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Conserved domains on  [gi|2181799110|ref|WP_235422083|]
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sensor histidine kinase [Collinsella tanakaei]

Protein Classification

sensor histidine kinase( domain architecture ID 11428470)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 232-346 9.46e-46

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16948:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 109  Bit Score: 152.05  E-value: 9.46e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 232 TDDKWMEFILGQLIQNSVKYArDEGATIEFRGAVVAEGmadecVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRST 311
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYS-KQGGKIEIYSETNEQG-----VVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQEST 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2181799110 312 GIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16948    75 GMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
14-348 2.15e-38

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 139.66  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  14 AFIVGSVALLICFVLVVGGVGWPLALLVTLMVVVAALAASVASWLQRRAFYTDLERSASDVRHPLWIAEMVDRPDFIEGE 93
Cdd:COG0642     6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  94 LTYDALRAISKAANDDVAsyRRQAADYREYVETWVHEAKSPLAAAHLMLENLvgsmpADDAADTALEKAEALEEELDRLE 173
Cdd:COG0642    86 LLLLLLLLLLLLALLLLL--EEANEAKSRFLANVSHELRTPLTAIRGYLELL-----LEELDEEQREYLETILRSADRLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 174 GYIEQALFFARSETLDRDYLIRKHRLGDLVSTAIkANARVMIATRVIPVQRNLD---IEVFTDDKWMEFILGQLIQNSVK 250
Cdd:COG0642   159 RLINDLLDLSRLEAGKLELEPEPVDLAELLEEVV-ELFRPLAEEKGIELELDLPddlPTVRGDPDRLRQVLLNLLSNAIK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 251 YArDEGATIEFRGAVvaegmADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKrSTGIGLYLVKRLCDKMGIGVE 330
Cdd:COG0642   238 YT-PEGGTVTVSVRR-----EGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIVELHGGTIE 310

                         330
                  ....*....|....*...
gi 2181799110 331 AQSDEGSGFTATLTFPAN 348
Cdd:COG0642   311 VESEPGKGTTFTVTLPLA 328
 
Name Accession Description Interval E-value
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 232-346 9.46e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 152.05  E-value: 9.46e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 232 TDDKWMEFILGQLIQNSVKYArDEGATIEFRGAVVAEGmadecVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRST 311
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYS-KQGGKIEIYSETNEQG-----VVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQEST 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2181799110 312 GIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16948    75 GMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
14-348 2.15e-38

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 139.66  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  14 AFIVGSVALLICFVLVVGGVGWPLALLVTLMVVVAALAASVASWLQRRAFYTDLERSASDVRHPLWIAEMVDRPDFIEGE 93
Cdd:COG0642     6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  94 LTYDALRAISKAANDDVAsyRRQAADYREYVETWVHEAKSPLAAAHLMLENLvgsmpADDAADTALEKAEALEEELDRLE 173
Cdd:COG0642    86 LLLLLLLLLLLLALLLLL--EEANEAKSRFLANVSHELRTPLTAIRGYLELL-----LEELDEEQREYLETILRSADRLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 174 GYIEQALFFARSETLDRDYLIRKHRLGDLVSTAIkANARVMIATRVIPVQRNLD---IEVFTDDKWMEFILGQLIQNSVK 250
Cdd:COG0642   159 RLINDLLDLSRLEAGKLELEPEPVDLAELLEEVV-ELFRPLAEEKGIELELDLPddlPTVRGDPDRLRQVLLNLLSNAIK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 251 YArDEGATIEFRGAVvaegmADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKrSTGIGLYLVKRLCDKMGIGVE 330
Cdd:COG0642   238 YT-PEGGTVTVSVRR-----EGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIVELHGGTIE 310

                         330
                  ....*....|....*...
gi 2181799110 331 AQSDEGSGFTATLTFPAN 348
Cdd:COG0642   311 VESEPGKGTTFTVTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
129-349 4.65e-35

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 128.49  E-value: 4.65e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 129 HEAKSPLAAAHLMLENLvgSMPADDAADTALEKAEALEEELDRLEGYIEQALFFARSETLDRDYLIRKHRLGDLVSTAIk 208
Cdd:COG2205    25 HELRTPLTSILGAAELL--LDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAELLEEAV- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 209 ANARVMIATRVIPVQRNLD---IEVFTDDKWMEFILGQLIQNSVKYARDEGaTIEFRGAVVAEGmadecVVLTVSDNGCG 285
Cdd:COG2205   102 EELRPLAEEKGIRLELDLPpelPLVYADPELLEQVLANLLDNAIKYSPPGG-TITISARREGDG-----VRISVSDNGPG 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2181799110 286 VPAADVPRVFDKGFTGENGRtGKRSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPANK 349
Cdd:COG2205   176 IPEEELERIFERFYRGDNSR-GEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 232-346 5.57e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 97.72  E-value: 5.57e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  232 TDDKWMEFILGQLIQNSVKYArDEGATIEFRGAVVaegmaDECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRST 311
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYT-PEGGRITVTLERD-----GDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGT 74

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2181799110  312 GIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:smart00387  75 GLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 67-347 2.16e-22

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 97.99  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  67 LERSASDVRHPlwiaEMVDRPDFIEGELtydalRAISKAanddVASYRRQAADyREYVETWV----HEAKSPLAAAHLML 142
Cdd:PRK11100  213 LTRYADAVTEG----KPVPLPKLGSSEL-----RELAQA----LESMRVKLEG-KAYVEQYVqtltHELKSPLAAIRGAA 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 143 ENLVGSMPADDAAdtalEKAEALEEELDRLEGYIEQALFFARSETldrdylirKHRLGDLVSTAIKANAR-VMIATRVIP 221
Cdd:PRK11100  279 ELLQEDPPPEDRA----RFTGNILTQSARLQQLIDRLLELARLEQ--------RQELEVLEPVALAALLEeLVEAREAQA 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 222 VQRNLDIEVFTDDKWME---FILGQLIQNSVKYARD---EGATIEFRGAVVAEGmadecVVLTVSDNGCGVPAADVPRVF 295
Cdd:PRK11100  347 AAKGITLRLRPDDARVLgdpFLLRQALGNLLDNAIDfspEGGTITLSAEVDGEQ-----VALSVEDQGPGIPDYALPRIF 421

