|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
1-383 |
1.74e-155 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 442.95 E-value: 1.74e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 1 MHTTTFLVHAGRETAHAVQAINPPLVRASTVVFDTLAAYKhAHHQTVFDSPRYGRSGTSTTFELQRCMAALSGAETCLAT 80
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALA-ARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 81 ASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFP--EGADITPYLRDNTSLVYIETPASLTMEM 158
Cdd:COG0626 80 ASGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDptDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 159 LDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS-GAHA 237
Cdd:COG0626 160 VDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNAlGAVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 238 APDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPcSEAAFA 317
Cdd:COG0626 240 SPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKG-GREAAR 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2212175695 318 AFIDALALFSLGTSWGGYESLVLP-------AVPYDLRHLATLPDegRLVRLHVGLEDAADLRADLAQALSGL 383
Cdd:COG0626 319 RFLDALKLFTLAVSLGGVESLITHpatmthrSLPPEERAALGITD--GLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
20-381 |
1.86e-123 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 360.75 E-value: 1.86e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 20 AINPPLVRASTVVFDTLAAYKHAHHQTVFDsPRYGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGR 99
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPAEAADLFALREGG-YIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 100 HLLLNQGVYGPTRIFCDQELVPQGTTVEYFP--EGADITPYLRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAV 177
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDpdDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 178 DATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFcDRS--GAHAAPDVCWLALRGLRTLAVR 255
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRF-LRLalGTILSPFDAWLLLRGLKTLPLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 256 LERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEAAfAAFIDALALFSLGTSWGGY 335
Cdd:cd00614 240 MERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAA-KKFLNALKLFSLAVSLGGV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2212175695 336 ESLVLPAVPydlRHLATLPDEGR--------LVRLHVGLEDAADLRADLAQALS 381
Cdd:cd00614 319 ESLVEHPAS---MTHSQLPPEERaaagitpgLVRLSVGIEDVEDLIADLEQALK 369
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
5-380 |
1.66e-118 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 348.45 E-value: 1.66e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVVFDTlaAYKHAHHQtvfdsprYGRSGTSTTFELQRCMAALSGAETCLATASGL 84
Cdd:pfam01053 2 TLAVHAGQRPDPQTGAVSVPIYLTSTYVFDF--AGEEGGYD-------YSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 85 AAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFP--EGADITPYLRDNTSLVYIETPASLTMEMLDAR 162
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDtsDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 163 AVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS-GAHAAPDV 241
Cdd:pfam01053 153 AIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNAtGAVLSPFD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 242 CWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEAAfAAFID 321
Cdd:pfam01053 233 AWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAA-KKFLD 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2212175695 322 ALALFSLGTSWGGYESLVLpaVPYDLRHlATLPDEGR--------LVRLHVGLEDAADLRADLAQAL 380
Cdd:pfam01053 312 NLKLFSLAVSLGGVESLIS--HPATMTH-ASIPPEEReaagitddLIRLSVGIEDVDDLIADLKQAL 375
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
5-383 |
1.71e-111 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 330.69 E-value: 1.71e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVVFDTLAAYKHAHHQTVfdsprYGRSGTSTTFELQRCMAALSGAETCLATASGL 84
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDSHAAQRRAKGELT-----YGRRGTLTHFALQDAMCELEGGAGCYLYPSGL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 85 AAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPE--GADITPYLRDNTSLVYIETPASLTMEMLDAR 162
Cdd:TIGR01324 76 AAVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPliGEDIATLIQPNTKVLFLEAPSSITFEIQDIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 163 AVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRR-FCDrSGAHAAPDV 241
Cdd:TIGR01324 156 AIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANARTWDQLREhSYL-MGQMVDADD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 242 CWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEAAFAAFID 321
Cdd:TIGR01324 235 AYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQVHAFLD 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2212175695 322 ALALFSLGTSWGGYESLVLPAVPY-DLRHLATLPDEGRLVRLHVGLEDAADLRADLAQALSGL 383
Cdd:TIGR01324 315 HLQLFGLGYSWGGYESLALCNQPElGHRPNIKRNLEGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
3-381 |
4.04e-106 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 317.91 E-value: 4.04e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 3 TTTFLVHAGRETAHAVQAINPPLVRASTVVFDTlAAYKHAHHQTVfdspRYGRSGTSTTFELQRCMAALSGAETCLATAS 82
Cdd:PRK05967 13 INTRLAHDGNDPGDYHGFVNPPVVHASTVLFPD-AETMATRGQKY----TYGTRGTPTTDALCKAIDALEGSAGTILVPS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 83 GLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYF-PE-GADITPYLRDNTSLVYIETPASLTMEMLD 160
Cdd:PRK05967 88 GLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYdPEiGAGIAKLMRPNTKVVHTEAPGSNTFEMQD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 161 ARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRSGAHAAPD 240
Cdd:PRK05967 168 IPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCWPQLLEAHGTLGLCAGPD 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 241 VCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELA---PCSEAAFA 317
Cdd:PRK05967 248 DTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAagpEKGKAKAH 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2212175695 318 AFIDALALFSLGTSWGGYESLVLPAVPYDlRHLATLPDEGRLVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK05967 328 AFLDALEIFGLGYSWGGYESLALHVKLGD-RTVAKAPYAGPVIRLQIGLEDVPDLKADLERGFA 390
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
2-377 |
7.23e-105 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 314.33 E-value: 7.23e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 2 HTTTFLVHAGRETAHAVQAINPPLVRASTVVFDTLAAYKHA----HHQTVFdsprYGRSGTSTTFELQRCMAALSGAETC 77
Cdd:PRK08114 5 KLDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEAKKHAtrnrANGELF----YGRRGTLTHFSLQEAMCELEGGAGC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 78 LATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPE--GADITPYLRDNTSLVYIETPASLT 155
Cdd:PRK08114 81 ALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPliGADIAKLIQPNTKVVFLESPGSIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 156 MEMLDARAVCAAARQRH--IPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS 233
Cdd:PRK08114 161 MEVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARCWEQLRENSYLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 234 GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFEL-APCS 312
Cdd:PRK08114 241 GQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLkKKLT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2212175695 313 EAAFAAFIDALALFSLGTSWGGYESLVLPAVPYDLRHLATLPD---EGRLVRLHVGLEDAADLRADLA 377
Cdd:PRK08114 321 DEQLANYLDNFSLFSMAYSWGGFESLILANQPEEIAAIRPAGEvdfTGTLIRLHIGLEDVDDLIADLA 388
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
