NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2161487207|ref|WP_231208520|]
View 

Ig-like domain-containing protein, partial [Escherichia coli]

Protein Classification

Ig-like domain-containing protein( domain architecture ID 1750458)

bacterial immunoglobulin (Ig)-like domain-containing protein frequently found in cell surface proteins and may play a vital role in host-pathogen interactions

PubMed:  34986320|33355339|7932691|22724448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Big_13 super family cl40590
Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in ...
 31-104 3.21e-04

Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in bacterial cell surface proteins.


The actual alignment was detected with superfamily member pfam19077:

Pssm-ID: 465968 [Multi-domain]  Cd Length: 102  Bit Score: 38.40  E-value: 3.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2161487207  31 AGDTLTLTVTKPDGTTdtvehTLTADEVAAGKADVTIPADkvTADGQYSVTAEITDPAGNTSgQGQPADFAVDT 104
Cdd:pfam19077  37 DGDVVTVTVSIDGNGV-----TGTATAGADGNWSFTPPAA--LADGTYTLTVTVTDIAGNTA-TSSPLSFTIDT 102
 
Name Accession Description Interval E-value
Big_13 pfam19077
Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in ...
 31-104 3.21e-04

Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in bacterial cell surface proteins.


Pssm-ID: 465968 [Multi-domain]  Cd Length: 102  Bit Score: 38.40  E-value: 3.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2161487207  31 AGDTLTLTVTKPDGTTdtvehTLTADEVAAGKADVTIPADkvTADGQYSVTAEITDPAGNTSgQGQPADFAVDT 104
Cdd:pfam19077  37 DGDVVTVTVSIDGNGV-----TGTATAGADGNWSFTPPAA--LADGTYTLTVTVTDIAGNTA-TSSPLSFTIDT 102
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 27-123 7.56e-04

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 39.68  E-value: 7.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161487207   27 KGSAAGDTLTLTVTKPDGTTDTvEHTLTADEVAAGKADVTIPADKVTadGQYSVTAEITDPAGNTSGQGQ-----PADFA 101
Cdd:COG2373    397 GKAPAGLPLTLELTDPDGKEVR-RQTLTLNEFGGYSFSFPLPEDAPT--GTWRLELYVDPKPALGSKSFRveefkPPRFK 473

                           90       100
                   ....*....|....*....|..
gi 2161487207  102 VDtVAPSAPVLKAEDDGSVSVE 123
Cdd:COG2373    474 VD-LTLDKEPLKPGDPVTVTVD 494
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 30-154 3.64e-03

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 37.71  E-value: 3.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161487207   30 AAGDTLTLTVTKPDGTTDTVEHTLTAdevaagKADVTIPAdkVTADGQYSVTAEITDpaGNTSGqgqPADFAVdTV--AP 107
Cdd:NF038112  1308 ADGDALTYAWTQTSGPAVTLTGATTA------TATFTAPE--VTADTQLTFTLTVSD--GTASA---TDTVTV-TVrnVN 1373

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2161487207  108 SAPVLKAEDDGSV----SVELPGDANKGDTVDVTFEDEKGGKHTVTLEKGD 154
Cdd:NF038112  1374 RAPVANAGADQTVdersTVTLSGSATDPDGDALTYAWTQTAGPTVTLTGAD 1424
 
Name Accession Description Interval E-value
Big_13 pfam19077
Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in ...
 31-104 3.21e-04

Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in bacterial cell surface proteins.


Pssm-ID: 465968 [Multi-domain]  Cd Length: 102  Bit Score: 38.40  E-value: 3.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2161487207  31 AGDTLTLTVTKPDGTTdtvehTLTADEVAAGKADVTIPADkvTADGQYSVTAEITDPAGNTSgQGQPADFAVDT 104
Cdd:pfam19077  37 DGDVVTVTVSIDGNGV-----TGTATAGADGNWSFTPPAA--LADGTYTLTVTVTDIAGNTA-TSSPLSFTIDT 102
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 27-123 7.56e-04

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 39.68  E-value: 7.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161487207   27 KGSAAGDTLTLTVTKPDGTTDTvEHTLTADEVAAGKADVTIPADKVTadGQYSVTAEITDPAGNTSGQGQ-----PADFA 101
Cdd:COG2373    397 GKAPAGLPLTLELTDPDGKEVR-RQTLTLNEFGGYSFSFPLPEDAPT--GTWRLELYVDPKPALGSKSFRveefkPPRFK 473

                           90       100
                   ....*....|....*....|..
gi 2161487207  102 VDtVAPSAPVLKAEDDGSVSVE 123
Cdd:COG2373    474 VD-LTLDKEPLKPGDPVTVTVD 494
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 30-154 3.64e-03

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 37.71  E-value: 3.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161487207   30 AAGDTLTLTVTKPDGTTDTVEHTLTAdevaagKADVTIPAdkVTADGQYSVTAEITDpaGNTSGqgqPADFAVdTV--AP 107
Cdd:NF038112  1308 ADGDALTYAWTQTSGPAVTLTGATTA------TATFTAPE--VTADTQLTFTLTVSD--GTASA---TDTVTV-TVrnVN 1373

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2161487207  108 SAPVLKAEDDGSV----SVELPGDANKGDTVDVTFEDEKGGKHTVTLEKGD 154
Cdd:NF038112  1374 RAPVANAGADQTVdersTVTLSGSATDPDGDALTYAWTQTAGPTVTLTGAD 1424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH