NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2188369297|ref|WP_236887353|]
View 

GNAT family N-acetyltransferase [Dehalococcoides mccartyi]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11450351)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
2-105 2.43e-36

Predicted N-acyltransferase, GNAT family [General function prediction only];


:

Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 119.90  E-value: 2.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   2 HDNTARHLVIHNEERALACCRIRMLDEALAKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVFHAQTGAAGFYAS 81
Cdd:COG2153    30 KDEDARHLLAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVGFYEK 109

                          90       100
                  ....*....|....*....|....
gi 2188369297  82 LGYVPNGETFIEDGIQHIRMHLRL 105
Cdd:COG2153   110 LGFVPVGEEFLEAGIPHIDMRKPL 133
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
2-105 2.43e-36

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 119.90  E-value: 2.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   2 HDNTARHLVIHNEERALACCRIRMLDEALAKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVFHAQTGAAGFYAS 81
Cdd:COG2153    30 KDEDARHLLAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVGFYEK 109

                          90       100
                  ....*....|....*....|....
gi 2188369297  82 LGYVPNGETFIEDGIQHIRMHLRL 105
Cdd:COG2153   110 LGFVPVGEEFLEAGIPHIDMRKPL 133
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 23-105 2.60e-12

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 58.44  E-value: 2.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297  23 IRMLDEAlaKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVF--HAQTGAAGFYASLGYVPNGETFIEDGIQHIR 100
Cdd:pfam13673  46 IALRDRG--HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELtvNASPYAVPFYEKLGFRATGPEQEFNGIRFVP 123


                  ....*
gi 2188369297 101 MHLRL 105
Cdd:pfam13673 124 MEKEL 128
PRK10314 PRK10314
GNAT family N-acetyltransferase;
7-101 4.49e-06

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 42.52  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   7 RHLVIHNEERALACCRIRMLDEALAK--IERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVF-HAQTGAAGFYASLG 83
Cdd:PRK10314   49 RHILGWKNDELVAYARILKSDDDLEPvvIGRVIVSEALRGEKVGQQLMSKTLESCTRHWPDKPVYlGAQAHLQNFYQSFG 128

                          90
                  ....*....|....*...
gi 2188369297  84 YVPNGETFIEDGIQHIRM 101
Cdd:PRK10314  129 FIPVTEVYEEDGIPHIGM 146
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 8-70 1.73e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.87  E-value: 1.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2188369297   8 HLVIHNEERALACCRIRMLDEAL--AKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVFH 70
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGdtAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
2-105 2.43e-36

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 119.90  E-value: 2.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   2 HDNTARHLVIHNEERALACCRIRMLDEALAKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVFHAQTGAAGFYAS 81
Cdd:COG2153    30 KDEDARHLLAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVGFYEK 109

                          90       100
                  ....*....|....*....|....
gi 2188369297  82 LGYVPNGETFIEDGIQHIRMHLRL 105
Cdd:COG2153   110 LGFVPVGEEFLEAGIPHIDMRKPL 133
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 1-105 6.05e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 60.01  E-value: 6.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   1 MHDNTARHLVIHNEERALACCRIRMLDEALAKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVFHAQTGAAGFYA 80
Cdd:COG1246    23 LEEEIGEFWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYE 102

                          90       100
                  ....*....|....*....|....*....
gi 2188369297  81 SLGYVPNGETFIEDGIQH----IRMHLRL 105
Cdd:COG1246   103 KLGFEEIDKEDLPYAKVWqrdsVVMEKDL 131
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 23-105 2.60e-12

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 58.44  E-value: 2.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297  23 IRMLDEAlaKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVF--HAQTGAAGFYASLGYVPNGETFIEDGIQHIR 100
Cdd:pfam13673  46 IALRDRG--HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELtvNASPYAVPFYEKLGFRATGPEQEFNGIRFVP 123


                  ....*
gi 2188369297 101 MHLRL 105
Cdd:pfam13673 124 MEKEL 128
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 4-86 1.16e-11

