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Conserved domains on  [gi|2427588833|ref|WP_270568025|]
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phosphatase PAP2 family protein [Clostridium beijerinckii]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130261)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Bacillus subtilis phosphatidylglycerophosphatase B that catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0016020|GO:0016791|GO:1901137|GO:0006629
PubMed:  9122162
SCOP:  3001110

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 4-171 1.26e-26

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


:

Pssm-ID: 239486  Cd Length: 182  Bit Score: 99.22  E-value: 1.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833   4 IQNIDNNILEFIQILmRTPVLDKIMPLITILGSKIT--IWTFIALILIMGKKYRKYGIMIICSLILcFIVGNLGLKPLVA 81
Cdd:cd03392     9 LTAFDQSVLSLLRSL-RTPLLTAFMTAITFLGSPAVllIIVLLLALLLLLKRRRRAALFLLLALLG-GGALNTLLKLLVQ 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  82 RTRPFNAEPILnmvhmklPTDFSFPSGHTMCSFAPATIINYM------NKRAGILALTLST----LIGFSRLYLYVHYPS 151
Cdd:cd03392    87 RPRPPLHLLVP-------EGGYSFPSGHAMGATVLYGFLAYLlarrlpRRRVRILLLILAAililLVGLSRLYLGVHYPS 159

                         170       180
                  ....*....|....*....|
gi 2427588833 152 DVFAAMVIGILIGNLVIVAF 171
Cdd:cd03392   160 DVLAGWLLGLAWLALLILLY 179
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 4-171 1.26e-26

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 99.22  E-value: 1.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833   4 IQNIDNNILEFIQILmRTPVLDKIMPLITILGSKIT--IWTFIALILIMGKKYRKYGIMIICSLILcFIVGNLGLKPLVA 81
Cdd:cd03392     9 LTAFDQSVLSLLRSL-RTPLLTAFMTAITFLGSPAVllIIVLLLALLLLLKRRRRAALFLLLALLG-GGALNTLLKLLVQ 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  82 RTRPFNAEPILnmvhmklPTDFSFPSGHTMCSFAPATIINYM------NKRAGILALTLST----LIGFSRLYLYVHYPS 151
Cdd:cd03392    87 RPRPPLHLLVP-------EGGYSFPSGHAMGATVLYGFLAYLlarrlpRRRVRILLLILAAililLVGLSRLYLGVHYPS 159

                         170       180
                  ....*....|....*....|
gi 2427588833 152 DVFAAMVIGILIGNLVIVAF 171
Cdd:cd03392   160 DVLAGWLLGLAWLALLILLY 179
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 4-172 1.16e-25

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 97.03  E-value: 1.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833   4 IQNIDNNILEFIQILMRTPVLDKIMPLITILGSKITIWTFIALILIMGKKYRKYGIMIICSLILCFIVGNLGLKPLVART 83
Cdd:COG0671    20 LALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  84 RPFNAEPILNMVHmkLPTDFSFPSGHTMCSFAPATIINYMNKR--AGILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGI 161
Cdd:COG0671   100 RPFVVPDLELLLG--TAGGYSFPSGHAAAAFALALVLALLLPRrwLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGL 177

                         170
                  ....*....|.
gi 2427588833 162 LIGNLVIVAFN 172
Cdd:COG0671   178 AIALLLLALLR 188
acidPPc smart00014
Acid phosphatase homologues;
73-164 3.89e-19

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 78.16  E-value: 3.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833   73 NLGLKPLVARTRPFNAEPILNM----VHMKLPTDFSFPSGHTMCSFAPATII------NYMNKRAGILALTLSTLIGFSR 142
Cdd:smart00014  11 NGVIKNYFGRPRPFFLSIGDACctpnFLLTLEAGYSFPSGHTAFAFAFALFLllylpaRAGRKLLIFLLLLLALVVGFSR 90

                           90       100
                   ....*....|....*....|..
gi 2427588833  143 LYLYVHYPSDVFAAMVIGILIG 164
Cdd:smart00014  91 VYLGAHWPSDVLAGSLLGILIA 112
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 57-173 2.39e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 68.60  E-value: 2.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  57 YGIMIICSLILCFIvgnlgLKPLVARTRPFNAE---PILNMVHMKLPTDFSFPSGHTMCSFAPATIINYMNKRAGI---- 129
Cdd:pfam01569   2 LLLALALAGLLSSV-----LKDYFGRPRPFFLLlegGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKivrv 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2427588833 130 ----LALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIGNLVIVAFNN 173
Cdd:pfam01569  77 llalLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 96-171 1.42e-05