1-384 |
2.54e-104 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 313.20 E-value: 2.54e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 1 MHTTTFLVHAGRETAHAVQAINPPLVRASTVVFDTLAAYK-HAHHQTVFdsPRYGRSGTSTTFELQRCMAALSGAETCLA 79
Cdd:PRK07050 8 RALQTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATMRaLDWRQDVQ--WRYGLHATPTSLALAQRLAEIEGGRHALL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 80 TASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPE--GADITPYLRDNTSLVYIETPASLTME 157
Cdd:PRK07050 86 QPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPliGAGIADLIQPNTRLIWLEAPGSVTME 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 158 MLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLG-LITGS---HADLASTRRfcdRS 233
Cdd:PRK07050 166 VPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGaTITADaelHAKLKLARM---RL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 234 GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFEL-APCS 312
Cdd:PRK07050 243 GIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFdERYS 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2212175695 313 EAAFAAFIDALALFSLGTSWGGYESLvlpAVPYDLRHL--ATLPDEGRLVRLHVGLEDAADLRADLAQALSGLG 384
Cdd:PRK07050 323 PAQVDAFVEALELFAIGWSWGGACSL---AMPYDVASMrtAKWPHRGTLVRLYIGLEDEADLIADLEQALEAAL 393
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
1-381 |
6.20e-104 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 312.05 E-value: 6.20e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 1 MHTTTFLVHAGRETAHAVQAINPPLVRASTVVFDTLAAYKHA----HHQTVFdsprYGRSGTSTTFELQRCMAALSGAET 76
Cdd:PRK09028 3 EKKATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAEMRHAaknrANGEMF----YGRRGTPTHFAFQAAIVELEGGAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 77 CLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPE--GADITPYLRDNTSLVYIETPASL 154
Cdd:PRK09028 79 TALYPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPmiGEGIRELIRPNTKVLFLESPGSI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 155 TMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRSG 234
Cdd:PRK09028 159 TMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQLREHSYLMG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 235 AHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEA 314
Cdd:PRK09028 239 QCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKQGDPK 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2212175695 315 AFAAFIDALALFSLGTSWGGYESLVLPAVPYDLRHLATLPD-EGRLVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK09028 319 AVTALVEGMQHFKMGFSWGGFESLILGVFGINKLRTATNWDfSKPLIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
1-384 |
1.48e-74 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 236.33 E-value: 1.48e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 1 MHTTTFLVHAGRETAHAVQAINPPLVRASTVVFDTLAAYKHAHhqtvfdsprYGRSGTSTTFELQRCMAALSGAETCLAT 80
Cdd:PRK06176 1 MRMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYE---------YSRSGNPTRFALEELIADLEGGVKGFAF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 81 ASGLAAIVAVLSAHaGPGRHLLLNQGVYGPTRIFCDQELVPQGT--TVEYFPEGADITPYLRDNTSLVYIETPASLTMEM 158
Cdd:PRK06176 72 ASGLAGIHAVFSLF-QSGDHVLLGDDVYGGTFRLFDKVLVKNGLscTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 159 LDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS-GAHA 237
Cdd:PRK06176 151 TDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAiGGVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 238 APDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEAafA 317
Cdd:PRK06176 231 GPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSEA--V 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2212175695 318 AFIDALALFSLGTSWGGYESLVlpAVPYDLRHlATLPDEGR--------LVRLHVGLEDAADLRADLAQALSGLG 384
Cdd:PRK06176 309 AFVESLKLFILGESLGGVESLV--GIPAFMTH-ACIPKEQReaagirdgLVRLSVGIEHEQDLLEDLEQAFAKIG 380
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
15-382 |
2.56e-74 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 235.75 E-value: 2.56e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 15 AHAVQAINPPLVRASTVVFDTLAAYkhahhQTVF----DSPRYGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAV 90
Cdd:PRK05968 20 GNAFDAVVPPIFQTSLFTFDSYDEM-----EDVYagekVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISST 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 91 LSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYF-PEGADITPYLRDNTSLVYIETPASLTMEMLDARAVCAAAR 169
Cdd:PRK05968 95 VLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVdGRDEEAVAKALPGAKLLYLESPTSWVFELQDVAALAALAK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 170 QRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLAstrRFCDRS----GAHAAPDVCWLA 245
Cdd:PRK05968 175 RHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIA---RINAEAypylGAKLSPFEAWLL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 246 LRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPghalwRAQFSGAAGPFTFELAPcsEAAFAAFIDALAL 325
Cdd:PRK05968 252 LRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHP-----PAGLSGTSGLFSFIFRE--GIDVRAFADALKL 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2212175695 326 FSLGTSWGGYESLVLPA-----VPYDLRHLATLPDEGRLVRLHVGLEDAADLRADLAQALSG 382
Cdd:PRK05968 325 FRLGVSWGGHESLVVPAevvlqQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALAA 386
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
5-381 |
4.18e-74 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 235.31 E-value: 4.18e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVVFDTLAAYKHAHHqtvfdsprYGRSGTSTTFELQRCMAALSGAETCLATASGL 84
Cdd:PRK07811 15 TRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLRGGYE--------YARTGNPTRTALEEQLAALEGGAYGRAFSSGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 85 AAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGttVEYFPegADIT------PYLRDNTSLVYIETPASLTMEM 158
Cdd:PRK07811 87 AATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWG--VEYTP--VDLSdldavrAAITPRTKLIWVETPTNPLLSI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 159 LDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS-GAHA 237
Cdd:PRK07811 163 TDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGaGAVP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 238 APDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEAAfA 317
Cdd:PRK07811 243 GPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAA-R 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 318 AFIDALALFSLGTSWGGYESLVlpAVPYDLRHLAT------LPDEgrLVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK07811 322 DFCARTKVFTLAESLGGVESLI--EHPSAMTHASTagsqleVPDD--LVRLSVGIEDVADLLADLEQALG 387
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
1-381 |
2.02e-68 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 220.37 E-value: 2.02e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 1 MHTTTFLVHAGRETAHAVQAINPPLVRASTvvFDTLAAYKHAHHQtvfdsprYGRSGTSTTFELQRCMAALSGAETCLAT 80
Cdd:PRK07671 1 MRAKTKLIHGGIIGDPSTGAVSVPIYQVST--YKQEAVGKHQGYE-------YSRTGNPTRAALEELIAVLEGGHAGFAF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 81 ASGLAAIVAVLSAHAGpGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPEG--ADITPYLRDNTSLVYIETPASLTMEM 158
Cdd:PRK07671 72 GSGMAAITAVMMLFSS-GDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSnlEEVEEAIRPNTKAIYVETPTNPLLKI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 159 LDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS-GAHA 237
Cdd:PRK07671 151 TDIKKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNStGGIL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 238 APDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELApcSEAAFA 317
Cdd:PRK07671 231 GPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDVG--SEETAN 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2212175695 318 AFIDALALFSLGTSWGGYESLVlpAVPYDLRHlATLPDEGR--------LVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK07671 309 KVLERLQYFTLAESLGAVESLI--SIPSQMTH-ASIPADRRkelgitdgLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
4-381 |
2.55e-68 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 220.83 E-value: 2.55e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 4 TTFLVHAGRETAHAVQAINPPLVRASTVVFDTlAAYKHAHHQTVFDSPRYGRSGTSTTFELQRCMAALSGAETCLATASG 83
Cdd:PRK07503 11 STRAIHHGYDPLDHGGALVPPVYLTATFAFPT-AEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 84 LAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEY--FPEGADITPYLRDNTSLVYIETPASLTMEMLDA 161
Cdd:PRK07503 90 MGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHvdLTDPAALKAAISDKTRMVYFETPANPNMRLVDI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 162 RAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFC--DRSGAHAAP 239
Cdd:PRK07503 170 AAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRIRLEGlkDMTGAVMSP 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 240 DVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEAAfAAF 319
Cdd:PRK07503 250 FDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAG-RRF 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2212175695 320 IDALALFSLGTSWGGYESLVlpAVPYDLRHLATLPDEGR-------LVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK07503 329 MNALQLFARAVSLGDAESLA--QHPASMTHSTYTPEERAehgisegLVRLSVGLEDVADILADLAQALD 395
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
2-383 |
1.64e-67 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 218.17 E-value: 1.64e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 2 HTTTFLVHAGRETAHAVQAINPPLVRASTVVFDTlAAYKHAHHQTVFDSPRYGRSGTSTTFELQRCMAALSGAETCLATA 81
Cdd:PRK06767 5 HMETALIHHGYTSEEHKGSLTPPLFQTSTFTFET-AQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 82 SGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCD--QELVPQGTTVEYFPEGADITPYLRDNTSLVYIETPASLTMEML 159
Cdd:PRK06767 84 SGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEvlEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 160 DARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS-GAHAA 238
Cdd:PRK06767 164 DLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDiGGIMA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 239 PDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPAlpsdpgHALWRAQFSGAAGPFTFELAPCSEAAfAA 318
Cdd:PRK06767 244 PFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPE------GELASRQMKRGGGVISFSIKGGKEET-QA 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2212175695 319 FIDALALFSLGTSWGGYESLVlpAVPYDLRHlATLPDEGR--------LVRLHVGLEDAADLRADLAQALSGL 383
Cdd:PRK06767 317 FINDLHFITIAVSLGDTETLI--QHPATMTH-AAIPAELRqemgiydnLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
5-383 |
6.48e-66 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 213.32 E-value: 6.48e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVvfdtlaaykHAHHQTVFDSPRYGRSGTSTTFELQRCMAALSGAEtCLATASGL 84
Cdd:PRK07582 6 TRSVHAGGPEAVPGEPVLPGPVFAAPY---------HLSPGEPTGPDTYGRASNPTWRALEAALGELEGAE-ALVFPSGM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 85 AAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPEGADITPYLrDNTSLVYIETPASLTMEMLDARAV 164
Cdd:PRK07582 76 AAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGMAEAAL-AGADLVLAETPSNPGLDVCDLAAL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 165 CAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADL-ASTRRFCDRSGAHAAPDVCW 243
Cdd:PRK07582 155 AAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELmAAVERWRLLAGAIPGPFEAW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 244 LALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELApcSEAAFAAFIDAL 323
Cdd:PRK07582 235 LAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFELA--DAAAAERFVAAS 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2212175695 324 ALFSLGTSWGGYESLVL------PAVPydlrhlatlpdEGrLVRLHVGLEDAADLRADLAQALSGL 383
Cdd:PRK07582 313 RLVVAATSFGGVHTSADrrarwgDAVP-----------EG-FVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
5-381 |
2.50e-65 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 212.71 E-value: 2.50e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVvfdtlaaykhahHQTVFDS---PRYGRSGTSTTFELQRCMAALSGAETCLATA 81
Cdd:PRK08064 9 TLLLHNQYKHDKQTGAVNVPIYHASTF------------HQFDFDTfgkYDYSRSGNPTREALEDIIAELEGGTKGFAFA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 82 SGLAAIVA---VLSAhagpGRHLLLNQGVYGPTRIFCDQELVPQGttVEY-FPEGAD---ITPYLRDNTSLVYIETPASL 154
Cdd:PRK08064 77 SGMAAISTaflLLSK----GDHVLISEDVYGGTYRMITEVLSRFG--IEHtFVDMTNleeVAQNIKPNTKLFYVETPSNP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 155 TMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS- 233
Cdd:PRK08064 151 LLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSf 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 234 GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELApcSE 313
Cdd:PRK08064 231 GAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQ--SE 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2212175695 314 AAFAAFIDALALFSLGTSWGGYESLVlpAVPYDLRHlATLPDEGR--------LVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK08064 309 EAVRQFVSHVKLPVFAVSLGAVESIL--SYPAKMSH-AAMPKEERdergitdgLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
58-382 |
1.30e-64 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 210.63 E-value: 1.30e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 58 TSTTFElQRcMAALSGAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPeGADITP 137
Cdd:PRK08133 62 TVTMFQ-ER-LAALEGAEACVATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVD-LTDLDA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 138 Y---LRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLG 214
Cdd:PRK08133 139 WraaVRPNTKLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 215 LITGSHADLASTRRFCDRSGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWR 294
Cdd:PRK08133 219 AVVGSKELMEEVFGFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAK 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 295 AQFSGAAGPFTFELAPCSEAAFaAFIDALALFSLGTSWGGYESLVlpAVPYDLRHlATLPDEGR--------LVRLHVGL 366
Cdd:PRK08133 299 RQQKGGGAIVSFEVKGGREAAW-RVIDATRLISITANLGDTKTTI--THPATTTH-GRLSPEARaaagitegLIRVAVGL 374
|
330
....*....|....*.
gi 2212175695 367 EDAADLRADLAQALSG 382
Cdd:PRK08133 375 EDVADIKADLARGLAA 390
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
53-380 |
1.27e-62 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 205.45 E-value: 1.27e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 53 YGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAhAGPGRHLLLNQGVYGPTRIFCDQeLVPQ-GTTVEYFP- 130
Cdd:TIGR01329 41 YTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITRL-LNNGDEIIAGDDLYGGTDRLLTQ-VVPRsGVVVVHVDt 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 131 -EGADITPYLRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHS 209
Cdd:TIGR01329 119 tDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 210 DLMLGLITGSHADLASTRRFCDRS-GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDP 288
Cdd:TIGR01329 199 DVMAGVLAVKGEEIAKKVYFLQNStGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHP 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 289 GHALWRAQFSGAAGPFTFELApcSEAAFAAFIDALALFSLGTSWGGYESLV-LP------AVPYDLRHLATLPDEgrLVR 361
Cdd:TIGR01329 279 GFHLHFSQAKGAGSVLSFETG--SVALSKRLVEATKLFSITVSFGSVNSLIsMPcfmshaSIPAEVREERGLPED--LVR 354
|
330
....*....|....*....
gi 2212175695 362 LHVGLEDAADLRADLAQAL 380
Cdd:TIGR01329 355 LSVGIEDVDDLISDLDIAF 373
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
8-380 |
1.54e-62 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 205.83 E-value: 1.54e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 8 VHAGRETAHAVQAINPPLVRASTVVFDTL--AAYKHAHHQtvfDSPRYGRSGTSTTFELQRCMAALSGAETCLATASGLA 85
Cdd:PRK06234 14 IHGGHIGDKQFGSLATPIYQTSTFIFDSAeqGGRRFAGEE---SGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 86 AIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYF----PEgaDITPYLRDNTSLVYIETPASLTMEMLDA 161
Cdd:PRK06234 91 AISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVdtsnLE--EVRNALKANTKVVYLETPANPTLKVTDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 162 RAVCAAARQRH--IPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGShADLASTRRFC---DRSGAH 236
Cdd:PRK06234 169 KAISNIAHENNkeCLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGK-EEFINQVKLFgikDMTGSV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 237 AAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEAAf 316
Cdd:PRK06234 248 IGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEG- 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2212175695 317 AAFIDALALFSLGTSWGGYESLVL-PA----VPY--DLRHLATLPDEgrLVRLHVGLEDAADLRADLAQAL 380
Cdd:PRK06234 327 KVVMNNVKLATLAVSLGDAETLIQhPAsmthSPYtaEERKEAGISDG--LVRLSVGLEDVDDIIADLKQAL 395
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
2-383 |
2.08e-60 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 199.16 E-value: 2.08e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 2 HTTTFLVHAGRETAHAVQAINPPlvrastVVFDTlaAYKHAH--HQTVFDsprYGRSGTSTTFELQRCMAALSGAETCLA 79
Cdd:PRK08247 4 TIETKLAQIGNRSDERTGTVNPP------VYFST--AYRHEGigESTGFD---YSRTGNPTRGVLEQAIADLEGGDQGFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 80 TASGLAAIVAVLSAHAGPGrHLLLNQGVYGPT-RIFcDQELVPQGTTVEY--FPEGADITPYLRDNTSLVYIETPASLTM 156
Cdd:PRK08247 73 CSSGMAAIQLVMSLFRSGD-ELIVSSDLYGGTyRLF-EEHWKKWNVRFVYvnTASLKAIEQAITPNTKAIFIETPTNPLM 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 157 EMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLItgshadLASTRRFCDR---- 232
Cdd:PRK08247 151 QETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLV------VAKGQELCERlayy 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 233 ---SGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPalpsdpghalwraqfsGAAGPFTFELA 309
Cdd:PRK08247 225 qnaAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP----------------GRGGMLSFRLQ 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 310 pcSEAAFAAFIDALALFSLGTSWGGYESLVlpAVPYDLRHlATLPDE--------GRLVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK08247 289 --DEEWVNPFLKSLKLITFAESLGGVESFI--TYPATQTH-ADIPEEiriangvcNRLLRFSVGIENVEDLIADLKQAFK 363
|
..
gi 2212175695 382 GL 383
Cdd:PRK08247 364 QV 365
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
2-383 |
6.95e-60 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 198.81 E-value: 6.95e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 2 HTTTFLVHAGRETAHAVQAINPPLVRASTVVFDTL------AAYKHAHHQtvfdsprYGRSGTSTTFELQRCMAALSGAE 75
Cdd:PRK08249 8 GVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIdewydvALGKKPGHI-------YSRNTNPTVQAFEEKVRILEGAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 76 TCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPT-RIFcdQELVP-QGTTVEYFPEG--ADITPYLRDNTSLVYIETP 151
Cdd:PRK08249 81 AATAFSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTnKIF--TEFLPrMGVDVTLCETGdhEQIEAEIAKGCDLLYLETP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 152 ASLTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCD 231
Cdd:PRK08249 159 TNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKELMEQVYHYRE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 232 RSGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPC 311
Cdd:PRK08249 239 INGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2212175695 312 SEAAfAAFIDALALFSLGTSWGGYESLVLPAvpYDLRHLATLPDEGR-------LVRLHVGLEDAADLRADLAQALSGL 383
Cdd:PRK08249 319 MDTV-KRLLPKLRYAHRAANLGAVETIYGPA--RTTSHVENTLEERAalgipegLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
52-383 |
3.33e-58 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 194.13 E-value: 3.33e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 52 RYGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTrIFCDQELVPQGT-TVEYFP 130
Cdd:PRK08574 46 KYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLFFSLLKAGDRVVLPMEAYGTT-LRLLKSLEKFGVkVVLAYP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 131 EGADITPYLRD-NTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHS 209
Cdd:PRK08574 125 STEDIIEAIKEgRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHN 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 210 DLMLGLITGSHA----DLASTRRfcdRSGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALP 285
Cdd:PRK08574 205 DVVGGVAVAWSGefleELWEWRR---RLGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLP 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 286 SDPGHALWRAQFSGA--AGPFTFELAPCSEAAFaAFIDALALFSLGTSWGGYESLVLpavpYDLRHLA-TLPDEGR---- 358
Cdd:PRK08574 282 SDPYHGVAKRLFGKDlyGGVVSFRVKGGRDAVL-KFLRSLKLIKPSPSLGGVESLAT----YPVKSAAsPIPEEDRkalg 356
|
330 340
....*....|....*....|....*....
gi 2212175695 359 ----LVRLHVGLEDAADLRADLAQALSGL 383
Cdd:PRK08574 357 itedLVRLSVGLEDVEDLIEDLDQALGSI 385
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
2-380 |
1.22e-57 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 193.28 E-value: 1.22e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 2 HTTTFLVHAG--RETAHAvqAINPPLVRASTVVFDTLAaykhahHQTVFDsprYGRSGTSTTFELQRCMAALSGAETCLA 79
Cdd:PRK08776 12 SAATAAVRAGidRDTAYG--AVTPPIVLSSNFSFDGFG------NKRQYD---YTRSGNPTRDLLGEALAELEGGAGGVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 80 TASGLAAIVAVLSAHAGPGRHLLLNQGVYGPT-RIFcdQELVPQG----TTVEyFPEGADITPYLRDNTSLVYIETPASL 154
Cdd:PRK08776 81 TATGMGAINLVLNALLQPGDTLVVPHDAYGGSwRLF--NALAKKGhfalITAD-LTDPRSLADALAQSPKLVLIETPSNP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 155 TMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS- 233
Cdd:PRK08776 158 LLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANAl 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 234 GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCsE 313
Cdd:PRK08776 238 GLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGG-E 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2212175695 314 AAFAAFIDALALFSLGTSWGGYESLVlpAVPYDLRHLATLPdEGR--------LVRLHVGLEDAADLRADLAQAL 380
Cdd:PRK08776 317 AAVRAFVDGLRYFTLAESLGGVESLI--AHPASMTHAAMTA-EARaaagisdgLLRLSVGIESAEDLLIDLRAGL 388
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-380 |
4.12e-56 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 189.47 E-value: 4.12e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 1 MHTTTFLVHAGRETAHAVQAINPPLVRASTVVFDTlaaykHAHHQTVFD----SPRYGRSGTSTTFELQRCMAALSGAET 76
Cdd:COG2873 6 YGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDD-----AEHAADLFAlkepGNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 77 CLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFP--EGADITPYLRDNTSLVYIETPASL 154
Cdd:COG2873 81 ALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDpdDPEAFEAAIDPNTKAIFGETIGNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 155 TMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLI----------TGSHADLA 224
Cdd:COG2873 161 ALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwaaNGKFPELT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 225 ST------RRFCDRSGAHA-----------------APDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLF 281
Cdd:COG2873 241 EPdpsyhgLVYTEAFGNAAfitkarvqllrdlgaalSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 282 PALPSDPGHALWRAQFSGAAGP-FTFELAPCSEAAfAAFIDALALFSLGTSWGGYESLVLpavpydlrHLAT-----LPD 355
Cdd:COG2873 321 PGLPSHPYHELAQKYLPKGAGGvLTFGLKGGREAG-KKFIDSLKLFSHLANIGDAKSLVI--------HPAStthsqLSE 391
|
410 420 430
....*....|....*....|....*....|...
gi 2212175695 356 EGR--------LVRLHVGLEDAADLRADLAQAL 380
Cdd:COG2873 392 EEQaaagvtpdLIRLSVGIEDIDDIIADLDQAL 424
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
68-380 |
1.04e-55 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 188.73 E-value: 1.04e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 68 MAALSGAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPEGADI--------TPYL 139
Cdd:PRK07049 92 LAVYEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFADGLSEaaigaaaeAAAA 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 140 RDNTSLVYIETPASLTMEMLD---ARAVCAA--ARQRHIP-VAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLML 213
Cdd:PRK07049 172 KGRVSLILIETPANPTNSLVDvaaVRRVADAieARQGHRPiIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVA 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 214 GLITGSHADLASTRRFCDRSGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPAL--PSDPGHA 291
Cdd:PRK07049 252 GAVLGRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGA 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 292 LWRAQFSGAAGPFTFELAPCSEAAFaAFIDALALFSLGTSWGGYESLV-LPA------VPYDLRHLATLPDEgrLVRLHV 364
Cdd:PRK07049 332 VYKRQCTGAGSTFSFDIKGGQAAAF-RFLNALQIFKLAVSLGGTESLAsHPAsmthsgVPADVRERIGVLES--TIRLSI 408
|
330
....*....|....*.
gi 2212175695 365 GLEDAADLRADLAQAL 380
Cdd:PRK07049 409 GIEHPDDLIADLAQAL 424
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
5-381 |
1.51e-52 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 179.32 E-value: 1.51e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVVFDTLAaykhahhqtvfDSPRY--GRSGTSTTFELQRCMAALSGAETCLATAS 82
Cdd:PRK08861 8 TIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFG-----------EVPKYdyTRSGNPNRGLLEQTLSELESGKGAVVTNC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 83 GLAAIVAVLSAHAGPGRHLLLNQGVYGPT-RIFCDQELvpQGTTVEYFPEGAD---ITPYLRDNTSLVYIETPASLTMEM 158
Cdd:PRK08861 77 GTSALNLWVSALLGPDDLIVAPHDCYGGTyRLFNTRAN--KGDFKVQFVDQSDaaaLDAALAKKPKLILLETPSNPLVRV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 159 LDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLI---TGSHADLASTRRFCdrSGA 235
Cdd:PRK08861 155 VDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLitkTKEHAEELAWWGNC--IGA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 236 HAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPCSEaA 315
Cdd:PRK08861 233 TGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFE-Q 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2212175695 316 FAAFIDALALFSLGTSWGGYESLVlpAVPYDLRHLAtLPDEG--------RLVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK08861 312 LKVFVKALALFSLAESLGGVESLI--CHPASMTHRA-MGEEAlaeagvsqQLLRLSVGLEDAQDLIADLDQAFA 382
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
23-380 |
2.35e-51 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 176.24 E-value: 2.35e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 23 PPLVRASTVVFdtlaaykhahhqTVFDSPR---YGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGR 99
Cdd:PRK08045 25 PPIHLSSTYNF------------TGFNEPRahdYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 100 HLLLNQGVYGPT-RIFcdQELVPQGTTVEYFPEGAD---ITPYLRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPV 175
Cdd:PRK08045 93 LLVAPHDCYGGSyRLF--DSLAKRGCYRVLFVDQGDeqaLRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVS 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 176 AVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRF-CDRSGAHAAPDVCWLALRGLRTLAV 254
Cdd:PRK08045 171 VVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWwANNIGVTGGAFDSYLLLRGLRTLVP 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 255 RLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELAPcSEAAFAAFIDALALFSLGTSWGG 334
Cdd:PRK08045 251 RMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDG-DEQTLRRFLGGLSLFTLAESLGG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2212175695 335 YESLVlpavpydlRHLATLPDEG-------------RLVRLHVGLEDAADLRADLAQAL 380
Cdd:PRK08045 330 VESLI--------SHAATMTHAGmapearaaagiseTLLRISTGIEDGEDLIADLENGF 380
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
53-381 |
1.11e-50 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 174.92 E-value: 1.11e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 53 YGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEyFPEG 132
Cdd:PRK07810 64 YSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETV-FVDG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 133 ADITPY---LRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHS 209
Cdd:PRK07810 143 EDLSQWeeaLSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQG 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 210 DLMLGLITGSHADL-ASTRRFCDRSGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDP 288
Cdd:PRK07810 223 RVLGGAILGDREYIdGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHP 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 289 GHALWRAQFSGAAGPFTFELAPCSEAAFA---AFIDALALFSLGTSWGGYESLVlpAVPYDLRHLATLPdEGR------- 358
Cdd:PRK07810 303 QYDLAKRQMSGGGTVVTFELDAPEDAAKKrafEVLDKLRVIDISNNLGDAKSLI--THPATTTHRAMGP-EGRaaiglgd 379
|
330 340
....*....|....*....|....
