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Conserved domains on  [gi|2188402727|ref|WP_236916456|]
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competence type IV pilus minor pilin ComGD [Coprobacillus cateniformis]

Protein Classification

type II secretion system protein( domain architecture ID 11450365)

type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0005886|GO:0015628|GO:0015627
PubMed:  30767847|1365398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComGD super family cl49130
competence type IV pilus minor pilin ComGD;
16-143 1.36e-20

competence type IV pilus minor pilin ComGD;


The actual alignment was detected with superfamily member NF040982:

Pssm-ID: 468912 [Multi-domain]  Cd Length: 140  Bit Score: 81.52  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188402727  16 NRGFTLVETLFVLFIICMLSLLTMTLHLPNK----NNQVIIQEITEFLNQAKLEAIVSKKTVTVQFLKDKVLWK------ 85
Cdd:NF040982    1 IKGFTLLESLLVLLIVSSLLLLTLSLSIPQTyeqvEEKLFFEQFENDLLYAQQYAIASQQSTTITFSPDEIQYQfqeggn 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188402727  86 -TTDKEKNYQLSENTYFDSYKMTFNSAGHIKTAK-TVTYHTLQQDFQFVYQVGSGCFYVQ 143
Cdd:NF040982   81 tSNRPYPLKIPISITVTKPNTITFNKNGGNNSLKgTFYIKGKKQTYTYQFQLGSGRYRKE 140
 
Name Accession Description Interval E-value
ComGD NF040982
competence type IV pilus minor pilin ComGD;
16-143 1.36e-20

competence type IV pilus minor pilin ComGD;


Pssm-ID: 468912 [Multi-domain]  Cd Length: 140  Bit Score: 81.52  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188402727  16 NRGFTLVETLFVLFIICMLSLLTMTLHLPNK----NNQVIIQEITEFLNQAKLEAIVSKKTVTVQFLKDKVLWK------ 85
Cdd:NF040982    1 IKGFTLLESLLVLLIVSSLLLLTLSLSIPQTyeqvEEKLFFEQFENDLLYAQQYAIASQQSTTITFSPDEIQYQfqeggn 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188402727  86 -TTDKEKNYQLSENTYFDSYKMTFNSAGHIKTAK-TVTYHTLQQDFQFVYQVGSGCFYVQ 143
Cdd:NF040982   81 tSNRPYPLKIPISITVTKPNTITFNKNGGNNSLKgTFYIKGKKQTYTYQFQLGSGRYRKE 140
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
9-76 1.98e-09

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 50.62  E-value: 1.98e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2188402727   9 MVKHMLTNRGFTLVETLFVLFIICMLSLLTMtlhlPN-----KNNQV--IIQEITEFLNQAKLEAIVSKKTVTVQ 76
Cdd:COG4970     1 MKRLRRRQRGFTLIELLVVLAILAILAAIAV----PSfssliARQRLraAANELAAALRLARSEAIRRGQPVTLS 71
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 13-39 8.99e-03

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 31.96  E-value: 8.99e-03
                          10        20
                  ....*....|....*....|....*..
gi 2188402727  13 MLTNRGFTLVETLFVLFIICMLSLLTM 39
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
 
Name Accession Description Interval E-value
ComGD NF040982
competence type IV pilus minor pilin ComGD;
16-143 1.36e-20

competence type IV pilus minor pilin ComGD;


Pssm-ID: 468912 [Multi-domain]  Cd Length: 140  Bit Score: 81.52  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188402727  16 NRGFTLVETLFVLFIICMLSLLTMTLHLPNK----NNQVIIQEITEFLNQAKLEAIVSKKTVTVQFLKDKVLWK------ 85
Cdd:NF040982    1 IKGFTLLESLLVLLIVSSLLLLTLSLSIPQTyeqvEEKLFFEQFENDLLYAQQYAIASQQSTTITFSPDEIQYQfqeggn 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188402727  86 -TTDKEKNYQLSENTYFDSYKMTFNSAGHIKTAK-TVTYHTLQQDFQFVYQVGSGCFYVQ 143
Cdd:NF040982   81 tSNRPYPLKIPISITVTKPNTITFNKNGGNNSLKgTFYIKGKKQTYTYQFQLGSGRYRKE 140
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
9-76 1.98e-09

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 50.62  E-value: 1.98e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2188402727   9 MVKHMLTNRGFTLVETLFVLFIICMLSLLTMtlhlPN-----KNNQV--IIQEITEFLNQAKLEAIVSKKTVTVQ 76
Cdd:COG4970     1 MKRLRRRQRGFTLIELLVVLAILAILAAIAV----PSfssliARQRLraAANELAAALRLARSEAIRRGQPVTLS 71
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 9-63 1.18e-05

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 41.44  E-value: 1.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2188402727   9 MVKHMLTNRGFTLVETLFVLFIICMLSLLTMtlhlPNKNNQVIIQEITEFLNQAK 63
Cdd:COG2165     3 LRRRRRRQRGFTLIELLVVIAIIGILAALAL----PALQGARERARRAELRSNLR 53
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 9-41 7.68e-04

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 36.92  E-value: 7.68e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2188402727   9 MVKHMLTNRGFTLVETLFVLFIICMLSLLTMTL 41
Cdd:COG4795     1 MKRARRRQRGFTLLELLVALAIFALLLLAAYRG 33
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
9-96 1.77e-03

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 35.67  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188402727   9 MVKHMLTNRGFTLVETLFVLFIICMLSLLTMTlHLPNKNNQVIIQ----EITEFLNQAKLEAIVSKKT-VTVQFLKD--- 80
Cdd:COG4537     4 KKRKLKKEKGFTLIEMLIVLLIISILLLIAVP-NLTKQRETAQEKgceaNIKMVQSQVELYELDHGTYpASLEELVDegy 82

                          90
                  ....*....|....*..
gi 2188402727  81 -KVLWKTTDKEKNYQLS 96
Cdd:COG4537    83 lKEKQPTCPNGGEYTID 99
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 13-39 8.99e-03

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 31.96  E-value: 8.99e-03
                          10        20
                  ....*....|....*....|....*..
gi 2188402727  13 MLTNRGFTLVETLFVLFIICMLSLLTM 39
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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