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Conserved domains on  [gi|2203897314|ref|WP_240422101|]
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MFS transporter [Latilactobacillus sakei]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 2-308 2.48e-35

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17502:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 337  Bit Score: 132.30  E-value: 2.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   2 IARTVMGIGAGGMNTLPFIIYADLYQdLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILCV 81
Cdd:cd17502    88 VGRAIQGIGGGGLMSLAFIIIADLVP-PRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  82 RYFFkeqpkthlsgsvdylgagimITSLVTLLTGiqmigtgsltliiglivaglillvvlyrvedraadpivpnrlfknp 161
Cdd:cd17502   167 RTIL--------------------LSSIFGFLFG---------------------------------------------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 162 qlvtdfilfvvlwGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHR-VVTLGTVAFLIA 240
Cdd:cd17502   181 -------------GALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKpLIVIGTILMSVG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSI 308
Cdd:cd17502   248 AGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 2-308 2.48e-35

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 132.30  E-value: 2.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   2 IARTVMGIGAGGMNTLPFIIYADLYQdLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILCV 81
Cdd:cd17502    88 VGRAIQGIGGGGLMSLAFIIIADLVP-PRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  82 RYFFkeqpkthlsgsvdylgagimITSLVTLLTGiqmigtgsltliiglivaglillvvlyrvedraadpivpnrlfknp 161
Cdd:cd17502   167 RTIL--------------------LSSIFGFLFG---------------------------------------------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 162 qlvtdfilfvvlwGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHR-VVTLGTVAFLIA 240
Cdd:cd17502   181 -------------GALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKpLIVIGTILMSVG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSI 308
Cdd:cd17502   248 AGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 1-313 1.45e-22

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 98.99  E-value: 1.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:TIGR00711  94 IIFRVIQGFGGGPLIPLSFSTLLNIYPP-EKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVV 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEQPKTHlSGSVDYLGAGIMITSLVTLLTGI---QMIGTGSLTLIIGLIVAGLILLVVLYRVEDRAADPIVPNRL 157
Cdd:TIGR00711 173 AFFILPRDKPAA-SENFDFLGLLLLSVGLGSLLYGLsegPERGWFDSNEILILSITGLVAIIAFVVWELTDDNPLVDLRL 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 158 FKNPQ----LVTDFILFVVLWGAFiafnIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLG 233
Cdd:TIGR00711 252 FKYRNftigCVYMSLLGLGLYGSF----YLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIG 327

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 234 TVAFLIAFSGMLMMGDR-APFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVI 312
Cdd:TIGR00711 328 LILYAVGFYWRAFTFTPdTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTI 407


                  .
gi 2203897314 313 L 313
Cdd:TIGR00711 408 L 408
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-303 1.54e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 85.80  E-value: 1.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:COG2814   102 LAARFLQGLGAGALFPAALALIADLVPP-ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEQpkthlsgsvdylgagimitslvtlltgiqmigtgsltliiglivaglillvvlyRVEDRAADPIVPNRLFKN 160
Cdd:COG2814   181 LLRLLPES------------------------------------------------------RPAARARLRGSLRELLRR 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIa 240
Cdd:COG2814   207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL- 285

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2203897314 241 fsGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQT 303
Cdd:COG2814   286 --GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
PRK14995 PRK14995
SmvA family efflux MFS transporter;
1-247 8.89e-14

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 72.45  E-value: 8.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSI-L 79
Cdd:PRK14995   98 IATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMgL 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  80 CVRYFFKEQPKThlSGSVDYLGAGIMITSLVTLLTGIQ--MIGTGSLTLIIGLIVAGLILLVVLYRVEDRAADPIVPNRL 157
Cdd:PRK14995  178 TARYVPRQAGRR--DQPLNLGHALMLIVAILLLVYSAKtaLKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRL 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 158 FKNPQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAV-TNLIGSLAGPAVQpRLGKHRVVTLGTVA 236
Cdd:PRK14995  256 FTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVaSGFSGPIAGILVS-RLGLRLVATGGMAL 334

