|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-576 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 692.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 1 MDIQRSILIVALAVVSYLMVLQWNEDYGQAALPAEVSTstaatpalpdtpaggddiptavaeptaaavaptaavsdELIR 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAAQAPAPQ--------------------------------------ARIT 42
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 81 VKTDVLDLAIDPRGGDIVQLRLPQYPRRQDrPDVPFQLFDNGNERTYLAQSGLIGPNAPDKSSG--RSLWSSEKQNYELA 158
Cdd:PRK01318 43 VETDVLRLSIDTKGGRIDDLLLKKYKETLD-SSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNpdRTLYTADGDSLVLA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 159 EGQDSLVVDLKLSE-NGVNYIKRYSLKRGLnpqcsareqqlkkpgcidpsaYQVDVRYLIDNQSEQAWSGNLFAQLKRDN 237
Cdd:PRK01318 122 DGQNELPVTLTWTNgNGLTFTKTYTLDRGD---------------------YMFTVEYSVNNNSGAPVNLSPYGQLKRTG 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 238 SGDpssttaTGTATYLGAALWTPDEPYKKVSMKDMDKQPfKETVQGGWVAWLQHYFVTAWVPsKDSTNLVQTRKDSQGNY 317
Cdd:PRK01318 181 SSN------FASYTFHGGAIGTPDEKYEKYTYKDIDDNL-NISSKGGWVAILDKYFATALIP-QNGQNNFYSKNLGNGLY 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 318 IVGFTGPSVQVAAGAQGETGAILYAGPKLQEHLATL-SPGLELTVDYGFLWFLAQPIFWLLEAIHSVLGNWGWSIIVLTI 396
Cdd:PRK01318 253 QVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAKEiAPGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTI 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 397 IIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLES 476
Cdd:PRK01318 333 IVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVS 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 477 VEMRQAPWLLWITDLSIKDPFFIL-----PIIMGATMFIQQQLNPTPPDPMQARVLKLMPIIFTFFFLWFPAGLVLYWVV 551
Cdd:PRK01318 413 IELRHAPFIGWIHDLSAPDPYFILhigllPILMGITMFLQQKLNPTPTDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIV 492
|
570 580
....*....|....*....|....*
gi 2285179005 552 NNILSIAQQWYITRKIEAAAKTANA 576
Cdd:PRK01318 493 NNLLTIIQQYLINRRLEKKKLLAAN 517
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
361-571 |
4.93e-123 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 360.97 E-value: 4.93e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 361 VDYGFLWFLAQPIFWLLEAIHSVLGNWGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQA 440
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 441 MMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWlLWITDLSIKDPFFI-LPIIMGATMFIQQQLNPTP- 518
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPF-LGIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPa 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2285179005 519 PDPMQARVLKLMPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYITRKIEAAA 571
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-385 |
5.16e-113 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 341.23 E-value: 5.16e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 3 IQRSILIVALAVVSYLMVLQWNEDYGQAAlPAEVSTSTAATPALPDTPAGGDDIPTAVAEPTAAAVAPTAAVSDELIRVK 82
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSDPGPPP-PKPPAAAQEASAASATAAATSAAAPAAADAPSAAAAADAAAATAKRITVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 83 TDVLDLAIDPRGGDIVQLRLPQYPRRQDRPDVPFQLFDNGNERTYLAQSGLIGPNAPD--KSSGRSLWSSEKQNYELAEG 160
Cdd:TIGR03593 80 TDVLRASISTKGGDIDSLELKKYKETLDKDSPPVLLLSDGAERLYVAQSGLIGANGADlaLPGHRTVWQAEGGEYTLTPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 161 QdsLVVDLKL-SENGVNYIKRYSLKRGlnpqcsareqqlkkpgcidpsAYQVDVRYLIDNQSEQAWSGNLFAQLKRDNSg 239
Cdd:TIGR03593 160 Q--LPVTLTWdNSNGVTVTKTYTFDRD---------------------SYLIDVEYKVTNNGDAPVSLSLYGQLKRDLS- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 240 DPSSTTATGTATYLGAALWTPDEPYKKVSMKDMDKQPFKETVQG--GWVAWLQHYFVTAWVP---SKDSTNLVQTRKDSQ 314
Cdd:TIGR03593 216 PTEKSTYFLHETFTGAAYYTDGEKYQKVSFKDIEKKKLNVETKGgaGWVGMLQHYFASAWIPpagSDGTTAFYYGRKLGN 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2285179005 315 GNYIVGFTGPSVQVAAGAQGETGAILYAGPKLQEHLATLSPGLELTVDYGFLWFLAQPIFWLLEAIHSVLG 385
Cdd:TIGR03593 296 NVYIAGFVSPVVTVAPGQSATIKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
387-565 |
6.71e-103 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 308.25 E-value: 6.71e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 387 WGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVF 466
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 467 LALYWVLLESVEMRQAPWLLWITDLSIKDP-----FFILPIIMGATMFIQQQLNPTPPD-PMQARV--LKLMPIIFTFFF 538
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDqPPQMKMmmLYFMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 2285179005 539 LWFPAGLVLYWVVNNILSIAQQWYITR 565
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
388-565 |
1.35e-102 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 307.38 E-value: 1.35e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 388 GWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFL 467
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 468 ALYWVLLESVEMRQAPWLLWITDLSIKDPFFILPIIMGATMFIQQQLNPTPPD---PMQARVLKLMPIIFTFFFLWFPAG 544
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqaPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 2285179005 545 LVLYWVVNNILSIAQQWYITR 565
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-576 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 692.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 1 MDIQRSILIVALAVVSYLMVLQWNEDYGQAALPAEVSTstaatpalpdtpaggddiptavaeptaaavaptaavsdELIR 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAAQAPAPQ--------------------------------------ARIT 42
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 81 VKTDVLDLAIDPRGGDIVQLRLPQYPRRQDrPDVPFQLFDNGNERTYLAQSGLIGPNAPDKSSG--RSLWSSEKQNYELA 158
Cdd:PRK01318 43 VETDVLRLSIDTKGGRIDDLLLKKYKETLD-SSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNpdRTLYTADGDSLVLA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 159 EGQDSLVVDLKLSE-NGVNYIKRYSLKRGLnpqcsareqqlkkpgcidpsaYQVDVRYLIDNQSEQAWSGNLFAQLKRDN 237
Cdd:PRK01318 122 DGQNELPVTLTWTNgNGLTFTKTYTLDRGD---------------------YMFTVEYSVNNNSGAPVNLSPYGQLKRTG 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 238 SGDpssttaTGTATYLGAALWTPDEPYKKVSMKDMDKQPfKETVQGGWVAWLQHYFVTAWVPsKDSTNLVQTRKDSQGNY 317
Cdd:PRK01318 181 SSN------FASYTFHGGAIGTPDEKYEKYTYKDIDDNL-NISSKGGWVAILDKYFATALIP-QNGQNNFYSKNLGNGLY 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 318 IVGFTGPSVQVAAGAQGETGAILYAGPKLQEHLATL-SPGLELTVDYGFLWFLAQPIFWLLEAIHSVLGNWGWSIIVLTI 396
Cdd:PRK01318 253 QVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAKEiAPGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTI 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 397 IIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLES 476
Cdd:PRK01318 333 IVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVS 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 477 VEMRQAPWLLWITDLSIKDPFFIL-----PIIMGATMFIQQQLNPTPPDPMQARVLKLMPIIFTFFFLWFPAGLVLYWVV 551
Cdd:PRK01318 413 IELRHAPFIGWIHDLSAPDPYFILhigllPILMGITMFLQQKLNPTPTDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIV 492
|
570 580
....*....|....*....|....*
gi 2285179005 552 NNILSIAQQWYITRKIEAAAKTANA 576
Cdd:PRK01318 493 NNLLTIIQQYLINRRLEKKKLLAAN 517
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
361-571 |
4.93e-123 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 360.97 E-value: 4.93e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 361 VDYGFLWFLAQPIFWLLEAIHSVLGNWGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQA 440
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 441 MMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWlLWITDLSIKDPFFI-LPIIMGATMFIQQQLNPTP- 518
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPF-LGIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPa 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2285179005 519 PDPMQARVLKLMPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYITRKIEAAA 571
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-385 |
5.16e-113 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 341.23 E-value: 5.16e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 3 IQRSILIVALAVVSYLMVLQWNEDYGQAAlPAEVSTSTAATPALPDTPAGGDDIPTAVAEPTAAAVAPTAAVSDELIRVK 82
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSDPGPPP-PKPPAAAQEASAASATAAATSAAAPAAADAPSAAAAADAAAATAKRITVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 83 TDVLDLAIDPRGGDIVQLRLPQYPRRQDRPDVPFQLFDNGNERTYLAQSGLIGPNAPD--KSSGRSLWSSEKQNYELAEG 160
Cdd:TIGR03593 80 TDVLRASISTKGGDIDSLELKKYKETLDKDSPPVLLLSDGAERLYVAQSGLIGANGADlaLPGHRTVWQAEGGEYTLTPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 161 QdsLVVDLKL-SENGVNYIKRYSLKRGlnpqcsareqqlkkpgcidpsAYQVDVRYLIDNQSEQAWSGNLFAQLKRDNSg 239
Cdd:TIGR03593 160 Q--LPVTLTWdNSNGVTVTKTYTFDRD---------------------SYLIDVEYKVTNNGDAPVSLSLYGQLKRDLS- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 240 DPSSTTATGTATYLGAALWTPDEPYKKVSMKDMDKQPFKETVQG--GWVAWLQHYFVTAWVP---SKDSTNLVQTRKDSQ 314
Cdd:TIGR03593 216 PTEKSTYFLHETFTGAAYYTDGEKYQKVSFKDIEKKKLNVETKGgaGWVGMLQHYFASAWIPpagSDGTTAFYYGRKLGN 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2285179005 315 GNYIVGFTGPSVQVAAGAQGETGAILYAGPKLQEHLATLSPGLELTVDYGFLWFLAQPIFWLLEAIHSVLG 385
Cdd:TIGR03593 296 NVYIAGFVSPVVTVAPGQSATIKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| yidC_oxa1_cterm |
TIGR03592 |
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ... |
386-563 |
7.13e-105 |
|
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274665 [Multi-domain] Cd Length: 179 Bit Score: 313.26 E-value: 7.13e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 386 NWGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPV 465
Cdd:TIGR03592 1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 466 FLALYWVLLESVEMRQAPWlLWITDLSIKDPFFILPIIMGATMFIQQQLNPT-PPDPMQARV-LKLMPIIFTFFFLWFPA 543
Cdd:TIGR03592 81 FIALYQVLLRSIELRHAPF-LWIIDLSSPDPYYILPILMGVTMFLQQKLSPKgPPDPAQQKMmMYFMPLMFLFFFLSFPA 159
|
170 180
....*....|....*....|
gi 2285179005 544 GLVLYWVVNNILSIAQQWYI 563
Cdd:TIGR03592 160 GLVLYWVVSNLFTIIQQLII 179
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
387-565 |
6.71e-103 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 308.25 E-value: 6.71e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 387 WGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVF 466
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 467 LALYWVLLESVEMRQAPWLLWITDLSIKDP-----FFILPIIMGATMFIQQQLNPTPPD-PMQARV--LKLMPIIFTFFF 538
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDqPPQMKMmmLYFMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 2285179005 539 LWFPAGLVLYWVVNNILSIAQQWYITR 565
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
388-565 |
1.35e-102 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 307.38 E-value: 1.35e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 388 GWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFL 467
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 468 ALYWVLLESVEMRQAPWLLWITDLSIKDPFFILPIIMGATMFIQQQLNPTPPD---PMQARVLKLMPIIFTFFFLWFPAG 544
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqaPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 2285179005 545 LVLYWVVNNILSIAQQWYITR 565
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| YidC_periplas |
pfam14849 |
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein ... |
79-363 |
6.20e-97 |
|
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins.