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 43.86  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  96 HMKLPTDFSFPSGHTM--CSFAPATIINYMNKR----AGILALTLSTLIGfSRLYLYVHYPSDVFAAMVIGILignLVIV 169
Cdd:PRK10699  150 HWQKETGFAFPSGHTMfaASWALLAVGLLWPRRryktVALLMLWATGVMG-SRLLLGMHWPRDLVVATLISWL---LVTV 225


                  ..
gi 2427588833 170 AF 171
Cdd:PRK10699  226 AT 227
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 4-171 1.26e-26

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 99.22  E-value: 1.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833   4 IQNIDNNILEFIQILmRTPVLDKIMPLITILGSKIT--IWTFIALILIMGKKYRKYGIMIICSLILcFIVGNLGLKPLVA 81
Cdd:cd03392     9 LTAFDQSVLSLLRSL-RTPLLTAFMTAITFLGSPAVllIIVLLLALLLLLKRRRRAALFLLLALLG-GGALNTLLKLLVQ 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  82 RTRPFNAEPILnmvhmklPTDFSFPSGHTMCSFAPATIINYM------NKRAGILALTLST----LIGFSRLYLYVHYPS 151
Cdd:cd03392    87 RPRPPLHLLVP-------EGGYSFPSGHAMGATVLYGFLAYLlarrlpRRRVRILLLILAAililLVGLSRLYLGVHYPS 159

                         170       180
                  ....*....|....*....|
gi 2427588833 152 DVFAAMVIGILIGNLVIVAF 171
Cdd:cd03392   160 DVLAGWLLGLAWLALLILLY 179
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 4-167 5.87e-26

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 97.72  E-value: 5.87e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833   4 IQNIDNNILEFIQILMRTPVLDKIMPLITilgsKITIWTFIALILIMGKKYRKYGIMIICSLILCFIVG------NLGLK 77
Cdd:cd03395     2 LEQIDVWLFLLLNGTLVHPLLDDLMPFLT----GKKLSVPIFLLLALFILFRKGPIGLLILLLVLLAVGfadqlaSGFLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  78 PLVARTRPFNAEPILNMVHMKLPTD-FSFPSGHTMCSFAPATIIN--YMNKRAGILALTLSTLIGFSRLYLYVHYPSDVF 154
Cdd:cd03395    78 PLVARLRPCNALDGVRLVVLGDQGGsYSFASSHAANSFALALFIWlfFRRGLFSPVLLLWALLVGYSRVYVGVHYPGDVI 157

                         170
                  ....*....|...
gi 2427588833 155 AAMVIGILIGNLV 167
Cdd:cd03395   158 AGALIGIISGLLF 170
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 4-172 1.16e-25

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 97.03  E-value: 1.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833   4 IQNIDNNILEFIQILMRTPVLDKIMPLITILGSKITIWTFIALILIMGKKYRKYGIMIICSLILCFIVGNLGLKPLVART 83
Cdd:COG0671    20 LALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  84 RPFNAEPILNMVHmkLPTDFSFPSGHTMCSFAPATIINYMNKR--AGILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGI 161
Cdd:COG0671   100 RPFVVPDLELLLG--TAGGYSFPSGHAAAAFALALVLALLLPRrwLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGL 177

                         170
                  ....*....|.
gi 2427588833 162 LIGNLVIVAFN 172
Cdd:COG0671   178 AIALLLLALLR 188
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 55-168 6.71e-23

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 88.29  E-value: 6.71e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  55 RKYGIMIICSLILCFIVGNLGLKPLVARTRPFNAEP--ILNMVHMKLPTDFSFPSGHTMCSFAPATII------NYMNKR 126
Cdd:cd01610     1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRcgPDGDPLLLTEGGYSFPSGHAAFAFALALFLalllprRLLRLL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2427588833 127 AGILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIGNLVI 168
Cdd:cd01610    81 LGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
acidPPc smart00014
Acid phosphatase homologues;
73-164 3.89e-19

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 78.16  E-value: 3.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833   73 NLGLKPLVARTRPFNAEPILNM----VHMKLPTDFSFPSGHTMCSFAPATII------NYMNKRAGILALTLSTLIGFSR 142
Cdd:smart00014  11 NGVIKNYFGRPRPFFLSIGDACctpnFLLTLEAGYSFPSGHTAFAFAFALFLllylpaRAGRKLLIFLLLLLALVVGFSR 90

                           90       100
                   ....*....|....*....|..
gi 2427588833  143 LYLYVHYPSDVFAAMVIGILIG 164
Cdd:smart00014  91 VYLGAHWPSDVLAGSLLGILIA 112
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 64-167 7.61e-18