                         250
                  ....*....|.
gi 2203897314 237 FLIAFSGMLMM 247
Cdd:PRK14995  335 SALSFYGLAMT 345
MFS_1 pfam07690
Major Facilitator Superfamily;
1-298 7.32e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.90  E-value: 7.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:pfam07690  89 LVLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VrYFFKEQPKTHLSGSvdylgagimitslvtlltgiqmigtgsltliiglivaglillvvlyrVEDRAADPIVPNRLFKN 160
Cdd:pfam07690 168 L-LLPRPPPESKRPKP-----------------------------------------------AEEARLSLIVAWKALLR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVtNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIA 240
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLR 298
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 2-308 2.48e-35

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 132.30  E-value: 2.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   2 IARTVMGIGAGGMNTLPFIIYADLYQdLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILCV 81
Cdd:cd17502    88 VGRAIQGIGGGGLMSLAFIIIADLVP-PRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  82 RYFFkeqpkthlsgsvdylgagimITSLVTLLTGiqmigtgsltliiglivaglillvvlyrvedraadpivpnrlfknp 161
Cdd:cd17502   167 RTIL--------------------LSSIFGFLFG---------------------------------------------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 162 qlvtdfilfvvlwGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHR-VVTLGTVAFLIA 240
Cdd:cd17502   181 -------------GALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKpLIVIGTILMSVG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSI 308
Cdd:cd17502   248 AGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 1-313 1.45e-22

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 98.99  E-value: 1.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:TIGR00711  94 IIFRVIQGFGGGPLIPLSFSTLLNIYPP-EKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVV 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEQPKTHlSGSVDYLGAGIMITSLVTLLTGI---QMIGTGSLTLIIGLIVAGLILLVVLYRVEDRAADPIVPNRL 157
Cdd:TIGR00711 173 AFFILPRDKPAA-SENFDFLGLLLLSVGLGSLLYGLsegPERGWFDSNEILILSITGLVAIIAFVVWELTDDNPLVDLRL 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 158 FKNPQ----LVTDFILFVVLWGAFiafnIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLG 233
Cdd:TIGR00711 252 FKYRNftigCVYMSLLGLGLYGSF----YLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIG 327

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 234 TVAFLIAFSGMLMMGDR-APFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVI 312
Cdd:TIGR00711 328 LILYAVGFYWRAFTFTPdTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTI 407


                  .
gi 2203897314 313 L 313
Cdd:TIGR00711 408 L 408
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-303 1.54e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 85.80  E-value: 1.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:COG2814   102 LAARFLQGLGAGALFPAALALIADLVPP-ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEQpkthlsgsvdylgagimitslvtlltgiqmigtgsltliiglivaglillvvlyRVEDRAADPIVPNRLFKN 160
Cdd:COG2814   181 LLRLLPES------------------------------------------------------RPAARARLRGSLRELLRR 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIa 240
Cdd:COG2814   207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL- 285

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2203897314 241 fsGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQT 303
Cdd:COG2814   286 --GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 1-382 4.60e-16

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 78.75  E-value: 4.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILc 80
Cdd:cd17321    88 IAARALQGIGAAAIMPASLALIAATFPG-ERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL- 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 vryffkeqpkthlsgsvdyLGAGIMITSLVTLLTGiqmigtgsltliiglivaglillvvlyrvedraadpivpnrlfkn 160
Cdd:cd17321   166 -------------------LARTFSGAVLAAFLLG--------------------------------------------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 pqlvtdfilfvvlwGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIA 240
Cdd:cd17321   182 --------------AALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVILNHALTQG 320
Cdd:cd17321   248 LLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSAN 327

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2203897314 321 LPNHTVQItmammnklsnlqrvhelpahLLPAMRAIMYQGLHNIMLIATVLLVVVLAFNLWL 382
Cdd:cd17321   328 LGDSGVAA--------------------LLSAAAAAFAAGFHLAFLVAAALALLAALLALLL 369
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 1-315 1.06e-15

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 78.00  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYqDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:cd17503    88 IIFRILQGFGGGVLIPLAQTILLRIY-PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VryffkeqpkthlsgsvdylgagimitslvtlltgiqmigtgsltliiglivaglillvvlyrvedraadPIVPNRLFKN 160
Cdd:cd17503   167 A---------------------------------------------------------------------PLLDLRLFKD 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIA 240
Cdd:cd17503   178 RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALG 257

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVILNH 315
Cdd:cd17503   258 TLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 1-324 1.29e-14

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 75.36  E-value: 1.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVM-GIGAGGMNTLPFIIYADLyqDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTF--SWHWVFYINVPIALVS 77
Cdd:cd06179    88 LIGGQALiGIGAGTQGLGAAVASELV--PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINAIFNALA 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  78 ILCVRYFFKEQPKTHLSGS--------VDYLGAGIMITSLVTLLTGIQMIGTG---SLTLIIGLIVAGLILLVV--LYRV 144
Cdd:cd06179   166 LILLFFFYHPPPRPQLHGSstrqklkrLDWVGLFLLIAGLVLFLLGLSWGGNPypwSSAHVIAPLVIGGVLLIAfgLYEW 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 145 EDRAADPIVPNRLFKNPQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRL 224
Cdd:cd06179   246 KGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKI 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 225 GKHRVVTLGTVAFLIAFSGMLMM---GDRAPFWFLLLMGafeGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILS 301
Cdd:cd06179   326 KHIKWQLVAGFVLFTAFLALLALitpDNKALAIAFSVLA---GIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALG 402

                         330       340
                  ....*....|....*....|...
gi 2203897314 302 QTFMSSIYGVILNHALTQGLPNH 324
Cdd:cd06179   403 GAVGTAIFTSILSNRLSKNLPAR 425
PRK14995 PRK14995
SmvA family efflux MFS transporter;
1-247 8.89e-14

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 72.45  E-value: 8.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSI-L 79
Cdd:PRK14995   98 IATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMgL 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  80 CVRYFFKEQPKThlSGSVDYLGAGIMITSLVTLLTGIQ--MIGTGSLTLIIGLIVAGLILLVVLYRVEDRAADPIVPNRL 157
Cdd:PRK14995  178 TARYVPRQAGRR--DQPLNLGHALMLIVAILLLVYSAKtaLKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRL 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 158 FKNPQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAV-TNLIGSLAGPAVQpRLGKHRVVTLGTVA 236
Cdd:PRK14995  256 FTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVaSGFSGPIAGILVS-RLGLRLVATGGMAL 334

                         250
                  ....*....|.
gi 2203897314 237 FLIAFSGMLMM 247
Cdd:PRK14995  335 SALSFYGLAMT 345
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-180 6.51e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 68.68  E-value: 6.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILc 80
Cdd:COG0477   106 IAARALQGIGAGGLMPGALALIAELFPA-RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEQPKTHLSGSVDYLGAGIMITSLVTLLTGIQMIGTGSLTLIIGLIVAGLILLVVLYRVEDRAADPIVPNRLFKN 160
Cdd:COG0477   184 LRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALL 263

                         170       180
                  ....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAF 180
Cdd:COG0477   264 LLLLLLLLLALLLALLLLLL 283
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 1-313 1.36e-12

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 68.37  E-value: 1.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGaGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:cd17504    88 IAGRALQGIG-GAVFPLAFALVREEFPP-ERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VryffkeqpkthlsgsvdylgagimitslvtlltgiqmigtgsltliiglivaglillvvlyrvedraadPIVPNRLFKN 160
Cdd:cd17504   166 V---------------------------------------------------------------------PLIDLRLLRR 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGM----TQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVA 236
Cdd:cd17504   177 RNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITeaglLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVI 256

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2203897314 237 FLIAFsgMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVIL 313
Cdd:cd17504   257 SAVGL--LLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
MFS_1 pfam07690
Major Facilitator Superfamily;
1-298 7.32e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.90  E-value: 7.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:pfam07690  89 LVLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VrYFFKEQPKTHLSGSvdylgagimitslvtlltgiqmigtgsltliiglivaglillvvlyrVEDRAADPIVPNRLFKN 160
Cdd:pfam07690 168 L-LLPRPPPESKRPKP-----------------------------------------------AEEARLSLIVAWKALLR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVtNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIA 240
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLR 298
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-271 6.75e-10

