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Conserved domains on  [gi|2282951782|ref|WP_256981016|]
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MULTISPECIES: helix-turn-helix domain-containing protein [unclassified Rhodococcus (in: high G+C Gram-positive bacteria)]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 12122938)

helix-turn-helix (HTH) domain-containing protein binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  10473770|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
124-191 5.65e-09

Helix-turn-helix domain;


:

Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 51.44  E-value: 5.65e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2282951782 124 RTLERRFRAATGLTRGGLEQIRRARRAAEMLAGRSD--VAGVVAALGYYDEPHLARGLRRFVGRTAGQLR 191
Cdd:pfam12833  10 RTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTGlsVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
 
Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
124-191 5.65e-09

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 51.44  E-value: 5.65e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2282951782 124 RTLERRFRAATGLTRGGLEQIRRARRAAEMLAGRSD--VAGVVAALGYYDEPHLARGLRRFVGRTAGQLR 191
Cdd:pfam12833  10 RTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTGlsVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
124-191 5.11e-08

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 52.09  E-value: 5.11e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2282951782 124 RTLERRFRAATGLTRGGLEQIRRARRAAEMLA-GRSDVAGVVAALGYYDEPHLARGLRRFVGRTAGQLR 191
Cdd:COG2207   183 RTLSRLFKEETGTSPKQYLRELRLERAKRLLAeTDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
124-191 1.54e-07

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 47.55  E-value: 1.54e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2282951782  124 RTLERRFRAATGLTRGGLEQIRRARRAAEMLA-GRSDVAGVVAALGYYDEPHLARGLRRFVGRTAGQLR 191
Cdd:smart00342  16 RHLQRLFKKETGTTPKQYLRDRRLERARRLLRdTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
ftrA PRK09393
transcriptional activator FtrA; Provisional
 124-196 3.77e-05

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 43.80  E-value: 3.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2282951782 124 RTLERRFRAATGLTRGGLEQIRRARRAAEML-AGRSDVAGVVAALGYYDEPHLARGLRRFVGRTAGQLRDGIGG 196
Cdd:PRK09393  249 RTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAYRKRFGR 322
 
Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
124-191 5.65e-09

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 51.44  E-value: 5.65e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2282951782 124 RTLERRFRAATGLTRGGLEQIRRARRAAEMLAGRSD--VAGVVAALGYYDEPHLARGLRRFVGRTAGQLR 191
Cdd:pfam12833  10 RTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTGlsVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
124-191 5.11e-08

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 52.09  E-value: 5.11e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2282951782 124 RTLERRFRAATGLTRGGLEQIRRARRAAEMLA-GRSDVAGVVAALGYYDEPHLARGLRRFVGRTAGQLR 191
Cdd:COG2207   183 RTLSRLFKEETGTSPKQYLRELRLERAKRLLAeTDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYR 251
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
124-191 1.54e-07

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 47.55  E-value: 1.54e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2282951782  124 RTLERRFRAATGLTRGGLEQIRRARRAAEMLA-GRSDVAGVVAALGYYDEPHLARGLRRFVGRTAGQLR 191
Cdd:smart00342  16 RHLQRLFKKETGTTPKQYLRDRRLERARRLLRdTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 124-191 1.84e-05

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 44.38  E-value: 1.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2282951782 124 RTLERRFRAATGLTRGGLEQIRRARRAAEML-AGRSDVAGVVAALGYYDEPHLARGLRRFVGRTAGQLR 191
Cdd:COG4977   241 RTLERRFRAATGTTPARYLQRLRLERARRLLeTTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYR 309
ftrA PRK09393
transcriptional activator FtrA; Provisional
 124-196 3.77e-05

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 43.80  E-value: 3.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2282951782 124 RTLERRFRAATGLTRGGLEQIRRARRAAEML-AGRSDVAGVVAALGYYDEPHLARGLRRFVGRTAGQLRDGIGG 196
Cdd:PRK09393  249 RTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAYRKRFGR 322
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
126-193 1.66e-04

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 41.70  E-value: 1.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2282951782 126 LERRFRAATGLTRGGLEQIRRARRAAEMLAGRSDVAGVVAALGYYDEPHLARGLRRFVGRTAGQLRDG 193
Cdd:PRK15435  116 LHRLFKATTGMTPKAWQQAWRARRLREALAKGESVTTSILNAGFPDSSSYYRKADETLGMTAKQFRHG 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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