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Conserved domains on  [gi|2439334478|ref|WP_272194428|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Bacteroides]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10657338)

helix-turn-helix domain-containing protein functions in DNA binding; HTH domains are often found in transcriptional regulators

Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  15808743|19076237|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 219-289 2.05e-07

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


:

Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 47.55  E-value: 2.05e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2439334478  219 EKLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADE-TLYTLIRRL-KPIVEDNNNLRITTDRGRAY 289
Cdd:smart00862   2 EPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDnTLDVHISRLrKKLEDDGDPRLIETVRGVGY 74
 
Name Accession Description Interval E-value
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 219-289 2.05e-07

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 47.55  E-value: 2.05e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2439334478  219 EKLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADE-TLYTLIRRL-KPIVEDNNNLRITTDRGRAY 289
Cdd:smart00862   2 EPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDnTLDVHISRLrKKLEDDGDPRLIETVRGVGY 74
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 217-289 1.84e-05

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 42.47  E-value: 1.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2439334478 217 QQEKLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADE-TLYTLIRRL-KPIVEDNNNLRITTDRGRAY 289
Cdd:cd00383    13 DGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDrTVDVHISRLrKKLEDDPEPRLIKTVRGVGY 87
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
218-289 2.49e-05

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 41.73  E-value: 2.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2439334478 218 QEKLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADE-TLYTLIRRLKPIVEDN--NNLRITTDRGRAY 289
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDnTVDVHISRLRKKLEDDprDPRLIKTVRGVGY 75
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
199-269 6.56e-03

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 35.65  E-value: 6.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2439334478 199 ITFGNLSLSLQEACFYNEQQEkLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADETLYTLIRRL 269
Cdd:COG3710     3 YRFGDFRLDPARRELLRDGEP-VRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNSLTQAISRL 72
 
Name Accession Description Interval E-value
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 219-289 2.05e-07

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 47.55  E-value: 2.05e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2439334478  219 EKLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADE-TLYTLIRRL-KPIVEDNNNLRITTDRGRAY 289
Cdd:smart00862   2 EPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDnTLDVHISRLrKKLEDDGDPRLIETVRGVGY 74
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 217-289 1.84e-05

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 42.47  E-value: 1.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2439334478 217 QQEKLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADE-TLYTLIRRL-KPIVEDNNNLRITTDRGRAY 289
Cdd:cd00383    13 DGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDrTVDVHISRLrKKLEDDPEPRLIKTVRGVGY 87
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
218-289 2.49e-05

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 41.73  E-value: 2.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2439334478 218 QEKLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADE-TLYTLIRRLKPIVEDN--NNLRITTDRGRAY 289
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDnTVDVHISRLRKKLEDDprDPRLIKTVRGVGY 75
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
199-269 6.56e-03

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 35.65  E-value: 6.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2439334478 199 ITFGNLSLSLQEACFYNEQQEkLKLTPMQYTLMEMFYLSSSHLLFKSDICQSLWPGKDNADETLYTLIRRL 269
Cdd:COG3710     3 YRFGDFRLDPARRELLRDGEP-VRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNSLTQAISRL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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