Pssm-ID: 464346 Cd Length: 266 Bit Score: 296.11 E-value: 6.20e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 79 IRVKTDVLDLAIDPRGGDIVQLRLPQYPRRQDRPDVPFQLFDNGNERTYLAQSGLIGPNAPDKSSGRSLWSSEKQNYELA 158
Cdd:pfam14849 1 ITVETDVLRGSISLKGGRIDDLELKKYRETLDDDSPPVVLLSPSGGRTYVAQSGLIGAGGPDLPPHDTVFTAEGGSYTLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 159 EGQDSLVVDLKLS-ENGVNYIKRYSLKRGlnpqcsareqqlkkpgcidpsAYQVDVRYLIDNQSEQAWSGNLFAQLKRDN 237
Cdd:pfam14849 81 DGTDELPVTLTWDnGNGVTFTKTYTFDRG---------------------SYLIDVTYEVENTSGAPVTLQPYGQLVRDP 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 238 SGDPsstTATGTATYLGAALWTPDEPYKKVSMKDMDK---QPFKETVQGGWVAWLQHYFVTAWVPSKDST-NLVQTRKDS 313
Cdd:pfam14849 140 GEPE---GSSFYITYTGAAGSTDEGKYQKVSFDDIEKggkLKVDTTTGGGWVAMTQHYFLSAWIPDQDGTtNEFYTRFLG 216
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2285179005 314 QGNYIVGFTGPSVQVAAGAQGETGAILYAGPKLQEHLATLSPGLELTVDY 363
Cdd:pfam14849 217 GNLYQAGYISPAVTVAPGASATVTARLFAGPKEQKVLEAIAPGLDLAVDY 266
|
|
| EcYidC-like_peri |
cd19961 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
77-363 |
7.96e-63 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Escherichia coli and similar domains; This subfamily is composed of Escherichia coli YidC and similar proteins. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contain a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich.
Pssm-ID: 411000 Cd Length: 255 Bit Score: 207.17 E-value: 7.96e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 77 ELIRVKTDVLDLAIDPRGGDIVQLRLPQYPRRQDrPDVPFQLFDNGNerTYLAQSGLIGPNAPDKSSGRSLWSSEKQNYE 156
Cdd:cd19961 1 KRITVETDLLKASISTKGGRIKSVELKKYKETLP-DSKPVELLSPDG--PYVAQLGLIGADGPLIPTADLLFTADSGSYE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 157 laeGQDSLVVDLKL-SENGVNYIKRYSLKRGlnpqcsareqqlkkpgcidpsAYQVDVRYLIDNQSEQAWSGNLFAQLKR 235
Cdd:cd19961 78 ---GGDSLTVTLTWtNGDGLTIEKTYTFDPD---------------------SYLIDVEVRVENNSSAPLSLSLYLQLQR 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 236 DNSGDpssTTATGTATYLGAAlWTPDEPYKKVSMKDMDKQPFKETvQGGWVAWLQHYFVTAWVPSKDSTNLVQTRKDsQG 315
Cdd:cd19961 134 KGGEP---EGSGSTITYEGPA-GTEDGKLEKLSFKDLEEEKLSSG-KVGWVAFKQKYFLSALIPDQGFFYSAKLSGK-DD 207
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2285179005 316 NYIVGFTGPSVQVAAGAQGETGAILYAGPKLQEHLATLSPGLELTVDY 363
Cdd:cd19961 208 GDGVKLLSAALTLPPGGSGTFSFRLYAGPKDYDILKAYGPGLELAVDF 255
|
|
| 5TM_YidC_Oxa1_Alb3 |
cd19751 |
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ... |
388-565 |
5.69e-61 |
|
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410992 [Multi-domain] Cd Length: 189 Bit Score: 200.09 E-value: 5.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 388 GWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDD------RQKMSQAMMELYKKEKINPLGGCLPILV 461
Cdd:cd19751 1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYKEKaskdkvQQEMQKEMLGLYKKHGVNPMAGCLPLFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 462 QMPVFLALYWVLLESVEMRQAPWlLWITDLSIKDPFFILPIIMGATMFIQQQLNPT------PPDPMQARVLKLMPIIFT 535
Cdd:cd19751 81 QLPIFMAFYFAIMRTEEIRYHTF-LWFFDLGQPDYLYILPFVAGITTYFQFKMTMShqqqmqMMQMQMKVMLYVMPVMII 159