gi 2212175695 359 -LVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK07810 380 gVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
19-380 |
4.61e-50 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 174.83 E-value: 4.61e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 19 QAINPPLVRASTvvFDTLAAYKHAHHQtvfdsprYGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAgPG 98
Cdd:PLN02509 102 DAMSTPLYQTAT--FKQPSAIENGPYD-------YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIK-NG 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 99 RHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPE------GADITPYlrdnTSLVYIETPASLTMEMLDARAVCAAARQRH 172
Cdd:PLN02509 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTtnldevAAAIGPQ----TKLVWLESPTNPRQQISDIRKIAEMAHAQG 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 173 IPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLASTRRFCDRS-GAHAAPDVCWLALRGLRT 251
Cdd:PLN02509 248 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSeGSGLAPFDCWLCLRGIKT 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 252 LAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELApcSEAAFAAFIDALALFSLGTS 331
Cdd:PLN02509 328 MALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITG--SVALSKHLVETTKYFSIAVS 405
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2212175695 332 WGGYESLVlpAVPYDLRHlATLPDEGR--------LVRLHVGLEDAADLRADLAQAL 380
Cdd:PLN02509 406 FGSVKSLI--SMPCFMSH-ASIPAEVReargltedLVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
2-382 |
6.53e-50 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 171.54 E-value: 6.53e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 2 HTTTFLVHAGRETAHAVQAINPPLVRASTvvfdtlaaYKHAH--HQTVFDsprYGRSGTSTTFELQRCMAALSGAETCLA 79
Cdd:PRK07269 6 HINTILAQAGIKSDEATGALVTPLHFSTT--------YQHPEfgQSTGFD---YTRTKNPTRAKLEETLAAIESADYALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 80 TASGLAAIVAVLSAHAgPGRHLLLNQGVYGPT-RIFCDQElvPQGT-TVEYFPEGADITPYLRDNTSLVYIETPASLTME 157
Cdd:PRK07269 75 TSSGMSAIVLAFSVFP-VGSKVVAVRDLYGGSfRWFNQQE--KEGRfHFTYANTEEELIAAIEEDTDIVYIETPTNPLMV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 158 MLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLITGSHADLAStRRFCDR--SGA 235
Cdd:PRK07269 152 EFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYE-KLFYNLntTGA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 236 HAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPalpsdpghalwraqfsGAAGPFTFELApcSEAA 315
Cdd:PRK07269 231 VLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYT----------------GKGGMISFKVA--DETR 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2212175695 316 FAAFIDALALFSLGTSWGGYESLV-LPA------VPYDLRHLATLPDEgrLVRLHVGLEDAADLRADLAQALSG 382
Cdd:PRK07269 293 IPHILNSLKVFTFAESLGGVESLItYPTtqthadIPAEVRHSYGLTDD--LLRLSIGIEDARDLIADLKQALEG 364
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
53-380 |
3.71e-47 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 165.31 E-value: 3.71e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 53 YGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRiFCDQELVPQGTTVEYFPEG 132
Cdd:PRK07504 59 YSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCR-YVVETLLPRYGIESTLVDG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 133 ADITPY---LRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHS 209
Cdd:PRK07504 138 LDLDNWekaVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQG 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 210 DLMLGLITGSHADLAST-RRFCDRSGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDP 288
Cdd:PRK07504 218 RCLGGVVLSDKAWIEEHlQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHP 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 289 GHALWRAQFSGAAGPFTFELAPCSEAAFaAFIDALALFSLGTSWGGYESLVlpavpydlRHLAT-----LPDEGR----- 358
Cdd:PRK07504 298 QADIIAKQMTGGSTLVAFELKGGKEAAF-RFLNALKIVRISNNLGDAKSLI--------THPATtthknLSPEARaelgi 368
|
330 340
....*....|....*....|....*
gi 2212175695 359 ---LVRLHVGLEDAADLRADLAQAL 380
Cdd:PRK07504 369 segFLRLSAGLEDTDDLIEDLAAAL 393
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
24-381 |
5.74e-47 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 164.69 E-value: 5.74e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 24 PLVRASTVVFDTlaAYKHAHHQTVFDSPR-YGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGRHLL 102
Cdd:PRK06434 30 PIFETSTFVYPN--SEKEAYMDSTRGMPYiYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAITSAILSLIKKGKRIL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 103 LNQGVYGPTRIFCDQELVPQGTTVEYFP----EGADITPylrDNTSLVYIETPASLTMEMLDARAVCAAARQRHipVAVD 178
Cdd:PRK06434 108 SISDLYGQTFYFFNKVLKTLGIHVDYIDtdrlNSLDFDP---SNYDLIYAESITNPTLKVPDIKNVSSFCHEND--VIVD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 179 ATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGlITGSHADLASTRRFCDRSGAHAAPDV--CWLALRGLRTLAVRL 256
Cdd:PRK06434 183 ATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMG-VAGTNNKSIFNNLVERRKTLGSNPDPiqAYLALRGLKTLGLRM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 257 ERHQQTALATAQWLQQQPQVRRVLFpalpsdPGHALWRAQFSGAAGPFTFELAPCSEAafAAFIDALALFSLGTSWGGYE 336
Cdd:PRK06434 262 EKHNKNGMELARFLRDSKKISNVYY------PDTEIGKKVLRGFGGMLSFELRSMEDV--HKFIRNLEIPMVAASLGGVE 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2212175695 337 SLVlpAVPYDLRHLATLPDEGR-------LVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK06434 334 SLI--TLPVETSHSSLSPEERErlgisdnLVRFSIGIEDIDDLIKDIENALS 383
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
52-383 |
1.54e-45 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 161.01 E-value: 1.54e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 52 RYGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCdQELVPQGTTVEYF-- 129
Cdd:PRK05939 40 TYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSSQFLFGNTNSLF-GTLRGLGVEVTMVda 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 130 PEGADITPYLRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHS 209
Cdd:PRK05939 119 TDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 210 DLMLGLIT-------GSHADLASTRRFCDRS---------------GAHAAPDVCWLALRGLRTLAVRLERHQQTALATA 267
Cdd:PRK05939 199 NALGGAVTdtglfdwSAYPNIFPAYRKGDPQqwgltqirkkglrdmGATLSSEAAHRIAIGAETLALRVDRSCSNALALA 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 268 QWLQQQPQVRRVLFPALPSDPGHALWRAQFSGAAGPFTFELApcSEAAFAAFIDALALFSLGTSWGGYESLVLPAVP--- 344
Cdd:PRK05939 279 QFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELA--DGIDCFDFLNRLKLVIKATHLGDTRTLVIPVAPtiy 356
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2212175695 345 YDL----RHLATLPDEgrLVRLHVGLEDAADLRADLAQALSGL 383
Cdd:PRK05939 357 YEMgaerRASMGIADS--LIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
52-383 |
8.61e-45 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 158.46 E-value: 8.61e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 52 RYGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPE 131
Cdd:PRK06460 38 RYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 132 GAD--ITPYLRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHS 209
Cdd:PRK06460 118 GSDniIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHN 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 210 DLMLGLITGSHADLAS---TRRfcdRSGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPS 286
Cdd:PRK06460 198 DVIAGLAAGYGKLLNVidqMRR---TLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKS 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 287 DPGHALWRAQFSGAAGPFTFELapcsEAAFAAFIDALALFSL---GTSWGGYESLVlpAVPYDLRHLATLPDEGR----- 358
Cdd:PRK06460 275 HVDYEIARRVLKGFGGVLSFEV----NGGQESALKVMKSLKLiipAQTLGGVNSVI--SHPATMSHRTLSLEERKivgit 348
|
330 340
....*....|....*....|....*..