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2181799110 296 DKGFTGENGRTGKRSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPA 347
Cdd:PRK11100  422 ERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 232-346 2.50e-20

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 85.11  E-value: 2.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 232 TDDKWMEFILGQLIQNSVKYARDEGatiefRGAVVAEgmADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGkrST 311
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAG-----EITVTLS--EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG--GT 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2181799110 312 GIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:pfam02518  72 GLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
170-349 7.37e-14

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 72.69  E-value: 7.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 170 DRLEGYIEQALFFARSetldRDYLIRKHRLGDLVSTAIKANARVMIATRvIPVQRNLDIE---VFTDDKWMEFILGQLIQ 246
Cdd:PRK11360  436 DRLNKVIDQLLEFSRP----RESQWQPVSLNALVEEVLQLFQTAGVQAR-VDFETELDNElppIWADPELLKQVLLNILI 510

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 247 NSVKyARDEGATIEFRGAVVAEGMadecVVLTVSDNGCGVPAADVPRVFDKGFTgengrTGKRSTGIGLYLVKRLCDKMG 326
Cdd:PRK11360  511 NAVQ-AISARGKIRIRTWQYSDGQ----VAVSIEDNGCGIDPELLKKIFDPFFT-----TKAKGTGLGLALSQRIINAHG 580

                         170       180
                  ....*....|....*....|...
gi 2181799110 327 IGVEAQSDEGSGFTATLTFPANK 349
Cdd:PRK11360  581 GDIEVESEPGVGTTFTLYLPINP 603
 
Name Accession Description Interval E-value
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 232-346 9.46e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 152.05  E-value: 9.46e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 232 TDDKWMEFILGQLIQNSVKYArDEGATIEFRGAVVAEGmadecVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRST 311
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYS-KQGGKIEIYSETNEQG-----VVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQEST 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2181799110 312 GIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16948    75 GMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
14-348 2.15e-38

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 139.66  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  14 AFIVGSVALLICFVLVVGGVGWPLALLVTLMVVVAALAASVASWLQRRAFYTDLERSASDVRHPLWIAEMVDRPDFIEGE 93
Cdd:COG0642     6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  94 LTYDALRAISKAANDDVAsyRRQAADYREYVETWVHEAKSPLAAAHLMLENLvgsmpADDAADTALEKAEALEEELDRLE 173
Cdd:COG0642    86 LLLLLLLLLLLLALLLLL--EEANEAKSRFLANVSHELRTPLTAIRGYLELL-----LEELDEEQREYLETILRSADRLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 174 GYIEQALFFARSETLDRDYLIRKHRLGDLVSTAIkANARVMIATRVIPVQRNLD---IEVFTDDKWMEFILGQLIQNSVK 250
Cdd:COG0642   159 RLINDLLDLSRLEAGKLELEPEPVDLAELLEEVV-ELFRPLAEEKGIELELDLPddlPTVRGDPDRLRQVLLNLLSNAIK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 251 YArDEGATIEFRGAVvaegmADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKrSTGIGLYLVKRLCDKMGIGVE 330
Cdd:COG0642   238 YT-PEGGTVTVSVRR-----EGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIVELHGGTIE 310

                         330
                  ....*....|....*...
gi 2181799110 331 AQSDEGSGFTATLTFPAN 348
Cdd:COG0642   311 VESEPGKGTTFTVTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
129-349 4.65e-35

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 128.49  E-value: 4.65e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 129 HEAKSPLAAAHLMLENLvgSMPADDAADTALEKAEALEEELDRLEGYIEQALFFARSETLDRDYLIRKHRLGDLVSTAIk 208
Cdd:COG2205    25 HELRTPLTSILGAAELL--LDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAELLEEAV- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 209 ANARVMIATRVIPVQRNLD---IEVFTDDKWMEFILGQLIQNSVKYARDEGaTIEFRGAVVAEGmadecVVLTVSDNGCG 285
Cdd:COG2205   102 EELRPLAEEKGIRLELDLPpelPLVYADPELLEQVLANLLDNAIKYSPPGG-TITISARREGDG-----VRISVSDNGPG 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2181799110 286 VPAADVPRVFDKGFTGENGRtGKRSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPANK 349
Cdd:COG2205   176 IPEEELERIFERFYRGDNSR-GEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
60-349 1.71e-28

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 114.26  E-value: 1.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  60 RRAFYTDLERSASDVRHPLWIAEMVDRPDFIEGELTYDALRAISKAANDDVASYRRQAADYREYVETWVHEAKSPLAAAH 139
Cdd:COG5002   105 LLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIR 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 140 LMLENLvgSMPADDAADTALEKAEALEEELDRLEGYIEQALFFARSETLDRDYLIRKHRLGDLVSTAIKAnARVMIATRV 219
Cdd:COG5002   185 GYLELL--LDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEE-LRPLAEEKG 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 220 IPVQRNL---DIEVFTDDKWMEFILGQLIQNSVKYArDEGATIEFRGAVvaegmADECVVLTVSDNGCGVPAADVPRVFD 296
Cdd:COG5002   262 IELELDLpedPLLVLGDPDRLEQVLTNLLDNAIKYT-PEGGTITVSLRE-----EDDQVRISVRDTGIGIPEEDLPRIFE 335

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2181799110 297 KGFTGENGRTGKRS-TGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPANK 349
Cdd:COG5002   336 RFYRVDKSRSRETGgTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 232-346 5.57e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 97.72  E-value: 5.57e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  232 TDDKWMEFILGQLIQNSVKYArDEGATIEFRGAVVaegmaDECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRST 311
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYT-PEGGRITVTLERD-----GDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGT 74

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2181799110  312 GIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:smart00387  75 GLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 67-347 2.16e-22

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 97.99  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  67 LERSASDVRHPlwiaEMVDRPDFIEGELtydalRAISKAanddVASYRRQAADyREYVETWV----HEAKSPLAAAHLML 142
Cdd:PRK11100  213 LTRYADAVTEG----KPVPLPKLGSSEL-----RELAQA----LESMRVKLEG-KAYVEQYVqtltHELKSPLAAIRGAA 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 143 ENLVGSMPADDAAdtalEKAEALEEELDRLEGYIEQALFFARSETldrdylirKHRLGDLVSTAIKANAR-VMIATRVIP 221
Cdd:PRK11100  279 ELLQEDPPPEDRA----RFTGNILTQSARLQQLIDRLLELARLEQ--------RQELEVLEPVALAALLEeLVEAREAQA 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 222 VQRNLDIEVFTDDKWME---FILGQLIQNSVKYARD---EGATIEFRGAVVAEGmadecVVLTVSDNGCGVPAADVPRVF 295
Cdd:PRK11100  347 AAKGITLRLRPDDARVLgdpFLLRQALGNLLDNAIDfspEGGTITLSAEVDGEQ-----VALSVEDQGPGIPDYALPRIF 421

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2181799110 296 DKGFTGENGRTGKRSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPA 347
Cdd:PRK11100  422 ERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 232-346 2.50e-20

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 85.11  E-value: 2.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 232 TDDKWMEFILGQLIQNSVKYARDEGatiefRGAVVAEgmADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGkrST 311
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAG-----EITVTLS--EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG--GT 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2181799110 312 GIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:pfam02518  72 GLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 129-347 2.55e-16

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 79.62  E-value: 2.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 129 HEAKSPLAAAHLMLENLVGSMPADDAADTALEKAEALEEEL--DRLEGYIEQALFFARSETLDRdyliRKHRLGDLVSta 206
Cdd:COG5000   210 HEIKNPLTPIQLSAERLRRKLADKLEEDREDLERALDTIIRqvDRLKRIVDEFLDFARLPEPQL----EPVDLNELLR-- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 207 ikanaRVMIATRVIPVQRNLDIEVFTDDKWMEFI-----LGQ----LIQNSVkYARDEGATIEFRGAVvaegmADECVVL 277
Cdd:COG5000   284 -----EVLALYEPALKEKDIRLELDLDPDLPEVLadrdqLEQvlinLLKNAI-EAIEEGGEIEVSTRR-----EDGRVRI 352

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 278 TVSDNGCGVPAADVPRVFDKGFTgengrTGKRSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPA 347
Cdd:COG5000   353 EVSDNGPGIPEEVLERIFEPFFT-----TKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 240-345 2.83e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 70.98  E-value: 2.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYArDEGaTIEFRgaVVAEGMADECVVL--TVSDNGCGVPAADVPRVFDKGFTGENGRTGKRS-TGIGLY 316
Cdd:cd16922     4 ILLNLLGNAIKFT-EEG-EVTLR--VSLEEEEEDGVQLrfSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGgTGLGLA 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2181799110 317 LVKRLCDKMG--IGVEAQSDEGSGFTATLTF 345
Cdd:cd16922    80 ISKKLVELMGgdISVESEPGQGSTFTFTLPL 110
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 240-349 1.71e-14

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 74.11  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYAR---DEGATIEFRgaVVAEgmaDECVVLTVSDNGCGVPAADVPRVFDKGFT--GENGRtgkrstGIG 314
Cdd:COG3290   285 ILGNLLDNAIEAVEklpEEERRVELS--IRDD---GDELVIEVEDSGPGIPEELLEKIFERGFStkLGEGR------GLG 353

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2181799110 315 LYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPANK 349
Cdd:COG3290   354 LALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 170-349 2.51e-14

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 74.05  E-value: 2.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 170 DRLEGYIEQALFFARSETLDRDylIRKHRLGDLVsTAIKANARVMIATRVIPVQRNLDIEVFTDDKWMEFILGQLIQNSV 249
Cdd:COG4251   331 ERMQALIDDLLAYSRVGRQELE--FEPVDLNELL-EEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAI 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 250 KYAR-DEGATIEFRGAVvaegmADECVVLTVSDNGCGVPAADVPRVFDkGFTGENGRTGKRSTGIGLYLVKRLCDKMG-- 326
Cdd:COG4251   408 KYSRpGEPPRIEIGAER-----EGGEWVFSVRDNGIGIDPEYAEKIFE-IFQRLHSRDEYEGTGIGLAIVKKIVERHGgr 481

                         170       180
                  ....*....|....*....|...
gi 2181799110 327 IGVEAQSDEGSGFtaTLTFPANK 349
Cdd:COG4251   482 IWVESEPGEGATF--YFTLPKAP 502
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
170-349 7.37e-14

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 72.69  E-value: 7.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 170 DRLEGYIEQALFFARSetldRDYLIRKHRLGDLVSTAIKANARVMIATRvIPVQRNLDIE---VFTDDKWMEFILGQLIQ 246
Cdd:PRK11360  436 DRLNKVIDQLLEFSRP----RESQWQPVSLNALVEEVLQLFQTAGVQAR-VDFETELDNElppIWADPELLKQVLLNILI 510

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 247 NSVKyARDEGATIEFRGAVVAEGMadecVVLTVSDNGCGVPAADVPRVFDKGFTgengrTGKRSTGIGLYLVKRLCDKMG 326
Cdd:PRK11360  511 NAVQ-AISARGKIRIRTWQYSDGQ----VAVSIEDNGCGIDPELLKKIFDPFFT-----TKAKGTGLGLALSQRIINAHG 580

                         170       180
                  ....*....|....*....|...
gi 2181799110 327 IGVEAQSDEGSGFTATLTFPANK 349
Cdd:PRK11360  581 GDIEVESEPGVGTTFTLYLPINP 603
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
170-349 3.94e-13

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 69.49  E-value: 3.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 170 DRLEGYIEQALFFARSETLDRDYL-IRK--HRLGDLVSTAIKANARVmiatrvipvQRNLD---IEVFTD-DKwmefiLG 242
Cdd:COG3852   181 DRLNNLVDRLLSFSRPRPPEREPVnLHEvlERVLELLRAEAPKNIRI---------VRDYDpslPEVLGDpDQ-----LI 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 243 QLIQNSVKYARD---EGATIEFR-----GAVVAEGMADECVVLTVSDNGCGVPAADVPRVFDKGFTG-ENGrtgkrsTGI 313
Cdd:COG3852   247 QVLLNLVRNAAEampEGGTITIRtrverQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTkEKG------TGL 320

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2181799110 314 GLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPANK 349
Cdd:COG3852   321 GLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQ 356
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 240-344 4.01e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 65.00  E-value: 4.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYARDEG---ATIEfrgaVVAEGMADEcVVLTVSDNGCGVPAADVPRVFDKGFT--GENGRtgkrstGIG 314
Cdd:cd16915     4 IVGNLIDNALDALAATGapnKQVE----VFLRDEGDD-LVIEVRDTGPGIAPELRDKVFERGVStkGQGER------GIG 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2181799110 315 LYLVKRLCDKMG--IGVEAQSDEGSGFTATLT 344
Cdd:cd16915    73 LALVRQSVERLGgsITVESEPGGGTTFSIRIP 104
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 129-347 2.77e-11

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 64.05  E-value: 2.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 129 HEAKSPLAAAHLMLENLVGSMPADDAADTALEKAEALEEELDRLEGYIEQALFFARSETLDRdyliRKHRLGDLVSTAIK 208
Cdd:COG4191   151 HEINNPLAAILGNAELLRRRLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEER----EPVDLNELIDEALE 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 209 AnARVMIATRVIPVQRNLDievfTDDKWMEFILGQLIQ---NSVKYARD-----EGATIEFRGAVvaegmADECVVLTVS 280
Cdd:COG4191   227 L-LRPRLKARGIEVELDLP----PDLPPVLGDPGQLEQvllNLLINAIDameegEGGRITISTRR-----EGDYVVISVR 296

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2181799110 281 DNGCGVPAADVPRVFDKGFTgengrT--GKRSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPA 347
Cdd:COG4191   297 DNGPGIPPEVLERIFEPFFT-----TkpVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 237-346 3.81e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 59.38  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 237 MEFILGQLIQNSVKYARdegatiefrGAV-VAEGMADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKrSTGIGL 315
Cdd:cd16950     1 LKRVLSNLVDNALRYGG---------GWVeVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTS-GTGLGL 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2181799110 316 YLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16950    71 AIVQRISDAHGGSLTLANRAGGGLCARIELP 101
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 226-347 5.00e-11

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 64.19  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 226 LDIEVFTDDKWMEFILGQLIQNSVKYARDEGATIEfrgaVVAEgmADECVVLTVSDNGCGVPAADVPRVFD-----KGFT 300
Cdd:PRK11091  388 LPHKVITDGTRLRQILWNLISNAVKFTQQGGVTVR----VRYE--EGDMLTFEVEDSGIGIPEDELDKIFAmyyqvKDSH 461

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2181799110 301 GENGRTGkrsTGIGLYLVKRLCDKMG--IGVEAQSDEGSGFTATLTFPA 347
Cdd:PRK11091  462 GGKPATG---TGIGLAVSKRLAQAMGgdITVTSEEGKGSCFTLTIHAPA 507
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 244-352 1.54e-09

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 59.22  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 244 LIQNSVKyARDEGATIefrgaVVAEG-MADECVVLTVSDNGCGVPAADVPRVFDKGFTgengrTGKRSTGIGLYLVKRLC 322
Cdd:COG5809   387 LLKNAIE-AMPEGGNI-----TIETKaEDDDKVVISVTDEGCGIPEERLKKLGEPFYT-----TKEKGTGLGLMVSYKII 455

                          90       100       110
                  ....*....|....*....|....*....|
gi 2181799110 323 DKMGIGVEAQSDEGSGFTATLTFPANKMHY 352
Cdd:COG5809   456 EEHGGKITVESEVGKGTTFSITLPIKLSEQ 485
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 221-343 1.95e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 55.21  E-value: 1.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 221 PVQRNLDIEVftddkwMEFILGQLIQNSVKYardeGATIEFRGAVVAEGMADecVVLTVSDNGCGVPAADVPRVFDKGFT 300
Cdd:cd16947    11 PIYANANTEA------LQRILKNLISNAIKY----GSDGKFLGMTLREDEKH--VYIDIWDKGKGISETEKDHVFERLYT 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2181799110 301 GENGRTG-KRSTGIGLYLVKRLCDKMG--IGVEAQSDEGSGFTATL 343
Cdd:cd16947    79 LEDSRNSaKQGNGLGLTITKRLAESMGgsIYVNSKPYEKTVFTVTL 124
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
170-349 3.07e-09

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 58.11  E-value: 3.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 170 DRLEGYIEqalffarsetldrdylIRKHRLGDlvstaikanarvmiatrvipvqrNLDIEVFTDDKWME-----FILGQL 244
Cdd:COG2972   304 ELIKSYLE----------------IQKLRFGD-----------------------RLEVEIEIDEELLDllipkLILQPL 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 245 IQNSVKYA---RDEGATIEFRGAvvaegMADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRtgkrstGIGLYLVK-- 319
Cdd:COG2972   345 VENAIEHGiepKEGGGTIRISIR-----KEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR------GIGLRNVRer 413

