLNGDANKRWKKLFK----QRDPVFRQVA 152
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 1-33 1.38e-08

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 51.28  E-value: 1.38e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2468165452   1 MIVFLVGYMGCGKTTIGRRLARRLGYDFADTDD 33
Cdd:COG3265     2 MVIVVMGVSGSGKSTVGQALAERLGWPFIDGDD 34
PRK00625 PRK00625
shikimate kinase; Provisional
 1-115 1.54e-08

shikimate kinase; Provisional


Pssm-ID: 134335 [Multi-domain]  Cd Length: 173  Bit Score: 51.30  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   1 MIVFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADV----CDIFHYAGEEYFRKAERGMLEQLIAsgDDLVVS 76
Cdd:PRK00625    1 MQIFLCGLPTVGKTSFGKALAKFLSLPFFDTDDLIVSNYHGALysspKEIYQAYGEEGFCREEFLALTSLPV--IPSIVA 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2468165452  77 TGGGLPVWADNMARMNGAGLTVYIRRSAEQIAARLSPHG 115
Cdd:PRK00625   79 LGGGTLMIEPSYAHIRNRGLLVLLSLPIATIYQRLQKRG 117
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 2-33 1.20e-06

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 45.71  E-value: 1.20e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2468165452   2 IVFLVGYMGCGKTTIGRRLARRLGYDFADTDD 33
Cdd:cd02021     1 IIVVMGVSGSGKSTVGKALAERLGAPFIDGDD 32
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
9-173 1.33e-06

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 46.36  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   9 MGCGKTTIGRRLARRLGYDFADTD--DRIEKQEGADVCDI------------FHYAGEEYFRKAERGMLEQLIASGDDLV 74
Cdd:COG1102     9 PGSGGTTIAKRLAEKLGLPLYDGEilREAAKERGLSEEEFekldekapsllyRDTAEEDEIDRALDKVIRELARKGNCVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  75 VSTGGGLpvwadnMARMNGAGLTVYIRRSAEQIAARLSphgrwkrpKLRGLDDRELVEFMSRNMAEREPFY--------G 146
Cdd:COG1102    89 VGRLADW------ILRDRPNVLKVFLTAPLEVRVKRIA--------EREGISEEEAEKEIKKRDKSRAKYYkyyygidwG 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 2468165452 147 QAA---LTIDGGAMNDDEILEFITEKLKER 173
Cdd:COG1102   155 DPSnydLVINTSRLGIEEAVDLILAAIEAR 184
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
2-153 8.82e-06

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 43.75  E-value: 8.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   2 IVFLVGYMGCGKTTIGRRLARRLGYDFADTdDRIEKQ-EGADVCDIFHYagEEYFRKAERGMLE---QLIASGDDLVVST 77
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRlFGAGLAPLERS--PEATARTYARLLAlarELLAAGRSVILDA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452  78 GGGLPVWADNMARM---NGAGLT-VYIRRSAEQIAARLSphgrwKRPKLRGLDDRELVEFMSRnMAEREPF--YGQAALT 151
Cdd:COG0645    78 TFLRRAQREAFRALaeeAGAPFVlIWLDAPEEVLRERLE-----ARNAEGGDSDATWEVLERQ-LAFEEPLteDEGFLLV 151


                  ..
gi 2468165452 152 ID 153
Cdd:COG0645   152 VD 153
AAA_18 pfam13238
AAA domain;
3-132 1.34e-05

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 42.42  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTD------DRIEKQEGADVCDIFhyagEEYFRKAERGMLEQLIA--SGDDLV 74
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDlalengLVLGDDPETRESKRL----DEDKLDRLLDLLEENAAleEGGNLI 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2468165452  75 VSTggglpVWADNMARMNGAGLTVYIRRSAEQIAARLSPHGrWKRPKLRGLDDRELVE 132
Cdd:pfam13238  77 IDG-----HLAELEPERAKDLVGIVLRASPEELLERLEKRG-YEEAKIKENEEAEILG 128
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 9-62 8.87e-05

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 41.08  E-value: 8.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2468165452   9 MGCGKTTIGRRLARRLGYDFADTD--DRIEKQEGADvcdifhyagEEYFRKAERGM 62
Cdd:pfam13189   8 YGSGGTTIAKKLAEKLGYPFYDREilDEIAKELGIS---------EEEFELFDEKS 54
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 3-111 9.28e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 40.37  E-value: 9.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452   3 VFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEKQEGADVCDIfhyagEEYFRKAER------GMLEQLIASGDDLVVS 76
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSI-----SYYTDATDRtyerlhELARIALRAGRPVILD 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2468165452  77 TgGGLPVWA----DNMARMNGAGLT-VYIRRSAEQIAARL 111
Cdd:pfam13671  77 A-TNLRRDErarlLALAREYGVPVRiVVFEAPEEVLRERL 115
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 10-31 2.97e-04

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 39.01  E-value: 2.97e-04
                          10        20
                  ....*....|....*....|..
gi 2468165452  10 GCGKTTIGRRLARRLGYDFADT 31
Cdd:cd02020     9 GSGKSTVAKLLAKKLGLPYLDT 30
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
7-31 3.14e-04

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 39.62  E-value: 3.14e-04
                          10        20
                  ....*....|....*....|....*
gi 2468165452   7 GYMGCGKTTIGRRLARRLGYDFADT 31
Cdd:COG0283     7 GPAGSGKSTVAKALAKRLGYHYLDT 31
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
1-37 4.42e-04

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 39.03  E-value: 4.42e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2468165452   1 MIVFLVGYMGCGKTTIGRRLARRLGYDFADTDDRIEK 37
Cdd:COG1936     1 MRIAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVKE 37
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-66 1.31e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 37.48  E-value: 1.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2468165452   1 MIVFLVGYMGCGKTTIGRRLARRLGYDfadtddriekqegadvcdifHYAGEEYFRK--AERGM-LEQL 66
Cdd:PRK04182    1 MIITISGPPGSGKTTVARLLAEKLGLK--------------------HVSAGEIFRElaKERGMsLEEF 49
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 2-75 2.18e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.58  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468165452    2 IVFLVGYMGCGKTTIGRRLARRLGYD------FADTDDRIEKQEGADVCDIFHYAGEEYFRKAERGMLEQLIASGDDLVV 75
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPgggviyIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLI 83
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 2-29 3.18e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 34.62  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|....*...
gi 2468165452   2 IVFLVGYMGCGKTTIGRRLARRLGYDFA 29
Cdd:cd02019     1 IIAITGGSGSGKSTVAKKLAEQLGGRSV 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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