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Conserved domains on  [gi|2211953699|ref|WP_242248556|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [unclassified Bacillus cereus group]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10611674)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 16-69 6.66e-15

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


:

Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 64.47  E-value: 6.66e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2211953699  16 ELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKNPSIAVLEQLCEFF 69
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARAL 54
 
Name Accession Description Interval E-value
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 16-69 6.66e-15

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 64.47  E-value: 6.66e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2211953699  16 ELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKNPSIAVLEQLCEFF 69
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARAL 54
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-78 1.85e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 63.86  E-value: 1.85e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2211953699  11 ETMENELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRkNPSIAVLEQLCEFFSLNPQTVLE 78
Cdd:COG1396     2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRR-NPSLETLLKLAKALGVSLDELLG 68
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 18-73 3.06e-11

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 54.87  E-value: 3.06e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2211953699  18 GAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRkNPSIAVLEQLCEFFSLNP 73
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKR-NPSLETLEKLAKALGVSL 55
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
20-74 5.58e-11

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 54.06  E-value: 5.58e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2211953699   20 FLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKnPSIAVLEQLCEFFSLNPQ 74
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRK-PSLETLKKLAKALGVSLD 54
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 16-65 3.99e-03

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 35.70  E-value: 3.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2211953699  16 ELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGdRKNPSIAVLEQL 65
Cdd:PRK08154   28 ALGERVRTLRARRGMSRKVLAQASGVSERYLAQLESG-QGNVSILLLRRV 76
 
Name Accession Description Interval E-value
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 16-69 6.66e-15

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 64.47  E-value: 6.66e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2211953699  16 ELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKNPSIAVLEQLCEFF 69
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARAL 54
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-78 1.85e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 63.86  E-value: 1.85e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2211953699  11 ETMENELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRkNPSIAVLEQLCEFFSLNPQTVLE 78
Cdd:COG1396     2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRR-NPSLETLLKLAKALGVSLDELLG 68
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 18-73 3.06e-11

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 54.87  E-value: 3.06e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2211953699  18 GAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRkNPSIAVLEQLCEFFSLNP 73
Cdd:cd00093     1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKR-NPSLETLEKLAKALGVSL 55
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
20-74 5.58e-11

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 54.06  E-value: 5.58e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2211953699   20 FLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKnPSIAVLEQLCEFFSLNPQ 74
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRK-PSLETLKKLAKALGVSLD 54
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 12-77 2.41e-10

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 52.88  E-value: 2.41e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2211953699  12 TMENELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKN-----PSIAVLEQLCEFFSLNPQTVL 77
Cdd:COG1426     1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDAlpgpvYVRGFLRSYARALGLDPEELL 71
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
13-69 2.73e-10

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 52.54  E-value: 2.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2211953699  13 MENELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRkNPSIAVLEQLCEFF 69
Cdd:COG1476     1 MKKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKY-NPSLELALKIARAL 56
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 16-69 2.02e-09

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 50.32  E-value: 2.02e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2211953699  16 ELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRkNPSIAVLEQLCEFF 69
Cdd:COG1813    12 DYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEA-TPSLDTLRKLEKAL 64
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 21-74 5.20e-09

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 49.08  E-value: 5.20e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2211953699  21 LKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRkNPSIAVLEQLCEFFSLNPQ 74
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKR-EPSLETLKKLAEALGVSLD 53
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 18-77 6.78e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 46.13  E-value: 6.78e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211953699  18 GAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGdRKNPSIAVLEQLCEFFSLNPQTVL 77
Cdd:pfam12844   1 GERLRKAREERGLTQEELAERLGISRSQLSAIENG-KSVPPAETLYKIAELLGVPANWLL 59
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 10-77 8.80e-08

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 46.94  E-value: 8.80e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2211953699  10 TETMENELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRkNPSIAVLEQLCEFFSLNPQTVL 77
Cdd:COG3620    11 TVSPDDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKR-DPTVSTLEKIAEALGKELSAVL 77
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
27-78 3.01e-07

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 44.75  E-value: 3.01e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2211953699  27 KKKLSLEKVAKAIGVSASYLHRLENGDRKNPSIAVLEQLCEFFSLNPQTVLE 78
Cdd:COG3655    12 ERGMTKKELAEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQPGDLLE 63
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 21-78 8.12e-07

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 43.30  E-value: 8.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2211953699  21 LKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKNPSIAVLEQLCEFFSLNPQTVLE 78
Cdd:pfam13443   2 LRKLMADRGISKSDLARATGISRATLSRLRKGKPKRVSLDTLDKICDALGCQPGDLLE 59
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 21-76 8.88e-06

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 40.56  E-value: 8.88e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2211953699  21 LKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKN-PSIAV----LEQLCEFFSLNPQTV 76
Cdd:pfam13413   2 LRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDAlPEPVYargfLRSYARALGLDPEEL 62
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 18-79 4.38e-04

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 36.71  E-value: 4.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2211953699  18 GAFLKSERNK-KKLSLEKVAKAIGVSASYLHRLENGDRK-NPSIAVleQLCEFFSLNPQTVLEM 79
Cdd:COG3093    10 GEILREEFLEpLGLSQTELAKALGVSRQRISEILNGKRAiTADTAL--RLARAFGTSAEFWLNL 71
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
18-65 9.50e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 35.29  E-value: 9.50e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2211953699  18 GAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGDRKnPSIAVLEQL 65
Cdd:COG2944     8 PEEIRALRERLGLSQAEFAALLGVSVSTVRRWEQGRRK-PSGAALKLL 54
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 16-65 3.99e-03

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 35.70  E-value: 3.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2211953699  16 ELGAFLKSERNKKKLSLEKVAKAIGVSASYLHRLENGdRKNPSIAVLEQL 65
Cdd:PRK08154   28 ALGERVRTLRARRGMSRKVLAQASGVSERYLAQLESG-QGNVSILLLRRV 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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