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 74.67  E-value: 7.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  64 SLILCFIVgNLGLKPLVARTRPFNAEPilnmvhmklpTDFSFPSGHTMCSFAPATIIN--YMNKRAGILALTLSTLIGFS 141
Cdd:cd03394    11 AAALTAAV-TEGLKFAVGRARPDGSNN----------GYRSFPSGHTASAFAAATFLQyrYGWRWYGIPAYALASLVGAS 79

                          90       100
                  ....*....|....*....|....*.
gi 2427588833 142 RLYLYVHYPSDVFAAMVIGILIGNLV 167
Cdd:cd03394    80 RVVANRHWLSDVLAGAAIGILVGYLV 105
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 57-173 2.39e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 68.60  E-value: 2.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  57 YGIMIICSLILCFIvgnlgLKPLVARTRPFNAE---PILNMVHMKLPTDFSFPSGHTMCSFAPATIINYMNKRAGI---- 129
Cdd:pfam01569   2 LLLALALAGLLSSV-----LKDYFGRPRPFFLLlegGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKivrv 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2427588833 130 ----LALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIGNLVIVAFNN 173
Cdd:pfam01569  77 llalLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 30-171 6.85e-15

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 68.89  E-value: 6.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  30 LITILGSKITIWTFIALILIMGKKYRKYGIMIICSLILCFIVGNLgLKPLVARTRP--FNAEPILNMVHMKLPTDF-SFP 106
Cdd:cd03389    43 LLFLLFRFGDLRGLSAPSRARFPKAAWAGLFLFATVALSGILVNL-LKFIIGRARPklLFDDGLYGFDPFHADYAFtSFP 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2427588833 107 SGHTMCSFAPATIINYMNKRAGILALTLSTLIGFSRLYLYVHYPSDVFAamviGILIGNLVIVAF 171
Cdd:cd03389   122 SGHSATAGAAAAALALLFPRYRWAFILLALLIAFSRVIVGAHYPSDVIA----GSLLGAVTALAL 182
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 82-164 7.05e-14

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 66.69  E-value: 7.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  82 RTRPFNA-----EPILNmVHMKLPTDFSFPSGHTMCSFAPATIINYMN--KRAGILALTLStlIGFSRLYLYVHYPSDVF 154
Cdd:cd03380   118 RPRPFVAirlqwLPICT-PEEGTPKHPSYPSGHATFGGAAALVLAELFpeRAAELLARAAE--AGNSRVVAGVHWPSDVE 194

                          90
                  ....*....|
gi 2427588833 155 AAMVIGILIG 164
Cdd:cd03380   195 AGRILGEAIA 204
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 24-168 1.38e-12

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 61.89  E-value: 1.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  24 LDKIMPLITilgsKITIWTFIALILIM----GKKYR----KYGIMIICSLILCFIVGNLGLKPlvartRPFnaepILNMV 95
Cdd:cd03385     1 LDALAIFIA----EYLIYILPLLLVVLwlwgGEKQRkvvlFATIAVAVALLINYIIGLLYFHP-----RPF----VVGLG 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2427588833  96 HMKLP--TDFSFPSGHTMCSFAPA-TIINYMNKRAGILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIGNLVI 168
Cdd:cd03385    68 HNLLPhaADSSFPSDHTTLFFSIAfSLLLRRRKWAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLVF 143
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 81-160 1.00e-10

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 58.50  E-value: 1.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  81 ARTRPF--NAEPILNM-VHMKLPTDFSFPSGHTMCSFAPATIINYMN--KRAGILALTLstLIGFSRLYLYVHYPSDVFA 155
Cdd:cd03397   125 NRPRPFvlNDEPICTPpDESGLAKDGSYPSGHTAAGYAWALILAELVpeRADEILARGS--EYGQSRIVCGVHWPSDVMG 202


                  ....*
gi 2427588833 156 AMVIG 160
Cdd:cd03397   203 GRIMA 207
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 47-163 5.31e-09

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 51.99  E-value: 5.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  47 ILIMGKKYRKYGIMIICSLILcfivgNLGLKPLVARTRPFNAEPILNMVHMKlPTDFSFPSGH--TMCSFAPATIINYMN 124
Cdd:cd03393     8 WLVDKRLGRYLGLALCASGYL-----NAALKEVFKIPRPFTYDGIQAIYEES-AGGYGFPSGHaqTSATFWGSLMLHVRK 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2427588833 125 KRAGILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILI 163
Cdd:cd03393    82 KWFTLIGVVLVVLISFSRLYLGVHWPSDVIGGVLIGLLV 120
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 102-163 1.90e-06

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 45.30  E-value: 1.90e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833 102 DFSFPSGHTMCSFA-PATIINYMNKRAG-------ILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILI 163
Cdd:cd03388    77 EYGFPSTHAMNATAiSFYLLIYLYDRYQypfvlglILALFYSTLVCLSRIYMGMHSVLDVIAGSLIGVLI 146
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 43-164 4.64e-06

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 44.57  E-value: 4.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  43 FIALILImgkKYRKYGIMIICSLILCFIVGNLgLKPLVARTRPFNAepilnmvHMKLPTDFSFPSGH--TMCSFAPATII 120
Cdd:cd03382    32 YATLILF---RRELEAIYLFIGLLANEALNYV-LKRIIKEPRPCSG-------AYFVRSGYGMPSSHsqFMGFFAVYLLL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2427588833 121 NYMNKR-----------AGILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIG 164
Cdd:cd03382   101 FIYLRLgrlnslvsrflLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLG 155
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 104-167 7.03e-06

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 44.72  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833 104 SFPSGHTMCSFAPATIINY-MNKRAGILALT-----------------LSTL---IGFSRLYLYVHYPSDVFAAMVIGIL 162
Cdd:cd03398   146 SYPSGHATFAGAAATVLKAlFGSDKVPDTVSepdeggpstgvtrvwaeLNELadeVAISRVYAGVHFRSDDAAGAALGEQ 225


                  ....*
gi 2427588833 163 IGNLV 167
Cdd:cd03398   226 IGAAA 230
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 96-171 1.42e-05

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 43.86  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  96 HMKLPTDFSFPSGHTM--CSFAPATIINYMNKR----AGILALTLSTLIGfSRLYLYVHYPSDVFAAMVIGILignLVIV 169
Cdd:PRK10699  150 HWQKETGFAFPSGHTMfaASWALLAVGLLWPRRryktVALLMLWATGVMG-SRLLLGMHWPRDLVVATLISWL---LVTV 225


                  ..
gi 2427588833 170 AF 171
Cdd:PRK10699  226 AT 227
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 75-167 1.56e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 43.08  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  75 GLKPLVARTRPfnAEPILNMVHMKLPTDFSFPSGHTMCSFAPATIINYMNKRAGILALTL---STLIGFSRLYLYVHYPS 151
Cdd:cd03391    65 ILKALVRRRRP--AYNSPDMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVPLRVLLvlwATVVGISRVLLGRHHVL 142

                          90
                  ....*....|....*.
gi 2427588833 152 DVFAAMVIGILIGNLV 167
Cdd:cd03391   143 DVLAGAFLGYLEALLV 158
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 28-167 1.66e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 43.36  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  28 MPLITILgskITIWTFIALILIMGKKYRKYGIMIIC---SLILCFIVGNLgLKPLVARTRP-FNA--EPILNMVHMKLPT 101
Cdd:cd03390    18 LVIISVG---IPLLVIILISLFFRRSLWDLHTSLLGlllSVSLNGVITNV-LKNYAGRPRPdFLArcFPDGGTPSDTLVG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833 102 DF---------------SFPSGHTMCSFAPATI--------INYMNKR-------AGILALTLSTLIGFSRLYLYVHYPS 151
Cdd:cd03390    94 IDicctgdpgvlkegrkSFPSGHSSFAFAGLGFlslylagkLHIFDPRgsswrllLALLPLLLAILVAVSRTRDYRHHFS 173

                         170
                  ....*....|....*.
gi 2427588833 152 DVFAAMVIGILIGNLV 167
Cdd:cd03390   174 DVIAGSLIGLIIAYLS 189
PLN02250 PLN02250
lipid phosphate phosphatase
 104-171 5.98e-05

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 42.22  E-value: 5.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833 104 SFPSGHTMCSFAPATIIN-YMN------KRAG--------ILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIGNLVI 168
Cdd:PLN02250  162 SFPSGHTSWSFAGLGFLSlYLSgkirvfDRRGhvaklcivFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCY 241


                  ...
gi 2427588833 169 VAF 171
Cdd:PLN02250  242 LQF 244
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 56-162 6.30e-05

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 41.54  E-value: 6.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  56 KYGIMIICSLILCFIVGNLGLKPlvartRPFNAEPILNMVHMKlPTDfSFPSGH--TMCSFAPATIInYMNKRAGILALT 133
Cdd:PRK11837   63 KIAIALAISLLVSWTIGHLFPHD-----RPFVEGIGYNFLHHA-ADD-SFPSDHgtVIFTFALAFLF-WHRLWSGSLLMA 134

                          90       100
                  ....*....|....*....|....*....
gi 2427588833 134 LSTLIGFSRLYLYVHYPSDVFAAMVIGIL 162
Cdd:PRK11837  135 IAVAIAWSRVYLGVHWPLDMLGALLVGMI 163
COG3907 COG3907
Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction ...
 17-167 1.85e-04

Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction only];


Pssm-ID: 443113  Cd Length: 236  Bit Score: 40.65  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  17 ILMRTPVLDKIM-----PLITILGSKITIWTFIALILIMGKKYRKYGIMIICSLILCFIVgNLGLKPLVARTRPFNAE-- 89
Cdd:COG3907    52 PLRDNWLLELLLhdggkWLVILVAVLLLLLLLASFKRPRLRRYRRRLLYLLLSLALGLLV-VSLLKSHTGRPCPWDLVef 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  90 -------PILNMVHMKLPTDFSFPSGHTMCSFA-------PATIINYMNKRAGILALTLSTLIGFSRLYLYVHYPSDVFA 155
Cdd:COG3907   131 ggdapyvPLFEPGPAGAGPGRCFPAGHASAGFAllalyflLRRRRPRLARLGLAAGLALGLLMGLAQMLRGAHFLSHTLW 210

                         170
                  ....*....|..
gi 2427588833 156 AMVIGILIGNLV 167
Cdd:COG3907   211 SAWICWLVALLL 222
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 104-163 2.38e-04

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 39.54  E-value: 2.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2427588833 104 SFPSGH-TMCSFAPATIINYMNKR------------AGILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILI 163
Cdd:cd03384    73 SFPSGHaSLSMYAAVFLALYLQARlklrgsrllrplLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVI 145
PAP2_diacylglycerolkinase cd03383
PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like ...
 106-171 2.49e-04

PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be determined.


Pssm-ID: 239478 [Multi-domain]  Cd Length: 109  Bit Score: 38.85  E-value: 2.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2427588833 106 PSGHTMCSFAPATIINYMNKRA--GILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIGNLVIVAF 171
Cdd:cd03383    42 PSGHAAIAFSIATAISLITNNPiiSILSVLLAVMVAHSRVEMKIHTMWEVVVGAILGALITLLIFKIF 109
PLN02715 PLN02715
lipid phosphate phosphatase
 104-164 2.65e-04

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 40.42  E-value: 2.65e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2427588833 104 SFPSGHTMCSFAPATIIN-YMNKRAG--------------ILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIG 164
Cdd:PLN02715  186 SFPSGHTSWSFAGLTFLSlYLSGKIKafngeghvaklclvIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVA 261
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 67-163 1.24e-03

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 38.57  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  67 LCFIVGNLgLKPLVARTRPfNAEPILNMVHMKLPTD----FSFPSGHTMCSFAPAT-IINYMNKRAG-----------IL 130
Cdd:PLN02525   46 FCDYVGNC-IKDVVSAPRP-SCPPVRRVTATKDEEEnameYGLPSSHTLNTVCLSGyLLHYVLSYLQnvdasvifaglAL 123

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2427588833 131 ALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILI 163
Cdd:PLN02525  124 FCLLVALVGFGRLYLGMHSPIDIIAGLAIGLVI 156
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 31-163 1.32e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 38.05  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833  31 ITILGSKITIWTFIALILIM-------GKKYRKYGIMIICSLILCF-IVGNLGLKPLVARTRPFNAEpILNMVHMKLPTD 102
Cdd:cd03396    33 LLHLGGRLLSIALAVLLLALallffrrKRLRRRRRALLLLILVIGLgLLVVAILKSHWGRPRPWDLT-EFGGDAPYTPLF 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2427588833 103 F----------SFPSGHTMC-------SFAPATIINYMNKRAGILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILI 163
Cdd:cd03396   112 SgpsngcgkgcSFPSGHASAgfallalYFLFRRRRPRLARLVLAAGLALGALMGLARMARGAHFLSDVLWSLLLVWLI 189
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 104-171 5.22e-03

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 36.55  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427588833 104 SFPSGHTMCSFAPATIIN-YMNKRAG--------------ILALTLSTLIGFSRLYLYVHYPSDVFAAMVIGILIGNLVI 168
Cdd:PLN02731  180 SFPSGHTSWSFSGLGFLSlYLSGKIQafdgkghvaklcivILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICY 259


                  ...
gi 2427588833 169 VAF 171
Cdd:PLN02731  260 LQF 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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