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Conserved domains on  [gi|2278193536|ref|WP_255355000|]
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MobF family relaxase [Micrococcus sp. CH3]

Protein Classification

TrwC domain-containing protein( domain architecture ID 10555408)

TrwC domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TrwC pfam08751
TrwC relaxase; Relaxases are DNA strand transferases which function during the conjugative ...
10-227 1.45e-46

TrwC relaxase; Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer. TrwC binds to the origin of transfer (oriT) and melts the double helix.


:

Pssm-ID: 430190 [Multi-domain]  Cd Length: 279  Bit Score: 155.85  E-value: 1.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  10 AGDGYRYLlnsvvTGDDDrdapsaltkYYLESGTPPGFWLGSgvlglsggIAAG----GPVSEEQLRRLMGfGQDPDTGE 85
Cdd:pfam08751   1 AGDAYAYY-----TRQDD---------YYTEGGEPPGRWLGK--------GAAAlglsGEVTEEQFEALLE-GRHPDTGE 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  86 QLGRPYRRFATAaerlerrleelpggltgqerdaqvslieaeealkpmgapVAGFDLTFSVPKSVSTLWAVADGGIqalI 165
Cdd:pfam08751  58 RLGRRRPRGRKH---------------------------------------RAGFDLTFSAPKSVSLLAAVGGDER---I 95
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2278193536 166 AQAHHAAIQDVIALFERDAAMTRIGakgPRGAVAQVEVQGVIAAAYDHYDSRASDPQLHTHV 227
Cdd:pfam08751  96 EAAHRAAVAEALAWLEKHAAQTRVG---KDGGVEQVDTGGLVAAAFRHDTSRAGDPQLHTHV 154
 
Name Accession Description Interval E-value
TrwC pfam08751
TrwC relaxase; Relaxases are DNA strand transferases which function during the conjugative ...
10-227 1.45e-46

TrwC relaxase; Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer. TrwC binds to the origin of transfer (oriT) and melts the double helix.


Pssm-ID: 430190 [Multi-domain]  Cd Length: 279  Bit Score: 155.85  E-value: 1.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  10 AGDGYRYLlnsvvTGDDDrdapsaltkYYLESGTPPGFWLGSgvlglsggIAAG----GPVSEEQLRRLMGfGQDPDTGE 85
Cdd:pfam08751   1 AGDAYAYY-----TRQDD---------YYTEGGEPPGRWLGK--------GAAAlglsGEVTEEQFEALLE-GRHPDTGE 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  86 QLGRPYRRFATAaerlerrleelpggltgqerdaqvslieaeealkpmgapVAGFDLTFSVPKSVSTLWAVADGGIqalI 165
Cdd:pfam08751  58 RLGRRRPRGRKH---------------------------------------RAGFDLTFSAPKSVSLLAAVGGDER---I 95
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2278193536 166 AQAHHAAIQDVIALFERDAAMTRIGakgPRGAVAQVEVQGVIAAAYDHYDSRASDPQLHTHV 227
Cdd:pfam08751  96 EAAHRAAVAEALAWLEKHAAQTRVG---KDGGVEQVDTGGLVAAAFRHDTSRAGDPQLHTHV 154
MobF NF041492
MobF family relaxase;
1-227 9.14e-31

MobF family relaxase;


Pssm-ID: 469380 [Multi-domain]  Cd Length: 288  Bit Score: 114.71  E-value: 9.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536   1 MTVSiRVMTAGDGYRYLLnsvvtgDDDRDApsaltkYYL-ESGTPPGFWLGSGVLGLSggiAAGGPVSEEQLRRLMGfGQ 79
Cdd:NF041492    2 LSIA-RIGSAGGAARYYT------EKDLDN------YYSeDGGTPAGRWFGKGAEALG---LSGGAVDGERFKALLD-GR 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  80 DPDTGEQLGRPYRRfataaerlerrleelpggltGQERdaqvslieaeealkpmgapvAGFDLTFSVPKSVSTLWAVadG 159
Cdd:NF041492   65 LPDGERLRRRRKGA--------------------GRHR--------------------PGYDLTFSAPKSVSLLALV--G 102
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2278193536 160 GIQALIaQAHHAAIQDVIALFERDAAMTRIGAKGPRGAVaQVEVQGVIAAAYDHYDSRASDPQLHTHV 227
Cdd:NF041492  103 GDKRLI-EAHDEAVKEALEYLEERLAQTRVTVDGKGRTS-LEKTGNLVAALFRHDTSRAGDPQLHTHA 168
TraI_TIGR TIGR02760
conjugative transfer relaxase protein TraI; This protein is a component of the relaxosome ...
139-227 7.03e-15

conjugative transfer relaxase protein TraI; This protein is a component of the relaxosome complex. In the process of conjugative plasmid transfer the realaxosome binds to the plasmid at the oriT (origin of transfer) site. The relaxase protein TraI mediates the single-strand nicking and ATP-dependent unwinding (relaxation, helicase activity) of the plasmid molecule. These two activities reside in separate domains of the protein.


Pssm-ID: 274285 [Multi-domain]  Cd Length: 1960  Bit Score: 73.40  E-value: 7.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  139 GFDLTFSVPKSVSTLWAVadGGIQALIaQAHHAAIQDVIALFERDAAMTRIGAKGPRgavAQVEVQGVIAAAYDHYDSRA 218
Cdd:TIGR02760   83 GFDLTFSAPKSVSILALV--GGDKRLI-EAHDKAVKIAVSEMEKDAAQARQTVDGKT---EFINTRNLVFAMFRHKTSRE 156

                   ....*....
gi 2278193536  219 SDPQLHTHV 227
Cdd:TIGR02760  157 NDPQLHTHA 165
PRK13709 PRK13709
conjugal transfer nickase/helicase TraI; Provisional
139-226 2.54e-11

conjugal transfer nickase/helicase TraI; Provisional


Pssm-ID: 237478 [Multi-domain]  Cd Length: 1747  Bit Score: 62.89  E-value: 2.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  139 GFDLTFSVPKSVSTLWAVadGGIQALIAqAHHAAIQDVIALFERDAAmTRIGAKGprgaVAQVEVQG-VIAAAYDHYDSR 217
Cdd:PRK13709    78 GYDLTFSAPKSVSMMAML--GGDKRLIE-AHNQAVDFAVRQVEALAS-TRVMTDG----QSETVLTGnLVMALFNHDTSR 149

                   ....*....
gi 2278193536  218 ASDPQLHTH 226
Cdd:PRK13709   150 DQDPQLHTH 158
 
Name Accession Description Interval E-value
TrwC pfam08751
TrwC relaxase; Relaxases are DNA strand transferases which function during the conjugative ...
10-227 1.45e-46

TrwC relaxase; Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer. TrwC binds to the origin of transfer (oriT) and melts the double helix.


Pssm-ID: 430190 [Multi-domain]  Cd Length: 279  Bit Score: 155.85  E-value: 1.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  10 AGDGYRYLlnsvvTGDDDrdapsaltkYYLESGTPPGFWLGSgvlglsggIAAG----GPVSEEQLRRLMGfGQDPDTGE 85
Cdd:pfam08751   1 AGDAYAYY-----TRQDD---------YYTEGGEPPGRWLGK--------GAAAlglsGEVTEEQFEALLE-GRHPDTGE 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  86 QLGRPYRRFATAaerlerrleelpggltgqerdaqvslieaeealkpmgapVAGFDLTFSVPKSVSTLWAVADGGIqalI 165
Cdd:pfam08751  58 RLGRRRPRGRKH---------------------------------------RAGFDLTFSAPKSVSLLAAVGGDER---I 95
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2278193536 166 AQAHHAAIQDVIALFERDAAMTRIGakgPRGAVAQVEVQGVIAAAYDHYDSRASDPQLHTHV 227
Cdd:pfam08751  96 EAAHRAAVAEALAWLEKHAAQTRVG---KDGGVEQVDTGGLVAAAFRHDTSRAGDPQLHTHV 154
MobF NF041492
MobF family relaxase;
1-227 9.14e-31

MobF family relaxase;