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 60.28  E-value: 6.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:cd17320    91 LIARFLQGLGAAAGSVVARAIVRDLYSG-AELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEqpkthlsgsvdylgagimitslvtlltgiqmigtgslTLIIGLIVAGLILLVVLYRvedraadpivpnRLFKN 160
Cdd:cd17320   170 VLLFLPE-------------------------------------TLPEEKRKPLLSSLLRAYK------------RVLKN 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIA 240
Cdd:cd17320   201 RRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAA 280

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2203897314 241 FSGMLMM---GDRAPFWFLLLMGAFeGFGLGMSF 271
Cdd:cd17320   281 ALVLLLAallGGLSLWPLVAPLFLI-FFGFGLIF 313
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 1-315 6.10e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 57.20  E-value: 6.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDtFSWHWVFYINVPIALVSILC 80
Cdd:cd17474    91 LAGRALQGIGAAGLGPLALTLIGDLFEG-GERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLA 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEQPKTHLSGSVDYLGAGIMITSLVTLLTgiqmIGTGSLTLIIGLIVagliLLVVLyrvedraadPIVPNRLFKN 160
Cdd:cd17474   169 ILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLT----FLVSAFLYFFLYFA----FLTYL---------PFLLELLYGI 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFvvlwgafiafniyipmwaqgllglsallggmtqIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIA 240
Cdd:cd17474   232 SPIIIGLLFA---------------------------------GWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALS 278

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2203897314 241 FSGMLMMGDrapFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVILNH 315
Cdd:cd17474   279 LLLLGFVPS---LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 1-160 2.32e-08

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 55.83  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIyADLyqdLRKRAQVIGYATASYS--AASIVGPLIGGWIVDTFSWHWVFYINVPIALVSI 78
Cdd:pfam06609 135 LAAMTLLGVAAGPAGASPLFI-GEL---MSNKTKFLGLLIVSAPtiAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  79 LCVRYFFKEQPKTHLSG----------SVDYLGAGIMITSLVTLLTGIQMIGTG----SLTLIIGLIVAGLILLVV--LY 142
Cdd:pfam06609 211 LLIIIWYHPPSFAQLHGkkarkrdelaKLDWIGIFLVIAGTSLFLLGVSWGGKPnnpwNSAKIIGLISSGAGSLVIfaLY 290

                         170
                  ....*....|....*...
gi 2203897314 143 RVEDRAADPIVPNRLFKN 160
Cdd:pfam06609 291 EVFGKPEQPIIPPALFKD 308
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-275 7.31e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.73  E-value: 7.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:cd17325    88 LLARFLQGLASAAVWPAAMALIADIAPP-EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEQPKTHLSGSVdylgagimitslvtlltgiqmigtgsltliiglivaglillvvlyrveDRAADPIVPNRLFKN 160
Cdd:cd17325   167 ALLLLPEPRPPPNKRAV------------------------------------------------SAARLRSGLRLLLRD 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIA 240
Cdd:cd17325   199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2203897314 241 FSGMLMMGDrapFWFLLLMGAFEGFGLGMSFNVLQ 275
Cdd:cd17325   279 LLLLPLATS---FWLLLLLLALLGLGLGLVFPATL 310
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-322 2.03e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.43  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVD--TFSWHWVFYINVPIALVSI 78
Cdd:cd06174    88 LLGRFLLGLGSGLIDPAVLALIADLFPE-RERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAA 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  79 LCVRYFFKEQPKTHLSGSVDYLGAGIMITSLvtlltgiqmigtgsltliiglivaglillvvlyrvedraadpivpnRLF 158
Cdd:cd06174   167 ILLLLVVPDPPESARAKNEEASSKSVLKLLK----------------------------------------------RVL 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 159 KNPQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFL 238
Cdd:cd06174   201 KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLM 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 239 IAFsgMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVILNHALT 318
Cdd:cd06174   281 ALG--LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG 358


                  ....
gi 2203897314 319 QGLP 322
Cdd:cd06174   359 LTGA 362
2_A_01_02 TIGR00880
Multidrug resistance protein;
1-87 5.17e-07

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 48.80  E-value: 5.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYqDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:TIGR00880  55 IIARFLQGFGAAFALVAGAALIADIY-PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133


                  ....*..
gi 2203897314  81 VRYFFKE 87
Cdd:TIGR00880 134 LAFLLPE 140
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 1-82 3.35e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.72  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDtFSWHWVFYI---NVPIALVS 77
Cdd:cd17473    92 LASRALLGIGVAGIMTLATALIGDYFEG-EERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVyllALPVLILV 169


                  ....*
gi 2203897314  78 ILCVR 82
Cdd:cd17473   170 LLFLP 174
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
100-271 5.66e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.97  E-value: 5.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 100 LGAGIMITSLVTLLTGIQMIGTGSLTLIIGLIVAGLILLVVLYRVEDRAADPIVPN------RLFKNPQLVTDFILFVVL 173
Cdd:COG2211   161 LLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSlkeslkALLKNRPFLLLLLAYLLF 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 174 WGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIAFSGMLMMGDRAPF 253
Cdd:COG2211   241 FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW 320

                         170
                  ....*....|....*...
gi 2203897314 254 WFLLLMGAFeGFGLGMSF 271
Cdd:COG2211   321 LLLVLAALA-GIGLGAIL 337
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-79 1.68e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.40  E-value: 1.68e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSIL 79
Cdd:COG2271   102 LLLRFLLGLGEAGFFPAALKLIAEWFPP-KERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-79 6.29e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.87  E-value: 6.29e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYqDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSIL 79
Cdd:cd17325   292 LLLLALLGLGLGLVFPATLALLADIV-PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 5-87 6.48e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 44.49  E-value: 6.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   5 TVMGIGAGGMntlpfiiyADLYqDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILCVRYF 84
Cdd:cd17323   103 SPLAIGAGTI--------ADLF-TPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLF 173


                  ...
gi 2203897314  85 FKE 87
Cdd:cd17323   174 LPI 176
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-92 8.57e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.08  E-value: 8.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:cd17324    91 LLARALAGLAHGGFWAIAAAYAADLVPP-EKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL 169

                          90
                  ....*....|..
gi 2203897314  81 VRYFFKEQPKTH 92
Cdd:cd17324   170 LWRLLPSLPPKK 181
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-79 1.96e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.94  E-value: 1.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYInvpIALVSIL 79
Cdd:cd17319    95 YVLRFLLGVAEAGFFPGAIKALAEWFPA-RERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII---EGLLGLL 169
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
46-87 2.30e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 42.98  E-value: 2.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2203897314  46 ASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILCVRYFFKE 87
Cdd:PRK11102  127 APLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-90 2.86e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYqDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:COG2271   275 IALLFLAGFGLGGAFGLLWALAAELF-PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALL 353

                          90
                  ....*....|
gi 2203897314  81 VRYFFKEQPK 90
Cdd:COG2271   354 ALLLLRETRK 363
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-315 3.32e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.56  E-value: 3.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGmNTLPFIIYADLYQDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:COG2223    97 LLLGLLLGIGGGG-SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VRYFFKEQPKthlsgsvdylgagimitslvtlltgiqmigtgsltliiglivaglillvvlYRVEDRAADPIVPNRLFKN 160
Cdd:COG2223   176 AWLFLRDPPA---------------------------------------------------GAAAAAKASLRDQLEALRD 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 PQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRvVTLGTVAFLIA 240
Cdd:COG2223   205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMAL 283

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFeGFGLGMSFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVILNH 315
Cdd:COG2223   284 GLLLLALALGSLWLFLVLFLLL-GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 33-321 3.47e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.22  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  33 AQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINV---PIALVSILCVRYFFKEQPKTHLSGSVDYLGAGIMItsl 109
Cdd:cd06173   127 VRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAlsfLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRY--- 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 110 vtlltgiqmigtgsltliiglivaglillvvlyrvedraadpivpnrLFKNPQLVTDFILFVVLWGAFIAFNIYIPMWAQ 189
Cdd:cd06173   204 -----------------------------------------------LRRSPLLRLLLLALALFALLGGALTVLLPLLAK 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 190 GLLGLSALLGGMTQIPGAVTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIAFSGMLMMGdraPFWFLLLMGAFEGFGLGM 269
Cdd:cd06173   237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP---SLWLLLAALFLLGLAGGL 313

