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Conserved domains on  [gi|2214601648|ref|WP_242923268|]
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Lrp/AsnC family transcriptional regulator [Caulobacter sp. CCUG 60055]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-146 2.00e-50

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 158.02  E-value: 2.00e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214601648   9 DRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAIERYAAVINQQAVGLPLNVFITITLNGQseaALRT 88
Cdd:COG1522     4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPH---RLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2214601648  89 FETEIAAVPEVMECYLMTGSADYLVRVVARDIDDLERIHSTRLTRLTGVARVTSSIAM 146
Cdd:COG1522    81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-146 2.00e-50

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 158.02  E-value: 2.00e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214601648   9 DRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAIERYAAVINQQAVGLPLNVFITITLNGQseaALRT 88
Cdd:COG1522     4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPH---RLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2214601648  89 FETEIAAVPEVMECYLMTGSADYLVRVVARDIDDLERIHSTRLTRLTGVARVTSSIAM 146
Cdd:COG1522    81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 9-117 8.13e-35

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 117.23  E-value: 8.13e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214601648    9 DRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAIERYAAVINQQAVGLPLNVFITITLNGQSeaALRT 88
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPD--KLEE 79

                           90       100
                   ....*....|....*....|....*....
gi 2214601648   89 FETEIAAVPEVMECYLMTGSADYLVRVVA 117
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-149 1.13e-26

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 98.29  E-value: 1.13e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214601648   1 MTKSASNFDRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAIERYAAVINQQAVGLPLNVFITITLNG 80
Cdd:PRK11169    5 KKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNR 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2214601648  81 QSEAALRTFETEIAAVPEVMECYLMTGSADYLVRVVARDIDDLERIHSTRLTRLTGVARVTSSIAMRQV 149
Cdd:PRK11169   85 GAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEV 153
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 74-148 1.06e-22

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 85.27  E-value: 1.06e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2214601648  74 ITITLNGQSeaALRTFETEIAAVPEVMECYLMTGSADYLVRVVARDIDDLERIHSTRLTRLTGVARVTSSIAMRQ 148
Cdd:pfam01037   1 VEVKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-57 2.08e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 2.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2214601648   9 DRTDLTLLRSLqRDGRATNAELARDASMSESACLRRVRLLEANGAIERY 57
Cdd:cd00090     6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-146 2.00e-50

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 158.02  E-value: 2.00e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214601648   9 DRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAIERYAAVINQQAVGLPLNVFITITLNGQseaALRT 88
Cdd:COG1522     4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPH---RLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2214601648  89 FETEIAAVPEVMECYLMTGSADYLVRVVARDIDDLERIHSTRLTRLTGVARVTSSIAM 146
Cdd:COG1522    81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 9-117 8.13e-35

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 117.23  E-value: 8.13e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214601648    9 DRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAIERYAAVINQQAVGLPLNVFITITLNGQSeaALRT 88
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPD--KLEE 79

                           90       100
                   ....*....|....*....|....*....
gi 2214601648   89 FETEIAAVPEVMECYLMTGSADYLVRVVA 117
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-149 1.13e-26

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 98.29  E-value: 1.13e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214601648   1 MTKSASNFDRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAIERYAAVINQQAVGLPLNVFITITLNG 80
Cdd:PRK11169    5 KKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNR 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2214601648  81 QSEAALRTFETEIAAVPEVMECYLMTGSADYLVRVVARDIDDLERIHSTRLTRLTGVARVTSSIAMRQV 149
Cdd:PRK11169   85 GAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEV 153
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 74-148 1.06e-22

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 85.27  E-value: 1.06e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2214601648  74 ITITLNGQSeaALRTFETEIAAVPEVMECYLMTGSADYLVRVVARDIDDLERIHSTRLTRLTGVARVTSSIAMRQ 148
Cdd:pfam01037   1 VEVKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 7-156 2.09e-11

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 58.18  E-value: 2.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214601648   7 NFDRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAIERYAAVINQQAVGLPLNVFITITLN--GQSEA 84
Cdd:PRK11179    6 QIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKsaKDYPS 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2214601648  85 ALRTFEteiaAVPEVMECYLMTGSADYLVRVVARDIDDLERIHSTRLTRLTGVARVTSSIAMRQVIKRAELP 156
Cdd:PRK11179   86 ALAKLE----SLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
9-49 1.07e-10

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 53.53  E-value: 1.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2214601648   9 DRTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLE 49
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
10-54 2.07e-08

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 47.81  E-value: 2.07e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2214601648  10 RTDLTLLRSLQRDGRATNAELARDASMSESACLRRVRLLEANGAI 54
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-57 2.08e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 2.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2214601648   9 DRTDLTLLRSLqRDGRATNAELARDASMSESACLRRVRLLEANGAIERY 57
Cdd:cd00090     6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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