|
170 180 190
....*....|....*....|....*....|
gi 2285179005 536 FFFLWFPAGLVLYWVVNNILSIAQQWYITR 565
Cdd:cd19751 160 IAGLSFPSALSLYWIISNLFMIIQTYFIVR 189
|
|
| PRK00145 |
PRK00145 |
putative inner membrane protein translocase component YidC; Provisional |
380-576 |
2.47e-51 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234665 [Multi-domain] Cd Length: 223 Bit Score: 175.70 E-value: 2.47e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 380 IHSVLGNWGWS----IIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGG 455
Cdd:PRK00145 20 VSSVISNPNFSygiaIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPLGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 456 CLPILVQMPVFLALYWVLLESVEMRQAPWlLWITDLSIKDPFFILPIIMGATMFIQQQLNpTPPDPMQARVLKLMPIIFT 535
Cdd:PRK00145 100 CLPLLIQWPILIALYYVFNNLTGINGVSF-LWIKDLAKPDITWILPILSGATTYLSGYLM-TKADSSQAGQMKTMNIGMS 177
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2285179005 536 FFFLW----FPAGLVLYWVVNNILSIAQQwYITRKIEAAAKTANA 576
Cdd:PRK00145 178 IFMGVmswkFKSALVLYWVIGNLIQIIQT-YFIKKLELKKKVEAK 221
|
|
| PRK02944 |
PRK02944 |
YidC family membrane integrase SpoIIIJ; |
372-564 |
1.82e-46 |
|
YidC family membrane integrase SpoIIIJ;
Pssm-ID: 179508 Cd Length: 255 Bit Score: 163.79 E-value: 1.82e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 372 PIFWLLEAIHSVLG-NWGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDD----RQKMSQAMMELYK 446
Cdd:PRK02944 43 PLSQLITYFANLFGsNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYSSKdqatQQKLQQEMMQLFQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 447 KEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWlLWItDLSIKDPFFILPIIMGATMFIQQQL----NPTpPDPM 522
Cdd:PRK02944 123 KNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSF-LWF-DLGQADPYYILPIVAGITTFIQQKLmmagTAG-QNPQ 199
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2285179005 523 QARVLKLMPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYIT 564
Cdd:PRK02944 200 MAMMLWLMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLIK 241
|
|
| PRK01001 |
PRK01001 |
putative inner membrane protein translocase component YidC; Provisional |
340-569 |
1.01e-45 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234887 [Multi-domain] Cd Length: 795 Bit Score: 172.68 E-value: 1.01e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 340 LYAGP------KLQEHLATLSPGLelTVDY-------GFLWFLAQP----IFWLLEAIHSVLGNWGWSIIVLTIIIKLIF 402
Cdd:PRK01001 514 VYAGPladptlKTLDRAYTNSKGE--NPEYldsitfrGFFSFITEPfaalLFIIMKFFKFLTGSWGISIILLTVFLKLLL 591
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 403 FPLSAASYRSMARMRAVSPKLQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQA 482
Cdd:PRK01001 592 YPLNAWSIRSMRRMQKLSPYIQEIQQKYKKEPKRAQMEIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLKSSFLLRGA 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 483 PWLL-WITDLSIKDPFF--------------ILPIIMGATMFIQQQLNPT-PPDPM-----QARVL-KLMPIIFTFFFLW 540
Cdd:PRK01001 672 SFIPgWIDNLTAPDVLFswetpiwfignefhLLPILLGVVMFAQQKISSLkRKGPVtdqqrQQEAMgTMMALLFTFMFYN 751
|
250 260
....*....|....*....|....*....