gi 2212175695 359 --LVRLHVGLEDAADLRADLAQALSGL 383
Cdd:PRK06460 349 dsLLRLSVGIEDVNDLIEDLDRALSTL 375
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
8-380 |
4.91e-41 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 149.90 E-value: 4.91e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 8 VHAGRETAHAVQAINPPLVRASTVVFDTLAaykHAHHQTVFDSPR--YGRSGTSTTFELQRCMAALSGAETCLATASGLA 85
Cdd:PRK07812 19 IHAGQTPDPATNARALPIYQTTSYTFDDTD---HAAALFGLAEPGniYTRIMNPTQDVVEQRIAALEGGVAALLLASGQA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 86 AIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPEGADITPY---LRDNTSLVYIETPASLTMEMLDAR 162
Cdd:PRK07812 96 AETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEDPDDLDAWraaVRPNTKAFFAETISNPQIDVLDIP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 163 AVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLIT-GSHADLASTR-------------- 227
Cdd:PRK07812 176 GVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdGGTFDWTQGRfpgfttpdpsyhgv 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 228 RFCDRS----------------GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHA 291
Cdd:PRK07812 256 VFAELGppayalkarvqllrdlGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 292 LWRAQF-SGAAGPFTFELAPCSEAAfAAFIDALALFSLGTSWGGYESLVLPavPYDLRHLATLPDEGR-------LVRLH 363
Cdd:PRK07812 336 RAKRLApKGTGAVLSFELAGGVEAG-KAFVNALTLHSHVANIGDVRSLVIH--PASTTHSQLTPEEQLatgvtpgLVRLA 412
|
410
....*....|....*..
gi 2212175695 364 VGLEDAADLRADLAQAL 380
Cdd:PRK07812 413 VGIEGIDDILADLEAGF 429
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
5-380 |
3.78e-39 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 144.60 E-value: 3.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVVF-DTlaaykhAHHQTVFDSPRYG----RSGTSTTFELQRCMAALSGAETCLA 79
Cdd:PRK08248 11 TLAIHAGQEIDPTTGSRAVPIYQTTSYGFrDS------EHAANLFSLKEFGniytRIMNPTTDVFEKRIAALEGGIGALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 80 TASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYF----PEG--ADITpylrDNTSLVYIETPAS 153
Cdd:PRK08248 85 VSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVdpsdPENfeAAIT----DKTKALFAETIGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 154 LTMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLIT-GSHADLASTRRF--- 229
Cdd:PRK08248 161 PKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdSGKFDWKGSGKFpgl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 230 --CDRS---------------------------GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVL 280
Cdd:PRK08248 241 tePDPSyhglvytdavgeaayitkarvqllrdlGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 281 FPALPSDPGHALWRAQF-SGAAGPFTFELAPCSEAAfAAFIDALALFSLGTSWGGYESLVLPavPYDLRHLATLPDEGR- 358
Cdd:PRK08248 321 YPGLPSHPSYELAKKYLpKGQGAILTFGIKGGVEAG-KKLIDSVKLFSHLANVGDSKSLIIH--PASTTHQQLSEEEQLa 397
|
410 420
....*....|....*....|....*...
gi 2212175695 359 ------LVRLHVGLEDAADLRADLAQAL 380
Cdd:PRK08248 398 agvtpgLVRLSVGTEAIDDILDDLRQAI 425
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
5-380 |
4.57e-39 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 144.50 E-value: 4.57e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVVFDTlaaykHAHHQTVFDSPR----YGRSGTSTTFELQRCMAALSGAETCLAT 80
Cdd:PRK08134 11 TLALHAGAAPDPATGARAVPIHLTTSFVFRD-----SDHAAALFNLERaghvYSRISNPTVAVLEERVAALEGGVGAIAT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 81 ASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPEGaDITPY---LRDNTSLVYIETPASLTME 157
Cdd:PRK08134 86 ASGQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPG-DIDGWraaIRPNTRLLFGETLGNPGLE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 158 MLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLG-LITGSHADLASTRRFCDRS--- 233
Cdd:PRK08134 165 VLDIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGvLVDGGRFDWEASGKFPELTepy 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 234 -----------------------------GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPAL 284
Cdd:PRK08134 245 agfhgmvfaeestvaafllrarreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPEL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 285 PSDPGHALWRAQF-SGAAGPFTFELAPcSEAAFAAFIDALALFSLGTSWGGYESLVL-PAVPYDLR-HLATLPDEG---R 358
Cdd:PRK08134 325 ESHPDHALAKRLLpRGAGSVFSFDLKG-GRAAGRKFIESLKLFSHLANVGDARSLVIhPASTTHFRmDAAALAAAGigeG 403
|
410 420
....*....|....*....|..
gi 2212175695 359 LVRLHVGLEDAADLRADLAQAL 380
Cdd:PRK08134 404 TIRLSIGLEDADDLIDDLKRAL 425
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
1-381 |
1.65e-38 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 142.73 E-value: 1.65e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 1 MHTTTFLVHAGRETAHAVQAINPPLVRASTVVFDtlaayKHAHHQTVFD----SPRYGRSGTSTTFELQRCMAALSGAET 76
Cdd:PRK06084 1 MKLETLAIHAGYSPDPTTKAVAVPIYQTTSYAFD-----DTQHGADLFDlkvpGNIYTRIMNPTNDVLEQRVAALEGGVG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 77 CLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPEG--ADITPYLRDNTSLVYIETPASL 154
Cdd:PRK06084 76 ALAVASGMAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDdiAALEALIDERTKAVFCESIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 155 TMEMLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLIT----------------- 217
Cdd:PRK06084 156 AGNIIDIQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVdsgkfpwaehkerfall 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 218 ----------------GSHADLASTRRFCDRS-GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVL 280
Cdd:PRK06084 236 ntpdpsyhgvtyteafGPAAFIGRCRVVPLRNmGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 281 FPALPSDPGHALWRAQFSGA-AGPFTFELAPCSEAAfAAFIDALALFSLGTSWGGYESLVLPAVPYDLRHL-------AT 352
Cdd:PRK06084 316 YAGLPDHPEHELARRYMGGKpASILSFGIKGGQAAG-ARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLndeelekAG 394
|
410 420
....*....|....*....|....*....
