|
Name |
Accession |
Description |
Interval |
E-value |
| AceE |
COG2609 |
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ... |
1-888 |
0e+00 |
|
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain] Cd Length: 891 Bit Score: 1951.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 1 MSEN----MLQDLDPLETQEWVESLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQE 76
Cdd:COG2609 1 MSMDglpsQLPDIDPQETQEWLESLDAVIEEEGPERARYLLERLLERARRSGVGLPFSATTPYINTIPVEQEPPYPGDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 77 MERRIRAIVRWNALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLEGR 156
Cdd:COG2609 81 LERRIRSIIRWNAMAMVVRANRKGGGLGGHISSFASAATLYEVGFNHFFRGPDHPGGGDLVYFQGHASPGIYARAFLEGR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 157 LSEEQLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEP 236
Cdd:COG2609 161 LTEEQLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLHNRGLKDTSDRKVWAFLGDGEMDEP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 237 EALGAIGLAAREELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLMNE 316
Cdd:COG2609 241 ESLGAISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAGWNVIKVIWGSEWDPLLAKDTDGALVKRMNE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 317 TVDGEYQNCKAKGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGL 396
Cdd:COG2609 321 TVDGDYQTYKAKDGAYVREHFFGKYPELKALVADMSDEDIWRLNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 397 GDAGEGKNIAHNVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMGYLPARRQKfSEEMQVP 476
Cdd:COG2609 401 GEAGEGRNITHQQKKLDLDDLKAFRDRFNIPISDEQLEELPYYKPAEDSPEMKYLHERRKALGGYLPQRRTK-AEPLEVP 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 477 SLKIFDAVLKGSNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDADQVAY 556
Cdd:COG2609 480 ELSAFAALLKGSGKREISTTMAFVRILNDLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPVGQLYTPVDADQLLY 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 557 YREDKSGQVLQEGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSGRTTLNG 636
Cdd:COG2609 560 YKESKDGQILQEGINEAGAMSSWIAAGTSYSTHGVPMIPFYIYYSMFGFQRVGDLAWAAGDQRARGFLIGATAGRTTLNG 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 637 EGLQHQDGHSHILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGEdQEDIFYYLTTMNENYVQPEMPQGVEEGIVKGIYK 716
Cdd:COG2609 640 EGLQHQDGHSHLLASTIPNCVSYDPAFAYELAVIVQDGLRRMYGE-QENVFYYITVMNENYAQPAMPEGVEEGILKGMYL 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 717 LESVAGSGKGKVQLMGCGTILEQVRKAAQALAKDFGISTDVFSVTSFNELARDGQAVERWNMLHPTKTAKVPYVSTVLAK 796
Cdd:COG2609 719 LKEGEGKGKPRVQLLGSGTILREVLAAAELLAEDWGVAADVWSVTSFNELRRDGLDVERWNLLHPEEEPRVPYVTQCLAG 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 797 -DAPAIVATDYMKIYGEQLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSLVDRNELPVDVLAKTIAE 875
Cdd:COG2609 799 aEGPVVAATDYMRAVPDQIRPWVPGRYTVLGTDGFGRSDTREALRRFFEVDRYSIVVAALKALADEGKIDASVVAEAIKK 878
|
890
....*....|...
gi 2178850460 876 YGIDADKIDPQHA 888
Cdd:COG2609 879 YGIDPDKPNPLTA 891
|
|
| aceE |
PRK09405 |
pyruvate dehydrogenase subunit E1; Reviewed |
1-888 |
0e+00 |
|
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain] Cd Length: 891 Bit Score: 1941.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 1 MSENMLQDLDPLETQEWVESLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERR 80
Cdd:PRK09405 4 GSESQLNDIDPIETQEWLEALDSVIREEGPERAHYLLEQLLERAREKGVSLPASATTPYINTIPVEEEPEYPGDLELERR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 81 IRAIVRWNALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLEGRLSEE 160
Cdd:PRK09405 84 IRSYIRWNAAAMVLRANKKDLGLGGHISSFASSATLYEVGFNHFFRAPNEPHGGDLVFFQGHASPGIYARAFLEGRLTEE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 161 QLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALG 240
Cdd:PRK09405 164 QLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFLKYLENRGLKDTSDQKVWAFLGDGEMDEPESLG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 241 AIGLAAREELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLMNETVDG 320
Cdd:PRK09405 244 AISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSRWDPLLAKDTSGKLVQLMNETVDG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 321 EYQNCKAKGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGLGDAG 400
Cdd:PRK09405 324 DYQTYKAKDGAYVREHFFGKYPETKALVADMSDDDIWALNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEAG 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 401 EGKNIAHNVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMGYLPARRQKFsEEMQVPSLKI 480
Cdd:PRK09405 404 EGKNIAHQVKKLDLDDLKHFRDRFNIPISDEQLEKLPYYKPGEDSPEIKYLHERRKALGGYLPARRPKF-EPLEVPALSA 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 481 FDAVLKGSNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDADQVAYYRED 560
Cdd:PRK09405 483 FEALLKGSGEREISTTMAFVRILNILLKDKEIGKRIVPIIPDEARTFGMEGLFRQIGIYNPHGQLYTPVDRDQLMYYKES 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 561 KSGQVLQEGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSGRTTLNGEGLQ 640
Cdd:PRK09405 563 KDGQILQEGINEAGAMASWIAAATSYSTHGEPMIPFYIYYSMFGFQRIGDLAWAAGDQRARGFLLGGTAGRTTLNGEGLQ 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 641 HQDGHSHILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGEdQEDIFYYLTTMNENYVQPEMPQGVEEGIVKGIYKLESV 720
Cdd:PRK09405 643 HEDGHSHILASTIPNCVSYDPAFAYEVAVIVQDGLRRMYGE-QENVFYYITVMNENYHQPAMPEGAEEGILKGMYKLETA 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 721 AGS-GKGKVQLMGCGTILEQVRKAAQALAKDFGISTDVFSVTSFNELARDGQAVERWNMLHPTKTAKVPYVSTVLAK-DA 798
Cdd:PRK09405 722 EGKkGKPKVQLLGSGTILREVLEAAEILAEDYGVAADVWSVTSFNELARDGQDVERWNMLHPTEEPRVPYVTQVLKGaEG 801
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 799 PAIVATDYMKIYGEQLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSLVDRNELPVDVLAKTIAEYGI 878
Cdd:PRK09405 802 PVVAATDYMKLFAEQIRAFVPGDYVVLGTDGFGRSDTREALRRFFEVDAEYVVVAALKALADEGEIDASVVAEAIKKYGI 881
|
890
....*....|
gi 2178850460 879 DADKIDPQHA 888
Cdd:PRK09405 882 DPDKANPRTA 891
|
|
| aceE |
TIGR00759 |
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ... |
8-888 |
0e+00 |
|
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain] Cd Length: 885 Bit Score: 1527.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 8 DLDPLETQEWVESLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERRIRAIVRW 87
Cdd:TIGR00759 5 DVDPIETQEWLESLDSVLAEEGPARARYLLEQLLEYAREHGVPIPAGTTTDYINTIPVEEQPAYPGDLELERRIRSIIRW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 88 NALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLEGRLSEEQLANFRQ 167
Cdd:TIGR00759 85 NAIAMVLRANKKDLGLGGHISTYASAATLYEVGFNHFFRGHSEGGGGDLVFFQGHAAPGIYARAFLEGRLTEEQLDNFRQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 168 EVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALGAIGLAAR 247
Cdd:TIGR00759 165 EVQGDGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLENRGLKDTGDQKVWAFLGDGEMDEPESKGAITFAAR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 248 EELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLMNETVDGEYQNCKA 327
Cdd:TIGR00759 245 EKLDNLTFVINCNLQRLDGPVRGNGKIIQELESLFRGAGWNVIKVLWGSEWDALLARDTSGVLVKLMNETVDGDYQTYKA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 328 KGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGLGDAGEGKNIAH 407
Cdd:TIGR00759 325 KDGAYVREHFFNRTPELKALVADMSDADIWALNRGGHDPRKVYAAYAAAQEHKGQPTVILAKTIKGYGMGDAAESRNTAH 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 408 NVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMGYLPARRQKFsEEMQVPSLKIFDAVLKG 487
Cdd:TIGR00759 405 QVKKLEVDALKNFRDRFELPLSDAQVEELPYYHPGEGSPEVRYLLARRQALGGYLPARRTFA-EHLTVPALEFFGALLKG 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 488 SNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDADQVAYYREDKSGQVLQ 567
Cdd:TIGR00759 484 SGEREVSTTMAFVRILNKLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPHGQTYTPVDADSLLAYKESKDGQILQ 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 568 EGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSGRTTLNGEGLQHQDGHSH 647
Cdd:TIGR00759 564 EGINEAGAMASWIAAATSYATHGEPMIPFYIYYSMFGFQRIGDLCWAAADQRARGFLLGATAGRTTLNGEGLQHEDGHSL 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 648 ILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGEdQEDIFYYLTTMNENYVQPEMPQGVEEGIVKGIYKLESVAG-SGKG 726
Cdd:TIGR00759 644 LQAATIPNCIAYDPAFAYEVAVIMEDGLRRMYGE-QEDVFYYVTVMNENYVQPPMPEGAEEGILKGLYRFETSTEeKAKG 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 727 KVQLMGCGTILEQVRKAAQALAKDFGISTDVFSVTSFNELARDGQAVERWNMLHPTKTAKVPYVSTVLA-KDAPAIVATD 805
Cdd:TIGR00759 723 HVQLLGSGAIMRAVIEAAQLLAADWGVASDVWSVTSFTELARDGHDVERWNLLHPTETPRVSYVAQVLNeADAPVIASTD 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 806 YMKIYGEQLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSLVDRNELPVDVLAKTIAEYGIDADKIDP 885
Cdd:TIGR00759 803 YVRAFAEQIRPYVPRKYVTLGTDGFGRSDTRENLRHFFEVDAKSVVLAALYALADDGEIDGDVVADAIAKYGIDPDKANP 882
|
...
gi 2178850460 886 QHA 888
Cdd:TIGR00759 883 VYR 885
|
|
| TPP_E1_EcPDC_like |
cd02017 |
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ... |
75-460 |
0e+00 |
|
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain] Cd Length: 386 Bit Score: 726.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 75 QEMERRIRAIVRWNALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLE 154
Cdd:cd02017 1 LEIERRIRSLIRWNAMAMVHRANKKDLGIGGHIATFASAATLYEVGFNHFFRARGEGGGGDLVYFQGHASPGIYARAFLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 155 GRLSEEQLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECD 234
Cdd:cd02017 81 GRLTEEQLDNFRQEVGGGGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFNRYLEDRGLKDTSDQKVWAFLGDGEMD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 235 EPEALGAIGLAAREELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLM 314
Cdd:cd02017 161 EPESLGAIGLAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSKWDELLAKDGGGALRQRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 315 NETVDGEYQNCKAKGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGY 394
Cdd:cd02017 241 EETVDGDYQTLKAKDGAYVREHFFGKYPELKALVTDLSDEDLWALNRGGHDPRKVYAAYKKAVEHKGKPTVILAKTIKGY 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2178850460 395 GLGDAGEGKNIAHNVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMG 460
Cdd:cd02017 321 GLGAAGEGRNHAHQVKKMTEDELKALRDRFGIPVSDEQLEEGPYYKPPEGSEEIKYLHERRHALGG 386
|
|
| PDH_E1_M |
pfam17831 |
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ... |
473-700 |
9.77e-121 |
|
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain] Cd Length: 229 Bit Score: 365.21 E-value: 9.77e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 473 MQVPSL--KIFDAVLKGSNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQD 550
Cdd:pfam17831 1 LEIPDLddKIFASQTGGSKGREISTTMAFVRILNGLVKDKKIGKQVVPIIPDEARTFGMEGMFRQLGIYTSEGQKYEPVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 551 ADQVAYYREDKSGQVLQEGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSG 630
Cdd:pfam17831 81 KGQIMFYREDKQGQILEEGISEAGAMSAWIAAATSYSNHNTTLLPFYVYYSMFGFQRIGDLAWAAGDMQARGFLVGGTAG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 631 RTTLNGEGLQHQDGHSHILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGeDQEDIFYYLTTMNENYVQP 700
Cdd:pfam17831 161 RTTLNGEGLQHQDGHSHIQASTIPNCRSYDPTYAHEVAVIVQDGLKRMFA-DKENCFYYLTVMNENYEHP 229
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AceE |
COG2609 |
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ... |
1-888 |
0e+00 |
|
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain] Cd Length: 891 Bit Score: 1951.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 1 MSEN----MLQDLDPLETQEWVESLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQE 76
Cdd:COG2609 1 MSMDglpsQLPDIDPQETQEWLESLDAVIEEEGPERARYLLERLLERARRSGVGLPFSATTPYINTIPVEQEPPYPGDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 77 MERRIRAIVRWNALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLEGR 156
Cdd:COG2609 81 LERRIRSIIRWNAMAMVVRANRKGGGLGGHISSFASAATLYEVGFNHFFRGPDHPGGGDLVYFQGHASPGIYARAFLEGR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 157 LSEEQLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEP 236
Cdd:COG2609 161 LTEEQLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLHNRGLKDTSDRKVWAFLGDGEMDEP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 237 EALGAIGLAAREELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLMNE 316
Cdd:COG2609 241 ESLGAISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAGWNVIKVIWGSEWDPLLAKDTDGALVKRMNE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 317 TVDGEYQNCKAKGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGL 396
Cdd:COG2609 321 TVDGDYQTYKAKDGAYVREHFFGKYPELKALVADMSDEDIWRLNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 397 GDAGEGKNIAHNVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMGYLPARRQKfSEEMQVP 476
Cdd:COG2609 401 GEAGEGRNITHQQKKLDLDDLKAFRDRFNIPISDEQLEELPYYKPAEDSPEMKYLHERRKALGGYLPQRRTK-AEPLEVP 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 477 SLKIFDAVLKGSNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDADQVAY 556
Cdd:COG2609 480 ELSAFAALLKGSGKREISTTMAFVRILNDLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPVGQLYTPVDADQLLY 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 557 YREDKSGQVLQEGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSGRTTLNG 636
Cdd:COG2609 560 YKESKDGQILQEGINEAGAMSSWIAAGTSYSTHGVPMIPFYIYYSMFGFQRVGDLAWAAGDQRARGFLIGATAGRTTLNG 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 637 EGLQHQDGHSHILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGEdQEDIFYYLTTMNENYVQPEMPQGVEEGIVKGIYK 716
Cdd:COG2609 640 EGLQHQDGHSHLLASTIPNCVSYDPAFAYELAVIVQDGLRRMYGE-QENVFYYITVMNENYAQPAMPEGVEEGILKGMYL 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 717 LESVAGSGKGKVQLMGCGTILEQVRKAAQALAKDFGISTDVFSVTSFNELARDGQAVERWNMLHPTKTAKVPYVSTVLAK 796
Cdd:COG2609 719 LKEGEGKGKPRVQLLGSGTILREVLAAAELLAEDWGVAADVWSVTSFNELRRDGLDVERWNLLHPEEEPRVPYVTQCLAG 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 797 -DAPAIVATDYMKIYGEQLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSLVDRNELPVDVLAKTIAE 875
Cdd:COG2609 799 aEGPVVAATDYMRAVPDQIRPWVPGRYTVLGTDGFGRSDTREALRRFFEVDRYSIVVAALKALADEGKIDASVVAEAIKK 878
|
890
....*....|...
gi 2178850460 876 YGIDADKIDPQHA 888
Cdd:COG2609 879 YGIDPDKPNPLTA 891
|
|
| aceE |
PRK09405 |
pyruvate dehydrogenase subunit E1; Reviewed |
1-888 |
0e+00 |
|
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain] Cd Length: 891 Bit Score: 1941.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 1 MSENMLQDLDPLETQEWVESLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERR 80
Cdd:PRK09405 4 GSESQLNDIDPIETQEWLEALDSVIREEGPERAHYLLEQLLERAREKGVSLPASATTPYINTIPVEEEPEYPGDLELERR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 81 IRAIVRWNALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLEGRLSEE 160
Cdd:PRK09405 84 IRSYIRWNAAAMVLRANKKDLGLGGHISSFASSATLYEVGFNHFFRAPNEPHGGDLVFFQGHASPGIYARAFLEGRLTEE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 161 QLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALG 240
Cdd:PRK09405 164 QLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFLKYLENRGLKDTSDQKVWAFLGDGEMDEPESLG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 241 AIGLAAREELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLMNETVDG 320
Cdd:PRK09405 244 AISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSRWDPLLAKDTSGKLVQLMNETVDG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 321 EYQNCKAKGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGLGDAG 400
Cdd:PRK09405 324 DYQTYKAKDGAYVREHFFGKYPETKALVADMSDDDIWALNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEAG 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 401 EGKNIAHNVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMGYLPARRQKFsEEMQVPSLKI 480
Cdd:PRK09405 404 EGKNIAHQVKKLDLDDLKHFRDRFNIPISDEQLEKLPYYKPGEDSPEIKYLHERRKALGGYLPARRPKF-EPLEVPALSA 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 481 FDAVLKGSNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDADQVAYYRED 560
Cdd:PRK09405 483 FEALLKGSGEREISTTMAFVRILNILLKDKEIGKRIVPIIPDEARTFGMEGLFRQIGIYNPHGQLYTPVDRDQLMYYKES 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 561 KSGQVLQEGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSGRTTLNGEGLQ 640
Cdd:PRK09405 563 KDGQILQEGINEAGAMASWIAAATSYSTHGEPMIPFYIYYSMFGFQRIGDLAWAAGDQRARGFLLGGTAGRTTLNGEGLQ 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 641 HQDGHSHILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGEdQEDIFYYLTTMNENYVQPEMPQGVEEGIVKGIYKLESV 720
Cdd:PRK09405 643 HEDGHSHILASTIPNCVSYDPAFAYEVAVIVQDGLRRMYGE-QENVFYYITVMNENYHQPAMPEGAEEGILKGMYKLETA 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 721 AGS-GKGKVQLMGCGTILEQVRKAAQALAKDFGISTDVFSVTSFNELARDGQAVERWNMLHPTKTAKVPYVSTVLAK-DA 798
Cdd:PRK09405 722 EGKkGKPKVQLLGSGTILREVLEAAEILAEDYGVAADVWSVTSFNELARDGQDVERWNMLHPTEEPRVPYVTQVLKGaEG 801
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 799 PAIVATDYMKIYGEQLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSLVDRNELPVDVLAKTIAEYGI 878
Cdd:PRK09405 802 PVVAATDYMKLFAEQIRAFVPGDYVVLGTDGFGRSDTREALRRFFEVDAEYVVVAALKALADEGEIDASVVAEAIKKYGI 881
|
890
....*....|
gi 2178850460 879 DADKIDPQHA 888
Cdd:PRK09405 882 DPDKANPRTA 891
|
|
| PRK13012 |
PRK13012 |
2-oxoacid dehydrogenase subunit E1; Provisional |
8-885 |
0e+00 |
|
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain] Cd Length: 896 Bit Score: 1568.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 8 DLDPLETQEWVESLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERRIRAIVRW 87
Cdd:PRK13012 19 DIDPQETAEWLEALDAVVAHAGPERARYLLDRLLERAAARGIALPGLLTTPYVNTIPVDQQPPYPGDLALEERLAAIIRW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 88 NALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLEGRLSEEQLANFRQ 167
Cdd:PRK13012 99 NALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRGRDDAGGGDLVYFQPHSAPGIYARAFLEGRLSEEQLDHFRQ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 168 EVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALGAIGLAAR 247
Cdd:PRK13012 179 EIGGPGLSSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQHRGLKDTSGRKVWGFFGDGEMDEPESIAALSLAAR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 248 EELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLMNETVDGEYQNCKA 327
Cdd:PRK13012 259 EGLDNLVFVINCNLQRLDGPVRGNGRIIQELEALFRGAGWNVIKVLWGSDWDALFARDTTGALVRRFAETVDGQFQTFKA 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 328 KGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGLGDAGEGKNIAH 407
Cdd:PRK13012 339 NDGAYNREHFFGQDPELAALVAHLSDEDIDRLKRGGHDPRKVYAAYAAAVRHKGQPTVILAKTKKGYGMGEAGEGRMTTH 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 408 NVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMGYLPARRQKfSEEMQVPSLKIFDAVLKG 487
Cdd:PRK13012 419 QQKKLDVEALKAFRDRFRLPLSDEQLEQLPFYKPAEDSPEMRYLHARRAALGGYLPRRRTA-APPLPVPPLSAFAQFALG 497
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 488 SNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDADQVAYYREDKSGQVLQ 567
Cdd:PRK13012 498 AGGKEMSTTMAFVRMLGNLLKDKALGPRIVPIVADEARTFGMANLFRQVGIYSPLGQLYEPEDAGSLLYYREAKDGQILE 577
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 568 EGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSGRTTLNGEGLQHQDGHSH 647
Cdd:PRK13012 578 EGITEAGAISSWIAAATSYSVHGLPMLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDGHSH 657
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 648 ILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGEdQEDIFYYLTTMNENYVQPEMPQGVEEGIVKGIYKLesVAGSGKGK 727
Cdd:PRK13012 658 LLASTIPNCRAYDPAFAYELAVIVDDGMRRMLEE-QEDVFYYLTVMNENYAQPALPEGAEEGILKGMYRL--AAAAEAPR 734
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 728 VQLMGCGTILEQVRKAAQALAKDFGISTDVFSVTSFNELARDGQAVERWNMLHPTKTAKVPYVSTVLA-KDAPAIVATDY 806
Cdd:PRK13012 735 VQLLGSGAILREVLAAARLLADDWGVDADVWSVTSFTELRRDGLAAERANLLGPAEEARVPYVTQCLAgTRGPVVAATDY 814
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2178850460 807 MKIYGEQLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSLVDRNELPVDVLAKTIAEYGIDADKIDP 885
Cdd:PRK13012 815 VRAVPEQIRAFVPARYVTLGTDGFGRSDTRAALRRFFEVDRHSIVLAALKALADDGEVERTVVAEAIERYGIDDDKTPP 893
|
|
| aceE |
TIGR00759 |
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ... |
8-888 |
0e+00 |
|
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain] Cd Length: 885 Bit Score: 1527.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 8 DLDPLETQEWVESLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERRIRAIVRW 87
Cdd:TIGR00759 5 DVDPIETQEWLESLDSVLAEEGPARARYLLEQLLEYAREHGVPIPAGTTTDYINTIPVEEQPAYPGDLELERRIRSIIRW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 88 NALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLEGRLSEEQLANFRQ 167
Cdd:TIGR00759 85 NAIAMVLRANKKDLGLGGHISTYASAATLYEVGFNHFFRGHSEGGGGDLVFFQGHAAPGIYARAFLEGRLTEEQLDNFRQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 168 EVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALGAIGLAAR 247
Cdd:TIGR00759 165 EVQGDGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLENRGLKDTGDQKVWAFLGDGEMDEPESKGAITFAAR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 248 EELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLMNETVDGEYQNCKA 327
Cdd:TIGR00759 245 EKLDNLTFVINCNLQRLDGPVRGNGKIIQELESLFRGAGWNVIKVLWGSEWDALLARDTSGVLVKLMNETVDGDYQTYKA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 328 KGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGLGDAGEGKNIAH 407
Cdd:TIGR00759 325 KDGAYVREHFFNRTPELKALVADMSDADIWALNRGGHDPRKVYAAYAAAQEHKGQPTVILAKTIKGYGMGDAAESRNTAH 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 408 NVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMGYLPARRQKFsEEMQVPSLKIFDAVLKG 487
Cdd:TIGR00759 405 QVKKLEVDALKNFRDRFELPLSDAQVEELPYYHPGEGSPEVRYLLARRQALGGYLPARRTFA-EHLTVPALEFFGALLKG 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 488 SNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDADQVAYYREDKSGQVLQ 567
Cdd:TIGR00759 484 SGEREVSTTMAFVRILNKLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPHGQTYTPVDADSLLAYKESKDGQILQ 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 568 EGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSGRTTLNGEGLQHQDGHSH 647
Cdd:TIGR00759 564 EGINEAGAMASWIAAATSYATHGEPMIPFYIYYSMFGFQRIGDLCWAAADQRARGFLLGATAGRTTLNGEGLQHEDGHSL 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 648 ILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGEdQEDIFYYLTTMNENYVQPEMPQGVEEGIVKGIYKLESVAG-SGKG 726
Cdd:TIGR00759 644 LQAATIPNCIAYDPAFAYEVAVIMEDGLRRMYGE-QEDVFYYVTVMNENYVQPPMPEGAEEGILKGLYRFETSTEeKAKG 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 727 KVQLMGCGTILEQVRKAAQALAKDFGISTDVFSVTSFNELARDGQAVERWNMLHPTKTAKVPYVSTVLA-KDAPAIVATD 805
Cdd:TIGR00759 723 HVQLLGSGAIMRAVIEAAQLLAADWGVASDVWSVTSFTELARDGHDVERWNLLHPTETPRVSYVAQVLNeADAPVIASTD 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 806 YMKIYGEQLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSLVDRNELPVDVLAKTIAEYGIDADKIDP 885
Cdd:TIGR00759 803 YVRAFAEQIRPYVPRKYVTLGTDGFGRSDTRENLRHFFEVDAKSVVLAALYALADDGEIDGDVVADAIAKYGIDPDKANP 882
|
...
gi 2178850460 886 QHA 888
Cdd:TIGR00759 883 VYR 885
|
|
| AKGDH_not_PDH |
TIGR03186 |
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ... |
8-880 |
0e+00 |
|
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain] Cd Length: 889 Bit Score: 1164.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 8 DLDPLETQEWVESLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERRIRAIVRW 87
Cdd:TIGR03186 5 DTDPQETAEWLDALDGVVAHAGAERAQYLLAQLAAHAARLGLAPPAAGATPYVNTIAVDQEPPYPGDLQLEERLAAILRW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 88 NALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLEGRLSEEQLANFRQ 167
Cdd:TIGR03186 85 NALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRAAGDASGGDLVYFQPHSAPGVYARAFLEGFLSDAQLAHYRQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 168 EVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALGAIGLAAR 247
Cdd:TIGR03186 165 EIAGPGLCSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQNRGLARTEGRKVWGFFGDGEMDEPESIGALSLAAR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 248 EELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLMNETVDGEYQNCKA 327
Cdd:TIGR03186 245 ERLDNLVFVINCNLQRLDGPVRGNGRIIDELESQFAGAGWNVIKVLWGSDWDALFARDATGALARAFAHTVDGQFQTFSA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 328 KGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGLGDAGEGKNIAH 407
Cdd:TIGR03186 325 NDGAYNRARFFGQDPALAALVAHLSDEDIDRLRRGGHDARKLYAAYDRAVRHEGRPTVILAKTMKGFGMGAIGQGRMTTH 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 408 NVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMGYLPARRQKFSEEMQVPSLKIFDAVLKG 487
Cdd:TIGR03186 405 QQKKLDVEALLAFRDRFRLPLSDADVEQLKFYKPDEDSAEMRYLHARRAALGGYLPRRRTAATHALAVPALPSWGRFALD 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 488 SNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDADQVAYYREDKSGQVLQ 567
Cdd:TIGR03186 485 AEGKEMSTTMAIVRMLGALLKDAELGPRIVPIVADEARTFGMANLFRQVGIYSPLGQRYEPEDLGSMLYYREDTDGQILE 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 568 EGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSGRTTLNGEGLQHQDGHSH 647
Cdd:TIGR03186 565 EGISEAGAISSWIAAATSYSVHDLPMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGKTTLGGEGLQHQDGTSH 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 648 ILANTIPNCISYDPTYGYEIAVIVQDGIRRMYgEDQEDIFYYLTTMNENYVQPEMPQG----VEEGIVKGIYKLESVAgS 723
Cdd:TIGR03186 645 LAASTVPNCRAWDPAFAYEVAVIVDEGMREML-ERQRDEFYYLTVTNENYAQPSLPEDrldaVRRGILKGMYPLDPAA-L 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 724 GKGKVQLMGCGTILEQVRKAAQALAKDFGISTDVFSVTSFNELARDGQAVERWNMLHPTKTAKVPYVSTVL-AKDAPAIV 802
Cdd:TIGR03186 723 AAARVQLLGSGAILGEVQAAARLLRDDWGIDAAVWSVTSFTELARDGRAAERAQRLGDAERPPSPHVAQALgATQGPVIA 802
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2178850460 803 ATDYMKIYGEQLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSLVDRNELPVDVLAKTIAEYGIDA 880
Cdd:TIGR03186 803 ATDYVRAVPELIRAYVPRRYVTLGTDGFGRSDTRAALRAFFEVDRASIVIAALQALADDGLVARDVVRQAIARYGKAA 880
|
|
| TPP_E1_EcPDC_like |
cd02017 |
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ... |
75-460 |
0e+00 |
|
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain] Cd Length: 386 Bit Score: 726.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 75 QEMERRIRAIVRWNALAMVLRGSKKDLELGGHISSFSSSATIYDVCFNHFFRAPNDKDGGDLVYFQGHIAPGIYARSFLE 154
Cdd:cd02017 1 LEIERRIRSLIRWNAMAMVHRANKKDLGIGGHIATFASAATLYEVGFNHFFRARGEGGGGDLVYFQGHASPGIYARAFLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 155 GRLSEEQLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECD 234
Cdd:cd02017 81 GRLTEEQLDNFRQEVGGGGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFNRYLEDRGLKDTSDQKVWAFLGDGEMD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 235 EPEALGAIGLAAREELDNLVFIVNCNLQRLDGPVRGNGQIIQELEGEFRGAGWEVVKVIWGRYWDPLLASDTSGKLLQLM 314
Cdd:cd02017 161 EPESLGAIGLAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSKWDELLAKDGGGALRQRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 315 NETVDGEYQNCKAKGGAWTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGY 394
Cdd:cd02017 241 EETVDGDYQTLKAKDGAYVREHFFGKYPELKALVTDLSDEDLWALNRGGHDPRKVYAAYKKAVEHKGKPTVILAKTIKGY 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2178850460 395 GLGDAGEGKNIAHNVKKMDIEAIRHFRDRFNIPIPDDKLDEIPFYHPGPDSEEVKYLKERREALMG 460
Cdd:cd02017 321 GLGAAGEGRNHAHQVKKMTEDELKALRDRFGIPVSDEQLEEGPYYKPPEGSEEIKYLHERRHALGG 386
|
|
| PDH_E1_M |
pfam17831 |
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ... |
473-700 |
9.77e-121 |
|
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain] Cd Length: 229 Bit Score: 365.21 E-value: 9.77e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 473 MQVPSL--KIFDAVLKGSNGREISSTMAFVRVLTALLKDKGIGKKIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQD 550
Cdd:pfam17831 1 LEIPDLddKIFASQTGGSKGREISTTMAFVRILNGLVKDKKIGKQVVPIIPDEARTFGMEGMFRQLGIYTSEGQKYEPVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 551 ADQVAYYREDKSGQVLQEGINELGAMSSWVSAATSYSVNDTPMIPFYIYYSMFGFQRIGDLAWAAGDMRARGFLVGGTSG 630
Cdd:pfam17831 81 KGQIMFYREDKQGQILEEGISEAGAMSAWIAAATSYSNHNTTLLPFYVYYSMFGFQRIGDLAWAAGDMQARGFLVGGTAG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 631 RTTLNGEGLQHQDGHSHILANTIPNCISYDPTYGYEIAVIVQDGIRRMYGeDQEDIFYYLTTMNENYVQP 700
Cdd:pfam17831 161 RTTLNGEGLQHQDGHSHIQASTIPNCRSYDPTYAHEVAVIVQDGLKRMFA-DKENCFYYLTVMNENYEHP 229
|
|
| TPP_TK |
cd02012 |
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ... |
85-407 |
3.57e-27 |
|
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain] Cd Length: 255 Bit Score: 111.44 E-value: 3.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 85 VRWNALAMVLRGSkkdlelGGHISSFSSSATIYDVCFNHFFR-APNDKDGGDLVYF---QGHIAPGIYARSFLEGRLSEE 160
Cdd:cd02012 3 IRRLSIDMVQKAG------SGHPGGSLSAADILAVLYFKVLKyDPADPKWPNRDRFvlsKGHASPALYAVLALAGYLPEE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 161 QLANFRQevDGKGLSSYPHPKLMPdywqFPTVSMG-LGpiQAI-------YQARFLKyltdrgikdcSEQTVYCFLGDGE 232
Cdd:cd02012 77 DLKTFRQ--LGSRLPGHPEYGLTP----GVEVTTGsLG--QGLsvavgmaLAEKLLG----------FDYRVYVLLGDGE 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 233 CDEPEALGAIGLAAREELDNLVFIVNCNLQRLDGPVRGNGQiIQELEGEFRGAGWEVVKVIwgrywdpllasdtsgkllq 312
Cdd:cd02012 139 LQEGSVWEAASFAGHYKLDNLIAIVDSNRIQIDGPTDDILF-TEDLAKKFEAFGWNVIEVD------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 313 lmnetvdgeyqnckakggawtrehffgkypetaemvanmsdddiwrlnrgGHDPVKIYAALDRAKKTKGRPTVILAKTVK 392
Cdd:cd02012 199 --------------------------------------------------GHDVEEILAALEEAKKSKGKPTLIIAKTIK 228
|
330
....*....|....*
gi 2178850460 393 GYGLGDAgEGKNIAH 407
Cdd:cd02012 229 GKGVPFM-ENTAKWH 242
|
|
| PRK05899 |
PRK05899 |
transketolase; Reviewed |
71-858 |
2.04e-23 |
|
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain] Cd Length: 586 Bit Score: 105.60 E-value: 2.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 71 MPGNQEMERRIRAIVRWNALAMVLR-GSkkdlelgGHISSFSSSATIYDVCFNHFFR----APNDKDGGDLVYFQGHIAP 145
Cdd:PRK05899 1 SMMDMELLQLLANAIRVLSIDAVQKaNS-------GHPGMPMGAADIAYVLWTRFLRhdpkNPKWPNRDRFVLSAGHGSM 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 146 GIYARSFLEG-RLSEEQLANFRQevdgkgLSS-YP-HPklmpDYWQFPTVSMGLGPI-QAI-------YQARFLKYLTDR 214
Cdd:PRK05899 74 LLYSLLHLAGyDLSIDDLKNFRQ------LGSkTPgHP----EYGHTPGVETTTGPLgQGLanavgmaLAEKYLAALFNR 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 215 GIKDCSEQTVYCFLGDGECDEpealG----AIGLAAREELDNLVFIVNCN-LQrLDGPVRgnGQIIQELEGEFRGAGWEV 289
Cdd:PRK05899 144 PGLDIVDHYTYVLCGDGDLME----GisheACSLAGHLKLGNLIVIYDDNrIS-IDGPTE--GWFTEDVKKRFEAYGWHV 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 290 VKViwgrywDpllasdtsgkllqlmnetvdgeyqnckakggawtrehffgkypetaemvanmsdddiwrlnrgGHDPVKI 369
Cdd:PRK05899 217 IEV------D---------------------------------------------------------------GHDVEAI 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 370 YAALDRAKKTKgRPTVILAKTVKGYGlgdagegkniAHNvkKMDIEAirhfrdrfnipipddkldeipfYHPGP-DSEEV 448
Cdd:PRK05899 228 DAAIEEAKAST-KPTLIIAKTIIGKG----------APN--KEGTHK----------------------VHGAPlGAEEI 272
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 449 KYLKE-----RREALMGYLparrQKFSEEMqvPSLKIFDAVLKGSNGREISSTMAFVrvltallkdkgigkkivpiipde 523
Cdd:PRK05899 273 AAAKKelgwdYRKASGKAL----NALAKAL--PELVGGSADLAGSNNTKIKGSKDFA----------------------- 323
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 524 artfgmeglfrqvgiyahegqkyvpqdadqvayyREDKSGQVLQEGINELGAmsswVSAATSYSVNDtPMIPF------- 596
Cdd:PRK05899 324 ----------------------------------PEDYSGRYIHYGVREFAM----AAIANGLALHG-GFIPFggtflvf 364
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 597 --YiyysMFGFQRIGDLawaagdMRARGFLVGgtsgrtTLNGEGLQhQDGHSHI----LAN--TIPNCISYDPTYGYEIA 668
Cdd:PRK05899 365 sdY----ARNAIRLAAL------MKLPVIYVF------THDSIGVG-EDGPTHQpveqLASlrAIPNLTVIRPADANETA 427
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 669 VIVQDGIRRMYGEdqedIFYYLTtmNENY-VQPEMPQgvEEGIVKGIYKLESvagsgKGKVQLMGCGTILEQVRKAAQAL 747
Cdd:PRK05899 428 AAWKYALERKDGP----SALVLT--RQNLpVLERTAQ--EEGVAKGGYVLRD-----DPDVILIATGSEVHLALEAADEL 494
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 748 AKDfGISTDVFSVTSFNELARDGQAverwnmlhptktakvpYVSTVLAKDAPAIVA-----TDYmkiygeqLRAYVPCDY 822
Cdd:PRK05899 495 EAE-GIKVRVVSMPSTELFDEQDAA----------------YKESVLPAAVTARVAveagvADG-------WYKYVGLDG 550
|
810 820 830
....*....|....*....|....*....|....*.
gi 2178850460 823 KVLGTDGFGRSDSRANLRHHFEVDAKFIVVAALKSL 858
Cdd:PRK05899 551 KVLGIDTFGASAPADELFKEFGFTVENIVAAAKELL 586
|
|
| Transketolase_N |
pfam00456 |
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ... |
104-407 |
7.12e-11 |
|
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain] Cd Length: 334 Bit Score: 64.72 E-value: 7.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 104 GGHISSFSSSATIYDVCFNHFFR-APNDKDGGD---LVYFQGHIAPGIYARSFLEG-RLSEEQLANFRQevdgKGLSSYP 178
Cdd:pfam00456 22 SGHPGAPMGMAPIAEVLFKRFLKhNPNDPKWINrdrFVLSNGHGSMLLYSLLHLTGyDLSMEDLKSFRQ----LGSKTPG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 179 HPklmpDYWQFPTVSMGLGPI-QAIYQA-------RFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALGAIGLAAREEL 250
Cdd:pfam00456 98 HP----EFGHTAGVEVTTGPLgQGIANAvgmaiaeRNLAATYNRPGFDIVDHYTYVFLGDGCLMEGVSSEASSLAGHLGL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 251 DNLVFIVNCNLQRLDGPVrgNGQIIQELEGEFRGAGWEVVKVIwgrywdpllasdtsgkllqlmnetvdgeyqnckakgg 330
Cdd:pfam00456 174 GNLIVFYDDNQISIDGET--KISFTEDTAARFEAYGWHVIEVE------------------------------------- 214
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2178850460 331 awtrehffgkypetaemvanmsdddiwrlnrGGHDPVKIYAALDRAKKTKGRPTVILAKTVKGYGlGDAGEGKNIAH 407
Cdd:pfam00456 215 -------------------------------DGHDVEAIAAAIEEAKAEKDKPTLIKCRTVIGYG-SPNKQGTHDVH 259
|
|
| TktA |
COG0021 |
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ... |
224-407 |
5.95e-07 |
|
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 439792 [Multi-domain] Cd Length: 661 Bit Score: 53.09 E-value: 5.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 224 VYCFLGDGECDEPEALGAIGLAAREELDNLVFIVNCNLQRLDGPVrgNGQIIQELEGEFRGAGWEVVKVIWGrywdplla 303
Cdd:COG0021 149 TYVIAGDGDLMEGISHEAASLAGHLKLGKLIVLYDDNGISIDGDT--DLAFSEDVAKRFEAYGWHVIRVEDG-------- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 304 sdtsgkllqlmnetvdgeyqnckakggawtrehffgkypetaemvanmsdddiwrlnrggHDPVKIYAALDRAKKTKGRP 383
Cdd:COG0021 219 ------------------------------------------------------------HDLEAIDAAIEAAKAETDKP 238
|
170 180
....*....|....*....|....
gi 2178850460 384 TVILAKTVKGYGLGDAgEGKNIAH 407
Cdd:COG0021 239 TLIICKTIIGYGSPNK-QGTAKAH 261
|
|
| PTZ00089 |
PTZ00089 |
transketolase; Provisional |
141-457 |
9.77e-05 |
|
transketolase; Provisional
Pssm-ID: 173383 [Multi-domain] Cd Length: 661 Bit Score: 46.21 E-value: 9.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 141 GHIAPGIYARSFLEGR-LSEEQLANFRQEVdgkglSSYP-HPKlmpdYWQFPTVSMGLGPI-QAIYQARFL----KYLTD 213
Cdd:PTZ00089 67 GHASALLYSMLHLTGYdLSMEDLKNFRQLG-----SRTPgHPE----RHITPGVEVTTGPLgQGIANAVGLaiaeKHLAA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 214 R------GIKDcseQTVYCFLGDGECDEPEALGAIGLAAREELDNLVFIVNCNLQRLDGPVrgNGQIIQELEGEFRGAGW 287
Cdd:PTZ00089 138 KfnrpghPIFD---NYVYVICGDGCLQEGVSQEALSLAGHLGLEKLIVLYDDNKITIDGNT--DLSFTEDVEKKYEAYGW 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 288 EVVKViwgrywdpllasdtsgkllqlmnetvdgeyqnckakggawtrehffgkypetaemvanmsdddiwrlNRGGHDPV 367
Cdd:PTZ00089 213 HVIEV-------------------------------------------------------------------DNGNTDFD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 368 KIYAALDRAKKTKGRPTVILAKTVKGYGLGDAGEGKniAHNVKKMDiEAIRHFRDRFNIPiPDDKldeipfYHPgpdSEE 447
Cdd:PTZ00089 226 GLRKAIEEAKKSKGKPKLIIVKTTIGYGSSKAGTEK--VHGAPLGD-EDIAQVKELFGLD-PEKK------FHV---SEE 292
|
330
....*....|
gi 2178850460 448 VKYLKERREA 457
Cdd:PTZ00089 293 VRQFFEQHVE 302
|
|
| PLN02790 |
PLN02790 |
transketolase |
708-859 |
3.32e-03 |
|
transketolase
Pssm-ID: 215424 [Multi-domain] Cd Length: 654 Bit Score: 41.16 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 708 EGIVKGIYKLESVAGSGKGKVQLMGCGTILEQVRKAAQALAKDfGISTDVFSVTSFnELArDGQAVErwnmlhptktakv 787
Cdd:PLN02790 523 EGVEKGGYVISDNSSGNKPDLILIGTGSELEIAAKAAKELRKE-GKKVRVVSMVCW-ELF-EEQSDE------------- 586
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2178850460 788 pYVSTVLAKDAPAIVATDYMKIYGeqLRAYVPCDYKVLGTDGFGRSDSRANLRHHFEVDAKfIVVAALKSLV 859
Cdd:PLN02790 587 -YKESVLPSSVTARVSVEAGSTFG--WEKYVGSKGKVIGVDRFGASAPAGILYKEFGFTVE-NVVAAAKSLL 654
|
|
| TMP_3 |
pfam20155 |
Tape measure protein; This entry represents phage tape measure proteins that are required to ... |
724-771 |
6.00e-03 |
|
Tape measure protein; This entry represents phage tape measure proteins that are required to assemble the page tail. The protein serves as a base for tail tube protein polymerization and acts as a template for tail length determination.
Pssm-ID: 466312 [Multi-domain] Cd Length: 192 Bit Score: 38.74 E-value: 6.00e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2178850460 724 GKGKVQLMGCGTILEQVRKAAQALAKDFGISTDvfsvtSFNELARDGQ 771
Cdd:pfam20155 102 ASGKLRGEEFNSVLEQAPGLLQALAKGLGVSTG-----ELRKMASDGK 144
|
|
| TPP_enzymes |
cd00568 |
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ... |
177-303 |
9.24e-03 |
|
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain] Cd Length: 168 Bit Score: 38.01 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178850460 177 YPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKyltdrgikdcsEQTVYCFLGDGECDepEALGAIGLAAREELdNLVFI 256
Cdd:cd00568 31 LPLRRGRRFLTSTGFGAMGYGLPAAIGAALAAP-----------DRPVVCIAGDGGFM--MTGQELATAVRYGL-PVIVV 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2178850460 257 VNCN--------LQRLDGPVRGNGQIIQE--LEGEFRGAGWEVVKVIWGRYWDPLLA 303
Cdd:cd00568 97 VFNNggygtirmHQEAFYGGRVSGTDLSNpdFAALAEAYGAKGVRVEDPEDLEAALA 153
|
|
| |