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2203897314 270 SFNVLQISVQEDAETRDVPIATSFAYLLRILSQTFMSSIYGVILNHALTQGL 321
Cdd:cd06173   314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-87 8.28e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.19  E-value: 8.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADlYQDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:TIGR00895 109 LILRFLAGLGLGGLMPNLNALVSE-YAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLL 187


                  ....*..
gi 2203897314  81 VRYFFKE 87
Cdd:TIGR00895 188 LMRFLPE 194
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 126-271 9.09e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 41.05  E-value: 9.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 126 LIIGLIVAGLILLVVL---YRVEDRAADPIVPN------RLFKNPQLVTDFILFVVLWGAFIAFNIYIPMWAQGLLGLSA 196
Cdd:cd17332   177 LIIGIIGIILLLICFFgtrERVVPPEEEKSKLPllkslkALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRA 256

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2203897314 197 LLGGMTQIPGAvTNLIGSLAGPAVQPRLGKHRVVTLGTVAFLIAFSGMLMMGDRAPFWFLLLMGAFeGFGLGMSF 271
Cdd:cd17332   257 ELVLLLLLILS-GALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLA-GIGYGGAN 329
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 1-87 1.32e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 40.44  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGGMNTLPFIIYADLYQDlRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:TIGR00710  97 LVLRFVQAFGASAGSVISQALVRDIYPG-EELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSAL 175


                  ....*..
gi 2203897314  81 VRYFFKE 87
Cdd:TIGR00710 176 IFFILPE 182
PRK10504 PRK10504
putative transporter; Provisional
 48-161 1.71e-03

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 40.49  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  48 IVGPLIGGWIVDTFSWHWVFYINVPIALV---SILCVRYFFKEQPKthlsgSVDYLGAGIMITSLVTL---LTGIQMIGT 121
Cdd:PRK10504  148 LLGPALGGLLVEYASWHWIFLINIPVGIIgaiATLMLMPNYTMQTR-----RFDLSGFLLLAVGMATLtlaLDGSKGLGL 222

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2203897314 122 GSLTLiIGLIVAGLILLVVLYRVEDRAADPIVPNRLFKNP 161
Cdd:PRK10504  223 SPLAI-AGLVAVGVVALLLYLLHARNNNRALFSLKLFRTR 261
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-275 3.54e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.11  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAGgMNTLPFIIYADLYQDLRKRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILC 80
Cdd:cd17489    88 LVLRLIHGIGWG-AFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314  81 VrYFFKEQPKTHLSGSVDYLGAGIMITSLVTLLTGIqmigtgsLTLIIGLIVAGLILLVVLYRVEdraadpivpnrlfkn 160
Cdd:cd17489   167 V-FLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPAL-------ILFLASIAYGAISTFLPLYAAE--------------- 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314 161 pqlvtdfiLFVVLWGAFIAFNiyipmwaqgllglsallggmtqipgAVTNLIGSLAGPAVQPRLGKHRVVTLGtvaFLIA 240
Cdd:cd17489   224 --------RGISNAGLFFTVY-------------------------AIALLLSRPFSGKLSDRKGPKTVIIPG---LLLL 267

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2203897314 241 FSGMLMMGDRAPFWFLLLMGAFEGFGLGMSFNVLQ 275
Cdd:cd17489   268 ALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQ 302
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 1-86 4.15e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 39.07  E-value: 4.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2203897314   1 MIARTVMGIGAG-GMNTLPFIIYADLYQDLRKRAqvIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSIL 79
Cdd:cd17380    93 ILSRILLGLGEGvHFPSMTSLFSRWVPVSERSRA--VSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWAL 170


                  ....*..
gi 2203897314  80 CVRYFFK 86
Cdd:cd17380   171 VWLIYLP 177
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 31-92 8.52e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 37.97  E-value: 8.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2203897314  31 KRAQVIGYATASYSAASIVGPLIGGWIVDTFSWHWVFYINVPIALVSILCVRYFFKEQPKTH 92
Cdd:cd17331   119 ERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSK 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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