gi 2212175695 353 LPDEgrLVRLHVGLEDAADLRADLAQALS 381
Cdd:PRK06084 395 VSRD--MVRLSIGIEHIDDIIADLAQALD 421
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
5-383 |
2.07e-38 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 142.54 E-value: 2.07e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 5 TFLVHAGRETAHAVQAINPPLVRASTVVFDTLAaykhaHHQTVFDSPRYG----RSGTSTTFELQRCMAALSGAETCLAT 80
Cdd:PRK05994 10 TLAVHAGAQPDPTTGARATPIYQTTSFVFNDAD-----HAASLFGLQAFGniytRITNPTNAVLEERVAALEGGTAALAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 81 ASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEyFPEGADITPYLR---DNTSLVYIETPASLTME 157
Cdd:PRK05994 85 ASGHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVR-WADADDPASFERaitPRTKAIFIESIANPGGT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 158 MLDARAVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGLIT-GSHADLASTRRFCDRS--- 233
Cdd:PRK05994 164 VTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdGGTFDWSKSGKYPMLSepr 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 234 -----------------------------GAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPAL 284
Cdd:PRK05994 244 peyhglvlhetfgnfafaiaarvlglrdlGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 285 PSDPGHALWRAQFSGAAGP-FTFELAPCSEAAfAAFIDALALFSLGTSWGGYESLVLPavPYDLRHlATLPDEGR----- 358
Cdd:PRK05994 324 PDDPYHALAQKYSPKGAGAvFTFGLKGGYEAG-VKLVSSLKLFSHLANIGDTRSLVIH--PASTTH-RQLTDEQKvaaga 399
|
410 420
....*....|....*....|....*...
gi 2212175695 359 ---LVRLHVGLEDAADLRADLAQALSGL 383
Cdd:PRK05994 400 gpdVVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
24-382 |
1.46e-33 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 129.40 E-value: 1.46e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 24 PLVRASTVVFDT---LAAYKHAHHQTVFdsprYGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGRH 100
Cdd:PRK06702 27 PLYQSTTYKYDTsddLAALFNLEAEGYI----YTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNICSSGDH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 101 LLLNQGVYGPTRIFCDQELVPQGTTVEYFP---EGADITPYLRDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAV 177
Cdd:PRK06702 103 LLCSSTVYGGTFNLFGVSLRKLGIDVTFFNpnlTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 178 DATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLGL-ITGSHADLASTR--------------RFCDRSGAHA----- 237
Cdd:PRK06702 183 DNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIvIDGGNFDWTNGKypelvepdpsyhgvSYVQNFGAAAyivka 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 238 ------------APDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPSDPGHALWRAQFS-GAAGPF 304
Cdd:PRK06702 263 rvqllrdygncmSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLKkGASGVL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 305 TFELAPCSEAAfAAFIDALALFSLGTSWGGYESLVLPAVPYDLRHLaTLPDE------GRLVRLHVGLEDAADLRADLAQ 378
Cdd:PRK06702 343 TFGIKGGLEAA-KEFIANVKLATLVTHVADARTCVIHPASTTHRQL-SAEDQrlagvtSDLIRLSVGIEDVSDIIADLEA 420
|
....
gi 2212175695 379 ALSG 382
Cdd:PRK06702 421 ALVG 424
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
8-383 |
1.64e-32 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 126.52 E-value: 1.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 8 VHAGRETAHAVQAINPPLVRASTVVFDTLaayKHAHHQTVFDS--PRYGRSGTSTTFELQRCMAALSGAETCLATASGLA 85
Cdd:PRK05613 19 IHAGQSVDSDTSARNLPIYQTTSYVFDSA---EHAKQRFALEDlgPIYSRLTNPTVEALENRIASLEGGVHAVAFASGQA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 86 AIVAVLSAHAGPGRHLLLNQGVYGPTRIFCDQELVPQGTTVEYFPEGADITPY---LRDNTSLVYIETPASLTMEMLDAR 162
Cdd:PRK05613 96 AETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENPDDPESWqaaVQPNTKAFFGETFANPQADVLDIP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 163 AVCAAARQRHIPVAVDATWGTPVFLDAHALGVHIAIHSATKYINGHSDLMLG-LITGSHADLASTR-------------- 227
Cdd:PRK05613 176 AVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGvLIDGGKFDWTVERdgkpvfpyfvtpdp 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 228 -----RFCD----------------RSGAHAAPDVCWLALRGLRTLAVRLERHQQTALATAQWLQQQPQVRRVLFPALPS 286
Cdd:PRK05613 256 ayhglKYADlgapafglkaragllrDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKD 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 287 DPGHALWRA---QFSGAAgpFTFELAPCSEAAFaAFIDALALFSLGTSWGGYESLVL-PAVPY----DLRHLATLPDEGR 358
Cdd:PRK05613 336 SPWYATKEKlglKYTGSV--LSFDIKGGKDEAW-AFIDALKLHSNLANIGDVRSLVVhPATTThsqsDEAGLARAGITQA 412
|
410 420
....*....|....*....|....*
gi 2212175695 359 LVRLHVGLEDAADLRADLAQALSGL 383
Cdd:PRK05613 413 TVRLSVGIEDIDDIIADLEGGFAAI 437
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
53-296 |
6.72e-21 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 93.29 E-value: 6.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 53 YGRSGTSTTFELQRCMAALSGAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGPTrifcdqelvpQGTTVEYFPEG 132
Cdd:PLN02242 70 YSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGT----------HALLAHFLPRK 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 133 ADITPYLRD--------------NTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWgTPVFLDAHALGVHIAI 198
Cdd:PLN02242 140 CNITTTFVDitdleavkkavvpgKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADVVV 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 199 HSATKYINGHSDLMLGLITGSHADLASTRRFCDRS----GAHAAPDVCW-LALRgLRTLAVRLERHQQTALATAQWLQQQ 273
Cdd:PLN02242 219 HSISKFISGGADIIAGAVCGPAELVNSMMDLHHGAlmllGPTMNPKVAFeLSER-LPHLSLRMKEHCRRAMEYAKRMKEL 297
|
250 260
....*....|....*....|...
gi 2212175695 274 PQvrRVLFPALPSDPGHALWRAQ 296
Cdd:PLN02242 298 GL--KVIYPGLEDHPQHALLKSM 318
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
63-207 |
1.45e-06 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 47.76 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2212175695 63 ELQRCMAALS--GAETCLATASGLAAIVAVLSAHAGPGRHLLLNQGVYGP------TRIFCDQELVPQGTTvEYFPEGAD 134
Cdd:cd01494 4 ELEEKLARLLqpGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSrywvaaELAGAKPVPVPVDDA-GYGGLDVA 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2212175695 135 ITPYL--RDNTSLVYIETPASLTMEMLDARAVCAAARQRHIPVAVDATWGTP----VFLDAHALGVHIAIHSATKYING 207
Cdd:cd01494 83 ILEELkaKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGaspaPGVLIPEGGADVVTFSLHKNLGG 161
|
|
| |