gi 2285179005 541 FPAGLVLYWVVNNILSIAQQWYITRKIEA 569
Cdd:PRK01001 752 FPSGLNIYWLSSMLLGVIQQWVTNKILDS 780
|
|
| 5TM_Oxa1-like |
cd20069 |
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ... |
387-561 |
7.57e-43 |
|
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410993 [Multi-domain] Cd Length: 201 Bit Score: 152.29 E-value: 7.57e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 387 WGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQF------GDD--RQKMSQAMMELYKKEKINPLGGCLP 458
Cdd:cd20069 4 WWATIAATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEKLkearasGDQleAAEARKELKELMKKHNVNPLKSLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 459 ILVQMPVFLALYWVL-----LESVEMRQAPwLLWITDLSIKDPFFILPIIMGATMFI------QQQLNPTPPDPMQARVL 527
Cdd:cd20069 84 PLVQAPVFISFFFALrkmanLPVPSFKTGG-LLWFTDLTVPDPYYILPILTSLTFLAtielgaETGTSGSPQSKTMKNVF 162
|
170 180 190
....*....|....*....|....*....|....
gi 2285179005 528 KLMPIIFTFFFLWFPAGLVLYWVVNNILSIAQQW 561
Cdd:cd20069 163 RGLPVLMIPFTANFPSAVFLYWITSNLFSLAQNL 196
|
|
| PRK01315 |
PRK01315 |
putative inner membrane protein translocase component YidC; Provisional |
365-565 |
1.28e-41 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234941 Cd Length: 329 Bit Score: 152.97 E-value: 1.28e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 365 FLWFLAQPIFWLLEAI----HSVLG---------NWGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFG 431
Cdd:PRK01315 7 FGSAIMTPLYWVISGIlvlfHTLLGflfgpdsglTWVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEKYK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 432 DDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEmRQAPWLLWITDLS------------IKDPFF- 498
Cdd:PRK01315 87 GDRERMSQEMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAAS-RGDGIGPINPPLLesfrhahifgapLAATFLq 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 499 --------------ILPIIMGATMFIQQ-QLNP--TPPD----PM---QARVLKLMPIIFTFFFLWFPAGLVLYWVVNNI 554
Cdd:PRK01315 166 alnagntavqvvaaVLIILMSASQFITQlQLMTknMPPEaktgPMaqqQKMLLYLFPLMFLVSGIAFPVGVLFYWLTSNV 245
|
250
....*....|.