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 55.54  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   4 NTARHLVIHNEERALACCRIRMLDEALAKIE-RVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVFHAQTGAAGFYASL 82
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKL 80


                  ....
gi 2188369297  83 GYVP 86
Cdd:pfam13508  81 GFEE 84
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 3-89 4.17e-10

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 52.75  E-value: 4.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   3 DNTARHLVIHNEERALACCRIRMLDEALAKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGV---VFHAQTGAAGFY 79
Cdd:COG0454    31 LAGAEFIAVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALeldTLDGNPAAIRFY 110

                          90
                  ....*....|
gi 2188369297  80 ASLGYVPNGE 89
Cdd:COG0454   111 ERLGFKEIER 120
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
33-105 5.98e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 52.78  E-value: 5.98e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2188369297  33 IERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVFHAQTGAAGFYASLGYVPNGETFIEDGIQHIRMHLRL 105
Cdd:COG3153    70 LGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEVFLAKEL 142
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 33-105 5.23e-09

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 48.88  E-value: 5.23e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2188369297  33 IERVAVDIDYRKSGLGREIMNYAASLLKTENVDGV---VFHAQTGAAGFYASLGYVPNGETFIEDGIQHIRMHLRL 105
Cdd:COG0456    16 IEDLAVDPEYRGRGIGRALLEAALERARERGARRLrleVREDNEAAIALYEKLGFEEVGERPNYYGDDALVMEKEL 91
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
16-89 1.11e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 47.98  E-value: 1.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2188369297  16 RALACCRIRMLDEALAKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGV---VFHAQTGAAGFYASLGYVPNGE 89
Cdd:COG3393     1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPflyVDADNPAARRLYERLGFRPVGE 77
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 2-84 1.55e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 45.97  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   2 HDNTARHLVIHNEERALACCRIRMLDEAL--AKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGV---VFHAQTGAA 76
Cdd:pfam00583  29 EDASEGFFVAEEDGELVGFASLSIIDDEPpvGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIfleVAADNLAAI 108


                  ....*...
gi 2188369297  77 GFYASLGY 84
Cdd:pfam00583 109 ALYEKLGF 116
PRK10314 PRK10314
GNAT family N-acetyltransferase;
7-101 4.49e-06

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 42.52  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188369297   7 RHLVIHNEERALACCRIRMLDEALAK--IERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVF-HAQTGAAGFYASLG 83
Cdd:PRK10314   49 RHILGWKNDELVAYARILKSDDDLEPvvIGRVIVSEALRGEKVGQQLMSKTLESCTRHWPDKPVYlGAQAHLQNFYQSFG 128

                          90
                  ....*....|....*...
gi 2188369297  84 YVPNGETFIEDGIQHIRM 101
Cdd:PRK10314  129 FIPVTEVYEEDGIPHIGM 146
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 8-70 1.73e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.87  E-value: 1.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2188369297   8 HLVIHNEERALACCRIRMLDEAL--AKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVFH 70
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGdtAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK07757 PRK07757
N-acetyltransferase;
10-84 4.77e-04

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 37.10  E-value: 4.77e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2188369297  10 VIHNEERALACCRIRMLDEALAKIERVAVDIDYRKSGLGREIMNYAASLLKTENVDGVVfhAQTGAAGFYASLGY 84
Cdd:PRK07757   45 VAEEEGEIVGCCALHILWEDLAEIRSLAVSEDYRGQGIGRMLVEACLEEARELGVKRVF--ALTYQPEFFEKLGF 117
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
34-89 3.41e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 34.59  E-value: 3.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2188369297  34 ERVAVDIDYRKSGLGREIMNYAASLLKTENVD---GVVFHAQTGAAGFYASLGYVPNGE 89
Cdd:COG1247    84 ESIYVDPDARGRGIGRALLEALIERARARGYRrlvAVVLADNEASIALYEKLGFEEVGT 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH