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Conserved domains on  [gi|2243420209|ref|WP_249826501|]
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replication endonuclease, partial [Escherichia coli]

Protein Classification

replication endonuclease( domain architecture ID 62063)

replication endonuclease similar to Shigella boydii probable replication endonuclease from prophage-like region, a possible endonuclease which induces a single-strand cut and initiates DNA replication

Gene Ontology:  GO:0006260|GO:0004519

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phage_GPA super family cl15276
Bacteriophage replication gene A protein (GPA); This family consists of a group of ...
 1-87 2.39e-27

Bacteriophage replication gene A protein (GPA); This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases.


The actual alignment was detected with superfamily member pfam05840:

Pssm-ID: 353932  Cd Length: 321  Bit Score: 101.03  E-value: 2.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2243420209   1 TMTAAMFSSTFEKLCDGFGATDGELTMDVTLKAYQMLARMALHLHAMPPHYdalttDKDRRNEPDTELLPGAILRLTCAE 80
Cdd:pfam05840   8 DEIAAAFSSTLEKLSDGDGADTEEDIDEELAQAYEVLAQLAISFTIDHPHY-----KKERKKKITAELLESAIARLTCEK 82


                  ....*..
gi 2243420209  81 WWKRKLW 87
Cdd:pfam05840  83 WWLRQLK 89
 
Name Accession Description Interval E-value
Phage_GPA pfam05840
Bacteriophage replication gene A protein (GPA); This family consists of a group of ...
 1-87 2.39e-27

Bacteriophage replication gene A protein (GPA); This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases.


Pssm-ID: 336220  Cd Length: 321  Bit Score: 101.03  E-value: 2.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2243420209   1 TMTAAMFSSTFEKLCDGFGATDGELTMDVTLKAYQMLARMALHLHAMPPHYdalttDKDRRNEPDTELLPGAILRLTCAE 80
Cdd:pfam05840   8 DEIAAAFSSTLEKLSDGDGADTEEDIDEELAQAYEVLAQLAISFTIDHPHY-----KKERKKKITAELLESAIARLTCEK 82


                  ....*..
gi 2243420209  81 WWKRKLW 87
Cdd:pfam05840  83 WWLRQLK 89
 
Name Accession Description Interval E-value
Phage_GPA pfam05840
Bacteriophage replication gene A protein (GPA); This family consists of a group of ...
 1-87 2.39e-27

Bacteriophage replication gene A protein (GPA); This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases.


Pssm-ID: 336220  Cd Length: 321  Bit Score: 101.03  E-value: 2.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2243420209   1 TMTAAMFSSTFEKLCDGFGATDGELTMDVTLKAYQMLARMALHLHAMPPHYdalttDKDRRNEPDTELLPGAILRLTCAE 80
Cdd:pfam05840   8 DEIAAAFSSTLEKLSDGDGADTEEDIDEELAQAYEVLAQLAISFTIDHPHY-----KKERKKKITAELLESAIARLTCEK 82


                  ....*..
gi 2243420209  81 WWKRKLW 87
Cdd:pfam05840  83 WWLRQLK 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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