gi 2285179005 555 LSIAQQWYITR 565
Cdd:PRK01315 246 WTMGQQFYVIR 256
|
|
| PRK01622 |
PRK01622 |
membrane protein insertase YidC; |
368-567 |
1.83e-36 |
|
membrane protein insertase YidC;
Pssm-ID: 179310 Cd Length: 256 Bit Score: 136.42 E-value: 1.83e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 368 FLAQPIFWLLEAIHSVL-GNWGWSIIVLTIIIKLIFFPLSAASYRSM----ARMRAVSPKLQALKEQFGDDRQKMSQA-- 440
Cdd:PRK01622 40 YFVYPFSFLIQFVAHHIgGSYGIAIIIVTLIIRSLMIPLAVSQYKSQrgmqEKMAVMKPELDKIQAKLKVTKDLEKQKey 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 441 ---MMELYKKEKINPLG-GCLPILVQMPVFLALYWVLLESVEMRQAPWlLWItdlSIKDPFFILPIIMGATMFIQ---QQ 513
Cdd:PRK01622 120 qkeMMELYKSGNINPLAmGCLPLLIQMPILSAFYYAIRRTEEIASHSF-LWF---NLGHADHILPIIAGLTYFIQmkvSQ 195
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2285179005 514 LNPTPPDPMQ-ARVLKLM-PIIFTFFFLWFPAGLVLYWVVNNILsIAQQWYITRKI 567
Cdd:PRK01622 196 SNGTSPEQVQmLKIQGIMmPAMILFMSFAAPSALVLYWITGGLF-LMGQTIVLRKV 250
|
|
| PRK03449 |
PRK03449 |
putative inner membrane protein translocase component YidC; Provisional |
366-576 |
3.44e-29 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 179580 Cd Length: 304 Bit Score: 117.47 E-value: 3.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 366 LWFLAQPIFWLLEAIHSVLG---------NWGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQALKEQFGDDRQK 436
Cdd:PRK03449 2 LDFIYYPVSAILWFWHKLFSfvlgpdngfAWALSVMFLVFTLRALLYKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 437 MSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLE-------------SVEMRQ---------------------- 481
Cdd:PRK03449 82 MALEMQKLQKEHGFNPILGCLPMLAQIPVFLGLFHVLRSfnrtgtgfgqlgmSVEENRntpnyvfsaedvqsfldarlfg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 482 APWLLWIT-DLSIKDPFF----------ILPIIMG---ATMF-----IQQQ-----LNPTPPdPMQARVLKLMP--IIFT 535
Cdd:PRK03449 162 APLSAYITmPRSGLDAFVdftrtniilvGVPLMIIagvATHFnsrasVARQsaeaaANPQTA-MMNKLALWVFPlgVLVG 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2285179005 536 FFFLwfPAGLVLYWVVNNILSIAQQWYITRKIEA----------AAKTANA 576
Cdd:PRK03449 241 GPFL--PLAILLYWVSNNIWTFGQQHYVFGKIDKeeeakkqakaERRAANA 289
|
|
| PRK02463 |
PRK02463 |
OxaA-like protein precursor; Provisional |
363-564 |
8.81e-28 |
|
OxaA-like protein precursor; Provisional
Pssm-ID: 235040 Cd Length: 307 Bit Score: 113.67 E-value: 8.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 363 YGFLW-FLAQPIFWLLE--AIHSVLGnWGWSIIVLTIIIKLIFFPLS-----AASYRSmARMRAVSPKLQALKEQFGD-- 432
Cdd:PRK02463 34 TGFIWnFLGAPMSYFIDyfANNLGLG-FGLAIIIVTIIVRLIILPLGlyqswKATYQS-EKMAYLKPVFEPINERLKNat 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 433 -DRQKMS--QAMMELYKKEKINPLG--GCLPILVQMPVFLALYWVLLESVEMRQAPWLlWItDLSIKDpfFILPIIMGAT 507
Cdd:PRK02463 112 tQEEKMAaqTELMAAQRENGISMLGgiGCLPLLIQMPFFSALYFAAQYTKGVSTSTFL-GI-DLGSPS--LVLTAIIGVL 187
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2285179005 508 MFIQQQLNPTPPDPMQARVLK----LMPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYIT 564
Cdd:PRK02463 188 YFFQSWLSMMGVPEEQREQMKammyMMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLITT 248
|
|
| PRK02654 |
PRK02654 |
putative inner membrane protein translocase component YidC; Provisional |
386-473 |
3.70e-24 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235058 Cd Length: 375 Bit Score: 104.29 E-value: 3.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 386 NWGWSIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKLQA----LKEQFGDDRQKMSQAMMELYkKEKINPLGGCLPILV 461
Cdd:PRK02654 26 SYGLAIVALTLVIRFALYPLSAGSIRNMRRMKIAQPVMQKrqaeIQERYKNDPQKQQEEMGKLM-KEFGNPLAGCLPLLV 104
|
90
....*....|..