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2181799110 320 -RLCDKMGIGVEAQSDEGSGFTATLTFPANK 349
Cdd:COG2972   414 lKLYYGEEYGLEIESEPGEGTTVTIRIPLEE 444
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 227-345 5.74e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 53.56  E-value: 5.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 227 DIEVFTDDKWMEFILGQLIQNSVKYArDEGATIEFRGAvvaegmADECVVLTVSDNGCGVPAADVPRVFDKgFTGENGRT 306
Cdd:cd16940     4 DIQVQGDALLLFLLLRNLVDNAVRYS-PQGSRVEIKLS------ADDGAVIRVEDNGPGIDEEELEALFER-FYRSDGQN 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2181799110 307 GKrSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTF 345
Cdd:cd16940    76 YG-GSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
PRK13557 PRK13557
histidine kinase; Provisional
 177-347 1.43e-08

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 56.22  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 177 EQALFFARSETLDRdyliRKHRLGDLVSTAIKANAR-----VMIATRVIPVQRNLDIevftDDKWMEFILGQLIQNsvky 251
Cdd:PRK13557  221 QQLLAFARKQRLEG----RVLNLNGLVSGMGELAERtlgdaVTIETDLAPDLWNCRI----DPTQAEVALLNVLIN---- 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 252 ARD-----EGATIEFRGAVVAE-------GMADEC-VVLTVSDNGCGVPAADVPRVFDKGF-TGENGrtgkRSTGIGLYL 317
Cdd:PRK13557  289 ARDampegGRVTIRTRNVEIEDedlamyhGLPPGRyVSIAVTDTGSGMPPEILARVMDPFFtTKEEG----KGTGLGLSM 364

                         170       180       190
                  ....*....|....*....|....*....|
gi 2181799110 318 VKRLCDKMGIGVEAQSDEGSGFTATLTFPA 347
Cdd:PRK13557  365 VYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 257-343 2.14e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 51.65  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 257 ATIEFRGAV-VAEGMADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGkrsTGIGLYLVKRLCDKMG--IGVEAQS 333
Cdd:cd16943    17 QAMEGRGRItIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEG---TGLGLSLSYRIIQKHGgtIRVASVP 93

                          90
                  ....*....|
gi 2181799110 334 DEGSGFTATL 343
Cdd:cd16943    94 GGGTRFTIIL 103
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-346 2.23e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 51.69  E-value: 2.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 233 DDKWMEFILGQLIQNSVKYArDEGATIEFRGAVVaegmaDECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTgkRS-- 310
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYT-DTGGKLRIRAAQT-----PQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRN--RAsg 72

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2181799110 311 -TGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16946    73 gSGLGLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 239-343 2.44e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 51.31  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 239 FILGQLIQNSVKYARD---EGATIEFRGAVVAEGmadecVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRSTGIGL 315
Cdd:cd16945     3 FLLRQAINNLLDNAIDfspEGGLIALQLEADTEG-----IELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGL 77

                          90       100
                  ....*....|....*....|....*....
gi 2181799110 316 YLVKRLCDKMGIGVEAQS-DEGSGFTATL 343
Cdd:cd16945    78 AFVQEVAQLHGGRITLRNrPDGVLAFLTL 106
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 244-346 6.83e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 50.28  E-value: 6.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 244 LIQNSVKYARDEGaTIEFRGAVVAEGMAdecvvLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRS-TGIGLYLVKRLC 322
Cdd:cd16952     8 LVSNAVKYTPPSD-TITVRWSQEESGAR-----LSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHVM 81

                          90       100
                  ....*....|....*....|....
gi 2181799110 323 DKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16952    82 SRHDARLLIASELGKGSRFTCLFP 105
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 240-343 9.65e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 49.63  E-value: 9.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYARD-EGATIEfrgaVVAEGMADEcVVLTVSDNGCGVPaadvPRVFDKGFT---GENGRTGKRSTGIGL 315
Cdd:cd16921     4 VLTNLLGNAIKFRRPrRPPRIE----VGAEDVGEE-WTFYVRDNGIGID----PEYAEKVFGifqRLHSREEYEGTGVGL 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 2181799110 316 YLVKRLCDKMG--IGVEAQSDEGSGFTATL 343
Cdd:cd16921    75 AIVRKIIERHGgrIWLESEPGEGTTFYFTL 104
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 237-347 1.69e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 48.97  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 237 MEFILGQLIQNSVKYARdegATIEfrgavVAEGMADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTgkRST---GI 313
Cdd:cd16939     1 MARALDNLLRNALRYAH---RTVR-----IALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRD--RATggfGL 70

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2181799110 314 GLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPA 347
Cdd:cd16939    71 GLAIVHRVALWHGGHVECDDSELGGACFRLTWPR 104
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
231-327 8.26e-07

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 47.60  E-value: 8.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 231 FTDDKWMEF--ILGQLIQNSVKYAR--DEGATIEFRGAVVaegmaDECVVLTVSDNGCGVPAADVPRVFDKGFTGengrt 306
Cdd:COG2172    27 LDEDDADDLvlAVSEAVTNAVRHAYggDPDGPVEVELELD-----PDGLEIEVRDEGPGFDPEDLPDPYSTLAEG----- 96

                          90       100
                  ....*....|....*....|.
gi 2181799110 307 gkrstGIGLYLVKRLCDKMGI 327
Cdd:COG2172    97 -----GRGLFLIRRLMDEVEY 112
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 240-340 1.21e-06

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 50.30  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYARD-EGATIEfrgavVAEGMADECVVLTVSDNGCGVPAADVPRVFDKGF-TGENGRtgkrstGIGLYL 317
Cdd:PRK11086  437 ILGNLIENALEAVGGeEGGEIS-----VSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYsTKGSNR------GVGLYL 505

