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Conserved domains on  [gi|2399427386|ref|WP_268213900|]
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helix-turn-helix transcriptional regulator [Staphylococcus pettenkoferi]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 2.16e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 80.70  E-value: 2.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2399427386  11 TEEEQLDFYEQMFSALADKIRLKILHSIRQSDtksLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKINE 90
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGE---LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD 78


                  ....*..
gi 2399427386  91 RQIQVVL 97
Cdd:COG0640    79 EALAELL 85
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 2.16e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 80.70  E-value: 2.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2399427386  11 TEEEQLDFYEQMFSALADKIRLKILHSIRQSDtksLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKINE 90
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGE---LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD 78


                  ....*..
gi 2399427386  91 RQIQVVL 97
Cdd:COG0640    79 EALAELL 85
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 21-89 9.59e-21

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 78.66  E-value: 9.59e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2399427386  21 QMFSALADKIRLKILHSIRQsdtKSLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKIN 89
Cdd:NF033788    3 ELFKALADPTRLRILELLAE---GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLA 68
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 23-91 6.79e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 68.86  E-value: 6.79e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2399427386  23 FSALADKIRLKILHSIRQSDtksLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKINER 91
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGP---LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
33-93 7.92e-12

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 55.68  E-value: 7.92e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2399427386   33 KILHSIRQsdtKSLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKINERQI 93
Cdd:smart00418   1 KILKLLAE---GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKV 58
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 28-75 8.52e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 52.45  E-value: 8.52e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2399427386  28 DKIRLKILHSIRQSdtkSLCVCDLEELLELKQSKLSYHLKKLVDANIL 75
Cdd:pfam01022   1 DPTRLKILKLLAEG---ELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 21-88 4.12e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.50  E-value: 4.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2399427386  21 QMFSALADKIRLKILHSIRQSDtkSLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKI 88
Cdd:PRK10141    8 QLFKILSDETRLGIVLLLRESG--ELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 2.16e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 80.70  E-value: 2.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2399427386  11 TEEEQLDFYEQMFSALADKIRLKILHSIRQSDtksLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKINE 90
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGE---LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD 78


                  ....*..
gi 2399427386  91 RQIQVVL 97
Cdd:COG0640    79 EALAELL 85
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 21-89 9.59e-21

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 78.66  E-value: 9.59e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2399427386  21 QMFSALADKIRLKILHSIRQsdtKSLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKIN 89
Cdd:NF033788    3 ELFKALADPTRLRILELLAE---GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLA 68
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 23-91 6.79e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 68.86  E-value: 6.79e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2399427386  23 FSALADKIRLKILHSIRQSDtksLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKINER 91
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGP---LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
33-93 7.92e-12

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 55.68  E-value: 7.92e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2399427386   33 KILHSIRQsdtKSLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKINERQI 93
Cdd:smart00418   1 KILKLLAE---GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKV 58
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 28-75 8.52e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 52.45  E-value: 8.52e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2399427386  28 DKIRLKILHSIRQSdtkSLCVCDLEELLELKQSKLSYHLKKLVDANIL 75
Cdd:pfam01022   1 DPTRLKILKLLAEG---ELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 23-75 6.99e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.92  E-value: 6.99e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2399427386  23 FSALADKIRLKILHSIRQSDTKSlcVCDLEELLELKQSKLSYHLKKLVDANIL 75
Cdd:pfam12840   4 AEALADPTRLRILRALVGDEPLT--ASELARRLDISRNTLSYHLRKLEEAGLV 54
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
20-79 7.15e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 48.80  E-value: 7.15e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2399427386  20 EQMFSALADKIRLKILHSIRQsdtKSLCVCDLEELLELKQSKLSYHLKKLVDANILIAEK 79
Cdd:COG4189    10 LEVLKALASETRLRILRLLAE---EPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEY 66
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 21-88 4.12e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.50  E-value: 4.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2399427386  21 QMFSALADKIRLKILHSIRQSDtkSLCVCDLEELLELKQSKLSYHLKKLVDANILIAEKYSTWNYYKI 88
Cdd:PRK10141    8 QLFKILSDETRLGIVLLLRESG--ELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
25-106 7.97e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 41.79  E-value: 7.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2399427386  25 ALADKIRLKILHSIRqsDTKSLCVCDLEELLELKQSKLSYHLKKLVDANILIAEK-------YSTWNYYKINERQIQVVL 97
Cdd:COG3398    17 VLDNDTRRRIYEYIR--ENPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKdggrtryFPNSGTYSEEEKKILAYL 94


                  ....*....
gi 2399427386  98 NKDTCCKIL 106
Cdd:COG3398    95 RRETPRRIL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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