gi 2285179005 462 QMPVFLALYWVL 473
Cdd:PRK02654 105 QMPILFALFATL 116
|
|
| PRK02201 |
PRK02201 |
putative inner membrane protein translocase component YidC; Provisional |
360-559 |
1.00e-21 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235012 Cd Length: 357 Bit Score: 97.00 E-value: 1.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 360 TVDYG-FLWFLAQPIFWLLEAIHSVLGNWGW-------SIIVLTIIIKLIFFPLSAASYRSMARMRAVSPKL---QALKE 428
Cdd:PRK02201 98 TWKYGpFYGLFVYPIAQIILSIMASQSLSELygwstilAIIVVVLIIRLISFLITFKSTFNQEKQEELQGKKakiDAKYK 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 429 QFGDD---RQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWL---LWITDLS-------IKD 495
Cdd:PRK02201 178 DYKKDkqmKQRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQSLPSIKVTTWLgidLSATSWQeifagnwIYL 257
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2285179005 496 PFFILPIIMGAT-MFIQQQLNP-----TPPDPMQARVLK-------LMPIIFTFFFLWFPAGLVLYWVVNNILSIAQ 559
Cdd:PRK02201 258 PILIIVVPVQALsQLLPQILNKkknkeRTLNVKEKEALKkqnktqnIISIVFIFFGVIFAAGVQIYWIIGGIWTILQ 334
|
|
| PRK00247 |
PRK00247 |
putative inner membrane protein translocase component YidC; Validated |
380-474 |
1.34e-13 |
|
putative inner membrane protein translocase component YidC; Validated
Pssm-ID: 178945 [Multi-domain] Cd Length: 429 Bit Score: 72.96 E-value: 1.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 380 IHSVLG-----NWGWSIIVLTIIIKLIFFPLSAASYRS---MARMRavsPKLQALKEQFGD-----DRQKMSQAMMELYK 446
Cdd:PRK00247 20 LHNVLGlddslAWFASLFGLVITVRAIIAPFTWQQYKSgrtAAHIR---PKRKALREEYKGktdeaSIRELQQKQKDLNK 96
|
90 100
....*....|....*....|....*...
gi 2285179005 447 KEKINPLGGCLPILVQMPVFLALYWVLL 474
Cdd:PRK00247 97 EYGYNPLAGCVPALIQIPVFLGLYQVLL 124
|
|
| YidC_peri |
cd19960 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
254-362 |
7.99e-04 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Gram-negative bacteria and similar domains; Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contains a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich. Other members of the YidC/Oxa1/Alb3 family include YidC1/YidC2 from gram-positive bacteria as well as eukaryotic members such as mitochondrial Oxa1/Oxa2 (or Cox18) and chloroplastic Alb3/Alb4; they are not part of this hierarchy as they do not possess the periplasmic domain.
Pssm-ID: 410999 Cd Length: 233 Bit Score: 41.47 E-value: 7.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2285179005 254 GAALWTPDEPYKKVSMKDMDK-QPFKetvQGGWVAWLQHYFVTAWVPSKDSTNLVQTrKDSQGNyivgftgPSVQVaaGA 332
Cdd:cd19960 137 GALVKTADGTITIIEDGDAEGtESFS---NVNIAASFDRYYATLFYNFDKGLNVVVT-KDASDN-------PLVFV--KG 203
|
90 100 110
....*....|....*....|....*....|
gi 2285179005 333 QGETGAILYAGPKLQEHLATLSPGLELTVD 362
Cdd:cd19960 204 NGNFSLHGYIGPKEYKLLKSIDPELTDVIE 233
|
|
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