                          90       100
                  ....*....|....*....|....*
gi 2181799110 318 VKRLCDKMG--IGVEAQSDEGSGFT 340
Cdd:PRK11086  506 VKQSVENLGgsIAVESEPGVGTQFF 530
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 240-326 2.07e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 45.92  E-value: 2.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYARdEGATIEfrgavVAEGMADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRSTGIGLYLVK 319
Cdd:cd16975     8 ALINIISNACQYAP-EGGTVS-----ISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAK 81


                  ....*..
gi 2181799110 320 RLCDKMG 326
Cdd:cd16975    82 NLVEKHG 88
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
252-348 2.72e-06

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 49.01  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 252 ARDEGATIEFRGAVVAEGmadecVVLTVSDNGCGVPAADVPRVFDKGFTgengrTGKRSTGIGLYLVKRLCDKMGIGVEA 331
Cdd:PRK10364  363 AIGQHGVISVTASESGAG-----VKISVTDSGKGIAADQLEAIFTPYFT-----TKAEGTGLGLAVVHNIVEQHGGTIQV 432

                          90
                  ....*....|....*..
gi 2181799110 332 QSDEGSGFTATLTFPAN 348
Cdd:PRK10364  433 ASQEGKGATFTLWLPVN 449
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 275-346 3.19e-06

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 45.45  E-value: 3.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2181799110 275 VVLTVSDNGCGVPAADVPRVFDKGF-TGENGrtgkRSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPFFtTKEVG----KGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
envZ PRK09467
osmolarity sensor protein; Provisional
 240-346 4.12e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 48.37  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYARDEgatIEfrgavVAEGMADECVVLTVSDNGCGVPAADVPRVFdKGFT-GENGRtGKRSTGIGLYLV 318
Cdd:PRK09467  335 ALANLVVNAARYGNGW---IK-----VSSGTEGKRAWFQVEDDGPGIPPEQLKHLF-QPFTrGDSAR-GSSGTGLGLAIV 404

                          90       100
                  ....*....|....*....|....*...
gi 2181799110 319 KRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:PRK09467  405 KRIVDQHNGKVELGNSEEGGLSARAWLP 432
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 170-346 5.06e-06

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 48.19  E-value: 5.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 170 DRLEGYIEQALFFARSETLDRDYLIRKHRLGDLVsTAIKANARVmiatrvipvqRNLDIEVFTDDKWMeFILG------Q 243
Cdd:COG5805   331 DRIESIISEFLALAKPQAVNKEKENINELIQDVV-TLLETEAIL----------HNIQIRLELLDEDP-FIYCdenqikQ 398

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 244 LIQNSVKYARDE---GATIEFRgaVVAEgmaDECVVLTVSDNGCGVPAADVPRVFDKGFTgengrTGKRSTGIGLYLVKR 320
Cdd:COG5805   399 VFINLIKNAIEAmpnGGTITIH--TEEE---DNSVIIRVIDEGIGIPEERLKKLGEPFFT-----TKEKGTGLGLMVSYK 468

                         170       180
                  ....*....|....*....|....*.
gi 2181799110 321 LCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:COG5805   469 IIENHNGTIDIDSKVGKGTTFTITLP 494
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 240-347 5.24e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 47.98  E-value: 5.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYA---RDEGA-TIEFRgavvaegMADECVVLTVSDNGCGVPAADVPRvfdkgftgengrtgkRSTGIGL 315
Cdd:COG3920   403 ILNELVTNALKHAflsGEGGRiRVSWR-------REDGRLRLTVSDNGVGLPEDVDPP---------------ARKGLGL 460

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2181799110 316 YLVKRLCDKMGiGvEAQSDEGSGFTATLTFPA 347
Cdd:COG3920   461 RLIRALVRQLG-G-TLELDRPEGTRVRITFPL 490
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 243-346 1.04e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 44.07  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 243 QLIQNSVKYARDegaTIEFRGAVVAEGM------ADECVVLTVSDNGCGVPAADVPRVFDKGFTgengrTGKRSTGIGLY 316
Cdd:cd16944     7 QVLTNILKNAAE---AIEGRPSDVGEVRirveadQDGRIVLIVCDNGKGFPREMRHRATEPYVT-----TRPKGTGLGLA 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 2181799110 317 LVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16944    79 IVKKIMEEHGGRISLSNREAGGACIRIILP 108
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
176-346 1.38e-05

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 46.98  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 176 IEQALFFARSetldRDYLIRKHRLGDLVsTAIKANARVMIATRV-IPVQRNLDIEVFTDDKW-MEFILGQLIQNSVKyAR 253
Cdd:PRK13837  503 IDQILAFGRK----GERNTKPFDLSELV-TEIAPLLRVSLPPGVeLDFDQDQEPAVVEGNPAeLQQVLMNLCSNAAQ-AM 576

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 254 DEGATIEF---RGAVVAEG-------MADECVVLTVSDNGCGVPAADVPRVFDKGFTgengrTGKRSTGIGLYLVKRLCD 323
Cdd:PRK13837  577 DGAGRVDIslsRAKLRAPKvlshgvlPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFT-----TRAGGTGLGLATVHGIVS 651

                         170       180
                  ....*....|....*....|...
gi 2181799110 324 KMGIGVEAQSDEGSGFTATLTFP 346
Cdd:PRK13837  652 AHAGYIDVQSTVGRGTRFDVYLP 674
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 243-343 2.21e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 42.83  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 243 QLIQNSVKYARDEGATIEFRGAVVAEGMADECVVLTVSDNGCGVPAADVPRVFDKGFTgenGRTGKRSTGIGLYLVKRLC 322
Cdd:cd16976     3 QVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT---TKPVGKGTGLGLSISYGIV 79

                          90       100
                  ....*....|....*....|...
gi 2181799110 323 DKMG--IGVEAQSDEGSGFTATL 343
Cdd:cd16976    80 EEHGgrLSVANEEGAGARFTFDL 102
PRK10490 PRK10490
sensor protein KdpD; Provisional
 221-317 2.44e-05

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 46.18  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 221 PVQRNLDIE---VFTDDKWMEFILGQLIQNSVKYArDEGATIEFRGAVVAEGMAdecvvLTVSDNGCGVPAADVPRVFDK 297
Cdd:PRK10490  760 PINLSLPEPltlIHVDGPLFERVLINLLENAVKYA-GAQAEIGIDAHVEGERLQ-----LDVWDNGPGIPPGQEQLIFDK 833

                          90       100
                  ....*....|....*....|..
gi 2181799110 298 gFTgengRTGKRST--GIGLYL 317
Cdd:PRK10490  834 -FA----RGNKESAipGVGLGL 850
PRK15347 PRK15347
two component system sensor kinase;
240-363 5.10e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 45.40  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYARDEGatIEFRGAVVaegmaDECVVLTVSDNGCGVPAADVPRVFDKGF-TGENgrtgKRSTGIGLYLV 318
Cdd:PRK15347  517 ILVNLLGNAVKFTETGG--IRLRVKRH-----EQQLCFTVEDTGCGIDIQQQQQIFTPFYqADTH----SQGTGLGLTIA 585

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2181799110 319 KRLCDKMGIGVEAQSDEGSGFTATLTFPANKmhYFERDPIKG--MAP 363
Cdd:PRK15347  586 SSLAKMMGGELTLFSTPGVGSCFSLVLPLNE--YAPPEPLKGelSAP 630
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 240-340 1.56e-04

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 43.67  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYA--RDEGatiefrGAVVAEGMADEC--VVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRstGIGL 315
Cdd:PRK15053  436 IVGNLLDNAFEASlrSDEG------NKIVELFLSDEGddVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEH--GIGL 507

                          90       100
                  ....*....|....*....|....*..
gi 2181799110 316 YLVKRLCDKMG--IGVEAQSDEGSGFT 340
Cdd:PRK15053  508 YLIASYVTRCGgvITLEDNDPCGTLFS 534
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 237-327 1.71e-04

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 39.94  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 237 MEFILGQLIQNSVKYARDEGATIEFRgaVVAEGmADECVVLTVSDNGcgvPAADVPRVFDkgfTGENGRTGkrstGIGLY 316
Cdd:cd16936     1 VELAVSEAVTNAVRHAYRHDGPGPVR--LELDL-DPDRLRVEVTDSG---PGFDPLRPAD---PDAGLREG----GRGLA 67

                          90
                  ....*....|.
gi 2181799110 317 LVKRLCDKMGI 327
Cdd:cd16936    68 LIRALMDEVGY 78
PRK10604 PRK10604
sensor protein RstB; Provisional
 170-346 1.78e-04

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 43.05  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 170 DRLEGYIEQALFFARsetLDRDYLIRKhrlgdLVSTAIKANARVMIA-TRVIPVQRNLDIEVFT-------DDKWMEFIL 241
Cdd:PRK10604  253 GQLEALIEELLTYAR---LDRPQNELH-----LSEPDLPAWLSTHLAdIQAVTPEKTVRLDTPHqgdygalDMRLMERVL 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 242 GQLIQNSVKYARDegatiefrgaVVAEGMA--DECVVLTVSDNGCGVPAADVPRVFDKgFT----GENGRTGkrSTGIGL 315
Cdd:PRK10604  325 DNLLNNALRYAHS----------RVRVSLLldGNQACLIVEDDGPGIPPEERERVFEP-FVrldpSRDRATG--GCGLGL 391

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2181799110 316 YLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:PRK10604  392 AIVHSIALAMGGSVNCDESELGGARFSFSWP 422
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 244-347 2.60e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 40.00  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 244 LIQNSVKYARDegaTIEFRGAVVAEGmadecVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKR-STGIGLYLVKRLC 322
Cdd:cd16949     8 VLRNALRYSPS---KILLDISQDGDQ-----WTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESgGTGLGLAIAERAI 79

                          90       100
                  ....*....|....*....|....*
gi 2181799110 323 DKMGIGVEAQSDEGSGFTATLTFPA 347
Cdd:cd16949    80 EQHGGKIKASNRKPGGLRVRIWLPA 104
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 240-346 2.88e-04

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 42.97  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 240 ILGQLIQNSVKYArDEGATIefrgavVAEGMADECVVLTVSDNGCGVPAADVPRVFdKGFTGENGRTGkrSTGIGLYLVK 319
Cdd:PRK11466  565 VITNLLSNALRFT-DEGSIV------LRSRTDGEQWLVEVEDSGCGIDPAKLAEIF-QPFVQVSGKRG--GTGLGLTISS 634

                          90       100
                  ....*....|....*....|....*..
gi 2181799110 320 RLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:PRK11466  635 RLAQAMGGELSATSTPEVGSCFCLRLP 661
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
227-347 4.19e-04

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 41.92  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 227 DIEVFTDDKWMEFILGQLIQNSVKYArDEGATIEFRGAVVAEGMadecvVLTVSDNGCGVPAADVPRVFDKGFTGENGR- 305
Cdd:PRK11006  308 SLKVFGNEDQLRSAISNLVYNAVNHT-PEGTHITVRWQRVPQGA-----EFSVEDNGPGIAPEHIPRLTERFYRVDKARs 381

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2181799110 306 --TGkrSTGIGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFPA 347
Cdd:PRK11006  382 rqTG--GSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 239-343 4.46e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 39.35  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 239 FILGQLIQNSVKYA----RDEGA-TIEFRgavvaegMADECVVLTVSDNGCGVPAADVPRVfdkgftgenGRTGKRSTGI 313
Cdd:cd16924     4 FTLQPLVENAIQHGlsplTDKGVvTISAL-------KEDNHVMIEVEDNGRGIDPKVLNIL---------GKKPKEGNGI 67