Pssm-ID: 469380 [Multi-domain]  Cd Length: 288  Bit Score: 114.71  E-value: 9.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536   1 MTVSiRVMTAGDGYRYLLnsvvtgDDDRDApsaltkYYL-ESGTPPGFWLGSGVLGLSggiAAGGPVSEEQLRRLMGfGQ 79
Cdd:NF041492    2 LSIA-RIGSAGGAARYYT------EKDLDN------YYSeDGGTPAGRWFGKGAEALG---LSGGAVDGERFKALLD-GR 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  80 DPDTGEQLGRPYRRfataaerlerrleelpggltGQERdaqvslieaeealkpmgapvAGFDLTFSVPKSVSTLWAVadG 159
Cdd:NF041492   65 LPDGERLRRRRKGA--------------------GRHR--------------------PGYDLTFSAPKSVSLLALV--G 102
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2278193536 160 GIQALIaQAHHAAIQDVIALFERDAAMTRIGAKGPRGAVaQVEVQGVIAAAYDHYDSRASDPQLHTHV 227
Cdd:NF041492  103 GDKRLI-EAHDEAVKEALEYLEERLAQTRVTVDGKGRTS-LEKTGNLVAALFRHDTSRAGDPQLHTHA 168
TraI_TIGR TIGR02760
conjugative transfer relaxase protein TraI; This protein is a component of the relaxosome ...
139-227 7.03e-15

conjugative transfer relaxase protein TraI; This protein is a component of the relaxosome complex. In the process of conjugative plasmid transfer the realaxosome binds to the plasmid at the oriT (origin of transfer) site. The relaxase protein TraI mediates the single-strand nicking and ATP-dependent unwinding (relaxation, helicase activity) of the plasmid molecule. These two activities reside in separate domains of the protein.


Pssm-ID: 274285 [Multi-domain]  Cd Length: 1960  Bit Score: 73.40  E-value: 7.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  139 GFDLTFSVPKSVSTLWAVadGGIQALIaQAHHAAIQDVIALFERDAAMTRIGAKGPRgavAQVEVQGVIAAAYDHYDSRA 218
Cdd:TIGR02760   83 GFDLTFSAPKSVSILALV--GGDKRLI-EAHDKAVKIAVSEMEKDAAQARQTVDGKT---EFINTRNLVFAMFRHKTSRE 156

                   ....*....
gi 2278193536  219 SDPQLHTHV 227
Cdd:TIGR02760  157 NDPQLHTHA 165
relax_trwC TIGR02686
conjugative relaxase domain, TrwC/TraI family; This domain is in the N-terminal (relaxase) ...
139-227 1.34e-13

conjugative relaxase domain, TrwC/TraI family; This domain is in the N-terminal (relaxase) region of TrwC, a relaxase-helicase that acts in plasmid R388 conjugation. The relaxase domain has DNA cleavage and strand transfer activities. Plasmid transfer protein TraI is also a member of this domain family. Members of this family on bacterial chromosomes typically are found near other genes typical of conjugative plasmids and appear to mark integrated plasmids. [Mobile and extrachromosomal element functions, Plasmid functions]


Pssm-ID: 274258 [Multi-domain]  Cd Length: 283  Bit Score: 68.25  E-value: 1.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536 139 GFDLTFSVPKSVSTLWAVadGGIQALIaQAHHAAIQDVIALFERDAAMTRIGAKGPRgavAQVEVQGVIAAAYDHYDSRA 218
Cdd:TIGR02686  67 GFDLTFSAPKSVSILALV--GGDPRLI-DAHDEAVKFTLEQLEKEAAAARVTQDGEI---EFEKTGNLVIALFRHDTSRA 140

                  ....*....
gi 2278193536 219 SDPQLHTHV 227
Cdd:TIGR02686 141 NDPQLHTHA 149
PRK13709 PRK13709
conjugal transfer nickase/helicase TraI; Provisional
139-226 2.54e-11

conjugal transfer nickase/helicase TraI; Provisional


Pssm-ID: 237478 [Multi-domain]  Cd Length: 1747  Bit Score: 62.89  E-value: 2.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2278193536  139 GFDLTFSVPKSVSTLWAVadGGIQALIAqAHHAAIQDVIALFERDAAmTRIGAKGprgaVAQVEVQG-VIAAAYDHYDSR 217
Cdd:PRK13709    78 GYDLTFSAPKSVSMMAML--GGDKRLIE-AHNQAVDFAVRQVEALAS-TRVMTDG----QSETVLTGnLVMALFNHDTSR 149

                   ....*....
gi 2278193536  218 ASDPQLHTH 226
Cdd:PRK13709   150 DQDPQLHTH 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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