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2181799110 314 GLYLV-KRLC----DKMGIGVEAQSDEGSGFTATL 343
Cdd:cd16924    68 GLYNVhQRLIllfgEDYGIHIASEPDKGTRITFTI 102
PRK09303 PRK09303
histidine kinase;
222-343 6.80e-04

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 41.09  E-value: 6.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 222 VQRNLDI-----EVFTDDKWMEFILGQLIQNSVKYARDEGaTIEfrgaVVAEGMADECVVLTVSDNGCGVPAADVPRVFD 296
Cdd:PRK09303  253 LEIQTDIpsdlpSVYADQERIRQVLLNLLDNAIKYTPEGG-TIT----LSMLHRTTQKVQVSICDTGPGIPEEEQERIFE 327

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2181799110 297 KGFtgengR----TGKRSTGIGLYLVKRLCDKMG--IGVEAQSDEGSGFTATL 343
Cdd:PRK09303  328 DRV-----RlprdEGTEGYGIGLSVCRRIVRVHYgqIWVDSEPGQGSCFHFTL 375
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 237-346 1.07e-03

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 38.24  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 237 MEFILGQLIQNSVKYARDEGATiefrGAVVAEGMADECVvLTVSDNGCGVPAADVPRVFDKGFTG-ENGRTGKRSTGIGL 315
Cdd:cd16925     5 YERVVLNLLSNAFKFTPDGGRI----RCILEKFRLNRFL-LTVSDSGPGIPPNLREEIFERFRQGdGSSTRAHGGTGLGL 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2181799110 316 YLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:cd16925    80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
239-346 1.70e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 39.60  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 239 FILGQLIQNSVKYARDEGATIEFRGAvvaegmaDECVVLTVSDNGCGVPAADVPRvfdkgftgengrtgkrsTGIGLYLV 318
Cdd:COG4585   165 RIVQEALTNALKHAGATRVTVTLEVD-------DGELTLTVRDDGVGFDPEAAPG-----------------GGLGLRGM 220

                          90       100
                  ....*....|....*....|....*...
gi 2181799110 319 KRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:COG4585   221 RERAEALGGTLTIGSAPGGGTRVRATLP 248
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 244-344 3.22e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 36.60  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 244 LIQNSVKYArDEGATIEfrgavVAEGMADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKRStGIGLYLVKRLCD 323
Cdd:cd16923     8 LLSNAIKYS-PENTRIY-----ITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGA-GLGLSIAKAIIE 80

                          90       100
                  ....*....|....*....|..
gi 2181799110 324 KMGIGVEAQSD-EGSGFTATLT 344
Cdd:cd16923    81 LHGGSASAEYDdNHDLFKVRLP 102
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
233-346 3.39e-03

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 39.72  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110  233 DDKWMEFILGQLIQNSVKYArDEGAtIEFRGAVVAEGMADECVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTgKRSTG 312
Cdd:PRK09959   825 DPQAFKQVLSNLLSNALKFT-TEGA-VKITTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQ-QTGSG 901

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2181799110  313 IGLYLVKRLCDKMGIGVEAQSDEGSGFTATLTFP 346
Cdd:PRK09959   902 LGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 237-336 3.68e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 36.61  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 237 MEFILGQLIQNSVKYARDEGATIEFRGAV---VAEGMADECVVLTVS--DNGCGVPAADVPRVFDKGFTG-ENGrtgkrs 310
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGSGGEIILRTRTqrqVTLGHPRHRLALRVSviDNGPGIPPDLQDTIFYPMVSGrENG------ 74

                          90       100
                  ....*....|....*....|....*.
gi 2181799110 311 TGIGLYLVKRLCDKMGIGVEAQSDEG 336
Cdd:cd16918    75 TGLGLAIAQNIVSQHGGVIECDSQPG 100
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
274-340 5.96e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 38.80  E-value: 5.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 274 CVVLTVS-----------DNGCGVPAADVPRVFDKGF-TGENGRTGKRSTGIGLYLVKRLCDKM--GIGVEAQSDEGSGF 339
Cdd:PRK10841  582 CIVLHVRvdgdylsfrvrDTGVGIPAKEVVRLFDPFFqVGTGVQRNFQGTGLGLAICEKLINMMdgDISVDSEPGMGSQF 661


                  .
gi 2181799110 340 T 340
Cdd:PRK10841  662 T 662
PRK13560 PRK13560
hypothetical protein; Provisional
 239-346 6.43e-03

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 38.50  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 239 FILGQLIQNSVKYARDEGATIEFRGAVVAEGmaDECVVLTVSDNGCGVPAAdvprvFDkgFTgengrtgkRSTGIGLYLV 318
Cdd:PRK13560  714 LIISELLSNALKHAFPDGAAGNIKVEIREQG--DGMVNLCVADDGIGLPAG-----FD--FR--------AAETLGLQLV 776

                          90       100
                  ....*....|....*....|....*...
gi 2181799110 319 KRLCDKMGIGVEAQSDEGSGFtaTLTFP 346
Cdd:PRK13560  777 CALVKQLDGEIALDSRGGARF--NIRFP 802
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 237-345 7.42e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 36.46  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2181799110 237 MEfILGQLIQNSVKYArDEGATIefrGAVVAEGMadecVVLTVSDNGCGVPAADVPRVFDKGFTGENGRTGKrstGIGLY 316
Cdd:cd16954    39 ME-LLGNLLDNACKWC-LEFVEV---TARQTDGG----LHLIVDDDGPGVPESQRSKIFQRGQRLDEQRPGQ---GLGLA 106

                          90       100
                  ....*....|....*....|....*....
gi 2181799110 317 LVKRLCDKMGIGVEAQSDEGSGFTATLTF 345
Cdd:cd16954   107 IAKEIVEQYGGELSLSDSPLGGARFEVVF 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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